메뉴 건너뛰기




Volumn 10, Issue 7, 2015, Pages 950-966

Towards next generation CHO cell biology: Bioinformatics methods for RNA-Seq-based expression profiling

Author keywords

Bioinformatics; Chinese hamster ovary; Next generation sequencing; RNA Seq; Transcriptomics

Indexed keywords

CELL CULTURE; CELLS; COST EFFECTIVENESS; CYTOLOGY; GENES; NUCLEIC ACIDS; QUALITY CONTROL; RNA;

EID: 84935691970     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201500107     Document Type: Review
Times cited : (18)

References (108)
  • 2
    • 37749031255 scopus 로고    scopus 로고
    • Next-generation sequencing transforms today's biology.
    • Schuster, S. C., Next-generation sequencing transforms today's biology. Nat. Methods 2008, 5, 16-18.
    • (2008) Nat. Methods , vol.5 , pp. 16-18
    • Schuster, S.C.1
  • 3
    • 84883807509 scopus 로고    scopus 로고
    • Chinese hamster genome sequenced from sorted chromosomes.
    • Brinkrolf, K., Rupp, O., Laux, H., Kollin, F. et al., Chinese hamster genome sequenced from sorted chromosomes. Nat. Biotechnol. 2013, 31, 694-695.
    • (2013) Nat. Biotechnol. , vol.31 , pp. 694-695
    • Brinkrolf, K.1    Rupp, O.2    Laux, H.3    Kollin, F.4
  • 4
    • 84883809015 scopus 로고    scopus 로고
    • Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome.
    • Lewis, N. E., Liu, X., Li, Y., Nagarajan, H. et al., Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome. Nat. Biotechnol. 2013, 31, 759-765.
    • (2013) Nat. Biotechnol. , vol.31 , pp. 759-765
    • Lewis, N.E.1    Liu, X.2    Li, Y.3    Nagarajan, H.4
  • 5
    • 84920502297 scopus 로고    scopus 로고
    • Biopharmaceutical benchmarks 2014.
    • Walsh, G., Biopharmaceutical benchmarks 2014. Nat. Biotechnol. 2014, 32, 992-1000.
    • (2014) Nat. Biotechnol. , vol.32 , pp. 992-1000
    • Walsh, G.1
  • 6
    • 80052389765 scopus 로고    scopus 로고
    • Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity.
    • Clarke, C., Doolan, P., Barron, N., Meleady, P. et al., Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity. J. Biotechnol. 2011, 155, 350-359.
    • (2011) J. Biotechnol. , vol.155 , pp. 350-359
    • Clarke, C.1    Doolan, P.2    Barron, N.3    Meleady, P.4
  • 7
    • 84869224817 scopus 로고    scopus 로고
    • Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate.
    • Clarke, C., Henry, M., Doolan, P., Kelly, S. et al., Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate. BMC Genomics 2012, 13, 656.
    • (2012) BMC Genomics , vol.13 , pp. 656
    • Clarke, C.1    Henry, M.2    Doolan, P.3    Kelly, S.4
  • 8
    • 78651504589 scopus 로고    scopus 로고
    • Predicting cell-specific productivity from CHO gene expression.
    • Clarke, C., Doolan, P., Barron, N., Meleady, P. et al., Predicting cell-specific productivity from CHO gene expression. J. Biotechnol. 2011, 151, 159-165.
    • (2011) J. Biotechnol. , vol.151 , pp. 159-165
    • Clarke, C.1    Doolan, P.2    Barron, N.3    Meleady, P.4
  • 9
  • 10
    • 84887620767 scopus 로고    scopus 로고
    • The emerging CHO systems biology era: Harnessing the 'omics revolution for biotechnology.
    • Kildegaard, H. F., Baycin-Hizal, D., Lewis, N. E., Betenbaugh, M., The emerging CHO systems biology era: Harnessing the 'omics revolution for biotechnology. Curr. Opin. Biotechnol. 2013, 24, 1102-1107.
    • (2013) Curr. Opin. Biotechnol. , vol.24 , pp. 1102-1107
    • Kildegaard, H.F.1    Baycin-Hizal, D.2    Lewis, N.E.3    Betenbaugh, M.4
  • 11
    • 77951555640 scopus 로고    scopus 로고
    • Microarray and proteomics expression profiling identifies several candidates, including the valosin-containing protein (VCP), involved in regulating high cellular growth rate in production CHO cell lines.
    • Doolan, P., Meleady, P., Barron, N., Henry, M. et al., Microarray and proteomics expression profiling identifies several candidates, including the valosin-containing protein (VCP), involved in regulating high cellular growth rate in production CHO cell lines. Biotechnol. Bioeng. 2010, 106, 42-56.
    • (2010) Biotechnol. Bioeng. , vol.106 , pp. 42-56
    • Doolan, P.1    Meleady, P.2    Barron, N.3    Henry, M.4
  • 12
    • 78651507094 scopus 로고    scopus 로고
    • Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7.
    • Barron, N., Kumar, N., Sanchez, N., Doolan, P. et al., Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7. J. Biotechnol. 2011, 151, 204-211.
    • (2011) J. Biotechnol. , vol.151 , pp. 204-211
    • Barron, N.1    Kumar, N.2    Sanchez, N.3    Doolan, P.4
  • 13
    • 84897586906 scopus 로고    scopus 로고
    • CHO cell culture longevity and recombinant protein yield are enhanced by depletion of miR-7 activity via sponge decoy vectors.
    • Sanchez, N., Kelly, P., Gallagher, C., Lao, N. T. et al., CHO cell culture longevity and recombinant protein yield are enhanced by depletion of miR-7 activity via sponge decoy vectors. Biotechnol. J. 2014, 9, 396-404.
    • (2014) Biotechnol. J. , vol.9 , pp. 396-404
    • Sanchez, N.1    Kelly, P.2    Gallagher, C.3    Lao, N.T.4
  • 14
    • 84886827175 scopus 로고    scopus 로고
    • Stable microRNA expression enhances therapeutic antibody productivity of Chinese hamster ovary cells.
    • Strotbek, M., Florin, L., Koenitzer, J., Tolstrup, A. et al., Stable microRNA expression enhances therapeutic antibody productivity of Chinese hamster ovary cells. Metab. Eng. 2013, 20, 157-166.
    • (2013) Metab. Eng. , vol.20 , pp. 157-166
    • Strotbek, M.1    Florin, L.2    Koenitzer, J.3    Tolstrup, A.4
  • 15
    • 84887988404 scopus 로고    scopus 로고
    • CHO microRNA engineering is growing up: Recent successes and future challenges.
    • Jadhav, V., Hackl, M., Druz, A., Shridhar, S. et al., CHO microRNA engineering is growing up: Recent successes and future challenges. Biotechnol. Adv. 2013, 31, 1501-1513.
    • (2013) Biotechnol. Adv. , vol.31 , pp. 1501-1513
    • Jadhav, V.1    Hackl, M.2    Druz, A.3    Shridhar, S.4
  • 16
    • 79961191745 scopus 로고    scopus 로고
    • The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.
    • Xu, X., Nagarajan, H., Lewis, N. E., Pan, S. et al., The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line. Nat. Biotechnol. 2011, 29, 735-741.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 735-741
    • Xu, X.1    Nagarajan, H.2    Lewis, N.E.3    Pan, S.4
  • 17
    • 84859895625 scopus 로고    scopus 로고
    • Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics.
    • Meleady, P., Hoffrogge, R., Henry, M., Rupp, O. et al., Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics. Biotechnol. Bioeng. 2012, 109, 1386-1394.
    • (2012) Biotechnol. Bioeng. , vol.109 , pp. 1386-1394
    • Meleady, P.1    Hoffrogge, R.2    Henry, M.3    Rupp, O.4
  • 18
    • 84878418186 scopus 로고    scopus 로고
    • Prediction of transcribed PIWI-interacting RNAs from CHO RNAseq data.
    • Gerstl, M. P., Hackl, M., Graf, A. B., Borth, N., Grillari, J., Prediction of transcribed PIWI-interacting RNAs from CHO RNAseq data. J. Biotechnol. 2013, 166, 51-57.
    • (2013) J. Biotechnol. , vol.166 , pp. 51-57
    • Gerstl, M.P.1    Hackl, M.2    Graf, A.B.3    Borth, N.4    Grillari, J.5
  • 19
    • 84929950336 scopus 로고    scopus 로고
    • Annotation of additional evolutionary conserved microRNAs in CHO cells from updated genomic data.
    • Diendorfer, A. B., Hackl, M., Klanert, G., Jadhav, V. et al., Annotation of additional evolutionary conserved microRNAs in CHO cells from updated genomic data. Biotechnol. Bioeng. 2015, 112, 1488-1493.
    • (2015) Biotechnol. Bioeng. , vol.112 , pp. 1488-1493
    • Diendorfer, A.B.1    Hackl, M.2    Klanert, G.3    Jadhav, V.4
  • 20
    • 84858296857 scopus 로고    scopus 로고
    • Computational identification of microRNA gene loci and precursor microRNA sequences in CHO cell lines.
    • Hackl, M., Jadhav, V., Jakobi, T., Rupp, O. et al., Computational identification of microRNA gene loci and precursor microRNA sequences in CHO cell lines. J. Biotechnol. 2012, 158, 151-155.
    • (2012) J. Biotechnol. , vol.158 , pp. 151-155
    • Hackl, M.1    Jadhav, V.2    Jakobi, T.3    Rupp, O.4
  • 21
    • 79955132774 scopus 로고    scopus 로고
    • Next-generation sequencing of the Chinese hamster ovary microRNA transcriptome: Identification, annotation and profiling of microRNAs as targets for cellular engineering.
    • Hackl, M., Jakobi, T., Blom, J., Doppmeier, D. et al., Next-generation sequencing of the Chinese hamster ovary microRNA transcriptome: Identification, annotation and profiling of microRNAs as targets for cellular engineering. J. Biotechnol. 2011, 153, 62-75.
    • (2011) J. Biotechnol. , vol.153 , pp. 62-75
    • Hackl, M.1    Jakobi, T.2    Blom, J.3    Doppmeier, D.4
  • 22
    • 84923637337 scopus 로고    scopus 로고
    • The DNA methylation landscape of Chinese hamster ovary (CHO) DP-12 cells.
    • Wippermann, A., Rupp, O., Brinkrolf, K., Hoffrogge, R., Noll, T., The DNA methylation landscape of Chinese hamster ovary (CHO) DP-12 cells. J. Biotechnol. 2015, 199, 38-46.
    • (2015) J. Biotechnol. , vol.199 , pp. 38-46
    • Wippermann, A.1    Rupp, O.2    Brinkrolf, K.3    Hoffrogge, R.4    Noll, T.5
  • 23
    • 84928740386 scopus 로고    scopus 로고
    • Sequencing the CHO DCB11 genome reveals regional variations in genomic stability and haploidy.
    • Kaas, C. S., Kristensen, C., Betenbaugh, M. J., Andersen, M. R., Sequencing the CHO DCB11 genome reveals regional variations in genomic stability and haploidy. BMC Genomics 2015, 16, 160.
    • (2015) BMC Genomics , vol.16 , pp. 160
    • Kaas, C.S.1    Kristensen, C.2    Betenbaugh, M.J.3    Andersen, M.R.4
  • 24
    • 84896455875 scopus 로고    scopus 로고
    • Construction of a public CHO cell line transcript database using versatile bioinformatics analysis pipelines.
    • Rupp, O., Becker, J., Brinkrolf, K., Timmermann, C. et al., Construction of a public CHO cell line transcript database using versatile bioinformatics analysis pipelines. PLoS One 2014, 9, e85568.
    • (2014) PLoS One , vol.9 , pp. e85568
    • Rupp, O.1    Becker, J.2    Brinkrolf, K.3    Timmermann, C.4
  • 25
    • 84898598769 scopus 로고    scopus 로고
    • Effects of copper on CHO cells: Insights from gene expression analyses.
    • Yuk, I. H., Zhang, J. D., Ebeling, M., Berrera, M. et al., Effects of copper on CHO cells: Insights from gene expression analyses. Biotechnol. Prog. 2014, 30, 429-442.
    • (2014) Biotechnol. Prog. , vol.30 , pp. 429-442
    • Yuk, I.H.1    Zhang, J.D.2    Ebeling, M.3    Berrera, M.4
  • 26
    • 84862778524 scopus 로고    scopus 로고
    • Profiling conserved microRNA expression in recombinant CHO cell lines using Illumina sequencing.
    • Hammond, S., Swanberg, J. C., Polson, S. W., Lee, K. H., Profiling conserved microRNA expression in recombinant CHO cell lines using Illumina sequencing. Biotechnol. Bioeng. 2012, 109, 1371-1375.
    • (2012) Biotechnol. Bioeng. , vol.109 , pp. 1371-1375
    • Hammond, S.1    Swanberg, J.C.2    Polson, S.W.3    Lee, K.H.4
  • 27
    • 84963690780 scopus 로고    scopus 로고
    • Next-generation bioprocess: An industry perspective of how the 'omics era will affect future biotherapeutic development.
    • Wright, C., Estes, S., Next-generation bioprocess: An industry perspective of how the 'omics era will affect future biotherapeutic development. Pharm. Bioprocess. 2014, 2, 371-375.
    • (2014) Pharm. Bioprocess. , vol.2 , pp. 371-375
    • Wright, C.1    Estes, S.2
  • 28
    • 77955504378 scopus 로고    scopus 로고
    • Statistical design and analysis of RNA sequencing data.
    • Auer, P. L., Doerge, R. W., Statistical design and analysis of RNA sequencing data. Genetics 2010, 185, 405-416.
    • (2010) Genetics , vol.185 , pp. 405-416
    • Auer, P.L.1    Doerge, R.W.2
  • 29
    • 84890286068 scopus 로고    scopus 로고
    • Characterization of the human ESC transcriptome by hybrid sequencing.
    • Au, K. F., Sebastiano, V., Afshar, P. T., Durruthy, J. D. et al., Characterization of the human ESC transcriptome by hybrid sequencing. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, E4821-E4830.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. E4821-E4830
    • Au, K.F.1    Sebastiano, V.2    Afshar, P.T.3    Durruthy, J.D.4
  • 30
    • 84893723345 scopus 로고    scopus 로고
    • Library preparation methods for next-generation sequencing: Tone down the bias.
    • Van Dijk, E. L., Jaszczyszyn, Y., Thermes, C., Library preparation methods for next-generation sequencing: Tone down the bias. Exp. Cell Res. 2014, 322, 12-20.
    • (2014) Exp. Cell Res. , vol.322 , pp. 12-20
    • Van Dijk, E.L.1    Jaszczyszyn, Y.2    Thermes, C.3
  • 31
    • 77952577869 scopus 로고    scopus 로고
    • Recent advances in DNA sequencing methods - general principles of sample preparation.
    • Linnarsson, S., Recent advances in DNA sequencing methods - general principles of sample preparation. Exp. Cell Res. 2010, 316, 1339-1343.
    • (2010) Exp. Cell Res. , vol.316 , pp. 1339-1343
    • Linnarsson, S.1
  • 32
    • 84872732277 scopus 로고    scopus 로고
    • Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection.
    • Zhang, Z., Theurkauf, W., Weng, Z., Zamore, P., Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection. Silence 2012, 3, 9.
    • (2012) Silence , vol.3 , pp. 9
    • Zhang, Z.1    Theurkauf, W.2    Weng, Z.3    Zamore, P.4
  • 33
    • 84862991525 scopus 로고    scopus 로고
    • Short structured RNAs with low GC content are selectively lost during extraction from a small number of cells.
    • Kim, Y.-K., Yeo, J., Kim, B., Ha, M., Kim, V. N., Short structured RNAs with low GC content are selectively lost during extraction from a small number of cells. Mol. Cell 2012, 46, 893-895.
    • (2012) Mol. Cell , vol.46 , pp. 893-895
    • Kim, Y.-K.1    Yeo, J.2    Kim, B.3    Ha, M.4    Kim, V.N.5
  • 34
    • 84885370853 scopus 로고    scopus 로고
    • An efficient rRNA removal method for RNA sequencing in GC-rich bacteria.
    • Peano, C., Pietrelli, A., Consolandi, C., Rossi, E. et al., An efficient rRNA removal method for RNA sequencing in GC-rich bacteria. Microb. Inform. Exp. 2013, 3, 1.
    • (2013) Microb. Inform. Exp. , vol.3 , pp. 1
    • Peano, C.1    Pietrelli, A.2    Consolandi, C.3    Rossi, E.4
  • 35
    • 54349086286 scopus 로고    scopus 로고
    • Factors in tissue handling and processing that impact RNA obtained from formalin-fixed, paraffin-embedded tissue.
    • Chung, J.-Y., Braunschweig, T., Williams, R., Guerrero, N. et al., Factors in tissue handling and processing that impact RNA obtained from formalin-fixed, paraffin-embedded tissue. J. Histochem. Cytochem. 2008, 56, 1033-1042.
    • (2008) J. Histochem. Cytochem. , vol.56 , pp. 1033-1042
    • Chung, J.-Y.1    Braunschweig, T.2    Williams, R.3    Guerrero, N.4
  • 36
    • 84897972088 scopus 로고    scopus 로고
    • Sequencing degraded rna addressed by 3' tag counting.
    • Sigurgeirsson, B., Emanuelsson, O., Lundeberg, J., Sequencing degraded rna addressed by 3' tag counting. PLoS One 2014, 9, e91851.
    • (2014) PLoS One , vol.9 , pp. e91851
    • Sigurgeirsson, B.1    Emanuelsson, O.2    Lundeberg, J.3
  • 37
    • 84878637612 scopus 로고    scopus 로고
    • Strand-specific RNA-Seq provides greater resolution of transcriptome profiling.
    • Mills, J. D., Kawahara, Y., Janitz, M., Strand-specific RNA-Seq provides greater resolution of transcriptome profiling. Curr. Genomics 2013, 14, 173-181.
    • (2013) Curr. Genomics , vol.14 , pp. 173-181
    • Mills, J.D.1    Kawahara, Y.2    Janitz, M.3
  • 40
    • 84904730587 scopus 로고    scopus 로고
    • Comparison of RNA-Seq by poly (A) capture, ribosomal RNA depletion, and DNA microarray for expression profiling.
    • Zhao, W., He, X., Hoadley, K., Parker, J. et al., Comparison of RNA-Seq by poly (A) capture, ribosomal RNA depletion, and DNA microarray for expression profiling. BMC Genomics 2014, 15, 419.
    • (2014) BMC Genomics , vol.15 , pp. 419
    • Zhao, W.1    He, X.2    Hoadley, K.3    Parker, J.4
  • 41
    • 84963690747 scopus 로고    scopus 로고
    • New and highly effective automated solutions for sample preparation for next-generation sequencing.
    • Essakali, S., Dennig, J., Glowatz, H., Fang, N. et al., New and highly effective automated solutions for sample preparation for next-generation sequencing. J. Biomol. Tech. JBT 2013, 24, S41-S42.
    • (2013) J. Biomol. Tech. JBT , vol.24 , pp. S41-S42
    • Essakali, S.1    Dennig, J.2    Glowatz, H.3    Fang, N.4
  • 42
    • 84879692466 scopus 로고    scopus 로고
    • Comprehensive comparative analysis of RNA sequencing methods for degraded or low input samples.
    • Adiconis, X., Borges-Rivera, D., Satija, R., DeLuca, D. S. et al., Comprehensive comparative analysis of RNA sequencing methods for degraded or low input samples. Nat. Methods 2013, 10, 623-629.
    • (2013) Nat. Methods , vol.10 , pp. 623-629
    • Adiconis, X.1    Borges-Rivera, D.2    Satija, R.3    DeLuca, D.S.4
  • 43
    • 52649157765 scopus 로고    scopus 로고
    • Substantial biases in ultra-short read data sets from high-throughput DNA sequencing.
    • Dohm, J. C., Lottaz, C., Borodina, T., Himmelbauer, H., Substantial biases in ultra-short read data sets from high-throughput DNA sequencing. Nucleic Acids Res. 2008, 36, e105-e105.
    • (2008) Nucleic Acids Res. , vol.36 , pp. e105-e105
    • Dohm, J.C.1    Lottaz, C.2    Borodina, T.3    Himmelbauer, H.4
  • 45
    • 84904776692 scopus 로고    scopus 로고
    • Analysis of stranded information using an automated procedure for strand specific RNA sequencing.
    • Sigurgeirsson, B., Emanuelsson, O., Lundeberg, J., Analysis of stranded information using an automated procedure for strand specific RNA sequencing. BMC Genomics 2014, 15, 631.
    • (2014) BMC Genomics , vol.15 , pp. 631
    • Sigurgeirsson, B.1    Emanuelsson, O.2    Lundeberg, J.3
  • 46
    • 77956340995 scopus 로고    scopus 로고
    • Comprehensive comparative analysis of strand-specific RNA sequencing methods.
    • Levin, J. Z., Yassour, M., Adiconis, X., Nusbaum, C. et al., Comprehensive comparative analysis of strand-specific RNA sequencing methods. Nat. Methods 2010, 7, 709-715.
    • (2010) Nat. Methods , vol.7 , pp. 709-715
    • Levin, J.Z.1    Yassour, M.2    Adiconis, X.3    Nusbaum, C.4
  • 47
    • 84899510266 scopus 로고    scopus 로고
    • Elimination of ligation dependent artifacts in T4 RNA ligase to achieve high efficiency and low bias microRNA capture.
    • Song, Y., Liu, K. J., Wang, T.-H., Elimination of ligation dependent artifacts in T4 RNA ligase to achieve high efficiency and low bias microRNA capture. PLoS One 2014, 9, e94619.
    • (2014) PLoS One , vol.9 , pp. e94619
    • Song, Y.1    Liu, K.J.2    Wang, T.-H.3
  • 48
    • 84866979410 scopus 로고    scopus 로고
    • Reducing ligation bias of small RNAs in libraries for next generation sequencing.
    • Sorefan, K., Pais, H., Hall, A. E., Kozomara, A. et al., Reducing ligation bias of small RNAs in libraries for next generation sequencing. Silence 2012, 3, 4.
    • (2012) Silence , vol.3 , pp. 4
    • Sorefan, K.1    Pais, H.2    Hall, A.E.3    Kozomara, A.4
  • 49
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: a revolutionary tool for transcriptomics.
    • Wang, Z., Gerstein, M., Snyder, M., RNA-Seq: a revolutionary tool for transcriptomics. Nat. Rev. Genet. 2009, 10, 57-63.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 50
    • 84855219212 scopus 로고    scopus 로고
    • Optimizing Illumina next-generation sequencing library preparation for extremely at-biased genomes.
    • Oyola, S. O., Otto, T. D., Gu, Y., Maslen, G. et al., Optimizing Illumina next-generation sequencing library preparation for extremely at-biased genomes. BMC Genomics 2012, 13, 1.
    • (2012) BMC Genomics , vol.13 , pp. 1
    • Oyola, S.O.1    Otto, T.D.2    Gu, Y.3    Maslen, G.4
  • 51
    • 57049122389 scopus 로고    scopus 로고
    • A large genome center's improvements to the Illumina sequencing system.
    • Quail, M. A., Kozarewa, I., Smith, F., Scally, A. et al., A large genome center's improvements to the Illumina sequencing system. Nat. Methods 2008, 5, 1005-1010.
    • (2008) Nat. Methods , vol.5 , pp. 1005-1010
    • Quail, M.A.1    Kozarewa, I.2    Smith, F.3    Scally, A.4
  • 52
    • 53649100100 scopus 로고    scopus 로고
    • The development and impact of 454 sequencing.
    • Rothberg, J. M., Leamon, J. H., The development and impact of 454 sequencing. Nat. Biotechnol. 2008, 26, 1117-1124.
    • (2008) Nat. Biotechnol. , vol.26 , pp. 1117-1124
    • Rothberg, J.M.1    Leamon, J.H.2
  • 54
    • 84864920004 scopus 로고    scopus 로고
    • Comparison of next-generation sequencing systems.
    • Liu, L., Li, Y., Li, S., Hu, N. et al., Comparison of next-generation sequencing systems. Biomed Res. Int. 2012, 2012, e251364.
    • (2012) Biomed Res. Int. , vol.2012 , pp. e251364
    • Liu, L.1    Li, Y.2    Li, S.3    Hu, N.4
  • 55
    • 84870495569 scopus 로고    scopus 로고
    • Progress in Ion Torrent semiconductor chip based sequencing.
    • Merriman, B., D Team, I. T., Rothberg, J. M., Progress in Ion Torrent semiconductor chip based sequencing. Electrophoresis 2012, 33, 3397-3417.
    • (2012) Electrophoresis , vol.33 , pp. 3397-3417
    • Merriman, B.1    Team, D.I.T.2    Rothberg, J.M.3
  • 56
    • 79960852002 scopus 로고    scopus 로고
    • Addressing challenges in the production and analysis of Illumina sequencing data.
    • Kircher, M., Heyn, P., Kelso, J., Addressing challenges in the production and analysis of Illumina sequencing data. BMC Genomics 2011, 12, 382.
    • (2011) BMC Genomics , vol.12 , pp. 382
    • Kircher, M.1    Heyn, P.2    Kelso, J.3
  • 58
    • 80053194792 scopus 로고    scopus 로고
    • Base-calling for next-generation sequencing platforms.
    • Ledergerber, C., Dessimoz, C., Base-calling for next-generation sequencing platforms. Brief. Bioinform. 2011, 12, 489-497.
    • (2011) Brief. Bioinform. , vol.12 , pp. 489-497
    • Ledergerber, C.1    Dessimoz, C.2
  • 59
    • 77951226627 scopus 로고    scopus 로고
    • The Sanger FASTQ file format for sequences with quality scores, and the Solexa/Illumina FASTQ variants.
    • Cock, P. J. A., Fields, C. J., Goto, N., Heuer, M. L., Rice, P. M., The Sanger FASTQ file format for sequences with quality scores, and the Solexa/Illumina FASTQ variants. Nucleic Acids Res. 2010, 38, 1767-1771.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 1767-1771
    • Cock, P.J.A.1    Fields, C.J.2    Goto, N.3    Heuer, M.L.4    Rice, P.M.5
  • 60
    • 84905049901 scopus 로고    scopus 로고
    • Trimmomatic: A flexible trimmer for Illumina sequence data.
    • Bolger, A. M., Lohse, M., Usadel, B., Trimmomatic: A flexible trimmer for Illumina sequence data. Bioinformatics 2014, 30, 2114-2120.
    • (2014) Bioinformatics , vol.30 , pp. 2114-2120
    • Bolger, A.M.1    Lohse, M.2    Usadel, B.3
  • 61
    • 79952422304 scopus 로고    scopus 로고
    • Quality control and preprocessing of metagenomic datasets.
    • Schmieder, R., Edwards, R., Quality control and preprocessing of metagenomic datasets. Bioinformatics 2011, 27, 863-864.
    • (2011) Bioinformatics , vol.27 , pp. 863-864
    • Schmieder, R.1    Edwards, R.2
  • 62
    • 77953727646 scopus 로고    scopus 로고
    • TagCleaner: Identification and removal of tag sequences from genomic and metagenomic datasets.
    • Schmieder, R., Lim, Y. W., Rohwer, F., Edwards, R., TagCleaner: Identification and removal of tag sequences from genomic and metagenomic datasets. BMC Bioinformatics 2010, 11, 341-341.
    • (2010) BMC Bioinformatics , vol.11 , pp. 341-341
    • Schmieder, R.1    Lim, Y.W.2    Rohwer, F.3    Edwards, R.4
  • 63
    • 79952709611 scopus 로고    scopus 로고
    • Improving RNA-Seq expression estimates by correcting for fragment bias.
    • Roberts, A., Trapnell, C., Donaghey, J., Rinn, J. L., Pachter, L., Improving RNA-Seq expression estimates by correcting for fragment bias. Genome Biol. 2011, 12, R22.
    • (2011) Genome Biol. , vol.12 , pp. R22
    • Roberts, A.1    Trapnell, C.2    Donaghey, J.3    Rinn, J.L.4    Pachter, L.5
  • 64
    • 84861548193 scopus 로고    scopus 로고
    • Summarizing and correcting the GC content bias in high-throughput sequencing.
    • Benjamini, Y., Speed, T. P., Summarizing and correcting the GC content bias in high-throughput sequencing. Nucleic Acids Res. 2012, 40, e72.
    • (2012) Nucleic Acids Res. , vol.40 , pp. e72
    • Benjamini, Y.1    Speed, T.P.2
  • 65
    • 79957842166 scopus 로고    scopus 로고
    • Computational methods for transcriptome annotation and quantification using RNA-seq.
    • Garber, M., Grabherr, M. G., Guttman, M., Trapnell, C., Computational methods for transcriptome annotation and quantification using RNA-seq. Nat. Methods 2011, 8, 469-477.
    • (2011) Nat. Methods , vol.8 , pp. 469-477
    • Garber, M.1    Grabherr, M.G.2    Guttman, M.3    Trapnell, C.4
  • 66
    • 77955081300 scopus 로고    scopus 로고
    • Into the unknown: Expression profiling without genome sequence information in CHO by next generation sequencing.
    • Birzele, F., Schaub, J., Rust, W., Clemens, C. et al., Into the unknown: Expression profiling without genome sequence information in CHO by next generation sequencing. Nucleic Acids Res. 2010, 38, 3999-4010.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 3999-4010
    • Birzele, F.1    Schaub, J.2    Rust, W.3    Clemens, C.4
  • 67
    • 84963677853 scopus 로고    scopus 로고
    • Opening the black box: Chinese hamster ovary research goes genome scale.
    • Borth, N., Opening the black box: Chinese hamster ovary research goes genome scale. Pharm. Bioprocess. 2014, 2, 367-369.
    • (2014) Pharm. Bioprocess. , vol.2 , pp. 367-369
    • Borth, N.1
  • 68
    • 78650210790 scopus 로고    scopus 로고
    • Conserved MicroRNAs in Chinese hamster ovary cell lines.
    • Johnson, K. C., Jacob, N. M., Nissom, P. M., Hackl, M. et al., Conserved MicroRNAs in Chinese hamster ovary cell lines. Biotechnol. Bioeng. 2011, 108, 475-480.
    • (2011) Biotechnol. Bioeng. , vol.108 , pp. 475-480
    • Johnson, K.C.1    Jacob, N.M.2    Nissom, P.M.3    Hackl, M.4
  • 69
    • 84891818318 scopus 로고    scopus 로고
    • miRBase: Annotating high confidence microRNAs using deep sequencing data.
    • Kozomara, A., Griffiths-Jones, S., miRBase: Annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res. 2014, 42, D68-D73.
    • (2014) Nucleic Acids Res. , vol.42 , pp. D68-D73
    • Kozomara, A.1    Griffiths-Jones, S.2
  • 70
    • 84855505301 scopus 로고    scopus 로고
    • proTRAC-a software for probabilistic piRNA cluster detection, visualization and analysis.
    • Rosenkranz, D., Zischler, H., proTRAC-a software for probabilistic piRNA cluster detection, visualization and analysis. BMC Bioinformatics 2012, 13, 5.
    • (2012) BMC Bioinformatics , vol.13 , pp. 5
    • Rosenkranz, D.1    Zischler, H.2
  • 71
    • 84924629458 scopus 로고    scopus 로고
    • Evaluation of de novo transcriptome assemblies from RNA-Seq data.
    • Li, B., Fillmore, N., Bai, Y., Collins, M. et al., Evaluation of de novo transcriptome assemblies from RNA-Seq data. Genome Biol. 2014, 15, 553.
    • (2014) Genome Biol. , vol.15 , pp. 553
    • Li, B.1    Fillmore, N.2    Bai, Y.3    Collins, M.4
  • 72
    • 43149115851 scopus 로고    scopus 로고
    • Velvet: Algorithms for de novo short read assembly using de Bruijn graphs.
    • Zerbino, D. R., Birney, E., Velvet: Algorithms for de novo short read assembly using de Bruijn graphs. Genome Res. 2008, 18, 821-829.
    • (2008) Genome Res. , vol.18 , pp. 821-829
    • Zerbino, D.R.1    Birney, E.2
  • 73
    • 79960264362 scopus 로고    scopus 로고
    • Full-length transcriptome assembly from RNA-Seq data without a reference genome.
    • Grabherr, M. G., Haas, B. J., Yassour, M., Levin, J. Z. et al., Full-length transcriptome assembly from RNA-Seq data without a reference genome. Nat. Biotechnol. 2011, 29, 644-652.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 644-652
    • Grabherr, M.G.1    Haas, B.J.2    Yassour, M.3    Levin, J.Z.4
  • 74
    • 80755159050 scopus 로고    scopus 로고
    • How to apply de Bruijn graphs to genome assembly.
    • Compeau, P. E. C., Pevzner, P. A., Tesler, G., How to apply de Bruijn graphs to genome assembly. Nat. Biotechnol. 2011, 29, 987-991.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 987-991
    • Compeau, P.E.C.1    Pevzner, P.A.2    Tesler, G.3
  • 75
    • 84855293838 scopus 로고    scopus 로고
    • miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades.
    • Friedländer, M. R., Mackowiak, S. D., Li, N., Chen, W., Rajewsky, N., miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res. 2012, 40, 37-52.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 37-52
    • Friedländer, M.R.1    Mackowiak, S.D.2    Li, N.3    Chen, W.4    Rajewsky, N.5
  • 76
    • 77957272611 scopus 로고    scopus 로고
    • A survey of sequence alignment algorithms for next-generation sequencing.
    • Li, H., Homer, N., A survey of sequence alignment algorithms for next-generation sequencing. Briefings Bioinf. 2010, 11, 473-483.
    • (2010) Briefings Bioinf. , vol.11 , pp. 473-483
    • Li, H.1    Homer, N.2
  • 77
    • 84859210032 scopus 로고    scopus 로고
    • Fast gapped-read alignment with Bowtie 2.
    • Langmead, B., Salzberg, S. L., Fast gapped-read alignment with Bowtie 2. Nat. Methods 2012, 9, 357-359.
    • (2012) Nat. Methods , vol.9 , pp. 357-359
    • Langmead, B.1    Salzberg, S.L.2
  • 78
    • 84876996918 scopus 로고    scopus 로고
    • TopHat2: Accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions.
    • Kim, D., Pertea, G., Trapnell, C., Pimentel, H. et al., TopHat2: Accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol. 2013, 14, R36.
    • (2013) Genome Biol. , vol.14 , pp. R36
    • Kim, D.1    Pertea, G.2    Trapnell, C.3    Pimentel, H.4
  • 79
    • 77952123055 scopus 로고    scopus 로고
    • Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation.
    • Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A. et al., Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat. Biotechnol. 2010, 28, 511-515.
    • (2010) Nat. Biotechnol. , vol.28 , pp. 511-515
    • Trapnell, C.1    Williams, B.A.2    Pertea, G.3    Mortazavi, A.4
  • 80
    • 84872198346 scopus 로고    scopus 로고
    • Differential analysis of gene regulation at transcript resolution with RNA-seq.
    • Trapnell, C., Hendrickson, D. G., Sauvageau, M., Goff, L. et al., Differential analysis of gene regulation at transcript resolution with RNA-seq. Nat. Biotechnol. 2013, 31, 46-53.
    • (2013) Nat. Biotechnol. , vol.31 , pp. 46-53
    • Trapnell, C.1    Hendrickson, D.G.2    Sauvageau, M.3    Goff, L.4
  • 81
    • 62349130698 scopus 로고    scopus 로고
    • Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
    • Langmead, B., Trapnell, C., Pop, M., Salzberg, S., Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol. 2009, 10, R25.
    • (2009) Genome Biol. , vol.10 , pp. R25
    • Langmead, B.1    Trapnell, C.2    Pop, M.3    Salzberg, S.4
  • 83
    • 68549104404 scopus 로고    scopus 로고
    • The Sequence Alignment/Map format and SAMtools.
    • Li, H., Handsaker, B., Wysoker, A., Fennell, T. et al., The Sequence Alignment/Map format and SAMtools. Bioinformatics 2009, 25, 2078-2079.
    • (2009) Bioinformatics , vol.25 , pp. 2078-2079
    • Li, H.1    Handsaker, B.2    Wysoker, A.3    Fennell, T.4
  • 84
    • 84861743958 scopus 로고    scopus 로고
    • RNA-SeQC: RNA-seq metrics for quality control and process optimization.
    • DeLuca, D. S., Levin, J. Z., Sivachenko, A., Fennell, T. et al., RNA-SeQC: RNA-seq metrics for quality control and process optimization. Bioinformatics 2012, 28, 1530-1532.
    • (2012) Bioinformatics , vol.28 , pp. 1530-1532
    • DeLuca, D.S.1    Levin, J.Z.2    Sivachenko, A.3    Fennell, T.4
  • 85
    • 78751570979 scopus 로고    scopus 로고
    • RNA sequencing: advances, challenges and opportunities.
    • Ozsolak, F., Milos, P. M., RNA sequencing: advances, challenges and opportunities. Nat. Rev. Genet. 2011, 12, 87-98.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 87-98
    • Ozsolak, F.1    Milos, P.M.2
  • 86
    • 84902690266 scopus 로고    scopus 로고
    • Differential expression analysis of RNA-seq data at single-base resolution.
    • Frazee, A. C., Sabunciyan, S., Hansen, K. D., Irizarry, R. A., Leek, J. T., Differential expression analysis of RNA-seq data at single-base resolution. Biostatistics 2014, 15, 413-426.
    • (2014) Biostatistics , vol.15 , pp. 413-426
    • Frazee, A.C.1    Sabunciyan, S.2    Hansen, K.D.3    Irizarry, R.A.4    Leek, J.T.5
  • 87
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles.
    • Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S. et al., Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 15545-15550.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3    Mukherjee, S.4
  • 88
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.
    • Lewis, B. P., Burge, C. B., Bartel, D. P., Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005, 120, 15-20.
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 89
    • 77958471357 scopus 로고    scopus 로고
    • Differential expression analysis for sequence count data.
    • Anders, S., Huber, W., Differential expression analysis for sequence count data. Genome Biol. 2010, 11, R106.
    • (2010) Genome Biol. , vol.11 , pp. R106
    • Anders, S.1    Huber, W.2
  • 90
    • 75249087100 scopus 로고    scopus 로고
    • edgeR: A Bioconductor package for differential expression analysis of digital gene expression data.
    • Robinson, M. D., McCarthy, D. J., Smyth, G. K., edgeR: A Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 2010, 26, 139-140.
    • (2010) Bioinformatics , vol.26 , pp. 139-140
    • Robinson, M.D.1    McCarthy, D.J.2    Smyth, G.K.3
  • 91
    • 84924629414 scopus 로고    scopus 로고
    • Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.
    • Love, M. I., Huber, W., Anders, S., Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014, 15, 550.
    • (2014) Genome Biol. , vol.15 , pp. 550
    • Love, M.I.1    Huber, W.2    Anders, S.3
  • 92
    • 78650539308 scopus 로고    scopus 로고
    • From RNA-seq reads to differential expression results.
    • Oshlack, A., Robinson, M., Young, M., From RNA-seq reads to differential expression results. Genome Biol. 2010, 11, 220.
    • (2010) Genome Biol. , vol.11 , pp. 220
    • Oshlack, A.1    Robinson, M.2    Young, M.3
  • 93
    • 84928987900 scopus 로고    scopus 로고
    • HTSeq - a Python framework to work with high-throughput sequencing data.
    • Anders, S., Pyl, P. T., Huber, W., HTSeq - a Python framework to work with high-throughput sequencing data. Bioinformatics 2015, 31, 166-169.
    • (2015) Bioinformatics , vol.31 , pp. 166-169
    • Anders, S.1    Pyl, P.T.2    Huber, W.3
  • 94
    • 77951770756 scopus 로고    scopus 로고
    • BEDTools: A flexible suite of utilities for comparing genomic features.
    • Quinlan, A. R., Hall, I. M., BEDTools: A flexible suite of utilities for comparing genomic features. Bioinformatics 2010, 26, 841-842.
    • (2010) Bioinformatics , vol.26 , pp. 841-842
    • Quinlan, A.R.1    Hall, I.M.2
  • 95
    • 77952123055 scopus 로고    scopus 로고
    • Transcript assembly and abundance estimation from RNA-Seq reveals thousands of new transcripts and switching among isoforms.
    • Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A. et al., Transcript assembly and abundance estimation from RNA-Seq reveals thousands of new transcripts and switching among isoforms. Nat. Biotechnol. 2010, 28, 511-515.
    • (2010) Nat. Biotechnol. , vol.28 , pp. 511-515
    • Trapnell, C.1    Williams, B.A.2    Pertea, G.3    Mortazavi, A.4
  • 96
    • 77949481052 scopus 로고    scopus 로고
    • Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments.
    • Bullard, J., Purdom, E., Hansen, K., Dudoit, S., Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments. BMC Bioinformatics 2010, 11, 94.
    • (2010) BMC Bioinformatics , vol.11 , pp. 94
    • Bullard, J.1    Purdom, E.2    Hansen, K.3    Dudoit, S.4
  • 97
    • 84887791432 scopus 로고    scopus 로고
    • A comprehensive evaluation of normalization methods for Illumina high-throughput RNA sequencing data analysis.
    • Dillies, M.-A., Rau, A., Aubert, J., Hennequet-Antier, C. et al., A comprehensive evaluation of normalization methods for Illumina high-throughput RNA sequencing data analysis. Briefings Bioinf. 2013, 14, 671-683.
    • (2013) Briefings Bioinf. , vol.14 , pp. 671-683
    • Dillies, M.-A.1    Rau, A.2    Aubert, J.3    Hennequet-Antier, C.4
  • 98
    • 84858068675 scopus 로고    scopus 로고
    • Removing technical variability in RNA-seq data using conditional quantile normalization.
    • Hansen, K. D., Irizarry, R. A., Wu, Z., Removing technical variability in RNA-seq data using conditional quantile normalization. Biostatistics 2012, 13, 204-216.
    • (2012) Biostatistics , vol.13 , pp. 204-216
    • Hansen, K.D.1    Irizarry, R.A.2    Wu, Z.3
  • 99
    • 84872033704 scopus 로고    scopus 로고
    • Measurement of mRNA abundance using RNA-seq data: RPKM measure is inconsistent among samples.
    • Wagner, G., Kin, K., Lynch, V., Measurement of mRNA abundance using RNA-seq data: RPKM measure is inconsistent among samples. Theory Biosci. 2012, 131, 281-285.
    • (2012) Theory Biosci. , vol.131 , pp. 281-285
    • Wagner, G.1    Kin, K.2    Lynch, V.3
  • 100
    • 77953176036 scopus 로고    scopus 로고
    • A scaling normalization method for differential expression analysis of RNA-seq data.
    • Robinson, M. D., Oshlack, A., A scaling normalization method for differential expression analysis of RNA-seq data. Genome Biol. 2010, 11, R25.
    • (2010) Genome Biol. , vol.11 , pp. R25
    • Robinson, M.D.1    Oshlack, A.2
  • 101
    • 77951940273 scopus 로고    scopus 로고
    • Modeling non-uniformity in short-read rates in RNA-Seq data.
    • Li, J., Jiang, H., Wong, W., Modeling non-uniformity in short-read rates in RNA-Seq data. Genome Biol. 2010, 11, R50.
    • (2010) Genome Biol. , vol.11 , pp. R50
    • Li, J.1    Jiang, H.2    Wong, W.3
  • 102
    • 84907700231 scopus 로고    scopus 로고
    • Error estimates for the analysis of differential expression from RNA-seq count data.
    • Burden, C. J., Qureshi, S. E., Wilson, S. R., Error estimates for the analysis of differential expression from RNA-seq count data. PeerJ 2014, 2, e576.
    • (2014) PeerJ , vol.2 , pp. e576
    • Burden, C.J.1    Qureshi, S.E.2    Wilson, S.R.3
  • 103
    • 84865527768 scopus 로고    scopus 로고
    • Detecting differential usage of exons from RNA-seq data.
    • Anders, S., Reyes, A., Huber, W., Detecting differential usage of exons from RNA-seq data. Genome Res. 2012, 22, 2008-2017.
    • (2012) Genome Res. , vol.22 , pp. 2008-2017
    • Anders, S.1    Reyes, A.2    Huber, W.3
  • 104
    • 3042615882 scopus 로고    scopus 로고
    • Using the miraEST assembler for reliable and automated mRNA transcript assembly and SNP detection in sequenced ESTs.
    • Chevreux, B., Pfisterer, T., Drescher, B., Driesel, A. J. et al., Using the miraEST assembler for reliable and automated mRNA transcript assembly and SNP detection in sequenced ESTs. Genome Res. 2004, 14, 1147-1159.
    • (2004) Genome Res. , vol.14 , pp. 1147-1159
    • Chevreux, B.1    Pfisterer, T.2    Drescher, B.3    Driesel, A.J.4
  • 106
    • 78649714014 scopus 로고    scopus 로고
    • Analysis and design of RNA sequencing experiments for identifying isoform regulation.
    • Katz, Y., Wang, E. T., Airoldi, E. M., Burge, C. B., Analysis and design of RNA sequencing experiments for identifying isoform regulation. Nat. Methods 2010, 7, 1009-1015.
    • (2010) Nat. Methods , vol.7 , pp. 1009-1015
    • Katz, Y.1    Wang, E.T.2    Airoldi, E.M.3    Burge, C.B.4
  • 107
    • 79951715071 scopus 로고    scopus 로고
    • Regulation of alternative splicing by the core spliceosomal machinery.
    • Saltzman, A. L., Pan, Q., Blencowe, B. J., Regulation of alternative splicing by the core spliceosomal machinery. Genes Dev. 2011, 25, 373-384.
    • (2011) Genes Dev. , vol.25 , pp. 373-384
    • Saltzman, A.L.1    Pan, Q.2    Blencowe, B.J.3
  • 108
    • 84911462077 scopus 로고    scopus 로고
    • A comparative encyclopedia of DNA elements in the mouse genome.
    • Yue, F., Cheng, Y., Breschi, A., Vierstra, J. et al., A comparative encyclopedia of DNA elements in the mouse genome. Nature 2014, 515, 355-364.
    • (2014) Nature , vol.515 , pp. 355-364
    • Yue, F.1    Cheng, Y.2    Breschi, A.3    Vierstra, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.