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Volumn 192, Issue 1, 2014, Pages 136-144

Leptin metabolically licenses T cells for activation to link nutrition and immunity

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER 1; LEPTIN;

EID: 84891090989     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1301158     Document Type: Article
Times cited : (211)

References (67)
  • 2
    • 80052457992 scopus 로고    scopus 로고
    • Interactions of diarrhea, pneumonia, and malnutrition in childhood: Recent evidence from developing countries
    • Schlaudecker, E. P., M. C. Steinhoff, and S. R. Moore. 2011. Interactions of diarrhea, pneumonia, and malnutrition in childhood: recent evidence from developing countries. Curr. Opin. Infect. Dis. 24: 496-502.
    • (2011) Curr. Opin. Infect. Dis. , vol.24 , pp. 496-502
    • Schlaudecker, E.P.1    Steinhoff, M.C.2    Moore, S.R.3
  • 5
    • 44449165597 scopus 로고    scopus 로고
    • Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways
    • Jacobs, S. R., C. E. Herman, N. J. Maciver, J. A. Wofford, H. L. Wieman, J. J. Hammen, and J. C. Rathmell. 2008. Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J. Immunol. 180: 4476-4486.
    • (2008) J. Immunol. , vol.180 , pp. 4476-4486
    • Jacobs, S.R.1    Herman, C.E.2    Maciver, N.J.3    Wofford, J.A.4    Wieman, H.L.5    Hammen, J.J.6    Rathmell, J.C.7
  • 7
    • 79960369458 scopus 로고    scopus 로고
    • HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    • Shi, L. Z., R. Wang, G. Huang, P. Vogel, G. Neale, D. R. Green, and H. Chi. 2011. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 208: 1367-1376.
    • (2011) J. Exp. Med. , vol.208 , pp. 1367-1376
    • Shi, L.Z.1    Wang, R.2    Huang, G.3    Vogel, P.4    Neale, G.5    Green, D.R.6    Chi, H.7
  • 8
    • 55249114228 scopus 로고    scopus 로고
    • Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
    • Cham, C. M., G. Driessens, J. P. O'Keefe, and T. F. Gajewski. 2008. Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells. Eur. J. Immunol. 38: 2438-2450.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 2438-2450
    • Cham, C.M.1    Driessens, G.2    O'Keefe, J.P.3    Gajewski, T.F.4
  • 13
    • 0033304576 scopus 로고    scopus 로고
    • Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects
    • Ozata, M., I. C. Ozdemir, and J. Licinio. 1999. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J. Clin. Endocrinol. Metab. 84: 3686-3695.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 3686-3695
    • Ozata, M.1    Ozdemir, I.C.2    Licinio, J.3
  • 14
    • 0018148843 scopus 로고
    • Impairment of cell-mediated immunity in mutation diabetic mice (db/db)
    • Mandel, M. A., and A. A. Mahmoud. 1978. Impairment of cell-mediated immunity in mutation diabetic mice (db/db). J. Immunol. 120: 1375-1377.
    • (1978) J. Immunol. , vol.120 , pp. 1375-1377
    • Mandel, M.A.1    Mahmoud, A.A.2
  • 16
    • 0018861450 scopus 로고
    • Cell-mediated immunity in genetically obese C57BL/6J ob/ob) mice
    • Chandra, R. K. 1980. Cell-mediated immunity in genetically obese C57BL/6J ob/ob) mice. Am. J. Clin. Nutr. 33: 13-16.
    • (1980) Am. J. Clin. Nutr. , vol.33 , pp. 13-16
    • Chandra, R.K.1
  • 19
    • 0036800760 scopus 로고    scopus 로고
    • Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    • Farooqi, I. S., G. Matarese, G. M. Lord, J. M. Keogh, E. Lawrence, C. Agwu, V. Sanna, S. A. Jebb, F. Perna, S. Fontana, et al. 2002. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J. Clin. Invest. 110: 1093-1103.
    • (2002) J. Clin. Invest. , vol.110 , pp. 1093-1103
    • Farooqi, I.S.1    Matarese, G.2    Lord, G.M.3    Keogh, J.M.4    Lawrence, E.5    Agwu, C.6    Sanna, V.7    Jebb, S.A.8    Perna, F.9    Fontana, S.10
  • 21
    • 63249135654 scopus 로고    scopus 로고
    • Three questions about leptin and immunity
    • Fantuzzi, G. 2009. Three questions about leptin and immunity. Brain Behav. Immun. 23: 405-410.
    • (2009) Brain Behav. Immun. , vol.23 , pp. 405-410
    • Fantuzzi, G.1
  • 22
    • 33744946045 scopus 로고    scopus 로고
    • Leptin receptor expression and signaling in lymphocytes: Kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice
    • Papathanassoglou, E., K. El-Haschimi, X. C. Li, G. Matarese, T. Strom, and C. Mantzoros. 2006. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J. Immunol. 176: 7745-7752.
    • (2006) J. Immunol. , vol.176 , pp. 7745-7752
    • Papathanassoglou, E.1    El-Haschimi, K.2    Li, X.C.3    Matarese, G.4    Strom, T.5    Mantzoros, C.6
  • 23
    • 0036378052 scopus 로고    scopus 로고
    • Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients
    • Sánchez-Margalet, V., C. Martín-Romero, C. González-Yanes, R. Goberna, J. Rodríguez-Baño, and M. A. Muniain. 2002. Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients. Clin. Exp. Immunol. 129: 119-124.
    • (2002) Clin. Exp. Immunol. , vol.129 , pp. 119-124
    • Sánchez-Margalet, V.1    Martín-Romero, C.2    González-Yanes, C.3    Goberna, R.4    Rodríguez-Baño, J.5    Muniain, M.A.6
  • 25
    • 0035885876 scopus 로고    scopus 로고
    • Human leptin activates PI3K and MAPK pathways in human peripheral blood mononuclear cells: Possible role of Sam68
    • Martín-Romero, C., and V. Sánchez-Margalet. 2001. Human leptin activates PI3K and MAPK pathways in human peripheral blood mononuclear cells: possible role of Sam68. Cell. Immunol. 212: 83-91.
    • (2001) Cell. Immunol. , vol.212 , pp. 83-91
    • Martín-Romero, C.1    Sánchez-Margalet, V.2
  • 26
    • 0035838266 scopus 로고    scopus 로고
    • Human leptin signaling in human peripheral blood mononuclear cells: Activation of the JAK-STAT pathway
    • Sanchez-Margalet, V., and C. Martin-Romero. 2001. Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway. Cell. Immunol. 211: 30-36.
    • (2001) Cell. Immunol. , vol.211 , pp. 30-36
    • Sanchez-Margalet, V.1    Martin-Romero, C.2
  • 29
    • 0032572722 scopus 로고    scopus 로고
    • Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
    • Lord, G. M., G. Matarese, J. K. Howard, R. J. Baker, S. R. Bloom, and R. I. Lechler. 1998. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394: 897-901.
    • (1998) Nature , vol.394 , pp. 897-901
    • Lord, G.M.1    Matarese, G.2    Howard, J.K.3    Baker, R.J.4    Bloom, S.R.5    Lechler, R.I.6
  • 31
    • 34247874513 scopus 로고    scopus 로고
    • Effect of leptin on activation and cytokine synthesis in peripheral blood lymphocytes of malnourished infected children
    • Rodríguez, L., J. Graniel, and R. Ortiz. 2007. Effect of leptin on activation and cytokine synthesis in peripheral blood lymphocytes of malnourished infected children. Clin. Exp. Immunol. 148: 478-485.
    • (2007) Clin. Exp. Immunol. , vol.148 , pp. 478-485
    • Rodríguez, L.1    Graniel, J.2    Ortiz, R.3
  • 33
    • 78649972071 scopus 로고    scopus 로고
    • Generation of leptin receptor bone marrow chimeras: Recovery from irradiation, immune cellularity, cytokine expression, and metabolic parameters
    • Gove, M. E., C. L. Sherry, M. Pini, and G. Fantuzzi. 2010. Generation of leptin receptor bone marrow chimeras: recovery from irradiation, immune cellularity, cytokine expression, and metabolic parameters. Obesity (Silver Spring) 18: 2274-2281.
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 2274-2281
    • Gove, M.E.1    Sherry, C.L.2    Pini, M.3    Fantuzzi, G.4
  • 35
    • 0029844267 scopus 로고    scopus 로고
    • Effect of fasting on serum leptin in normal human subjects
    • Boden, G., X. Chen, M. Mozzoli, and I. Ryan. 1996. Effect of fasting on serum leptin in normal human subjects. J. Clin. Endocrinol. Metab. 81: 3419-3423.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 3419-3423
    • Boden, G.1    Chen, X.2    Mozzoli, M.3    Ryan, I.4
  • 38
    • 54249141095 scopus 로고    scopus 로고
    • Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival
    • Maciver, N. J., S. R. Jacobs, H. L. Wieman, J. A. Wofford, J. L. Coloff, and J. C. Rathmell. 2008. Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. J. Leukoc. Biol. 84: 949-957.
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 949-957
    • Maciver, N.J.1    Jacobs, S.R.2    Wieman, H.L.3    Wofford, J.A.4    Coloff, J.L.5    Rathmell, J.C.6
  • 39
    • 17044422629 scopus 로고    scopus 로고
    • Glucose availability regulates IFNgamma production and p70S6 kinase activation in CD8+ effector T cells
    • Cham, C. M., and T. F. Gajewski. 2005. Glucose availability regulates IFNgamma production and p70S6 kinase activation in CD8+ effector T cells. J. Immunol. 174: 4670-4677.
    • (2005) J. Immunol. , vol.174 , pp. 4670-4677
    • Cham, C.M.1    Gajewski, T.F.2
  • 40
    • 0032904873 scopus 로고    scopus 로고
    • Comparing effects of leptin and insulin on glucose metabolism in skeletal muscle: Evidence for an effect of leptin on glucose uptake and decarboxylation
    • Ceddia, R. B.,W. N.William, Jr., and R. Curi. 1999. Comparing effects of leptin and insulin on glucose metabolism in skeletal muscle: evidence for an effect of leptin on glucose uptake and decarboxylation. Int. J. Obes. Rel. Metab. Dis. 23: 75-82.
    • (1999) Int. J. Obes. Rel. Metab. Dis. , vol.23 , pp. 75-82
    • Ceddia, R.B.1    William Jr., W.N.2    Curi, R.3
  • 41
    • 30044448374 scopus 로고    scopus 로고
    • Direct metabolic regulation in skeletal muscle and fat tissue by leptin: Implications for glucose and fatty acids homeostasis
    • Ceddia, R. B. 2005. Direct metabolic regulation in skeletal muscle and fat tissue by leptin: implications for glucose and fatty acids homeostasis. Int. J. Obes. (Lond) 29: 1175-1183.
    • (2005) Int. J. Obes. (Lond) , vol.29 , pp. 1175-1183
    • Ceddia, R.B.1
  • 43
    • 34247184208 scopus 로고    scopus 로고
    • Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking
    • Wieman, H. L., J. A. Wofford, and J. C. Rathmell. 2007. Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Mol. Biol. Cell 18: 1437-1446.
    • (2007) Mol. Biol. Cell , vol.18 , pp. 1437-1446
    • Wieman, H.L.1    Wofford, J.A.2    Rathmell, J.C.3
  • 44
    • 41349093966 scopus 로고    scopus 로고
    • IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival
    • Wofford, J. A., H. L. Wieman, S. R. Jacobs, Y. Zhao, and J. C. Rathmell. 2008. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood 111: 2101-2111.
    • (2008) Blood , vol.111 , pp. 2101-2111
    • Wofford, J.A.1    Wieman, H.L.2    Jacobs, S.R.3    Zhao, Y.4    Rathmell, J.C.5
  • 45
    • 24644456824 scopus 로고    scopus 로고
    • Glucose transporter 1 expression identifies a population of cycling CD4+ CD8+ human thymocytes with high CXCR4-induced chemotaxis
    • Swainson, L., S. Kinet, N. Manel, J. L. Battini, M. Sitbon, and N. Taylor. 2005. Glucose transporter 1 expression identifies a population of cycling CD4+ CD8+ human thymocytes with high CXCR4-induced chemotaxis. Proc. Natl. Acad. Sci. USA 102: 12867-12872.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 12867-12872
    • Swainson, L.1    Kinet, S.2    Manel, N.3    Battini, J.L.4    Sitbon, M.5    Taylor, N.6
  • 47
    • 84875464349 scopus 로고    scopus 로고
    • Cutting edge: Leptin-induced RORgt expression in CD4+ T cells promotes Th17 responses in systemic lupus erythematosus
    • Yu, Y., Y. Liu, F. D. Shi, H. Zou, G. Matarese, and A. La Cava. 2013. Cutting edge: Leptin-induced RORgt expression in CD4+ T cells promotes Th17 responses in systemic lupus erythematosus. J. Immunol. 190: 3054-3058.
    • (2013) J. Immunol. , vol.190 , pp. 3054-3058
    • Yu, Y.1    Liu, Y.2    Shi, F.D.3    Zou, H.4    Matarese, G.5    La Cava, A.6
  • 49
    • 84870475160 scopus 로고    scopus 로고
    • T cell-derived leptin contributes to increased frequency of T helper type 17 cells in female patients with Hashimoto's thyroiditis
    • Wang, S., S. E. Baidoo, Y. Liu, C. Zhu, J. Tian, J. Ma, J. Tong, J. Chen, X. Tang, H. Xu, and L. Lu. 2013. T cell-derived leptin contributes to increased frequency of T helper type 17 cells in female patients with Hashimoto's thyroiditis. Clin. Exp. Immunol. 171: 63-68.
    • (2013) Clin. Exp. Immunol. , vol.171 , pp. 63-68
    • Wang, S.1    Baidoo, S.E.2    Liu, Y.3    Zhu, C.4    Tian, J.5    Ma, J.6    Tong, J.7    Chen, J.8    Tang, X.9    Xu, H.10    Lu, L.11
  • 51
    • 84876248594 scopus 로고    scopus 로고
    • Childhood weight gain and thyroid autoimmunity at age 60-64 years: The 1946 British birth cohort study
    • Medical Research Council National Survey of Health and Development Scientific and Data Collection Teams.
    • Ong, K. K., D. Kuh, M. Pierce, and J. A. Franklyn; Medical Research Council National Survey of Health and Development Scientific and Data Collection Teams. 2013. Childhood weight gain and thyroid autoimmunity at age 60-64 years: the 1946 British birth cohort study. J. Clin. Endocrinol. Metab. 98: 1435-1442.
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , pp. 1435-1442
    • Ong, K.K.1    Kuh, D.2    Pierce, M.3    Franklyn, J.A.4
  • 52
    • 34548487258 scopus 로고    scopus 로고
    • The link between the epidemics of obesity and allergic diseases: Does obesity induce decreased immune tolerance?
    • Hersoug, L. G., and A. Linneberg. 2007. The link between the epidemics of obesity and allergic diseases: does obesity induce decreased immune tolerance? Allergy 62: 1205-1213.
    • (2007) Allergy , vol.62 , pp. 1205-1213
    • Hersoug, L.G.1    Linneberg, A.2
  • 53
    • 79955725584 scopus 로고    scopus 로고
    • Environmental factors and thyroid autoimmunity
    • Duntas, L. H. 2011. Environmental factors and thyroid autoimmunity. Ann. Endocrinol. (Paris) 72: 108-113.
    • (2011) Ann. Endocrinol. (Paris) , vol.72 , pp. 108-113
    • Duntas, L.H.1
  • 54
    • 84859140799 scopus 로고    scopus 로고
    • Metabolic pathways in T cell fate and function
    • Gerriets, V. A., and J. C. Rathmell. 2012. Metabolic pathways in T cell fate and function. Trends Immunol. 33: 168-173.
    • (2012) Trends Immunol. , vol.33 , pp. 168-173
    • Gerriets, V.A.1    Rathmell, J.C.2
  • 55
    • 66249108601 scopus 로고    scopus 로고
    • Understanding theWarburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden, M. G., L. C. Cantley, and C. B. Thompson. 2009. Understanding theWarburg effect: the metabolic requirements of cell proliferation. Science 324: 1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 56
    • 84863202384 scopus 로고    scopus 로고
    • Molecular mechanisms of metabolic reprogramming in proliferating cells: Implications for T-cell-mediated immunity
    • Marelli-Berg, F. M., H. Fu, and C. Mauro. 2012. Molecular mechanisms of metabolic reprogramming in proliferating cells: implications for T-cell-mediated immunity. Immunology 136: 363-369.
    • (2012) Immunology , vol.136 , pp. 363-369
    • Marelli-Berg, F.M.1    Fu, H.2    Mauro, C.3
  • 57
    • 54249147709 scopus 로고    scopus 로고
    • Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis
    • Piccio, L., J. L. Stark, and A. H. Cross. 2008. Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis. J. Leukoc. Biol. 84: 940-948.
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 940-948
    • Piccio, L.1    Stark, J.L.2    Cross, A.H.3
  • 58
    • 84863135746 scopus 로고    scopus 로고
    • Cutting edge: Fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus
    • Liu, Y., Y. Yu, G. Matarese, and A. La Cava. 2012. Cutting edge: fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus. J. Immunol. 188: 2070-2073.
    • (2012) J. Immunol. , vol.188 , pp. 2070-2073
    • Liu, Y.1    Yu, Y.2    Matarese, G.3    La Cava, A.4
  • 59
    • 84866168094 scopus 로고    scopus 로고
    • Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses
    • Procaccini, C., V. De Rosa, M. Galgani, F. Carbone, S. Cassano, D. Greco, K. Qian, P. Auvinen, G. Calì, G. Stallone, et al. 2012. Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses. J. Immunol. 189: 2941-2953.
    • (2012) J. Immunol. , vol.189 , pp. 2941-2953
    • Procaccini, C.1    De Rosa, V.2    Galgani, M.3    Carbone, F.4    Cassano, S.5    Greco, D.6    Qian, K.7    Auvinen, P.8    Calì, G.9    Stallone, G.10
  • 63
    • 2942692043 scopus 로고    scopus 로고
    • Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression
    • Makimura, H., T. M. Mizuno, F. Isoda, J. Beasley, J. H. Silverstein, and C. V. Mobbs. 2003. Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression. BMC Physiol. 3: 5.
    • (2003) BMC Physiol. , vol.3 , pp. 5
    • Makimura, H.1    Mizuno, T.M.2    Isoda, F.3    Beasley, J.4    Silverstein, J.H.5    Mobbs, C.V.6
  • 64
    • 3042833447 scopus 로고    scopus 로고
    • Overview of the actions of glucocorticoids on the immune response: A good model to characterize new pathways of immunosuppression for new treatment strategies
    • Franchimont, D. 2004. Overview of the actions of glucocorticoids on the immune response: a good model to characterize new pathways of immunosuppression for new treatment strategies. Ann. N. Y. Acad. Sci. 1024: 124-137.
    • (2004) Ann. N. Y. Acad. Sci. , vol.1024 , pp. 124-137
    • Franchimont, D.1
  • 65
    • 70349766380 scopus 로고    scopus 로고
    • Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution
    • Gruver, A. L., M. S. Ventevogel, and G. D. Sempowski. 2009. Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution. J. Endocrinol. 203: 75-85.
    • (2009) J. Endocrinol. , vol.203 , pp. 75-85
    • Gruver, A.L.1    Ventevogel, M.S.2    Sempowski, G.D.3
  • 66
    • 33845567333 scopus 로고    scopus 로고
    • Leptin: Nourishment for the immune system
    • Fantuzzi, G. 2006. Leptin: nourishment for the immune system. Eur. J. Immunol. 36: 3101-3104.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 3101-3104
    • Fantuzzi, G.1


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