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Volumn 30, Issue 2, 2014, Pages 429-442

Effects of copper on CHO cells: Insights from gene expression analyses

Author keywords

Chinese Hamster ovary cells; Copper; Gene expression; Lactate; Microarray; RNA Seq; Transcriptomics

Indexed keywords

BIRDS; CELL PROLIFERATION; GENE EXPRESSION; GENES; METABOLISM; MICROARRAYS; PHYSIOLOGY; RNA; TRANSCRIPTION;

EID: 84898598769     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1868     Document Type: Article
Times cited : (42)

References (63)
  • 1
    • 84868481008 scopus 로고    scopus 로고
    • Multivariate analysis of cell culture bioprocess data-lactate consumption as a process indicator
    • Le H, Kabbur S, Pollastrini L, Sun Z, Mills K, Johnson K, Karypis G, Hu W-S. Multivariate analysis of cell culture bioprocess data-lactate consumption as a process indicator. J Biotechnol. 2012;162:210-223.
    • (2012) J Biotechnol , vol.162 , pp. 210-223
    • Le Kabbur, H.1    Pollastrini, S.2    Sun, L.3    Mills, Z.4    Johnson, K.5    Karypis, K.6    Hu, G.7
  • 2
    • 70350136377 scopus 로고    scopus 로고
    • A single nutrient feed supports both chemically defined NS0 and CHO fed-batch cultures: improved productivity and lactate metabolism
    • Ma N, Ellet J, Okediadi C, Hermes P, McCormick E, Casnocha S. A single nutrient feed supports both chemically defined NS0 and CHO fed-batch cultures: improved productivity and lactate metabolism. Biotechnol Prog. 2009;25:1353-1363.
    • (2009) Biotechnol Prog , vol.25 , pp. 1353-1363
    • Ma, N.1    Ellet, J.2    Okediadi, C.3    Hermes, P.4    McCormick, E.5    Casnocha, S.6
  • 4
    • 84871722305 scopus 로고    scopus 로고
    • Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption
    • Martinez VS, Dietmair S, Quek LE, Hodson MP, Gray P, Nielsen LK. Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption. Biotechnol Bioeng. 2013;110:660-666.
    • (2013) Biotechnol Bioeng , vol.110 , pp. 660-666
    • Martinez, V.S.1    Dietmair, S.2    Quek, L.E.3    Hodson, M.P.4    Gray, P.5    Nielsen, L.K.6
  • 5
    • 84858000888 scopus 로고    scopus 로고
    • On metabolic shift to lactate consumption in fed-batch culture of mammalian cells
    • Mulukutla BC, Gramer M, Hu W-S. On metabolic shift to lactate consumption in fed-batch culture of mammalian cells. Metab Eng. 2012;14:138-149.
    • (2012) Metab Eng , vol.14 , pp. 138-149
    • Mulukutla, B.C.1    Gramer, M.2    Hu, W.-S.3
  • 6
    • 84872371605 scopus 로고    scopus 로고
    • Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity
    • Zagari F, Jordan M, Stettler M, Broly H, Wurm FM. Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity. New Biotechnol. 2012;30:238-245.
    • (2012) New Biotechnol , vol.30 , pp. 238-245
    • Zagari, F.1    Jordan, M.2    Stettler, M.3    Broly, H.4    Wurm, F.M.5
  • 7
    • 84898602217 scopus 로고    scopus 로고
    • High expression of the aspartate-glutamate carrier Aralar1 favors lactate consumption in CHO cell culture
    • Zagari F, Stettler M, Baldi L, Broly H, Wurm FM, Jordan M. High expression of the aspartate-glutamate carrier Aralar1 favors lactate consumption in CHO cell culture. Pharm Bioprocess. 2013;1:19-27.
    • (2013) Pharm Bioprocess , vol.1 , pp. 19-27
    • Zagari, F.1    Stettler, M.2    Baldi, L.3    Broly, H.4    Wurm, F.M.5    Jordan, M.6
  • 8
    • 81455141232 scopus 로고    scopus 로고
    • Comparative metabolite analysis to understand lactate metabolism shift in Chinese Hamster ovary cell culture process
    • Luo J, Vijayasankaran N, Autsen J, Santuray R, Hudson T, Amanullah A, Li F. Comparative metabolite analysis to understand lactate metabolism shift in Chinese Hamster ovary cell culture process. Biotechnol Bioeng. 2012;109:146-156.
    • (2012) Biotechnol Bioeng , vol.109 , pp. 146-156
    • Luo, J.1    Vijayasankaran, N.2    Autsen, J.3    Santuray, R.4    Hudson, T.5    Amanullah, A.6    Li, F.7
  • 10
    • 39349112330 scopus 로고    scopus 로고
    • Mechanisms for copper acquisition, distribution and regulation
    • Kim B-E, Nevitt T, Thiele DJ. Mechanisms for copper acquisition, distribution and regulation. Nat Chem Biol. 2008;4:176-185.
    • (2008) Nat Chem Biol , vol.4 , pp. 176-185
    • Kim, B.-E.1    Nevitt, T.2    Thiele, D.J.3
  • 11
    • 79953329777 scopus 로고    scopus 로고
    • Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 signaling pathway that drives tumor angiogenesis
    • Vegran F, Boidot R, Michiels C, Sonveaux P, Feron O. Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 signaling pathway that drives tumor angiogenesis. Cancer Res. 2011;71:2550-2560.
    • (2011) Cancer Res , vol.71 , pp. 2550-2560
    • Vegran, F.1    Boidot, R.2    Michiels, C.3    Sonveaux, P.4    Feron, O.5
  • 12
    • 84881617305 scopus 로고    scopus 로고
    • Chinese Hamster ovary (CHO) K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase (DHFR) deficient host cell
    • Hu Z, Guo D, Yip SSM, Zhan D, Misaghi S, Joly JC, Snedecor BR, Shen AY. Chinese Hamster ovary (CHO) K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase (DHFR) deficient host cell. Biotechnol Prog. 2013;29:980-985.
    • (2013) Biotechnol Prog , vol.29 , pp. 980-985
    • Hu, Z.1    Guo, D.2    Yip, S.S.M.3    Zhan, D.4    Misaghi, S.5    Joly, J.C.6    Snedecor, B.R.7    Shen, A.Y.8
  • 13
    • 84868461356 scopus 로고    scopus 로고
    • Advanced microscale bioreactor system: a representative scale-down model for bench-top bioreactors
    • Hsu W-T, Aulakh RPS, Traul DL, Yuk IH. Advanced microscale bioreactor system: a representative scale-down model for bench-top bioreactors. Cytotechnology. 2012;64:667-678.
    • (2012) Cytotechnology , vol.64 , pp. 667-678
    • Hsu, W.-T.1    Aulakh, R.P.S.2    Traul, D.L.3    Yuk, I.H.4
  • 14
    • 17044408782 scopus 로고    scopus 로고
    • A non-radioactive method for measuring Cu uptake in HepG2 cells
    • Fosset C, McGaw BA, Reid MD, McArdle HJ. A non-radioactive method for measuring Cu uptake in HepG2 cells. J Inorg Biochem. 2005;99:1018-1022.
    • (2005) J Inorg Biochem , vol.99 , pp. 1018-1022
    • Fosset, C.1    McGaw, B.A.2    Reid, M.D.3    McArdle, H.J.4
  • 16
    • 84875515777 scopus 로고    scopus 로고
    • LDH-C can be differentially expressed during fermentation of CHO cells
    • P
    • Szperalski B, Jung C, Shao Z, Kantardjieff A, Hu W-S. LDH-C can be differentially expressed during fermentation of CHO cells. BMC Proc. 2011;5:P107.
    • (2011) BMC Proc. , vol.5 , pp. 107
    • Szperalski, B.1    Jung, C.2    Shao, Z.3    Kantardjieff, A.4    Hu, W.-S.5
  • 19
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical Bayes methods for assessing differential expression in microarray experiments
    • Article 3.
    • Smyth GK. Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 2004;3:Article 3.
    • (2004) Stat Appl Genet Mol Biol , vol.3
    • Smyth, G.K.1
  • 20
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B Methodol. 1995;57:289-300.
    • (1995) J R Stat Soc B Methodol , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 23
    • 0023232695 scopus 로고
    • Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant
    • Lim RW, Varnum BC, Herschman HR. Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant. Oncogene. 1987;1:263-270.
    • (1987) Oncogene , vol.1 , pp. 263-270
    • Lim, R.W.1    Varnum, B.C.2    Herschman, H.R.3
  • 24
    • 0023491356 scopus 로고
    • A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor
    • Milbrandt J. A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science. 1987;238:797-799.
    • (1987) Science , vol.238 , pp. 797-799
    • Milbrandt, J.1
  • 25
    • 73349086892 scopus 로고    scopus 로고
    • Is EGR1 a potential target for prostate cancer therapy?
    • Gitenay D, Baron VT. Is EGR1 a potential target for prostate cancer therapy? Future Oncol. 2012;5:993-1003.
    • (2012) Future Oncol , vol.5 , pp. 993-1003
    • Gitenay, D.1    Baron, V.T.2
  • 26
    • 41049088525 scopus 로고    scopus 로고
    • Egr1 and Gas6 facilitate the adaptation of HEK-293 cells to serum-free media by conferring enhanced viability and higher growth rates
    • Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J. Egr1 and Gas6 facilitate the adaptation of HEK-293 cells to serum-free media by conferring enhanced viability and higher growth rates. Biotechnol Bioeng. 2008;99:1443-1452.
    • (2008) Biotechnol Bioeng , vol.99 , pp. 1443-1452
    • Jaluria, P.1    Konstantopoulos, K.2    Betenbaugh, M.3    Shiloach, J.4
  • 27
    • 84857758814 scopus 로고    scopus 로고
    • Consistency test of the cell cycle: roles for p53 and EGR1
    • Zwang Y, Oren M, Yarden Y. Consistency test of the cell cycle: roles for p53 and EGR1. Cancer Res. 2012;72:1051-1054.
    • (2012) Cancer Res , vol.72 , pp. 1051-1054
    • Zwang, Y.1    Oren, M.2    Yarden, Y.3
  • 28
    • 77957174189 scopus 로고    scopus 로고
    • EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin
    • Kumbrink J, Kirsch KH, Johnson JP. EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin. J Cell Biochem. 2010;111:207-217.
    • (2010) J Cell Biochem , vol.111 , pp. 207-217
    • Kumbrink, J.1    Kirsch, K.H.2    Johnson, J.P.3
  • 29
    • 66349113241 scopus 로고    scopus 로고
    • A key role for early growth response-1 and nuclear factor-κB in mediating and maintaining GRO/CXCR2 proliferative signaling in esophageal cancer
    • Wang B, Khachigian LM, Esau L, Birrer MJ, Zhao X, Parker MI, Hendricks DT. A key role for early growth response-1 and nuclear factor-κB in mediating and maintaining GRO/CXCR2 proliferative signaling in esophageal cancer. Mol Cancer Res. 2009;7:755-764.
    • (2009) Mol Cancer Res , vol.7 , pp. 755-764
    • Wang, B.1    Khachigian, L.M.2    Esau, L.3    Birrer, M.J.4    Zhao, X.5    Parker, M.I.6    Hendricks, D.T.7
  • 31
    • 32544446276 scopus 로고    scopus 로고
    • Regulation of the neuronal proteasome by Zif268 (Egr1)
    • James AB, Conway A-M, Morris BJ. Regulation of the neuronal proteasome by Zif268 (Egr1). J Neurosci. 2006;26:1624-1634.
    • (2006) J Neurosci , vol.26 , pp. 1624-1634
    • James, A.B.1    Conway, A.-M.2    Morris, B.J.3
  • 32
    • 79958789619 scopus 로고    scopus 로고
    • E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression
    • Lau M-T, Klausen C, Leung PCK. E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression. Oncogene. 2011;30:2753-2766.
    • (2011) Oncogene , vol.30 , pp. 2753-2766
    • Lau, M.-T.1    Klausen, C.2    Leung, P.C.K.3
  • 33
    • 34247610407 scopus 로고    scopus 로고
    • Gene expression profiling of liver cells after copper overload in vivo and in vitro reveals new copper-related genes
    • Muller P, van Bakel H, van de Sluis B, Holstege F, Wijmenga C, Klomp LWJ. Gene expression profiling of liver cells after copper overload in vivo and in vitro reveals new copper-related genes. J Biol Inorg Chem. 2007;12:495-507.
    • (2007) J Biol Inorg Chem , vol.12 , pp. 495-507
    • Muller, P.1    van Bakel, H.2    van de Sluis, B.3    Holstege, F.4    Wijmenga, C.5    Klomp, L.W.J.6
  • 34
    • 68849129372 scopus 로고    scopus 로고
    • Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper
    • Song MO, Li J, Freedman JH. Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009;38:386-401.
    • (2009) Physiol Genomics , vol.38 , pp. 386-401
    • Song, M.O.1    Li, J.2    Freedman, J.H.3
  • 35
    • 20144386738 scopus 로고    scopus 로고
    • Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loop
    • Pines A, Bivi N, Romanello M, Damante G, Kelley MR, Adamson ED, D'Andrea P, Quadrifoglio F, Moro L, Tell G. Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loop. Free Radic Res. 2005;39:269-281.
    • (2005) Free Radic Res , vol.39 , pp. 269-281
    • Pines, A.1    Bivi, N.2    Romanello, M.3    Damante, G.4    Kelley, M.R.5    Adamson, E.D.6    D'Andrea, P.7    Quadrifoglio, F.8    Moro, L.9    Tell, G.10
  • 37
    • 84859415411 scopus 로고    scopus 로고
    • Intrapulmonary administration of Leukotriene B4 augments neutrophil accumulation and responses in the lung to Klebsiella infection in CXCL1 knockout mice
    • Batra S, Cai S, Balamayooron G, Jeyaseelan S. Intrapulmonary administration of Leukotriene B4 augments neutrophil accumulation and responses in the lung to Klebsiella infection in CXCL1 knockout mice. J Immunol. 2012;188:3458-3468.
    • (2012) J Immunol , vol.188 , pp. 3458-3468
    • Batra, S.1    Cai, S.2    Balamayooron, G.3    Jeyaseelan, S.4
  • 38
    • 0037234487 scopus 로고    scopus 로고
    • Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular location and enzymatic activity
    • Firestone GL, Giampaolo JR, O'Keeffe BA. Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular location and enzymatic activity. Cell Physiol Biochem. 2003;13:1-12.
    • (2003) Cell Physiol Biochem , vol.13 , pp. 1-12
    • Firestone, G.L.1    Giampaolo, J.R.2    O'Keeffe, B.A.3
  • 39
    • 0036260697 scopus 로고    scopus 로고
    • Cellular response to oxidative stress: signaling for suicide and survival
    • Martindale JL, Holbrook NJ. Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol. 2002;192:1-15.
    • (2002) J Cell Physiol , vol.192 , pp. 1-15
    • Martindale, J.L.1    Holbrook, N.J.2
  • 41
    • 0037082109 scopus 로고    scopus 로고
    • Copper ions strongly activate the phosphoinositide-3-kinase/Akt pathway independent of the generation of reactive oxygen species
    • Ostrakhovitch EA, Lordnejad MR, Schliess F, Sies H, Klotz L-O. Copper ions strongly activate the phosphoinositide-3-kinase/Akt pathway independent of the generation of reactive oxygen species. Arch Biochem Biophys. 2002;397:232-239.
    • (2002) Arch Biochem Biophys , vol.397 , pp. 232-239
    • Ostrakhovitch, E.A.1    Lordnejad, M.R.2    Schliess, F.3    Sies, H.4    Klotz, L.-O.5
  • 42
    • 70350131071 scopus 로고    scopus 로고
    • Copper activation of NF-κB signaling in HepG2 cells
    • McElwee MK, Song MK, Freedman JH. Copper activation of NF-κB signaling in HepG2 cells. J Mol Biol. 2009;393:1013-1021.
    • (2009) J Mol Biol , vol.393 , pp. 1013-1021
    • McElwee, M.K.1    Song, M.K.2    Freedman, J.H.3
  • 43
    • 0742323126 scopus 로고    scopus 로고
    • Copper-inducible transcription: regulation by metal- and oxidative stress-responsive pathways
    • Mattie MD, Freedman JH. Copper-inducible transcription: regulation by metal- and oxidative stress-responsive pathways. Am J Physiol Cell Physiol. 2004;286:C293-C301.
    • (2004) Am J Physiol Cell Physiol , vol.286
    • Mattie, M.D.1    Freedman, J.H.2
  • 44
    • 69949124867 scopus 로고    scopus 로고
    • Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells
    • Feron O. Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells. Radiother Oncol. 2009;92:329-333.
    • (2009) Radiother Oncol , vol.92 , pp. 329-333
    • Feron, O.1
  • 45
    • 79960009576 scopus 로고    scopus 로고
    • The Myc-ARF-Egr1 pathway
    • Boone DN, Hann SR. The Myc-ARF-Egr1 pathway. Cell Cycle. 2011;10:2043-2044.
    • (2011) Cell Cycle , vol.10 , pp. 2043-2044
    • Boone, D.N.1    Hann, S.R.2
  • 46
    • 77954219913 scopus 로고    scopus 로고
    • Placenta growth factor-induced early growth response 1 (Egr-1) regulates hypoxia-inducible factor-1α (HIF-1α) in endothelial cells
    • Patel N, Kalra VK. Placenta growth factor-induced early growth response 1 (Egr-1) regulates hypoxia-inducible factor-1α (HIF-1α) in endothelial cells. J Biol Chem. 2010;285:20570-20579.
    • (2010) J Biol Chem , vol.285 , pp. 20570-20579
    • Patel, N.1    Kalra, V.K.2
  • 50
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: a revolutionary tool for transcriptomics
    • Wang Z, Gerstein M, Snyder M. RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet. 2009;10:57-63.
    • (2009) Nat Rev Genet , vol.10 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 51
    • 0036690151 scopus 로고    scopus 로고
    • Endogenous kynurenines as targets for drug discovery and development
    • Stone TW, Darlington LG. Endogenous kynurenines as targets for drug discovery and development. Nat Rev Drug Discov. 2002;1:609-620.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 609-620
    • Stone, T.W.1    Darlington, L.G.2
  • 52
    • 0035344460 scopus 로고    scopus 로고
    • Versatility of the mitochondrial protein import machinery
    • Pfanner N, Geissler A. Versatility of the mitochondrial protein import machinery. Nat Rev Mol Cell Biol. 2001;2:339-349.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 339-349
    • Pfanner, N.1    Geissler, A.2
  • 54
    • 34848866023 scopus 로고    scopus 로고
    • Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs
    • Nguyen AD, McDonald JG, Bruick RK, DeBose-Boyd RA. Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs. J Biol Chem. 2007;282:27436-27446.
    • (2007) J Biol Chem , vol.282 , pp. 27436-27446
    • Nguyen, A.D.1    McDonald, J.G.2    Bruick, R.K.3    DeBose-Boyd, R.A.4
  • 55
    • 31444444162 scopus 로고    scopus 로고
    • Integration of oxygen signaling at the consensus HRE
    • Wenger RH, Daniel PS, Camenisch G. Integration of oxygen signaling at the consensus HRE. Sci STKE. 2005;306:re12.
    • (2005) Sci STKE , vol.306
    • Wenger, R.H.1    Daniel, P.S.2    Camenisch, G.3
  • 57
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003;3:721-732.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 59
    • 78650483039 scopus 로고    scopus 로고
    • Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation
    • Mick DU, Fox TD, Rehling P. Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation. Nat Rev Mol Cell Biol. 2011;12:14-20.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 14-20
    • Mick, D.U.1    Fox, T.D.2    Rehling, P.3
  • 60
    • 33846643485 scopus 로고    scopus 로고
    • Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese Hamster ovary cells producing thrombopoietin
    • Kim SH, Lee GM. Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese Hamster ovary cells producing thrombopoietin. Appl Microbiol Biotechnol. 2007;74:152-159.
    • (2007) Appl Microbiol Biotechnol , vol.74 , pp. 152-159
    • Kim, S.H.1    Lee, G.M.2
  • 61
    • 79955540196 scopus 로고    scopus 로고
    • Decreasing lactate level and increasing antibody production in Chinese Hamster ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases
    • Zhou M, Crawford Y, Ng D, Tung J, Pynn AFJ, Meier A, Yuk IH, Vijayasankaran N, Leach K, Joly J, Snedecor B, Shen A. Decreasing lactate level and increasing antibody production in Chinese Hamster ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases. J Biotechnol. 2011;153:27-34.
    • (2011) J Biotechnol , vol.153 , pp. 27-34
    • Zhou, M.1    Crawford, Y.2    Ng, D.3    Tung, J.4    Pynn, A.F.J.5    Meier, A.6    Yuk, I.H.7    Vijayasankaran, N.8    Leach, K.9    Joly, J.10    Snedecor, B.11    Shen, A.12
  • 62
    • 14644430464 scopus 로고    scopus 로고
    • NAD(H) enhances the Cu(II)-mediated inactivation of lactate dehydrogenase by increasing the accessibility of sulfhydryl groups
    • Pamp K, Bramey T, Kirsch M, de Groot H, Petrat F. NAD(H) enhances the Cu(II)-mediated inactivation of lactate dehydrogenase by increasing the accessibility of sulfhydryl groups. Free Radic Res. 2005;39:31-40.
    • (2005) Free Radic Res , vol.39 , pp. 31-40
    • Pamp, K.1    Bramey, T.2    Kirsch, M.3    de Groot, H.4    Petrat, F.5
  • 63
    • 0035936718 scopus 로고    scopus 로고
    • Paradoxical effects of copper and manganese on brain mitochondrial function
    • Heron P, Cousins K, Boyd C, Daya S. Paradoxical effects of copper and manganese on brain mitochondrial function. Life Sci. 2001;68:1575-1583.
    • (2001) Life Sci , vol.68 , pp. 1575-1583
    • Heron, P.1    Cousins, K.2    Boyd, C.3    Daya, S.4


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