Brain estrogen deficiency accelerates Aβ plaque formation in an Alzheimer's disease animal model

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 52, 2005, Pages 19198-19203

  Yue, Xu ^a   Lu, Melissa ^a   Lancaster, Techie ^a   Cao, Phillip ^a   Honda, Shin Ichiro ^b   Staufenbiel, Matthias ^c   Harada, Nobuhiro ^b   Zhong, Zhenyu ^a   Shen, Yong ^a   Li, Rena ^a  

^a SUN HEALTH RESEARCH INSTITUTE   (United States)

^b FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Amyloid deposition; Aromatase; Transgenic animal

Indexed keywords

AMYLOID BETA PROTEIN; AROMATASE; ESTROGEN; GENE PRODUCT;

AGED; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPSY; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; ESTROGEN BLOOD LEVEL; ESTROGEN DEFICIENCY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KNOCKOUT GENE; MOUSE; NEUROPATHOLOGY; NEWBORN; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN DEGRADATION; RISK FACTOR; SENILE PLAQUE; SEX DIFFERENCE; TRANSGENIC MOUSE;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BLOTTING, WESTERN; BRAIN; DISEASE MODELS, ANIMAL; ENDOPEPTIDASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTRADIOL; ESTROGENS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEURONS; PHAGOCYTOSIS; RADIOIMMUNOASSAY; RISK FACTORS; SEX FACTORS; TIME FACTORS;

ANIMALIA; MUS MUSCULUS;

EID: 30044438885     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0505203102     Document Type: Article

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