The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat

Diabetes

Volumn 52, Issue 1, 2003, Pages 172-179

  Nieves, Delma J ^a   Cnop, Miriam ^a   Retzlaff, Barbara ^a   Walden, Carolyn E ^a,c   Brunzell, John D ^a   Knopp, Robert H ^a   Kahn, Steven E ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; INSULIN; INTERMEDIATE DENSITY LIPOPROTEIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ABDOMEN; ADULT; ARTICLE; ATHEROGENESIS; BODY FAT; BODY MASS; CHOLESTEROL BLOOD LEVEL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DENSITY; DENSITY GRADIENT CENTRIFUGATION; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN EXPERIMENT; INSULIN RESISTANCE; INSULIN SENSITIVITY; LINEAR REGRESSION ANALYSIS; LIPOPROTEIN BLOOD LEVEL; MALE; MULTIPLE REGRESSION; NORMAL HUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; TRIACYLGLYCEROL BLOOD LEVEL;

ABDOMEN; ADIPOSE TISSUE; ARTERIOSCLEROSIS; BODY CONSTITUTION; FEMALE; HUMANS; INSULIN RESISTANCE; LIPOPROTEINS; MALE; MIDDLE AGED; OBESITY;

EID: 0037219294     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.1.172     Document Type: Article

References (65)

1. Kolterman OG, Insel J, Saekow M, Olefsky JM: Mechanisms of insulin resistance in human obesity: Evidence for receptor and postreceptor defects. J Clin Invest 65:1272-1284, 1980
2. Lillioja S, Bogardus C: Obesity and insulin resistance: Lessons learned from the Pima Indians. Diabetes Metab Rev 4:517-540, 1988
3. Bjomtorp P: Visceral obesity: A "civilization syndrome." Obes Res 1:206-222, 1993
4. Peiris AN, Mueller RA, Smith GA, Struve MF, Kissebah AH: Splanchnic insulin metabolism in obesity: Influence of body fat distribution. J Clin Invest 78:1648-1657, 1986
5. Modan M, Halkin H, Almog S, Lusky A, Eshkol A, Shefi M, Shitrit A, Fuchs Z: Hyperinsulinemia: A link between hypertension obesity and glucose intolerance. J Clin Invest 75:809-817, 1985
6. Reaven GM: Role of insulin resistance in human disease. Diabetes 37:1595-1607, 1988
7. DeFronzo RA, Ferrannini E: Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173-194, 1991
8. Dunaif A, Segal KR, Futterweit W, Dobrjansky A: Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 38:1165-1174, 1989
9. Banerji MA, Lebowitz J, Chaiken RL, Gordon D, Kral JG, Lebovitz HE: Relationship of visceral adipose tissue and glucose disposal is independent of sex in black NIDDM subjects. Am J Physiol 273:E425-E432, 1997
10. Cnop M, Landchild MJ, Vidal J, Havel PJ, Knowles NG, Carr DR, Wang F, Hull RL, Retzlaff BM, Walden CE, Knopp RH, Kahn SE: The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: Distinct metabolic effects of two fat compartments. Diabetes 51:1005-1015, 2002
11. Weinsier RL, Hunter GR, Gower BA, Schutz Y, Darnell BE, Zuckerman PA: Body fat distribution in white and black women: Different patterns of intraabdominal and subcutaneous abdominal adipose tissue utilization with weight loss. Am J Clin Nutr 74:631-636, 2001
12. Matsuzawa Y, Shimomura I, Nakamura T, Keno Y, Tokunaga K: Pathophysiology and pathogenesis of visceral fat obesity. Ann N Y Acad Sci 748:399-406, 1995
13. Banerji MA, Faridi N, Atluri R, Chaiken RL, Lebovitz HE: Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men. J Clin Endocrinol Metab 84:137-144, 1999
14. Shuman WP, Newell Morris LL, Leonetti DL, Wahl PW, Moceri VM, Moss AA, Fujimoto WY: Abnormal body fat distribution detected by computed tomography in diabetic men. Invest Radiol 21:483-487, 1986
15. Fujimoto WY, Bergstrom RW, Leonetti DL, Newell-Morris LL, Shuman WP, Wahl PW: Metabolic and adipose risk factors for NIDDM and coronary disease in third-generation Japanese-American men and women with impaired glucose tolerance. Diabetologia 37:524-532, 1994
16. Carey DG, Jenkins AB, Campbell LV, Freund J, Chisholm DJ: Abdominal fat and insulin resistance in normal and overweight women: Direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM. Diabetes 45:633-638, 1996
17. Pouliot MC, Despres JP, Nadeau A, Moorjani S, Prud'Homme D, Lupien PJ, Tremblay A, Bouchard C: Visceral obesity in men: Associations with glucose tolerance, plasma insulin, and lipoprotein levels. Diabetes 41:826-834, 1992
18. Brochu M, Starling RD, Tchernof A, Matthews DE, Garcia-Rubi E, Poehlman ET: Visceral adipose tissue is an independent correlate of glucose disposal in older obese postmenopausal women. J Clin Endocrinol Metab 85:2378-2384, 2000
19. Rendell M, Hulthen UL, Tornquist C, Groop L, Mattiasson I: Relationship between abdominal fat compartments and glucose and lipid metabolism in early postmenopausal women. J Clin Endocrinol Metab 86:744-749, 2001
20. Sparrow D, Borkan GA, Gerzof SG, Wisniewski C, Silbert CK: Relationship of fat distribution to glucose tolerance: Results of computed tomography in male participants of the Normative Aging Study. Diabetes 35:411-415, 1986
21. Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S: Contribution of intraabdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism 36:54-59, 1987
22. Despres JP, Nadeau A, Tremblay A, Ferland M, Moorjani S, Lupien PJ, Theriault G, Pinault S, Bouchard C: Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women. Diabetes 38:304-309, 1989
23. Abate N, Garg A, Peshock RM, Stray-Gundersen J, Grundy SM: Relationships of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest 96:88-98, 1995
24. Goodpaster BH, Thaete FL, Simoneau JA, Kelley DE: Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 46:1579-1585, 1997
25. Expert Panel on Detection Evaluation and Treatment of High Blood Cholesterol in Adults: Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285:2486-2497, 2001
26. Terry RB, Wood PD, Haskell WL, Stefanick ML, Krauss RM: Regional adiposity patterns in relation to lipids, lipoprotein cholesterol, and lipoprotein subfraction mass in men. J Clin Endocrinol Metab 68:191-199, 1989
27. Fujimoto WY, Abbate SL, Kahn SE, Hokanson JE, Brunzell JD: The visceral adiposity syndrome in Japanese-American men. Obes Res 2:364-371, 1994
28. Tchernof A, Lamarche B, Prud'Homme D, Nadeau A, Moorjani S, Labrie F, Lupien PJ, Despres JP: The dense LDL phenotype: Association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men. Diabetes Care 19:629-637, 1996
29. Festa A, D'Agostino R Jr, Mykkanen L, Tracy RP, Hales CN, Howard BV, Haffner SM: LDL particle size in relation to insulin, proinsulin, and insulin sensitivity: The Insulin Resistance Atherosclerosis Study. Diabetes Care 22:1688-1693, 1999
30. Reaven GM, Chen YD, Jeppesen J, Maheux P, Krauss RM: Insulin resistance and hyperinsulinemia in individuals with small, dense low density Iipoprotein particles. J Clin Invest 92:141-146, 1993
31. Abbasi F, McLaughlin T, Lamendola C, Yeni-Komshian H, Tanaka A, Wang T, Nakajima K, Reaven GM: Fasting remnant lipoprotein cholesterol and triglyceride concentrations are elevated in nondiabetic, insulin-resistant, female volunteers. J Clin Endocrinol Metab 84:3903-3906, 1999
32. Williams PT, Haskell WL, Vranizan KM, Krauss RM: The associations of high-density lipoprotein subclasses with insulin and glucose levels, physical activity, resting heart rate, and regional adiposity in men with coronary artery disease: The Stanford Coronary Risk Intervention Project baseline survey. Metabolism 44:106-114, 1995
33. Carr MC, Hokanson JE, Deeb SS, Purnell JQ, Mitchell ES, Brunzell JD: A hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intra-abdominal fat in women. Arterioscler Thromb Vasc Biol 19:2701-2707, 1999
34. Knopp RH, Retzlaff BM, Walden CE, Wallick S, Fish B, Anderson M, Kahn SE: Effects of insulin resistance and obesity on the LDL response to egg ingestion. Circulation 100 (Suppl. 1):I-116, 1999
35. Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP, Porte D Jr: Quantification of the relationship between insulin sensitivity and B-cell function in human subjects: Evidence for a hyperbolic function. Diabetes 42:1663-1672, 1993
36. Krotkiewski M, Bjorntorp P, Sjostrom L, Smith U: Impact of obesity on metabolism in men and women: Importance of regional adipose tissue distribution. J Clin Invest 72:1150-1162, 1983
37. Schwartz RS, Shuman WP, Larson V, Cain KC, Fellingham GW, Beard JC, Kahn SE, Stratton JR, Cerqueira MD, Abrass IB: The effect of intensive endurance exercise training on body fat distribution in young and older men. Metabolism 40:545-551, 1991
38. Bergman RN, Ider YZ, Bowden CR, Cobelli C: Quantitative estimation of insulin sensitivity. Am J Physiol 236:E667-E677, 1979
39. Beard JC, Bergman RN, Ward WK, Porte D Jr: The insulin sensitivity index in man: Correlation between clamp-derived and IVGTT-derived values. Diabetes 35:362-369, 1986
40. Prigeon RL, Kahn SE, Porte D Jr: Reliability of error estimates from the minimal model: Implications for measurements in physiological studies. Am J Physiol 266:E279-E286, 1994
41. Abbate SL, Fujimoto WY, Brunzell JD, Kahn SE: Effect of heparin on insulin-glucose interactions measured by the minimal model technique: Implications for reproducibility using this method. Metabolism 42:353-357, 1993
42. Morgan DR, Lazarow A: Immunoassay of insulin: Two antibody system: Plasma insulin levels of normal, subdiabetic, and diabetic rats. Diabetes 12:115-126, 1963
43. Marcovina SM, Albers JJ, Kennedy H, Mei JV, Henderson LO, Hannon WH: International Federation of Clinical Chemistry standardization project for measurements of apolipoproteins A-I and B. IV. Comparability of apolipoprotein B values by use of international reference material. Clin Chem 40:586-592, 1994
44. Purnell JQ, Marcovina SM, Hokanson JE, Kennedy H, Cleary PA, Steffes MW, Brunzell JD: Levels of lipoprotein(a), apolipoprotein B, and lipoprotein cholesterol distribution in IDDM: Results from follow-up in the Diabetes Control and Complications Trial. Diabetes 44:1218-1226, 1995
45. National Heart Lung and Blood Institute: Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: The evidence report. Obes Res 6 (Suppl. 2):51S-209S, 1998
46. Despres J-P, Krauss RM: Obesity and lipoprotein metabolism. In Handbook of Obesity. Bray GA, Bouchard C, James WPT, Eds. New York, Marcel Dekker, 1998, p. 651-675
47. Haffner SM: The insulin resistance syndrome revisited. Diabetes Care 19:275-277, 1996
48. Brunzell JD, Hokanson JE: Dyslipidemia of central obesity and insulin resistance. Diabetes Care 22 (Suppl. 3):C10-C13, 1999
49. Olefsky J, Reaven GM, Farquhar JW: Effects of weight reduction on obesity: Studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects. J Clin Invest 53:64-76, 1974
50. Sorbris R, Petersson BG, Nilsson-Ehle P: Effects of weight reduction on plasma lipoproteins and adipose tissue metabolism in obese subjects. Eur J Clin Invest 11:491-498, 1981
51. Colman E, Katzel LI, Rogus E, Coon P, Muller D, Goldberg AP: Weight loss reduces abdominal fat and improves insulin action in middle-aged and older men with impaired glucose tolerance. Metabolism 44:1502-1508, 1995
52. Katzel LI, Bleecker ER, Colman EG, Rogus EM, Sorkin JD, Goldberg AP: Effects of weight loss vs. aerobic exercise training on risk factors for coronary disease in healthy, obese, middle-aged and older men: A randomized controlled trial. JAMA 274:1915-1921, 1995
53. Purnell JQ, Kahn SE, Albers JJ, Nevin DN, Brunzell JD, Schwartz RS: Effect of weight loss with reduction of intra-abdominal fat on lipid metabolism in older men. J Clin Endocrinol Metab 85:977-982, 2000
54. Goldstein DJ: Beneficial health effects of modest weight loss. Int J Obes Relat Metab Disord 16:397-415, 1992
55. Franssila-Kallunki A, Rissanen A, Ekstrand A, Ollus A, Groop L: Effects of weight loss on substrate oxidation, energy expenditure, and insulin sensitivity in obese individuals. Am J Clin Nutr 55:356-361, 1992
56. Goodpaster BH, Kelley DE, Wing RR, Meier A, Thaete FL: Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes 48:839-847, 1999
57. Schwartz RS, Cain KC, Shuman WP, Larson V, Stratton JR, Beard JC, Kahn SE, Cerqueira MD, Abrass IB: Effect of intensive endurance training on lipoprotein profiles in young and older men. Metabolism 41:649-654, 1992
58. Kahn SE, Larson VG, Beard JC, Cain KC, Fellingham GW, Schwartz RS, Veith RC, Stratton JR, Cerqueira MD, Abrass IB: Effect of exercise on insulin action, glucose tolerance and insulin secretion in aging. Am J Physiol 258:E937-E943, 1990
59. Despres JP, Ferland M, Moorjani S, Nadeau A, Tremblay A, Lupien PJ, Theriault G, Bouchard C: Role of hepatic-triglyceride lipase activity in the association between intra-abdominal fat and plasma HDL cholesterol in obese women. Arteriosclerosis 9:485-492, 1989
60. Carr MC, Hokanson JE, Zambon A, Deeb SS, Barrett PH, Purnell JQ, Brunzell JD: The contribution of intraabdominal fat to gender differences in hepatic lipase activity and low/high density lipoprotein heterogeneity. J Clin Endocrinol Metab 86:2831-2837, 2001
61. Patsch JR, Prasad S, Gotto AM Jr, Patsch W: High density lipoprotein2: Relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase. J Clin Invest 80:341-347, 1987
62. Kuusi T, Ehnholm C, Viikari J, Harkonen R, Vartiainen E, Puska P, Taskinen MR: Postheparin plasma lipoprotein and hepatic lipase are determinants of hypo- and hyperalphalipoproteinemia. J Lipid Res 30:1117-1126, 1989
63. Zambon A, Austin MA, Brown BG, Hokanson JE, Brunzell JD: Effect of hepatic lipase on LDL in normal men and those with coronary artery disease. Arterioscler Thromb 13:147-153, 1993
64. Havel RJ: Genetic underpinnings of LDL size and density: A role for hepatic lipase? Am J Clin Nutr 71:1390-1391, 2000
65. Zambon A, Hokanson JE, Brown BG, Brunzell JD: Evidence for a new pathophysiological mechanism for coronary artery disease regression: Hepatic lipase-mediated changes in LDL density. Circulation 99:1959-1964, 1999