Estrogen modulates abdominal adiposity and protects female mice from obesity and impaired glucose tolerance

European Journal of Nutrition

Volumn 51, Issue 7, 2012, Pages 861-870

  Stubbins, Renee E ^a   Holcomb, Valerie B ^a   Hong, Jina ^a   Núñez, Nomelí P ^a  

^a The University of Texas at Austin   (United States)

Author keywords

Calorie restriction; Diet; Obesity; Ovariectomy; Sex

Indexed keywords

ESTRADIOL; ESTROGEN; HORMONE SENSITIVE LIPASE; LEPTIN; MESSENGER RNA; PLACEBO;

ABDOMINAL FAT; ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; CALORIC INTAKE; CALORIC RESTRICTION; CELL SIZE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; IMPAIRED GLUCOSE TOLERANCE; LIPID DIET; LIPOGENESIS; LIPOLYSIS; MALE; MOUSE; NONHUMAN; OBESITY; OVARIECTOMY; SEX DIFFERENCE; WEIGHT GAIN;

ABDOMINAL FAT; ADIPOGENESIS; ADIPOSITY; ANIMALS; BODY COMPOSITION; CALORIC RESTRICTION; DIET, FAT-RESTRICTED; DIET, HIGH-FAT; DIETARY SUPPLEMENTS; ESTRADIOL; ESTROGENS; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE INTOLERANCE; INSULIN; LEPTIN; LIPOGENESIS; LIPOLYSIS; MALE; MICE; MICE, INBRED C57BL; OBESITY; OVARIECTOMY; RESISTIN; SEX FACTORS; STEROL ESTERASE;

MUS;

EID: 84870255429     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-011-0266-4     Document Type: Article

References (39)

1. Flegal K, Carroll M, Ogden C, Johnson C (2002) Prevalence and trends in obesity among US adults, 1999-2000. JAMA 288:1723-1727
2. Hong J, Stubbins R, Smith R, Harvey A, Núñez N (2009) Differential susceptibility to obesity between male, female and ovariectomized female mice. Nutr J 8:11-16
3. Cooke PS, Naaz A (2004) Role of estrogens in adipocyte development and function. Exp Biol Med (Maywood) 229:1127-1135 (Pubitemid 39602255)
4. Wade GN, Gray JM, Bartness TJ (1985) Gonadal influences on adiposity. Int J Obes 9 Suppl 1:83-92 (Pubitemid 16173371)
5. Meli R, Pacilio M, Raso GM, Esposito E, Coppola A, Nasti A, Di Carlo C, Nappi C, Di Carlo R (2004) Estrogen and raloxifene modulate leptin and its receptor in hypothalamus and adipose tissue from ovariectomized rats. Endocrinology 145:3115-3121 (Pubitemid 38829980)
6. Jones M, Thorburn A, Britt K, Hewitt K, Wreford N, Proietto J, Oz O, Leury B, Robertson K, Yao S, Simpson E (2000) Aromatase- deficient (ArKO) mice have a phenotype of increased adiposity. Proc Natl Acad Sci USA 97:12735-12740
7. Hao L, Wang Y, Duan Y, Bu S (2010) Effects of treadmill exercise training on liver fat accumulation and estrogen receptor alpha expression in intact and ovariectomized rats with or without estrogen replacement treatment. Eur J Appl Physiol 109:879-886
8. Heine P, Taylor J, Iwamoto G, Lubahn D, Cooke P (2000) Increased adipose tissue in male and female estrogen receptoralpha knockout mice. Proc Natl Acad Sci USA 97:12729-12734
9. Brown LM, Clegg DJ (2010) Central effects of estradiol in the regulation of food intake, body weight, and adiposity. J Steroid Biochem Mol Biol 122:65-73
10. Eckel LA (2011) The ovarian hormone estradiol plays a crucial role in the control of food intake in females. Physiol Behav 104:517-524
11. Musatov S, Chen W, Pfaff D, Mobbs C, Yang X, Clegg D, Kaplitt M, Ogawa S (2007) Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Proc Natl Acad Sci USA 104:2501-2506 (Pubitemid 46391425)
12. Homma H, Kurachi H, Nishio Y, Takeda T, Yamamoto T, Adachi K, Morishige K, Ohmichi M, Matsuzawa Y, Murata Y (2000) Estrogen suppresses transcription of lipoprotein lipase gene. Existence of a unique estrogen response element on the lipoprotein lipase promoter. J Biol Chem 275:11404-11411
13. D'Eon T, Souza S, Aronovitz M, Obin M, Fried S, Greenberg A (2005) Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways. J Biol Chem 280:35983-35991
14. Wu Z, Xie Y, Bucher NL, Farmer SR (1995) Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. Genes Dev 9:2350-2363
15. Phan J, Peterfy M, Reue K (2005) Biphasic expression of lipin suggests dual roles in adipocyte development. Drug News Perspect 18:5-11 (Pubitemid 40543257)
16. Tontonoz P, Hu E, Spiegelman BM (1994) Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 79:1147-1156
17. Yakar S, Nunez N, Pennisi P, Brodt P, Sun H, Fallavollita L, Zhao H, Scavo L, Novosyadlyy R, Kurshan N, Stannard B, East- Palmer J, Smith N, Perkins S, Fuchs-Young R, Barrett J, Hursting S, LeRoith D (2006) Increased tumor growth in mice with dietinduced obesity: impact of ovarian hormones. Endocrinology 147:5826-5834 (Pubitemid 44833499)
18. Giovannucci E, Ascherio A, Rimm E, Colditz G, Stampfer M, Willett W (1995) Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Intern Med 122:327-334
19. Macotela Y, Boucher J, Tran TT, Kahn CR (2009) Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism. Diabetes 58:803-812
20. Núñez N, Carpenter C, Perkins S, Berrigan D, Jaque S, Ingles S, Bernstein L, Forman M, Barrett J, Hursting S (2007) Extreme obesity reduces bone mineral density: complementary evidence from mice and women. Obesity (Silver Spring) 15:1980-1987 (Pubitemid 47402230)
21. Karas RH, Schulten H, Pare G, Aronovitz MJ, Ohlsson C, Gustafsson JA, Mendelsohn ME (2001) Effects of estrogen on the vascular injury response in estrogen receptor alpha, beta (double) knockout mice. Circ Res 89:534-539 (Pubitemid 34133991)
22. Jo J, Gavrilova O, Pack S, Jou W, Mullen S, Sumner A, Cushman S, Periwal V (2009) Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth. PLoS Comput Biol 5:e1000324
23. Hinz S, Rais-Bahrami S, Kempkensteffen C, Weiske W, Miller K, Magheli A (2010) Effect of obesity on sex hormone levels, antisperm antibodies, and fertility after vasectomy reversal. Urology 76:851-856
24. Oh J, Barrett-Connor E, Wedick N, Wingard D, Study RB (2002) Endogenous sex hormones and the development of type 2 diabetes in older men and women: the Rancho Bernardo study. Diabetes Care 25:55-60 (Pubitemid 41070783)
25. de Ferranti S, Mozaffarian D (2008) The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem 54:945-955 (Pubitemid 351793400)
26. Imbeault P, Lemieux S, Prud'homme D, Tremblay A, Nadeau A, Després J, Mauriège P (1999) Relationship of visceral adipose tissue to metabolic risk factors for coronary heart disease: is there a contribution of subcutaneous fat cell hypertrophy? Metabolism 48:355-362 (Pubitemid 29115999)
27. Roberts R, Hodson L, Dennis A, Neville M, Humphreys S, Harnden K, Micklem K, Frayn K (2009) Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans. Diabetologia 52:882-890
28. Fenton J, Nuñez N, Yakar S, Perkins S, Hord N, Hursting SD (2009) Diet-induced adiposity alters the serum profile of inflammation in C57BL/6 N mice as measured by antibody array. Diabetes Obes Metab 11:343-354
29. Frederich R, Hamann A, Anderson S, Löllmann B, Lowell B, Flier J (1995) Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1:1311-1314
30. Dandona P, Mohanty P, Ghanim H, Aljada A, Browne R, Hamouda W, Prabhala A, Afzal A, Garg R (2001) The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. J Clin Endocrinol Metab 86:355-362 (Pubitemid 32109818)
31. Lundholm L, Zang H, Hirschberg A, Gustafsson J, Arner P, Dahlman-Wright K (2008) Key lipogenic gene expression can be decreased by estrogen in human adipose tissue. Fertil Steril 90:44-48
32. Hewitt K, Pratis K, Jones M, Simpson E (2004) Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse. Endocrinology 145:1842-1848 (Pubitemid 38402393)
33. Abraham S, Hillyard L, Hansen F, Lin C (1980) Tissue specificity for the effect of estrogen on lipogenic activity in male and female rats. Biochim Biophys Acta 620:167-171 (Pubitemid 11254890)
34. Hu E, Tontonoz P, Spiegelman BM (1995) Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha. Proc Natl Acad Sci USA 92:9856-9860
35. Koh YK, Lee MY, Kim JW, Kim M, Moon JS, Lee YJ, Ahn YH, Kim KS (2008) Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2. J Biol Chem 283:34896-34906
36. Yepuru M, Eswaraka J, Kearbey J, Barrett C, Raghow S, Veverka K, Miller D, Dalton J, Narayanan R (2010) Estrogen receptor- {beta} selective ligands alleviate high-fat diet- and ovariectomyinduced obesity in mice. J Biol Chem 285:31292-31303
37. Campbell SE, Mehan KA, Tunstall RJ, Febbraio MA, Cameron- Smith D (2003) 17beta-estradiol upregulates the expression of peroxisome proliferator-activated receptor alpha and lipid oxidative genes in skeletal muscle. J Mol Endocrinol 31:37-45 (Pubitemid 37063077)
38. Campbell S, Febbraio M (2001) Effect of ovarian hormones on mitochondrial enzyme activity in the fat oxidation pathway of skeletal muscle. Am J Physiol Endocrinol Metab 281:E803-E808
39. Morise A, Thomas C, Landrier J, Besnard P, Hermier D (2009) Hepatic lipid metabolism response to dietary fatty acids is differently modulated by PPARalpha in male and female mice. Eur J Nutr 48:465-473