In yeast, loss of Hog1 leads to osmosensitivity of autophagy

Biochemical Journal

Volumn 394, Issue 1, 2006, Pages 153-161

  Prick, Tanja ^a   Thumm, Michael ^b   Köhrer, Karl ^a   Häussinger, Dieter ^a   Vom Dahl, Stephan ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Autophagy; High osmolarity glycerol 1 gene (HOG1); Liver; Osmosensitivity; p38 mitogen activated protein kinase (p38MAPK); Rapamycin

Indexed keywords

AMINO ACIDS; CELLS; ENZYMES; FLUORESCENCE; GLYCEROL; OSMOSIS; YEAST;

AUTOPHAGY; HIGH-OSMOLARITY GLYCEROL 1 GENE (HOG1); OSMOSENSITIVITY; P38 MITOGEN-ACTIVATED PROTEIN KINASE (P38MAPK); RAPAMYCIN;

BIOLOGICAL ORGANS;

MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN HIGH OSMOLARITY GLYCEROL 1; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HYPEROSMOLARITY; NONHUMAN; OSMOLARITY; OSMOTIC FRAGILITY; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; WESTERN BLOTTING; YEAST;

AUTOPHAGY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, FUNGAL; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; NITROGEN; OSMOTIC PRESSURE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIROLIMUS; TIME FACTORS;

MAMMALIA;

EID: 32944460806     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051243     Document Type: Article

References (47)

1. Codogno, P., Ogier-Denis, E. and Houri, J. J. (1997) Signal transduction pathways in macroautophagy. Cell. Signalling 9, 125-130
2. Klionsky, D. J. and Emr, S. D. (2000) Autophagy as a regulated pathway of cellular degradation. Science 290, 1717-1721
3. Meijer, A. J. and Codogno, P. (2004) Regulation and role of autophagy in mammalian cells. Int. J. Biochem. Cell Biol. 36, 2445-2462
4. Mortimore, G. E. and Pösö, R. A. (1987) Intracellular protein catabolism and its control during nutrient deprivation and supply. Annu. Rev. Nutr. 7, 539-564
5. vom Dahl, S. and Häussinger, D. (2004) Role of amino acids in the control of proteolysis. In Amino Acid Metabolism and Therapy in Health and Disease (Cynober, L., ed.), pp. 275-289, CRC Press, Boca Raton
6. Ogier-Denis, E. and Codogno, P. (2003) Autophagy: a barrier or an adaptive response to cancer. Biochim. Biophys. Acta 1603, 113-128
7. Pfeifer, U. (1978) Inhibition by insulin of the formation of autophagic vacuoles in rat liver: a morphometric approach to the kinetics of intracellular degradation by autophagy. J. Cell Biol. 78, 152-167
8. vom Dahl, S., Hallbrucker, C., Lang, F., Gerok, W. and Häussinger, D. (1991) Regulation of liver cell volume and proteolysis by glucagon and insulin. Biochem. J. 278, 771-777
9. Schworer, C. M. and Mortimore, G. E. (1979) Glucagon-induced autophagy and proteolysis in rat liver: mediation by selective deprivation of intracellular amino acids. Proc. Natl. Acad. Sci. U.S.A. 76, 3169-3173
10. vom Dahl, S. and Häussinger, D. (1996) The role of the nutritional state in the control of proteolysis by the cellular hydration state in the perfused rat liver. J. Nutr. 126, 395-402
11. Häussinger, D., Hallbrucker, C., vom Dahl, S., Lang, F. and Gerok, W. (1990) Cell swelling inhibits proteolysis in perfused rat liver. Biochem. J. 272, 239-242
12. MAPK in the regulation of proteolysis by liver cell hydration. Gastroenterology 116, 921-935
13. Schliess, F., Reissmann, R., Reinehr, R., vom Dahl, S. and Häussinger, D. (2004) Involvement of integrins and Src in insulin signaling toward autophagic proteolysis in rat liver. J. Biol. Chem. 279, 21294-21301
14. MAPK activation. Biochem. J. 354, 31-36
15. vom Dahl, S., Schliess, F., Reissmann, R., Gorg, B., Weiergraber, O., Kocalkova, M., Dombrowski, F. and Häussinger, D. (2003) Involvement of integrins in osmosensing and signaling toward autophagic proteolysis in rat liver. J. Biol. Chem. 278, 27088-27095
16. Huang, W. P. and Klionsky, D. J. (2002) Autophagy in yeast: a review of the molecular machinery. Cell Struct. Funct. 27, 409-420
17. Bursch, W., Grasl-Kraupp, B., Wastl, U., Hufnagl, K., Chabicovsky, M., Taper, H. and Schulte-Hermann, R. (2004) Role of apoptosis for mouse liver growth regulation and tumor promotion: comparative analysis of mice with high (C3H/He) and low (C57BI/6J) cancer susceptibility. Toxicol. Lett. 149, 25-35
18. O'Rourke, S. M. and Herskowitz, I. (1998) The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae. Genes Dev. 12, 2874-2886
19. Chellappan, S. P. (2001) HOG on the promoter: regulation of the osmotic stress response. Science STKE 2001, PE1
20. Hohmann, S. (2002) Osmotic stress signaling and osmoadaptation in yeasts. Microbiol. Mol. Biol. Rev. 66, 300-372
21. Meiling-Wesse, K., Barth, H., Voss, C., Eskelinen, E. L., Epple, U. D. and Thumm, M. (2004) Atg21 is required for effective recruitment of Atg8 to the preautophagosomal structure during the Cvt pathway. J. Biol. Chem. 279, 37741-37750
22. Whittaker, C. A. and Hynes, R. O. (2002) Distribution and evolution of von Willebrand/ integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. Mol. Biol. Cell 13, 3369-3387
23. Barth, H. and Thumm, M. (2001) A genomic screen identifies AUT8 as a novel gene essential for autophagy in the yeast Saccharomyces cerevisiae. Gene 274, 151-156
24. Gueldener, U., Heinisch, J., Koehler, G. J., Voss, D. and Hegemann, J. H. (2002) A second set of loxP marker cassettes for Cre-mediated multiple gene knockouts in budding yeast. Nucleic. Acids Res. 30, e23
25. Suzuki, K., Kirisako, T., Kamada, Y., Mizushima, N., Noda, T. and Ohsumi, Y. (2001) The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J. 20, 5971-5981
26. Meiling-Wesse, K., Bratsika, F. and Thumm, M. (2004) ATG23, a novel gene required for maturation of proaminopeptidase I, but not for autophagy. FEMS Yeast Res. 4, 459-465
27. Takeshige, K., Baba, M., Tsuboi, S., Noda, T. and Ohsumi, Y. (1992) Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction. J. Cell Biol. 119, 301-311
28. Noda, T., Matsuura, A., Wada, Y. and Ohsumi, Y. (1995) Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 210, 126-132
29. Kirisako, T., Ichimura, Y., Okada, H., Kabeya, Y., Mizushima, N., Yoshimori, T., Ohsumi, M., Takao, T., Noda, T. and Ohsumi, Y. (2000) The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J. Cell Biol. 151, 263-276
30. Scott, S. V., Nice, 3rd, D. C., Nau, J. J., Weisman, L. S., Kamada, Y., Keizer-Gunnink, I., Funakoshi, T., Veenhuis, M., Ohsumi, Y. and Klionsky, D. J. (2000) Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting. J. Biol. Chem. 275, 25840-25849
31. O'Rourke, S. M., Herskowitz, I. and O'Shea, E. K. (2002) Yeast go the whole HOG for the hyperosmotic response. Trends Genet. 18, 405-412
32. Khalfan, W. A. and Klionsky, D. J. (2002) Molecular machinery required for autophagy and the cytoplasm to vacuole targeting (Cvt) pathway in S. cerevisiae. Curr. Opin. Cell Biol. 14, 468-475
33. Wang, C. W. and Klionsky, D. J. (2003) The molecular mechanism of autophagy. Mol. Med. 9, 65-76
34. Reggiori, F., Tucker, K. A., Stromhaug, P. E. and Klionsky, D. J. (2004) The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure. Dev. Cell 6, 79-90
35. Marino, G. and Lopez-Otin, C. (2004) Autophagy: molecular mechanisms, physiological functions and relevance in human pathology. Cell. Mol. Life Sci. 61, 1439-1454
36. MAPK activation. Biochem. J. 354, 31-36
37. MAPK in the regulation Of proteolysis by liver cell hydration. Gastroenterology 116, 921-935
38. Kirisako, T., Baba, M., Ishihara, N., Miyazawa, K., Ohsumi, M., Yoshimori, T., Noda, T. and Ohsumi, Y. (1999) Formation process of autophagosome is traced with Apg8/Aut7p in yeast. J. Cell Biol. 147, 435-446
39. Maeda, T., Takekawa, M. and Saito, H. (1995) Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. Science 269, 554-558
40. Tanida, I., Mizushima, N., Kiyooka, M., Ohsumi, M., Ueno, T., Ohsumi, Y. and Kominami, E. (1999) Apg7p/Cvt2p: a novel protein-activating enzyme essential for autophagy. Mol. Biol. Cell 10, 1367-1379
41. Ichimura, Y., Kirisako, T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N., Mizushima, N., Tanida, I., Kominami, E., Ohsumi, M. et al. (2000) A ubiquitin-like system mediates protein lipidation. Nature (London) 408, 488-492
42. Huang, W. P., Scott, S. V., Kim, J. and Klionsky, D. J. (2000) The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways. J. Biol. Chem. 275, 5845-5851
43. Kanazawa, T., Taneike, I., Akaishi, R., Yoshizawa, F., Furuya, N., Fujimura, S. and Kadowaki, M. (2004) Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes. J. Biol. Chem. 279, 8452-8459
44. Schliess, F., Reissmann, R., Reinehr, R., vom Dahl, S. and Häussinger, D. (2004) Involvement of integrins and Src in insulin signaling toward autophagic proteolysis in rat liver. J. Biol. Chem. 279, 21294-21301
45. Thumm, M., Egner, R., Koch, B., Schlumpberger, M., Straub, M., Veenhuis, M. and Wolf, D. H. (1994) Isolation of autophagocytosis mutants of Saccharomyces cerevisiae. FEBS Lett. 349, 275-280
46. Lang, T., Reiche, S., Straub, M., Bredschneider, M. and Thumm, M. (2000) Autophagy and the cvt pathway both depend on AUT9. J. Bacteriol. 182, 2125-2133
47. Lang, T., Schaeffeler, E., Bernreuther, D., Bredschneider, M., Wolf, D. H. and Thumm, M. (1998) Aut2p and Aut7p, two novel microtubule-associated proteins are essential for delivery of autophagic vesicles to the vacuole. EMBO J. 17, 3597-3607