Amino-acid-dependent signal transduction

Biochemical Journal

Volumn 351, Issue 3, 2000, Pages 545-550

  Van Sluijters, D A ^a   Dubbelhuis, P F ^a   Blommaart, E F C ^a   Meijer, A J ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Autophagy; Insulin; Phosphatidylinositol 3 kinase; Protein kinase B; S6

Indexed keywords

AMINO ACID; INITIATION FACTOR 4E; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; S6 KINASE;

AMINOACYLATION; AUTOPHAGY; ENZYME PHOSPHORYLATION; HUMAN; METABOLISM; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

AMINO ACIDS; SIGNAL TRANSDUCTION;

EID: 0034329612     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3510545     Document Type: Review

References (66)

1. Autophagic proteolysis: Control and specificity
2. Cell swelling and the control of autophagic proteolysis in hepatocytes: Involvement of phosphorylation of ribosomal protein S6?
3. Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes
4. Rapamycin selectively represses translation of the 'polypyrimidine tract' mRNA family
5. Rapamycin selectively inhibits translation of mRNAS encoding elongation factors and ribosomal proteins
6. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
7. Amino acid sufficiency and roTOR regulate p70 S6 kinase and elF-4E BP1 through a common effector mechanism
8. Amino acid availability regulates p70 S6 kinase and multiple translation factors
9. Amino acids stimulate phosphorylation of p70 S6 kinase and organization of rat adipocytes into multicellular clusters
10. Bidirectional modulation of insulin action by amino acids
11. Control of the expression and activity of the Gα-interacting protein (GAIP) in human intestinal cells
12. Implication of elF2B rather than etF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts
13. Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling
14. Phosphorylation and activation of p70 S6 kinase by PDK1
15. Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies
16. Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
17. Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorytation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252
18. Nutrients differentially regulate multiple translation factors and their control by insulin
19. Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of elF4E and phosphorylation of ribosomal protein S6
20. Structural requirement of teucine for activation of p70 S6 kinase
21. Swelling of rat hepatocytes stimulates glycogen synthesis
22. L-Asparaginase inhibits the rapamycin-targeted signaling pathway
23. Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a PKB signaling pathway
24. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
25. Regulation of 4E-BP1 phosphorylation: A novel two-step mechanism
26. Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase
27. Molecular mechanisms for the control of translation by insulin
28. Insulin mediates glucose-stimulated phosphorylation of PHAS-I by pancreatic beta cells. An insulin-receptor mechanism for autoregulation of protein synthesis by translation
29. Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy incultured hepatoma cells
30. Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation
31. Ribosomal S6 kinase signaling and the control of translation
32. The PI3K-PDK1 connection: More than just a road to PKB
33. Protein kinase signaling pathway triggered by cell swelling and involved in the activation of glycogen synthase and acetyl-CoA carboxylase in isolated rat hepatocytes
34. Differential regulation of the phosphatidylinositol 3-kinase/Akt and p70 S6 kinase pathways by the α(1A)-adrenergic receptor in rat-1 fibrolasts
35. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
36. Signaling by distinct classes of phosphoinositide 3-kinases
37. Regulation of protein kinase cascades by protein phosphatase 2A
38. The alpha-isoform of class II phosphoinositide 3-kinase is more effectively activated by insulin receptors than IGF receptors, and activation requires receptor NPEY motifs
39. Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle
40. Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
41. Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002
42. The tumor suppressor, PTEN/MMAC1, dephospborylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
43. Mammalian target of rapamycin is a direct target for PKB: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
44. Attenuation of mammalian target of rapamycin activity by increased cAMP in 3T3-L1 adipocytes
45. Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A
46. Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycin associated protein
47. Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase
48. Inactivation and dephosphorylation of protein kinase Bα (PKBα) promoted by hyperosmotic stress
49. Role of Janus kinase-2 in insulin-mediated phosphorylation and inactivation of protein phosphatase-2A and its impact on upstream insulin signalling components
50. Target of rapamycin (TOR): Balancing the opposing forces of protein synthesis and degradation
51. TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals
52. Rapamycin-modulated transcription defines the subset of the nutrient-sensitive signaling pathways directly controlled by the Tor proteins
53. Inhibition of macroautophagy and proteolysis in the isolated rat hepatocyte by a nontransportable derivative of the multiple antigen peptide Leu8-Lys4-Lys2-Lys-beta Ala
54. Leucine-specific binding of photoreactive Leu7-MAP to a high molecular weight protein on the plasma membrane of the isolated rat hepatocyte
55. Translational regulation of yeast GCN4. A window on factors that control initiator-tRNA binding to the ribosome
56. The role of cellular hydration in the regulation of cell function
57. Mechanism of activation of liver glycogen synthase by swelling
58. Chloride affects the interaction between tyrosyl-tRNA synthetase and tRNA
59. Contribution of amino acids and insulin to protein anabolism during meal absorption
60. Postprandial stimulation of muscle protein synthesis is independent of changes in insulin
61. Effect of dietary protein on translation initiation in rat skeletal muscle and liver
62. Stimulative effect of dietary protein on the phosphorylation of p70 S6 kinase in the skeletal muscle and liver of fooddeprived rats
63. Extreme hyperinsulinemia unmasks insulin's effect to stimulate protein synthesis in the human forearm
64. Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
65. L-Leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: Evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of System A amino acid transport