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Volumn 9, Issue 3, 2013, Pages 144-152

The role of hepatokines in metabolism

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN RELATED GROWTH FACTOR; CYTOKINE; FETUIN A; FIBROBLAST GROWTH FACTOR 21; GROWTH FACTOR; HEPATOKINE; LIPOPROTEIN; SELENOPROTEIN P; SEX HORMONE BINDING GLOBULIN; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN; UNCLASSIFIED DRUG;

EID: 84875549943     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2012.258     Document Type: Review
Times cited : (395)

References (120)
  • 1
    • 79951558318 scopus 로고    scopus 로고
    • National regional and global trends in body-mass index since 1980: Systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants
    • Finucane, M. M. et al. National, regional, and global trends in body-mass index since 1980: Systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 377, 557-567 (2011).
    • (2011) Lancet , vol.377 , pp. 557-567
    • Finucane, M.M.1
  • 2
    • 10844262691 scopus 로고    scopus 로고
    • Adiposity as compared with physical activity in predicting mortality among women
    • Hu, F. B. et al. Adiposity as compared with physical activity in predicting mortality among women. N. Engl. J. Med. 351, 2694-2703 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2694-2703
    • Hu, F.B.1
  • 3
    • 56249131806 scopus 로고    scopus 로고
    • General and abdominal adiposity and risk of death in Europe
    • Pischon, T. et al. General and abdominal adiposity and risk of death in Europe. N. Engl. J. Med. 359, 2105-2120 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 2105-2120
    • Pischon, T.1
  • 4
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • Zimmet, P., Alberti, K. G. & Shaw, J. Global and societal implications of the diabetes epidemic. Nature 414, 782-787 (2001).
    • (2001) Nature , vol.414 , pp. 782-787
    • Zimmet, P.1    Alberti, K.G.2    Shaw, J.3
  • 5
    • 33644859289 scopus 로고    scopus 로고
    • Obesity as compared with physical activity in predicting risk of coronary heart disease in women
    • Li, T. Y. et al. Obesity as compared with physical activity in predicting risk of coronary heart disease in women. Circulation 113, 499-506 (2006).
    • (2006) Circulation , vol.113 , pp. 499-506
    • Li, T.Y.1
  • 6
    • 33845886915 scopus 로고    scopus 로고
    • Abdominal obesity and metabolic syndrome
    • Després, J. P. & Lemieux, I. Abdominal obesity and metabolic syndrome. Nature 444, 881-887 (2006).
    • (2006) Nature , vol.444 , pp. 881-887
    • Després, J.P.1    Lemieux, I.2
  • 7
    • 84866133825 scopus 로고    scopus 로고
    • Adiponectin: Mechanistic insights and clinical implications
    • Turer, A. T. & Scherer P. E. Adiponectin: Mechanistic insights and clinical implications. Diabetologia 55, 2319-2326 (2012).
    • (2012) Diabetologia , vol.55 , pp. 2319-2326
    • Turer, A.T.1    Scherer, P.E.2
  • 9
    • 84864283300 scopus 로고    scopus 로고
    • Muscles exercise and obesity: Skeletal muscle as a secretory organ
    • Pedersen, B. K. & Febbraio, M. A. Muscles, exercise and obesity: Skeletal muscle as a secretory organ. Nat. Rev. Endocrinol. 8, 457-465 (2012).
    • (2012) Nat. Rev. Endocrinol. , vol.8 , pp. 457-465
    • Pedersen, B.K.1    Febbraio, M.A.2
  • 10
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel, A. R. & Kahn, C. R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806 (2001).
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 11
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages inflammation, and insulin resistance
    • Olefsky, J. M. & Glass, C. K. Macrophages, inflammation, and insulin resistance. Annu. Rev. Physiol. 72, 219-246 (2010).
    • (2010) Annu. Rev. Physiol. , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 12
    • 84860483727 scopus 로고    scopus 로고
    • The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling
    • Fu, S., Watkins, S. M. & Hotamisligil, G. S. The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling. Cell Metab. 15, 623-634 (2012).
    • (2012) Cell Metab. , vol.15 , pp. 623-634
    • Fu, S.1    Watkins, S.M.2    Hotamisligil, G.S.3
  • 13
    • 79960202841 scopus 로고    scopus 로고
    • Type 2 diabetes across generations: From pathophysiology to prevention and management
    • Nolan, C. J., Damm, P. & Prentki, M. Type 2 diabetes across generations: From pathophysiology to prevention and management. Lancet 378, 169-181 (2011).
    • (2011) Lancet , vol.378 , pp. 169-181
    • Nolan, C.J.1    Damm, P.2    Prentki, M.3
  • 14
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • Kadowaki, T. et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Invest. 116, 1784-1792 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 1784-1792
    • Kadowaki, T.1
  • 15
    • 85027954948 scopus 로고    scopus 로고
    • Obesity: Glypican?4Role in insulin signalling
    • Mitchell, F. Obesity: Glypican?4Role in insulin signalling. Nat. Rev. Endocrinol. 8, 505 (2012).
    • (2012) Nat. Rev. Endocrinol. , vol.8 , pp. 505
    • Mitchell, F.1
  • 16
    • 37249074063 scopus 로고    scopus 로고
    • The role of interleukin?6 in insulin resistance, body fat distribution and energy balance
    • Hoene, M. & Weigert, C. The role of interleukin?6 in insulin resistance, body fat distribution and energy balance. Obes. Rev. 9, 20-29 (2008).
    • (2008) Obes. Rev. , vol.9 , pp. 20-29
    • Hoene, M.1    Weigert, C.2
  • 17
    • 84862776702 scopus 로고    scopus 로고
    • A PGC1-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
    • Boström, P. et al. A PGC1-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481, 463-468 (2012).
    • (2012) Nature , vol.481 , pp. 463-468
    • Boström, P.1
  • 18
    • 84858705567 scopus 로고    scopus 로고
    • Basic research: Irisinbehind the benefits of exercise
    • Cunha, A. Basic research: Irisin - behind the benefits of exercise. Nat. Rev. Endocrinol. 8, 195 (2012).
    • (2012) Nat. Rev. Endocrinol. , vol.8 , Issue.195
    • Cunha, A.1
  • 19
    • 77957964151 scopus 로고    scopus 로고
    • The stress response of the liver to physical exercise
    • Hoene, M. & Weigert, C. The stress response of the liver to physical exercise. Exerc. Immunol. Rev. 16, 163-183 (2010).
    • (2010) Exerc. Immunol. Rev. , vol.16 , pp. 163-183
    • Hoene, M.1    Weigert, C.2
  • 20
    • 34249852535 scopus 로고    scopus 로고
    • Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention
    • Stefan, N. et al. Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention. J. Clin. Endocrinol. Metab. 92, 1827-1833 (2007).
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 1827-1833
    • Stefan, N.1
  • 21
    • 42049105146 scopus 로고    scopus 로고
    • Variations in PPARD determine the change in body composition during lifestyle intervention: A whole-body magnetic resonance study
    • Thamer, C. et al. Variations in PPARD determine the change in body composition during lifestyle intervention: A whole-body magnetic resonance study. J. Clin. Endocrinol. Metab. 93, 1497-1500 (2008).
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 1497-1500
    • Thamer, C.1
  • 22
    • 66649084619 scopus 로고    scopus 로고
    • Short-term exercise training does not stimulate skeletal muscle ATP synthesis in relatives of humans with type 2 diabetes
    • Kacerovsky-Bielesz, G. et al. Short-term exercise training does not stimulate skeletal muscle ATP synthesis in relatives of humans with type 2 diabetes. Diabetes 58, 1333-1341 (2009).
    • (2009) Diabetes , vol.58 , pp. 1333-1341
    • Kacerovsky-Bielesz, G.1
  • 23
    • 68849104744 scopus 로고    scopus 로고
    • High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease
    • Kantartzis, K. et al. High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease. Gut 58, 1281-1288 (2009).
    • (2009) Gut , vol.58 , pp. 1281-1288
    • Kantartzis, K.1
  • 24
    • 49449092403 scopus 로고    scopus 로고
    • Identification and characterization of metabolically benign obesity in humans
    • Stefan, N. et al. Identification and characterization of metabolically benign obesity in humans. Arch. Intern. Med. 168, 1609-1616 (2008).
    • (2008) Arch. Intern. Med. , vol.168 , pp. 1609-1616
    • Stefan, N.1
  • 25
    • 70349326750 scopus 로고    scopus 로고
    • Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
    • Fabbrini, E. et al. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc. Natl Acad. Sci. USA 106, 15430-15435 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 15430-15435
    • Fabbrini, E.1
  • 26
    • 57349116780 scopus 로고    scopus 로고
    • Causes and metabolic consequences of fatty liver
    • Stefan, N., Kantartzis, K. & Häring, H. U. Causes and metabolic consequences of fatty liver. Endocr. Rev. 29, 939-960 (2008).
    • (2008) Endocr. Rev. , vol.29 , pp. 939-960
    • Stefan, N.1    Kantartzis, K.2    Häring, H.U.3
  • 27
    • 33745107554 scopus 로고    scopus 로고
    • Mechanisms of disease: Hepatic steatosis in type 2 diabetespathogenesis and clinical relevance
    • Roden, M. Mechanisms of disease: hepatic steatosis in type 2 diabetes - pathogenesis and clinical relevance. Nat. Clin. Pract. Endocrinol. Metab. 2, 335-348 (2006).
    • (2006) Nat. Clin. Pract. Endocrinol. Metab. , vol.2 , pp. 335-348
    • Roden, M.1
  • 28
    • 33845490856 scopus 로고    scopus 로고
    • Review: The role of insulin resistance in nonalcoholic fatty liver disease
    • Utzschneider, K. M. & Kahn, S. E. Review: The role of insulin resistance in nonalcoholic fatty liver disease. J. Clin. Endocrinol. Metab. 91, 4753-4761 (2006).
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 4753-4761
    • Utzschneider, K.M.1    Kahn, S.E.2
  • 30
    • 77957375969 scopus 로고    scopus 로고
    • Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease
    • Targher, G., Day, C. P. & Bonora, E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N. Engl. J. Med. 363, 1341-1350 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1341-1350
    • Targher, G.1    Day, C.P.2    Bonora, E.3
  • 31
    • 75549087984 scopus 로고    scopus 로고
    • Viewpoints on the way to a consensus session: Where does insulin resistance start?
    • Perseghin, G. Viewpoints on the way to a consensus session: where does insulin resistance start? The liver. Diabetes Care 32 (Suppl. 2), S164-S167 (2009).
    • (2009) The liver. Diabetes Care , vol.32 , Issue.SUPPL. 2
    • Perseghin, G.1
  • 32
    • 84859404868 scopus 로고    scopus 로고
    • Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: Pathophysiology and clinical implications
    • Cusi, K. Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: Pathophysiology and clinical implications. Gastroenterology 142, 711.e6-725.e6 (2012).
    • (2012) Gastroenterology , vol.142
    • Cusi, K.1
  • 33
    • 34547514221 scopus 로고    scopus 로고
    • Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects
    • Gastaldelli, A. et al. Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. Gastroenterology 133, 496-506 (2007).
    • (2007) Gastroenterology , vol.133 , pp. 496-506
    • Gastaldelli, A.1
  • 34
    • 79959541652 scopus 로고    scopus 로고
    • Fatty liver index and mortality: The Cremona study in the 15th year of follow-up
    • Calori, G. et al. Fatty liver index and mortality: The Cremona study in the 15th year of follow-up. Hepatology 54, 145-152 (2011).
    • (2011) Hepatology , vol.54 , pp. 145-152
    • Calori, G.1
  • 35
    • 0029948212 scopus 로고    scopus 로고
    • Mechanism of free fatty acid-induced insulin resistance in humans
    • Roden, M. et al. Mechanism of free fatty acid-induced insulin resistance in humans. J. Clin. Invest. 97, 2859-2865 (1996).
    • (1996) J. Clin. Invest. , vol.97 , pp. 2859-2865
    • Roden, M.1
  • 36
    • 9444262473 scopus 로고    scopus 로고
    • Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes
    • Krssak, M. et al. Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes. Diabetes 53, 3048-3056 (2004).
    • (2004) Diabetes , vol.53 , pp. 3048-3056
    • Krssak, M.1
  • 37
    • 0141566770 scopus 로고    scopus 로고
    • Hepatic glucose metabolism in humansits role in health and disease
    • Roden, M. & Bernroider, E. Hepatic glucose metabolism in humans - its role in health and disease. Best Pract. Res. Clin. Endocrinol. Metab. 17, 365-383 (2003).
    • (2003) Best Pract. Res. Clin. Endocrinol. Metab. , vol.17 , pp. 365-383
    • Roden, M.1    Bernroider, E.2
  • 38
    • 80052345224 scopus 로고    scopus 로고
    • Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs
    • Ramnanan, C. J. et al. Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs. J. Clin. Invest. 121, 3713-3723 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 3713-3723
    • Ramnanan, C.J.1
  • 39
    • 77953868236 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance: Unravelling the mechanism
    • Samuel, V. T., Petersen, K. F. & Shulman, G. I. Lipid-induced insulin resistance: Unravelling the mechanism. Lancet 375, 2267-2277 (2010).
    • (2010) Lancet , vol.375 , pp. 2267-2277
    • Samuel, V.T.1    Petersen, K.F.2    Shulman, G.I.3
  • 40
    • 84860455885 scopus 로고    scopus 로고
    • The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance
    • Farese, R. V. Jr, Zechner, R., Newgard, C. B. & Walther, T. C. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab. 15, 570-573 (2012).
    • (2012) Cell Metab. , vol.15 , pp. 570-573
    • Farese Jr., R.V.1    Zechner, R.2    Newgard, C.B.3    Walther, T.C.4
  • 41
    • 84860441011 scopus 로고    scopus 로고
    • Inflammation and lipid signaling in the etiology of insulin resistance
    • Glass, C. K. & Olefsky, J. M. Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab. 15, 635-645 (2012).
    • (2012) Cell Metab , vol.15 , pp. 635-645
    • Glass, C.K.1    Olefsky, J.M.2
  • 42
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: Old questions and new insights
    • Cohen, J. C., Horton, J. D. & Hobbs, H. H. Human fatty liver disease: Old questions and new insights. Science 332, 1519-1523 (2011).
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 44
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil, G. S. Inflammation and metabolic disorders. Nature 444, 860-867 (2006).
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 45
    • 51549107903 scopus 로고    scopus 로고
    • Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
    • Cao, H. et al. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 134, 933-944 (2008).
    • (2008) Cell , vol.134 , pp. 933-944
    • Cao, H.1
  • 46
    • 23744445741 scopus 로고    scopus 로고
    • A proposed new paradigm for insulin resistance
    • Lautt, W. W. A proposed new paradigm for insulin resistance. Metab. Syndr. Relat. Disord. 1, 261-270 (2003).
    • (2003) Metab. Syndr. Relat. Disord. , vol.1 , pp. 261-270
    • Lautt, W.W.1
  • 47
    • 34247637323 scopus 로고    scopus 로고
    • Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes
    • Misu, H. et al. Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes. Diabetologia 50, 268-277 (2007).
    • (2007) Diabetologia , vol.50 , pp. 268-277
    • Misu, H.1
  • 48
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK and NFB
    • Cai, D. et al. Local and systemic insulin resistance resulting from hepatic activation of IKK and NFB. Nat. Med. 11, 183-190 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 183-190
    • Cai, D.1
  • 49
    • 20244380182 scopus 로고    scopus 로고
    • Angiopoietin-related growth factor antagonizes obesity and insulin resistance
    • Oike, Y. et al. Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat. Med. 11, 400-408 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 400-408
    • Oike, Y.1
  • 50
    • 62349113882 scopus 로고    scopus 로고
    • Serum levels of angiopoietin-related growth factor in diabetes mellitus and chronic hemodialysis
    • Ebert, T. et al. Serum levels of angiopoietin-related growth factor in diabetes mellitus and chronic hemodialysis. Metabolism 58, 547-551 (2009).
    • (2009) Metabolism , vol.58 , pp. 547-551
    • Ebert, T.1
  • 51
    • 0344393623 scopus 로고    scopus 로고
    • Tissue distribution and activity testing suggest a similar but not identical function of fetuin?B and fetuin?A
    • Denecke, B. et al. Tissue distribution and activity testing suggest a similar but not identical function of fetuin?B and fetuin?A. Biochem. J. 376, 135-145 (2003).
    • (2003) Biochem. J. , vol.376 , pp. 135-145
    • Denecke, B.1
  • 52
    • 0024340523 scopus 로고
    • Characterization of a natural inhibitor of the insulin receptor tyrosine kinase: CDNA cloning, purification, and anti-mitogenic activity
    • Auberger, P. et al. Characterization of a natural inhibitor of the insulin receptor tyrosine kinase: CDNA cloning, purification, and anti-mitogenic activity. Cell 58, 631-640 (1989).
    • (1989) Cell , vol.58 , pp. 631-640
    • Auberger, P.1
  • 53
    • 0026516756 scopus 로고
    • The nucleotide and partial amino acid sequences of rat fetuin Identity with the natural tyrosine kinase inhibitor of the rat insulin receptor
    • Rauth, G. et al. The nucleotide and partial amino acid sequences of rat fetuin. Identity with the natural tyrosine kinase inhibitor of the rat insulin receptor. Eur. J. Biochem. 204, 523-529 (1992).
    • (1992) Eur. J. Biochem. , vol.204 , pp. 523-529
    • Rauth, G.1
  • 54
    • 0027333427 scopus 로고
    • Serum ?2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level
    • Srinivas, P. R. et al. Serum ?2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level. Mol. Endocrinol. 7, 1445-1455 (1993).
    • (1993) Mol. Endocrinol. , vol.7 , pp. 1445-1455
    • Srinivas, P.R.1
  • 55
    • 0030829986 scopus 로고    scopus 로고
    • Bovine fetuin is an inhibitor of insulin receptor tyrosine kinase
    • Mathews, S. T. et al. Bovine fetuin is an inhibitor of insulin receptor tyrosine kinase. Life Sci. 61, 1583-1592 (1997).
    • (1997) Life Sci. , vol.61 , pp. 1583-1592
    • Mathews, S.T.1
  • 56
    • 0034690814 scopus 로고    scopus 로고
    • 2-HSG, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor
    • Mathews, S. T. et al. ?2-HSG, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor. Mol. Cell. Endocrinol. 164, 87-98 (2000).
    • (2000) Mol. Cell. Endocrinol. , vol.164 , pp. 87-98
    • Mathews, S.T.1
  • 57
    • 79952702741 scopus 로고    scopus 로고
    • The "thrifty" gene encoding AHSG/Fetuin?A meets the insulin receptor: Insights into the mechanism of insulin resistance
    • Goustin, A. S. & Abou-Samra, A. B. The "thrifty" gene encoding AHSG/Fetuin?A meets the insulin receptor: Insights into the mechanism of insulin resistance. Cell Signal. 23, 980-990 (2011).
    • (2011) Cell Signal , vol.23 , pp. 980-990
    • Goustin, A.S.1    Abou-Samra, A.B.2
  • 58
    • 0036328567 scopus 로고    scopus 로고
    • Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene
    • Mathews, S. T. et al. Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene. Diabetes 51, 2450-2458 (2002).
    • (2002) Diabetes , vol.51 , pp. 2450-2458
    • Mathews, S.T.1
  • 59
    • 23644433509 scopus 로고    scopus 로고
    • A synonymous coding polymorphism in the ?2-Heremans-Schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians
    • Siddiq, A., Lepretre, F., Hercberg, S., Froguel, P. & Gibson, F. A synonymous coding polymorphism in the ?2-Heremans-Schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians. Diabetes 54, 2477-2481 (2005).
    • (2005) Diabetes , vol.54 , pp. 2477-2481
    • Siddiq, A.1    Lepretre, F.2    Hercberg, S.3    Froguel, P.4    Gibson, F.5
  • 60
    • 48449101972 scopus 로고    scopus 로고
    • AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: Studies of metabolic traits in 7,683 white Danish subjects
    • Andersen, G. et al. AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: Studies of metabolic traits in 7,683 white Danish subjects. Diabetes 57, 1427-1432 (2008).
    • (2008) Diabetes , vol.57 , pp. 1427-1432
    • Andersen, G.1
  • 61
    • 33746367157 scopus 로고    scopus 로고
    • 2-Heremans-Schmid glycoprotein/fetuin?A is associated with insulin resistance and fat accumulation in the liver in humans
    • Stefan, N. et al. ?2-Heremans-Schmid glycoprotein/fetuin?A is associated with insulin resistance and fat accumulation in the liver in humans. Diabetes Care 29, 853-857 (2006).
    • (2006) Diabetes Care , vol.29 , pp. 853-857
    • Stefan, N.1
  • 62
    • 57349109502 scopus 로고    scopus 로고
    • Fetuin?A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss
    • Reinehr, T. & Roth, C. L. Fetuin?A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss. J. Clin. Endocrinol. Metab. 93, 4479-4485 (2008).
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 4479-4485
    • Reinehr, T.1    Roth, C.L.2
  • 63
    • 84857926081 scopus 로고    scopus 로고
    • Fetuin A in nonalcoholic fatty liver disease: In vivo and in vitro studies
    • Haukeland, J. W. et al. Fetuin A in nonalcoholic fatty liver disease: In vivo and in vitro studies. Eur. J. Endocrinol. 166, 503-510 (2012).
    • (2012) Eur. J. Endocrinol. , vol.166 , pp. 503-510
    • Haukeland, J.W.1
  • 64
    • 77955069684 scopus 로고    scopus 로고
    • NFB mediates lipid-induced fetuin?A expression in hepatocytes that impairs adipocyte function effecting insulin resistance
    • Dasgupta, S. et al. NFB mediates lipid-induced fetuin?A expression in hepatocytes that impairs adipocyte function effecting insulin resistance. Biochem. J. 429, 451-462 (2010).
    • (2010) Biochem. J. , vol.429 , pp. 451-462
    • Dasgupta, S.1
  • 65
    • 73249130996 scopus 로고    scopus 로고
    • High glucose induces transactivation of the ?2-HS glycoprotein gene through the ERK1/2 signaling pathway
    • Takata, H. et al. High glucose induces transactivation of the ?2-HS glycoprotein gene through the ERK1/2 signaling pathway. J. Atheroscler. Thromb. 16, 448-456 (2009).
    • (2009) J. Atheroscler. Thromb. , vol.16 , pp. 448-456
    • Takata, H.1
  • 66
    • 70450267544 scopus 로고    scopus 로고
    • High plasma fetuin?A is associated with increased carotid intima-media thickness in a middle-aged population
    • Rittig, K. et al. High plasma fetuin?A is associated with increased carotid intima-media thickness in a middle-aged population. Atherosclerosis 207, 341-342 (2009).
    • (2009) Atherosclerosis , vol.207 , pp. 341-342
    • Rittig, K.1
  • 67
    • 84873533674 scopus 로고    scopus 로고
    • Plasma fetuin?A is associated with endothelial dysfunction and subclinical atherosclerosis in subjects with nonalcoholic fatty liver disease
    • Dogru, T. et al. Plasma fetuin?A is associated with endothelial dysfunction and subclinical atherosclerosis in subjects with nonalcoholic fatty liver disease. Clin. Endocrinol. (Oxf.) http://dx.doi.org/10.1111/j.1365?2265. 2012.04460.x.
    • Clin. Endocrinol. (Oxf.)
    • Dogru, T.1
  • 68
    • 33646690516 scopus 로고    scopus 로고
    • Association between human fetuin?A and the metabolic syndrome: Data from the heart and soul study
    • Ix, J. H. et al. Association between human fetuin?A and the metabolic syndrome: Data from the Heart and Soul Study. Circulation 113, 1760-1767 (2006).
    • (2006) Circulation , vol.113 , pp. 1760-1767
    • Ix, J.H.1
  • 69
    • 33646367662 scopus 로고    scopus 로고
    • Association of serum fetuin?A with insulin resistance in type 2 diabetic and nondiabetic subjects
    • Mori, K. et al. Association of serum fetuin?A with insulin resistance in type 2 diabetic and nondiabetic subjects. Diabetes Care 29, 468 (2006).
    • (2006) Diabetes Care , vol.29 , pp. 468
    • Mori, K.1
  • 70
    • 77952095022 scopus 로고    scopus 로고
    • The impact of liver fat vs visceral fat in determining categories of prediabetes
    • Kantartzis, K. et al. The impact of liver fat vs visceral fat in determining categories of prediabetes. Diabetologia 53, 882-889 (2010).
    • (2010) Diabetologia , vol.53 , pp. 882-889
    • Kantartzis, K.1
  • 71
    • 79955542928 scopus 로고    scopus 로고
    • Serum fetuin?A is correlated with metabolic syndrome in middle-aged and elderly Chinese
    • Xu, Y. et al. Serum fetuin?A is correlated with metabolic syndrome in middle-aged and elderly Chinese. Atherosclerosis 216, 180-186 (2011).
    • (2011) Atherosclerosis , vol.216 , pp. 180-186
    • Xu, Y.1
  • 72
    • 77958525379 scopus 로고    scopus 로고
    • Serum fetuin?A is an independent marker of insulin resistance in Japanese men
    • Ishibashi, A. et al. Serum fetuin?A is an independent marker of insulin resistance in Japanese men. J. Atheroscler. Thromb. 17, 925-933 (2010).
    • (2010) J. Atheroscler. Thromb. , vol.17 , pp. 925-933
    • Ishibashi, A.1
  • 73
    • 84867259254 scopus 로고    scopus 로고
    • Cardiometabolic correlates and heritability of fetuin?A, retinol-binding protein 4 and fatty-acid binding protein 4 in the Framingham Heart Study
    • Kaess, B. M. et al. Cardiometabolic correlates and heritability of fetuin?A, retinol-binding protein 4 and fatty-acid binding protein 4 in the Framingham Heart Study. J. Clin. Endocrinol. Metab. 97, E1943-E1947 (2012).
    • (2012) J. Clin. Endocrinol. Metab. , vol.97
    • Kaess, B.M.1
  • 74
    • 56649094538 scopus 로고    scopus 로고
    • Plasma fetuin?A levels and the risk of type 2 diabetes
    • Stefan, N. et al. Plasma fetuin?A levels and the risk of type 2 diabetes. Diabetes 57, 2762-2767 (2008).
    • (2008) Diabetes , vol.57 , pp. 2762-2767
    • Stefan, N.1
  • 75
    • 47049126504 scopus 로고    scopus 로고
    • Health ABC Study Fetuin?A and incident diabetes mellitus in older persons
    • Ix, J. H. et al. Health ABC Study. Fetuin?A and incident diabetes mellitus in older persons. JAMA 300, 182-188 (2008).
    • (2008) JAMA , vol.300 , pp. 182-188
    • Ix, J.H.1
  • 76
    • 84861229192 scopus 로고    scopus 로고
    • Association of fetuin?A with incident diabetes mellitus in community-living older adults: The cardiovascular health study
    • Ix, J. H. et al. Association of fetuin?A with incident diabetes mellitus in community-living older adults: The cardiovascular health study. Circulation 125, 2316-2322 (2012).
    • (2012) Circulation , vol.125 , pp. 2316-2322
    • Ix, J.H.1
  • 77
    • 84872012316 scopus 로고    scopus 로고
    • Plasma levels of fetuin?A and hepatic enzymes and risk of type 2 diabetes in women in the US
    • Sun, Q., Cornelis, M. C., Manson, J. E. & Hu, F. B. Plasma levels of fetuin?A and hepatic enzymes and risk of type 2 diabetes in women in the U.S. Diabetes 62, 49-55 (2013).
    • (2013) Diabetes , vol.62 , pp. 49-55
    • Sun, Q.1    Cornelis, M.C.2    Manson, J.E.3    Hu, F.B.4
  • 78
    • 46149124353 scopus 로고    scopus 로고
    • Fetuin?A induces cytokine expression and suppresses adiponectin production
    • Hennige, A. M. et al. Fetuin?A induces cytokine expression and suppresses adiponectin production. PLoS ONE 3, e1765 (2008).
    • (2008) PLoS ONE , vol.3
    • Hennige, A.M.1
  • 79
    • 84864657351 scopus 로고    scopus 로고
    • Fetuin?A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
    • Pal, D. et al. Fetuin?A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat. Med. http://dx.doi.org/10.1038/nm.2851.
    • Nat. Med.
    • Pal, D.1
  • 80
    • 84864696458 scopus 로고    scopus 로고
    • Fetuin?A: The missing link in lipid-induced inflammation
    • Heinrichsdorff, J. & Olefsky, J. M. Fetuin?A: The missing link in lipid-induced inflammation. Nat. Med. 18, 1182-1183 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 1182-1183
    • Heinrichsdorff, J.1    Olefsky, J.M.2
  • 81
    • 58149393662 scopus 로고    scopus 로고
    • Plasma fetuin?A levels and the risk of myocardial infarction and ischemic stroke
    • Weikert, C. et al. Plasma fetuin?A levels and the risk of myocardial infarction and ischemic stroke. Circulation 118, 2555-2562 (2008).
    • (2008) Circulation , vol.118 , pp. 2555-2562
    • Weikert, C.1
  • 82
    • 77449147603 scopus 로고    scopus 로고
    • Association of AHSG gene polymorphisms with fetuin?A plasma levels and cardiovascular diseases in the EPIC-Potsdam study
    • Fisher, E. et al. Association of AHSG gene polymorphisms with fetuin?A plasma levels and cardiovascular diseases in the EPIC-Potsdam study. Circ. Cardiovasc. Genet. 2, 607-613 (2009).
    • (2009) Circ. Cardiovasc. Genet. , vol.2 , pp. 607-613
    • Fisher, E.1
  • 83
    • 20444435873 scopus 로고    scopus 로고
    • FGF?21 as a novel metabolic regulator
    • Kharitonenkov, A. et al. FGF?21 as a novel metabolic regulator. J. Clin. Invest. 115, 1627-1635 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 1627-1635
    • Kharitonenkov, A.1
  • 84
    • 77957376253 scopus 로고    scopus 로고
    • Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse
    • Fon Tacer, K. et al. Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Mol. Endocrinol. 24, 2050-2064 (2010).
    • (2010) Mol. Endocrinol. , vol.24 , pp. 2050-2064
    • Fon Tacer, K.1
  • 85
    • 61649127208 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
    • Xu, J. et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 58, 250-259 (2009).
    • (2009) Diabetes , vol.58 , pp. 250-259
    • Xu, J.1
  • 86
    • 84857185764 scopus 로고    scopus 로고
    • Endocrine fibroblast growth factors 15/19 and 21: From feast to famine
    • Potthoff, M. J., Kliewer, S. A. & Mangelsdorf, D. J. Endocrine fibroblast growth factors 15/19 and 21: From feast to famine. Genes Dev. 26, 312-324 (2012).
    • (2012) Genes Dev. , vol.26 , pp. 312-324
    • Potthoff, M.J.1    Kliewer, S.A.2    Mangelsdorf, D.J.3
  • 87
    • 0028958031 scopus 로고
    • Insulin-like growth factors and their binding proteins: Biological actions
    • Jones, J. I. & Clemmons, D. R. Insulin-like growth factors and their binding proteins: Biological actions. Endocr. Rev. 16, 3-34 (1995).
    • (1995) Endocr. Rev. , vol.16 , pp. 3-34
    • Jones, J.I.1    Clemmons, D.R.2
  • 88
    • 68549092476 scopus 로고    scopus 로고
    • The role of liver-derived insulin-like growth factor?I
    • Ohlsson, C. et al. The role of liver-derived insulin-like growth factor?I. Endocr. Rev. 30, 494-535 (2009).
    • (2009) Endocr. Rev. , vol.30 , pp. 494-535
    • Ohlsson, C.1
  • 89
    • 68549126809 scopus 로고    scopus 로고
    • Unraveling insulin-like growth factor binding protein?3 actions in human disease
    • Jogie-Brahim, S., Feldman, D. & Oh, Y. Unraveling insulin-like growth factor binding protein?3 actions in human disease. Endocr. Rev. 30, 417-437 (2009).
    • (2009) Endocr. Rev. , vol.30 , pp. 417-437
    • Jogie-Brahim, S.1    Feldman, D.2    Oh, Y.3
  • 90
    • 0028223994 scopus 로고
    • Comparison of the metabolic effects of recombinant human insulin-like growth factor?I and insulin Dose-response relationships in healthy young and middle-aged adults
    • Boulware, S. D., Tamborlane, W. V., Rennert, N. J., Gesundheit, N. & Sherwin, R. S. Comparison of the metabolic effects of recombinant human insulin-like growth factor?I and insulin. Dose-response relationships in healthy young and middle-aged adults. J. Clin. Invest. 93, 1131-1139 (1994).
    • (1994) J. Clin. Invest. , vol.93 , pp. 1131-1139
    • Boulware, S.D.1    Tamborlane, W.V.2    Rennert, N.J.3    Gesundheit, N.4    Sherwin, R.S.5
  • 91
    • 0030032795 scopus 로고    scopus 로고
    • Recombinant human insulin-like growth factor I increases insulin sensitivity and improves glycemic control in type II diabetes
    • Moses, A. C., Young, S. C., Morrow, L. A., O'Brien, M. & Clemmons, D. R. Recombinant human insulin-like growth factor I increases insulin sensitivity and improves glycemic control in type II diabetes. Diabetes 45, 91-100 (1996).
    • (1996) Diabetes , vol.45 , pp. 91-100
    • Moses, A.C.1    Young, S.C.2    Morrow, L.A.3    O'Brien, M.4    Clemmons, D.R.5
  • 92
    • 84865489973 scopus 로고    scopus 로고
    • Insulin-like growth factor axis and risk of type 2 diabetes in women
    • Rajpathak, S. N. et al. Insulin-like growth factor axis and risk of type 2 diabetes in women. Diabetes 61, 2248-2254 (2012).
    • (2012) Diabetes , vol.61 , pp. 2248-2254
    • Rajpathak, S.N.1
  • 93
    • 80053483980 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is associated with low circulating levels of insulin-like growth factor?I
    • Arturi, F. et al. Nonalcoholic fatty liver disease is associated with low circulating levels of insulin-like growth factor?I. J. Clin. Endocrinol. Metab. 96, E1640-E1644 (2011).
    • (2011) J. Clin. Endocrinol. Metab. , vol.96
    • Arturi, F.1
  • 94
    • 78650690095 scopus 로고    scopus 로고
    • Hepatic gene networks in morbidly obese patients with nonalcoholic fatty liver disease
    • Gawrieh, S. et al. Hepatic gene networks in morbidly obese patients with nonalcoholic fatty liver disease. Obes. Surg. 20, 1698-1709 (2010).
    • (2010) Obes. Surg. , vol.20 , pp. 1698-1709
    • Gawrieh, S.1
  • 95
    • 78049428301 scopus 로고    scopus 로고
    • A liver-derived secretory protein, selenoprotein P, causes insulin resistance
    • Misu, H. et al. A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Cell Metab. 12, 483-495 (2010).
    • (2010) Cell Metab. , vol.12 , pp. 483-495
    • Misu, H.1
  • 96
    • 79961235988 scopus 로고    scopus 로고
    • Serum selenoprotein P levels in patients with type 2 diabetes and prediabetes: Implications for insulin resistance, inflammation, and atherosclerosis
    • Yang, S. J. et al. Serum selenoprotein P levels in patients with type 2 diabetes and prediabetes: Implications for insulin resistance, inflammation, and atherosclerosis. J. Clin. Endocrinol. Metab. 96, E1325-E1329 (2011).
    • (2011) J. Clin. Endocrinol. Metab. , vol.96
    • Yang, S.J.1
  • 97
    • 84859327136 scopus 로고    scopus 로고
    • Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes
    • Misu, H. et al. Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes. PLoS ONE 7, e34952 (2012).
    • (2012) PLoS ONE , vol.7
    • Misu, H.1
  • 98
    • 0019757020 scopus 로고
    • Secretion of testosterone-estradiol-binding globulin by a human hepatoma-derived cell line
    • Khan, M. S., Knowles. B. B., Aden, D. P. & Rosner, W. Secretion of testosterone-estradiol-binding globulin by a human hepatoma-derived cell line. J. Clin. Endocrinol. Metab. 53, 448-449 (1981).
    • (1981) J. Clin. Endocrinol. Metab. , vol.53 , pp. 448-449
    • Khan, M.S.1    Knowles, B.B.2    Aden, D.P.3    Rosner, W.4
  • 99
    • 70349235444 scopus 로고    scopus 로고
    • Sex hormone-binding globulin and risk of type 2 diabetes in women and men
    • Ding, E. L. et al. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N. Engl. J. Med. 361, 1152-1163 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1152-1163
    • Ding, E.L.1
  • 100
    • 77949911881 scopus 로고    scopus 로고
    • Genetic Evidence That Raised Sex Hormone Binding Globulin (SHBG) Levels Reduce The Risk Of Type 2 Diabetes
    • Perry, J. R. et al. Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum. Mol. Genet. 19, 535-544 (2010).
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 535-544
    • Perry, J.R.1
  • 101
    • 20144365466 scopus 로고    scopus 로고
    • Sex-hormone-binding globulin and the free androgen index are related to cardiovascular risk factors in multiethnic premenopausal and perimenopausal women enrolled in the Study of Women Across the Nation (SWAN)
    • Sutton-Tyrrell, K. et al. Sex-hormone-binding globulin and the free androgen index are related to cardiovascular risk factors in multiethnic premenopausal and perimenopausal women enrolled in the Study of Women Across the Nation (SWAN). Circulation 111, 1242-1249 (2005).
    • (2005) Circulation , vol.111 , pp. 1242-1249
    • Sutton-Tyrrell, K.1
  • 102
    • 36849037569 scopus 로고    scopus 로고
    • Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene
    • Selva, D. M., Hogeveen, K. N., Innis, S. M. & Hammond, G. L. Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. J. Clin. Invest. 117, 3979-3987 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 3979-3987
    • Selva, D.M.1    Hogeveen, K.N.2    Innis, S.M.3    Hammond, G.L.4
  • 103
    • 84856514277 scopus 로고    scopus 로고
    • Potential role of tumor necrosis factor in downregulating sex hormone-binding globulin
    • Simó, R., Barbosa-Desongles, A., Lecube, A., Hernandez, C. & Selva, D. M. Potential role of tumor necrosis factor in downregulating sex hormone-binding globulin. Diabetes 61, 372-382 (2012).
    • (2012) Diabetes , vol.61 , pp. 372-382
    • Simó, R.1    Barbosa-Desongles, A.2    Lecube, A.3    Hernandez, C.4    Selva, D.M.5
  • 104
    • 84868089300 scopus 로고    scopus 로고
    • IL1? down-regulation of sex hormone-binding globulin production by decreasing HNF?4? via MEK?1/2 and JNK MAPK pathways
    • Simó, R., Barbosa-Desongles, A., Hernandez, C. & Selva, D. M. IL1? down-regulation of sex hormone-binding globulin production by decreasing HNF?4? via MEK?1/2 and JNK MAPK pathways. Mol. Endocrinol. 26, 1917?1927 (2012).
    • (2012) Mol. Endocrinol. , vol.26 , pp. 1917-1927
    • Simó, R.1    Barbosa-Desongles, A.2    Hernandez, C.3    Selva, D.M.4
  • 105
    • 74049133977 scopus 로고    scopus 로고
    • Sex hormone-binding globulin and risk of type 2 diabetes
    • Stefan, N., Schick, F. & Häring, H. U. Sex hormone-binding globulin and risk of type 2 diabetes. N. Engl. J. Med. 361, 2675-2676 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 2675-2676
    • Stefan, N.1    Schick, F.2    Häring, H.U.3
  • 106
    • 72849152902 scopus 로고    scopus 로고
    • Increased androgen bioavailability is associated with non-alcoholic fatty liver disease in women with polycystic ovary syndrome
    • Vassilatou, E. et al. Increased androgen bioavailability is associated with non-alcoholic fatty liver disease in women with polycystic ovary syndrome. Hum. Reprod. 25, 212-220 (2010).
    • (2010) Hum. Reprod. , vol.25 , pp. 212-220
    • Vassilatou, E.1
  • 107
    • 78650042692 scopus 로고    scopus 로고
    • Relationships of circulating sex hormone-binding globulin with metabolic traits in humans
    • Peter, A. et al. Relationships of circulating sex hormone-binding globulin with metabolic traits in humans. Diabetes 59, 3167-3173 (2010).
    • (2010) Diabetes , vol.59 , pp. 3167-3173
    • Peter, A.1
  • 108
    • 0026545114 scopus 로고
    • Sex hormone-binding globulin Binding to cell membranes and generation of a second messenger
    • Rosner, W. et al. Sex hormone-binding globulin. Binding to cell membranes and generation of a second messenger. J. Androl. 13, 101-106 (1992).
    • (1992) J. Androl. , vol.13 , pp. 101-106
    • Rosner, W.1
  • 109
  • 110
    • 0032977457 scopus 로고    scopus 로고
    • Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane
    • Rosner, W., Hryb, D. J., Khan, M. S., Nakhla, A. M. & Romas, N. A. Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane. J. Steroid Biochem. Mol. Biol. 69, 481-485 (1999).
    • (1999) J. Steroid Biochem. Mol. Biol. , vol.69 , pp. 481-485
    • Rosner, W.1    Hryb, D.J.2    Khan, M.S.3    Nakhla, A.M.4    Romas, N.A.5
  • 112
    • 84861591910 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American gastroenterological association, american association for the study of liver diseases, and american college of gastroenterology
    • Chalasani, N. et al. The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 142, 1592-1609 (2012).
    • (2012) Gastroenterology , vol.142 , pp. 1592-1609
    • Chalasani, N.1
  • 113
    • 34249699540 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis and cancer
    • Bugianesi, E. Non-alcoholic steatohepatitis and cancer. Clin. Liver Dis. 11, 191-207 (2007).
    • (2007) Clin. Liver Dis. , vol.11 , pp. 191-207
    • Bugianesi, E.1
  • 114
    • 77951456114 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection
    • Starley, B. Q., Calcagno, C. J. & Harrison, S. A. Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection. Hepatology 51, 1820-1832 (2010).
    • (2010) Hepatology , vol.51 , pp. 1820-1832
    • Starley, B.Q.1    Calcagno, C.J.2    Harrison, S.A.3
  • 115
    • 77957375969 scopus 로고    scopus 로고
    • Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease
    • Targher, G., Day, C. P. & Bonora, E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N. Engl. J. Med. 363, 1341-1350 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1341-1350
    • Targher, G.1    Day, C.P.2    Bonora, E.3
  • 116
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo, S. et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet. 40, 1461-1465 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 1461-1465
    • Romeo, S.1
  • 117
    • 70350550096 scopus 로고    scopus 로고
    • Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene
    • Kantartzis, K. et al. Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes 58, 2616-2623 (2009).
    • (2009) Diabetes , vol.58 , pp. 2616-2623
    • Kantartzis, K.1
  • 118
    • 67349174005 scopus 로고    scopus 로고
    • A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
    • Kotronen, A. et al. A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans. Diabetologia 52, 1056-1060 (2009).
    • (2009) Diabetologia , vol.52 , pp. 1056-1060
    • Kotronen, A.1
  • 119
    • 77956630787 scopus 로고    scopus 로고
    • PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
    • Speliotes, E. K. et al. PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. Hepatology 52, 904-912 (2010).
    • (2010) Hepatology , vol.52 , pp. 904-912
    • Speliotes, E.K.1
  • 120
    • 80052840577 scopus 로고    scopus 로고
    • The metabolically benign and malignant fatty liver
    • Stefan, N. & Häring, H. U. The metabolically benign and malignant fatty liver. Diabetes 60, 2011-2017 (2011).
    • (2011) Diabetes , vol.60 , pp. 2011-2017
    • Stefan, N.1    Häring, H.U.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.