In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids

Journal of Biological Chemistry

Volumn 279, Issue 41, 2004, Pages 42628-42637

  Mothe Satney, Isabelle ^a   Gautiert, Nadine ^a   Hinault, Charlotte ^a   Lawrence Jr , John C ^b   Van Obberghen, Emmanuel ^a  

^a INSERM   (France)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DRUG PRODUCTS; ENZYMES; INSULIN; LIVING SYSTEMS STUDIES; RNA;

GLUCAGON; PHOSOPHORYLATIONS; RAPAMYCIN;

CELLS;

AMINO ACID; CELL PROTEIN; GLUCAGON; INITIATION FACTOR 4E; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; RAPAMYCIN; S6 KINASE; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL GROWTH; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; LIVER CELL CULTURE; MALE; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

AMINO ACIDS; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CARRIER PROTEINS; CELLS, CULTURED; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUCAGON; HEPATOCYTES; IMMUNOPRECIPITATION; INSULIN; MALE; OKADAIC ACID; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SERINE; SIROLIMUS; THREONINE; TIME FACTORS;

ANIMALIA; EUKARYOTA; MAMMALIA;

EID: 5644285347     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M405173200     Document Type: Article

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