New insight into adiponectin role in obesity and obesity-related diseases

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Nigro, Ersilia ^a   Scudiero, Olga ^a,b   Monaco, Maria Ludovica ^a   Palmieri, Alessia ^a   Mazzarella, Gennaro ^c   Costagliola, Ciro ^d   Bianco, Andrea ^d   Daniele, Aurora ^a,c  

^a CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

^d UNIVERSITY OF MOLISE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPOCYTOKINE; ADIPONECTIN; ADIPONECTIN RECEPTOR; ARCTIGENIN; ARCTIIN; CADHERIN; CAPSAICIN; CURCUMIN; GINGEROL; GRAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MATAIRESINOL; METFORMIN; NATURAL PRODUCT; NATURAL PRODUCTS AND THEIR SYNTHETIC DERIVATIVES; PARTHENOLIDE;

ADIPOSE TISSUE; ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ATHEROSCLEROSIS; CALORIC RESTRICTION; CARDIOVASCULAR DISEASE; CELL PROLIFERATION; CHRONIC KIDNEY DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; DIABETIC RETINOPATHY; ENERGY METABOLISM; EXERCISE; HEART PROTECTION; HUMAN; HYPERTENSION; INFLAMMATION; INSULIN RESISTANCE; METABOLIC SYNDROME X; NEOPLASM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; RESPIRATORY TRACT DISEASE; REVIEW; SLEEP DISORDERED BREATHING; SYNDROME; METABOLIC DISORDER; METABOLISM;

ADIPONECTIN; HUMANS; METABOLIC DISEASES; OBESITY;

EID: 84904792209     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/658913     Document Type: Review

References (169)

1. Wright S. M., Aronne L. J., Causes of obesity. Abdominal Imaging 2012 37 5 730 732 10.1007/s00261-012-9862-x 2-s2.0-84868019776
2. Friedman J. M., Obesity in the new millennium. Nature 2000 404 6778 632 634 2-s2.0-0034611675 (Pubitemid 30205067)
3. Fitzgerald K. R., Review of article: prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010 by Katherine M. Flegal, PhD; Margaret D. Carroll, MSPH; Brian K. Kit, MD; Cynthia L. Ogden, PhD (JAMA 2012;307:491-7). Journal of Vascular Nursing 2013 31 3 131 132 10.1016/j.jvn.2013.06.004
4. Fakhouri T. H. I., Ogden C. L., Carroll M. D., Kit B. K., Flegal K. M., Prevalence of obesity among older adults in the United States, 2007-2010. National Center for Health Statistics Data Brief 2012 106 1 8 2-s2.0-84875893421
5. Berghöfer A., Pischon T., Reinhold T., Apovian C. M., Sharma A. M., Willich S. N., Obesity prevalence from a European perspective: a systematic review. BMC Public Health 2008 8, article 200 10.1186/1471-2458-8-200 2-s2.0-46249090304 (Pubitemid 351907992)
6. Hales C. N., Barker D. J. P., The thrifty phenotype hypothesis. British Medical Bulletin 2001 60 5 20 10.1093/bmb/60.1.5 2-s2.0-0035704552 (Pubitemid 34123501)
7. Srivastava N., Lakhan R., Mittal B., Pathophysiology and genetics of obesity. Indian Journal of Experimental Biology 2007 45 11 929 936 2-s2.0-38449085957
8. Xia Q., Grant S. F. A., The genetics of human obesity. Annals of the New York Academy of Sciences 2013 1281 1 178 190 10.1111/nyas.12020 2-s2.0-84875669545
9. Alfieri A., Pasanisi F., Salzano S., Esposito L., Martone D., Tafuri D., Daniele A., Contaldo F., Sacchetti L., Zagari A., Buono P., Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy. Gene 2010 457 1-2 35 41 10.1016/j.gene.2010.03.001 2-s2.0-77951935284
10. Kakar N., Ahmad J., Kubisch C., Borck G., Exon skipping and severe childhood-onset obesity caused by a leptin receptor mutation. American Journal of Medical Genetics A 2013 161 10 2672 2674 10.1002/ajmg.a.36125 2-s2.0-84881510577
11. Farooqi I. S., Drop S., Clements A., Keogh J. M., Biernacka J., Lowenbein S., Challis B. G., O'Rahilly S., Heterozygosity for a POMC-null mutation and increased obesity risk in humans. Diabetes 2006 55 9 2549 2553 10.2337/db06-0214 2-s2.0-33750592655 (Pubitemid 44871155)
12. Argyropoulos G., Rankinen T., Neufeld D. R., Rice T., Province M. A., Leon A. S., Skinner J. S., Wilmore J. H., Rao D. C., Bouchard C., A polymorphism in the human agouti-related protein is associated with late-onset obesity. The Journal of Clinical Endocrinology and Metabolism 2002 87 9 4198 4202 10.1210/jc.2002-011834 2-s2.0-18544363922
13. Goldlust I. S., Hermetz K. E., Catalano L. M., Mouse model implicates GNB3 duplication in a childhood obesity syndrome. Proceedings of the National Academy of Sciences 2013 110 37 14990 14994 10.1073/pnas.1305999110
14. Willer C. J., Speliotes E. K., Loos R. J., Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genetics 2009 41 1 25 34 10.1038/ng.287
15. Cao J., Puri N., Sodhi K., Bellner L., Abraham N. G., Kappas A., Apo A1 mimetic rescues the diabetic phenotype of HO-2 knockout mice via an increase in HO-1 adiponectin and LKBI signaling pathway. International Journal of Hypertension 2012 2012 8 628147 10.1155/2012/628147 2-s2.0-84868275688
16. Speliotes E. K., Willer C. J., Berndt S. I., Association analyses of 249, 796 individuals reveal eighteen new loci associated with body mass index. Nature Genetics 2010 42 11 937 948
17. Thorleifsson G., Walters G. B., Gudbjartsson D. F., Steinthorsdottir V., Sulem P., Helgadottir A., Styrkarsdottir U., Gretarsdottir S., Thorlacius S., Jonsdottir I., Jonsdottir T., Olafsdottir E. J., Olafsdottir G. H., Jonsson T., Jonsson F., Borch-Johnsen K., Hansen T., Andersen G., Jorgensen T., Lauritzen T., Aben K. K., Verbeek A. L. M., Roeleveld N., Kampman E., Yanek L. R., Becker L. C., Tryggvadottir L., Rafnar T., Becker D. M., Gulcher J., Kiemeney L. A., Pedersen O., Kong A., Thorsteinsdottir U., Stefansson K., Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nature Genetics 2009 41 1 18 24 10.1038/ng.274 2-s2.0-58149163141
18. Mohamed-Ali V., Pinkney J. H., Coppack S. W., Adipose tissue as an endocrine and paracrine organ. International Journal of Obesity 1998 22 12 1145 1158 10.1038/sj.ijo.0800770 2-s2.0-0031736064 (Pubitemid 28548534)
19. Rega-Kaun G., Kaun C., Wojta J., More than a simple storage organ: adipose tissue as a source of adipokines involved in cardiovascular disease. Thrombosis and Haemostasis 2013 110 4 641 50 10.1160/TH13-03-0212
20. Kwon H., Pessin J. E., Adipokines mediate inflammation and insulin resistance. Frontiers in Endocrinology 2013 4, article 71 10.3389/fendo.2013. 00071
21. Scherer P. E., Williams S., Fogliano M., Baldini G., Lodish H. F., A novel serum protein similar to C1q, produced exclusively in adipocytes. The Journal of Biological Chemistry 1995 270 45 26746 26749 10.1074/jbc.270.45.26746 2-s2.0-0028787490
22. Maeda K., Okubo K., Shimomura I., Funahashi T., Matsuzawa Y., Matsubara K., cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochemical and Biophysical Research Communications 1996 221 2 286 289 10.1006/bbrc.1996.0587 2-s2.0-0029980285 (Pubitemid 26136463)
23. Nakano Y., Tobe T., Choi-Miura N., Mazda T., Tomita M., Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. Journal of Biochemistry 1996 120 4 803 812 10.1093/oxfordjournals. jbchem.a021483 2-s2.0-0029836585 (Pubitemid 26385421)
24. Kadowaki T., Yamauchi T., Adiponectin and adiponectin receptors. Endocrine Reviews 2005 26 3 439 451 10.1210/er.2005-0005 2-s2.0-18844432308 (Pubitemid 40686653)
25. Kern P. A., di Gregorio G. B., Lu T., Rassouli N., Ranganathan G., Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor- α expression. Diabetes 2003 52 7 1779 1785 10.2337/diabetes.52.7.1779 2-s2.0-0037677604 (Pubitemid 36792470)
26. Lee B., Shao J., Adiponectin and energy homeostasis. Reviews in Endocrine and Metabolic Disorders 2014 15 2 149 156 10.1007/s11154-013-9283-3
27. Ohashi K., Ouchi N., Matsuzawa Y., Anti-inflammatory and anti-atherogenic properties of adiponectin. Biochimie 2012 94 10 2137 2142 10.1016/j.biochi. 2012.06.008 2-s2.0-84866072974
28. Daniele A., Cammarata R., Masullo M., Nerone G., Finamore F., D'Andrea M., Pilla F., Oriani G., Analysis of adiponectin gene and comparison of its expression in two different pig breeds. Obesity 2008 16 8 1869 1874 10.1038/oby.2008.275 2-s2.0-48749104020
29. de Rosa A., Ludovica Monaco M., Capasso M., Forestieri P., Pilone V., Nardelli C., Buono P., Daniele A., Adiponectin oligomers as potential indicators of adipose tissue improvement in obese subjects. European Journal of Endocrinology 2013 169 1 37 43 10.1530/EJE-12-1039 2-s2.0-84879989100
30. Schraw T., Wang Z. V., Halberg N., Hawkins M., Scherer P. E., Plasma adiponectin complexes have distinct biochemical characteristics. Endocrinology 2008 149 5 2270 2282 10.1210/en.2007-1561 2-s2.0-42449113834 (Pubitemid 351574488)
31. Fruebis J., Tsao T. S., Javorschi S., Ebbets-Reed D., Erickson M. R. S., Yen F. T., Bihain B. E., Lodish H. F., Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proceedings of the National Academy of Sciences of the United States of America 2001 98 4 2005 2010 10.1073/pnas.041591798 2-s2.0-0035852760 (Pubitemid 32165613)
32. Kishida K., Nagaretani H., Kondo H., Kobayashi H., Tanaka S., Maeda N., Nagasawa A., Hibuse T., Ohashi K., Kumada M., Nishizawa H., Okamoto Y., Ouchi N., Maeda K., Kihara S., Funahashi T., Matsuzawa Y., Disturbed secretion of mutant adiponectin associated with the metabolic syndrome. Biochemical and Biophysical Research Communications 2003 306 1 286 292 10.1016/S0006-291X(03) 00940-9 2-s2.0-0038054254 (Pubitemid 36629439)
33. Ge H., Xiong Y., Lemon B., Lee K. J., Tang J., Wang P., Weiszmann J., Hawkins N., Laudemann J., Min X., Penny D., Wolfe T., Liu Q., Zhang R., Yeh W., Shen W., Lindberg R., Wang Z., Sheng J., Li Y., Generation of novel long-acting globular adiponectin molecules. Journal of Molecular Biology 2010 399 1 113 119 10.1016/j.jmb.2010.03.062 2-s2.0-77953048952
34. Waki H., Yamauchi T., Kamon J., Kita S., Ito Y., Hada Y., Uchida S., Tsuchida A., Takekawa S., Kadowaki T., Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. Endocrinology 2005 146 2 790 796 10.1210/en.2004-1096 2-s2.0-19944431559 (Pubitemid 40129836)
35. Almer G., Saba-Lepek M., Haj-Yahya S., Globular domain of adiponectin: promising target molecule for detection of atherosclerotic lesions. Biologics 2011 5 95 105 10.2147/BTT.S22863
36. Wen J. P., Liu C. E., Hu Y. T., Chen G., Lin L. X., Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus. Molecular and Cellular Biochemistry 2010 344 1-2 109 115 10.1007/s11010-010-0534-2 2-s2.0-78449267024
37. Pajvani U. B., Du X., Combs T. P., Berg A. H., Rajala M. W., Schulthess T., Engel J., Brownlee M., Scherer P. E., Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin: Implications for metabolic regulation and bioactivity. The Journal of Biological Chemistry 2003 278 11 9073 9085 10.1074/jbc.M207198200 2-s2.0-0037984387 (Pubitemid 36800387)
38. Simpson F., Whitehead J. P., Adiponectin-it's all about the modifications. The International Journal of Biochemistry & Cell Biology 2010 42 6 785 788 10.1016/j.biocel.2009.12.021 2-s2.0-77953806826
39. Calton E. K., Miller V. S., Soares M. J., Factors determining the risk of the metabolic syndrome: is there a central role for adiponectin? The European Journal of Clinical Nutrition 2013 67 5 485 491 10.1038/ejcn.2013.1 2-s2.0-84877148674
40. Daniele A., de Rosa A., de Cristofaro M., Monaco M. L., Masullo M., Porcile C., Capasso M., Tedeschi G., Oriani G., di Costanzo A., Decreased concentration of adiponectin together with a selective reduction of its high molecular weight oligomers is involved in metabolic complications of myotonic dystrophy type 1. European Journal of Endocrinology 2011 165 6 969 975 10.1530/EJE-11-0537 2-s2.0-81555222575
41. Daniele A., De Rosa A., Nigro E., Scudiero O., Capasso M., Masullo M., De Laurentiis G., Oriani G., Sofia M., Bianco A., Adiponectin oligomerization state and adiponectin receptors airway expression in chronic obstructive pulmonary disease. The International Journal of Biochemistry and Cell Biology 2012 44 3 563 569 10.1016/j.biocel.2011.12.016 2-s2.0-84857233845
42. Liu M., Liu F., Up- and down-regulation of adiponectin expression and multimerization: mechanisms and therapeutic implication. Biochimie 2012 94 10 2126 2130 10.1016/j.biochi.2012.01.008 2-s2.0-84866091920
43. Vasseur F., Helbecque N., Dina C., Lobbens S., Delannoy V., Gaget S., Boutin P., Vaxillaire M., Leprêtre F., Dupont S., Hara K., Clément K., Bihain B., Kadowaki T., Froguel P., Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Human Molecular Genetics 2002 11 21 2607 2614 10.1093/hmg/11.21.2607 2-s2.0-18644369745 (Pubitemid 35174690)
44. Hara K., Boutin P., Mori Y., Tobe K., Dina C., Yasuda K., Yamauchi T., Otabe S., Okada T., Eto K., Kadowaki H., Hagura R., Akanuma Y., Yazaki Y., Nagai R., Taniyama M., Matsubara K., Yoda M., Nakano Y., Kimura S., Tomita M., Ito C., Froguel P., Kadowaki T., Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002 51 2 536 540 2-s2.0-0036230657 (Pubitemid 34764814)
45. Waki H., Yamauchi T., Kamon J., Ito Y., Uchida S., Kita S., Hara K., Hada Y., Vasseur F., Froguel P., Kimura S., Nagai R., Kadowaki T., Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. The Journal of Biological Chemistry 2003 278 41 40352 40363 10.1074/jbc.M300365200 2-s2.0-0141924849 (Pubitemid 37248604)
46. Kondo H., Shimomura I., Matsukawa Y., Kumada M., Takahashi M., Matsuda M., Ouchi N., Kihara S., Kawamoto T., Sumitsuji S., Funahashi T., Matsuzawa Y., Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. Diabetes 2002 51 7 2325 2328 10.2337/diabetes.51.7.2325 2-s2.0-0036303146 (Pubitemid 34729044)
47. Daniele A., Cammarata R., Pasanisi F., Finelli C., Salvatori G., Calcagno G., Bracale R., Labruna G., Nardelli C., Buono P., Sacchetti L., Contaldo F., Oriani G., Molecular analysis of the adiponectin gene in severely obese patients from Southern Italy. Annals of Nutrition and Metabolism 2009 53 3-4 155 161 10.1159/000172976 2-s2.0-60749136777
48. Bracale R., Labruna G., Finelli C., Daniele A., Sacchetti L., Oriani G., Contaldo F., Pasanisi F., The absence of polymorphisms in ADRB3, UCP1, PPAR γ and ADIPOQ genes protects morbid obese patients toward insulin resistance. Journal of Endocrinological Investigation 2012 35 1 2 4 10.1007/BF03345413 2-s2.0-84861970088
49. Bermúdez V. J., Rojas E., Toledo A., Rodríguez-Molina D., Vega K., Suárez L., Pacheco M., Canelón R., Arráiz N., Rojas J., Velasco M., Single-nucleotide polymorphisms in adiponectin, AdipoR1, and AdipoR2 genes: Insulin resistance and type 2 diabetes mellitus candidate genes. American Journal of Therapeutics 2013 20 4 414 421 10.1097/MJT. 0b013e318235f206 2-s2.0-84880799655
50. Hug C., Wang J., Ahmad N. S., Bogan J. S., Tsao T. S., Lodish H. F., T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proceedings of the National Academy of Sciences of the United States of America 2004 101 28 10308 10313 10.1073/pnas.0403382101 2-s2.0-3142761477 (Pubitemid 38924921)
51. Yamauchi T., Nio Y., Maki T., Kobayashi M., Takazawa T., Iwabu M., Okada-Iwabu M., Kawamoto S., Kubota N., Kubota T., Ito Y., Kamon J., Tsuchida A., Kumagai K., Kozono H., Hada Y., Ogata H., Tokuyama K., Tsunoda M., Ide T., Murakami K., Awazawa M., Takamoto I., Froguel P., Hara K., Tobe K., Nagai R., Ueki K., Kadowaki T., Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nature Medicine 2007 13 3 332 339 10.1038/nm1557 2-s2.0-33847733103 (Pubitemid 46376688)
52. Ye R., Scherer P. E., Adiponectin, driver or passenger on the road to insulin sensitivity? Molecular Metabolism 2013 2 3 133 141 10.1016/j.molmet. 2013.04.001 2-s2.0-84883234646
53. Wu X., Motoshima H., Mahadev K., Stalker T. J., Scalia R., Goldstein B. J., Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes 2003 52 6 1355 1363 10.2337/diabetes.52.6.1355 2-s2.0-0037983775 (Pubitemid 36666188)
54. Rao J. R., Keating D. J., Chen C., Parkington H. C., Adiponectin increases insulin content and cell proliferation in MIN6 cells via PPAR γ -dependent and PPAR γ -independent mechanisms. Diabetes, Obesity and Metabolism 2012 14 11 983 989 10.1111/j.1463-1326.2012.01626.x 2-s2.0-84867139111
55. Wijesekara N., Krishnamurthy M., Bhattacharjee A., Suhail A., Sweeney G., Wheeler M. B., Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. The Journal of Biological Chemistry 2010 285 44 33623 33631 10.1074/jbc.M109.085084 2-s2.0-77958568034
56. Wedellová Z., Dietrich J., Šiklová- Vítková M., Kološtová K., Kováč iková M., Dušková M., Brož J., Vedral T., Štich V., Polák J., Adiponectin inhibits spontaneous and catecholamine-induced lipolysis in human adipocytes of non-obese subjects through AMPK-dependent mechanisms. Physiological Research 2011 60 1 139 148 2-s2.0-79955816295
57. Villarreal-Molina M. T., Antuna-Puente B., Adiponectin: anti-inflammatory and cardioprotective effects. Biochimie 2012 94 10 2143 2149 10.1016/j.biochi.2012.06.030 2-s2.0-84866054662
58. Ouchi N., Walsh K., Adiponectin as an anti-inflammatory factor. Clinica Chimica Acta 2007 380 1-2 24 30 10.1016/j.cca.2007.01.026 2-s2.0-33947627537 (Pubitemid 46498041)
59. Subedi A., Park P. H., Autocrine and paracrine modulation of microRNA-155 expression by globular adiponectin in RAW 264.7 macrophages: involvement of MAPK/NF- κ B pathway. Cytokine 2013 64 3 638 641
60. Nigro E., Scudiero O., Sarnataro D., Mazzarella G., Sofia M., Bianco A., Daniele A., Adiponectin affects lung epithelial A549 cell viability counteracting TNFa and IL-1ß toxicity through AdipoR1. International Journal of Biochemistry and Cell Biology 2013 45 6 1145 1153 10.1016/j.biocel.2013.03.003 2-s2.0-84875926584
61. Ouchi N., Ohishi M., Kihara S., Funahashi T., Nakamura T., Nagaretani H., Kumada M., Ohashi K., Okamoto Y., Nishizawa H., Kishida K., Maeda N., Nagasawa A., Kobayashi H., Hiraoka H., Komai N., Kaibe M., Rakugi H., Ogihara T., Matsuzawa Y., Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 2003 42 3 231 234 10.1161/01.HYP.0000083488.67550.B8 2-s2.0-10744223954 (Pubitemid 37093465)
62. Shibata R., Ouchi N., Kihara S., Sato K., Funahashi T., Walsh K., Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of AMP-activated protein kinase signaling. Journal of Biological Chemistry 2004 279 27 28670 28674 10.1074/jbc.M402558200 2-s2.0-3142616447 (Pubitemid 38900150)
63. Kobayashi H., Ouchi N., Kihara S., Walsh K., Kumada M., Abe Y., Funahashi T., Matsuzawa Y., Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circulation research 2004 94 4 e27 31 10.1161/01.RES.0000119921.86460.37 2-s2.0-2942720979
64. Dalamaga M., Diakopoulos K. N., Mantzoros C. S., The role of adiponectin in cancer: a review of current evidence. Endocrine Reviews 2012 33 4 547 594 10.1210/er.2011-1015 2-s2.0-84866079242
65. Obeid S., Hebbard L., Role of adiponectin and its receptors in cancer. Cancer Biology and Medicine 2012 9 4 213 220 10.7497/j.issn.2095-3941.2012.04. 001 2-s2.0-84876328432
66. Lang K., Ratke J., Leptin and Adiponectin: new players in the field of tumor cell and leukocyte migration. Cell Communication and Signaling 2009 7, article 27 10.1186/1478-811X-7-27 2-s2.0-76149142449
67. Scheid M. P., Sweeney G., The role of adiponectin signaling in metabolic syndrome and cancer. Reviews in Endocrine and Metabolic Disorders 2013 15 2 157 167
68. Kim A. Y., Lee Y. S., Kim K. H., Lee J. H., Lee H. K., Jang S., Kim S., Lee G. Y., Lee J., Jung S., Chung H. Y., Jeong S., Kim J. B., Adiponectin represses colon cancer cell proliferation via AdipoR1- and -R2-mediated AMPK activation. Molecular Endocrinology 2010 24 7 1441 1452 10.1210/me.2009-0498 2-s2.0-77954828973
69. Nalabolu M. R., Palasamudram K., Jamil K., Adiponectin and leptin molecular actions and clinical significance in breast cancer. International Journal of Hematology-Oncology and Stem Cell Research 2014 8 1 31 40
70. Ogunwobi O. O., Beales I. L. P., Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells. Regulatory Peptides 2006 134 2-3 105 113 10.1016/j.regpep.2006.02.001 2-s2.0-33646190053
71. Lee M. H., Klein R. L., El-Shewy H. M., Luttrell D. K., Luttrell L. M., The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth. Biochemistry 2008 47 44 11682 11692 10.1021/bi801451f 2-s2.0-55249090400
72. Kaser S., Tatarczyk T., Stadlmayr A., Ciardi C., Ress C., Tschoner A., Sandhofer A., Paulweber B., Ebenbichler C. F., Patsch J. R., Effect of obesity and insulin sensitivity on adiponectin isoform distribution. European Journal of Clinical Investigation 2008 38 11 827 834 10.1111/j.1365-2362.2008.02028.x 2-s2.0-54349114710
73. Meyer L. K., Ciaraldi T. P., Henry R. R., Wittgrove A. C., Phillips S. A., Adipose tissue depot and cell size dependency of adiponectin synthesis and secretion in human obesity. Adipocyte 2013 2 4 217 226 10.4161/adip.24953
74. Hamilton M. P., Gore M. O., Ayers C. R., Wu X., McGuire D. K., Scherer P. E., Adiponectin and cardiovascular risk profile in patients with type 2 diabetes mellitus: Parameters associated with adiponectin complex distribution. Diabetes and Vascular Disease Research 2011 8 3 190 194 10.1177/1479164111407784 2-s2.0-80052052932
75. Drolet R., Bélanger C., Fortier M., Huot C., Mailloux J., Légaré D., Tchernof A., Fat depot-specific impact of visceral obesity on adipocyte adiponectin release in women. Obesity 2009 17 3 424 430 10.1038/oby.2008.555 2-s2.0-60849113459
76. Ramya K., Ayyappa K. A., Ghosh S., Mohan V., Radha V., Genetic association of ADIPOQ gene variants with type 2 diabetes, obesity and serum adiponectin levels in south Indian population. Gene 2013 532 2 253 262 10.1016/j.gene.2013.09.012
77. Pollin T. I., Tanner K., O'Connell J. R., Ott S. H., Damcott C. M., Shuldiner A. R., McLenithan J. C., Mitchell B. D., Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene. Diabetes 2005 54 1 268 274 10.2337/diabetes.54.1.268 2-s2.0-12144283038 (Pubitemid 40105122)
78. Stumvoll M., Tschritter O., Fritsche A., Staiger H., Renn W., Weisser M., Machicao F., Häring H., Association of the T-G polymorphism in adiponectin (Exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes 2002 51 1 37 41 10.2337/diabetes.51.1.37 2-s2.0-0036091918 (Pubitemid 34517977)
79. Woo J. G., Dolan L. M., Deka R., Kaushal R. D., Shen Y., Pal P., Daniels S. R., Martin L. J., Interactions between noncontiguous haplotypes in the adiponectin gene ACDC are associated with plasma adiponectin. Diabetes 2006 55 2 523 529 10.2337/diabetes.55.02.06.db05-0446 2-s2.0-33644745284 (Pubitemid 43343285)
80. de Pergola G., Silvestris F., Obesity as a major risk factor for cancer. Journal of Obesity 2013 2013 11 291546 10.1155/2013/291546
81. Avogaro A., de Kreutzenberg S. V., Mechanisms of endothelial dysfunction in obesity. Clinica Chimica Acta 2005 360 1-2 9 26 10.1016/j.cccn.2005.04.020 2-s2.0-24144498067 (Pubitemid 41226497)
82. Diaz-Melean C. M., Somers V. K., Rodriguez-Escudero J. P., Mechanisms of adverse cardiometabolic consequences of obesity. Current Atherosclerosis Reports 2013 15 11 364
83. Matsuda M., Shimomura I., Roles of adiponectin and oxidative stress in obesity-associated metabolic and cardiovascular diseases. Reviews in Endocrine and Metabolic Disorders 2014 15 1 1 10
84. Cnop M., Havel P. J., Utzschneider K. M., Carr D. B., Sinha M. K., Boyko E. J., Retzlaff B. M., Knopp R. H., Brunzell J. D., Kahn S. E., Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 2003 46 4 459 469 2-s2.0-0038293399 (Pubitemid 36577787)
85. Kim N. H., Cho N. H., Yun C. H., Association of obstructive sleep apnea and glucose metabolism in subjects with or without obesity. Diabetes Care 2013 36 12 3909 3915 10.2337/dc13-0375
86. Wolf A. M., Wolf D., Rumpold H., Enrich B., Tilg H., Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes. Biochemical and Biophysical Research Communications 2004 323 2 630 635 10.1016/j.bbrc.2004.08.145 2-s2.0-4544334655 (Pubitemid 39221142)
87. Demirci H., Nuhoglu C., Ursavas I. S., Isildak S., Basaran E. O., Kilic M. Y., Obesity and asymptomatic hypertension among children aged 6-13 years living in Bursa, Turkey. Family Practice 2013 30 6 629 633
88. Ouchi N., Kihara S., Funahashi T., Matsuzawa Y., Walsh K., Obesity, adiponectin and vascular inflammatory disease. Current Opinion in Lipidology 2003 14 6 561 566 10.1097/00041433-200312000-00003 2-s2.0-0347334429 (Pubitemid 41623184)
89. Iwashima Y., Katsuya T., Ishikawa K., Ouchi N., Ohishi M., Sugimoto K., Fu Y., Motone M., Yamamoto K., Matsuo A., Ohashi K., Kihara S., Funahashi T., Rakugi H., Matsuzawa Y., Ogihara T., Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension 2004 43 6 1318 1323 10.1161/01.HYP. 0000129281.03801.4b 2-s2.0-2542473288 (Pubitemid 38691756)
90. Di Chiara T., Licata A., Argano C., Duro G., Corrao S., Scaglione R., Plasma adiponectin: a contributing factor for cardiac changes in visceral obesity-associated hypertension. Blood Pressure 2014 23 3 147 153 10.3109/08037051.2013.823767
91. Ouchi N., Kihara S., Arita Y., Nishida M., Matsuyama A., Okamoto Y., Ishigami M., Kuriyama H., Kishida K., Nishizawa H., Hotta K., Muraguchi M., Ohmoto Y., Yamashita S., Funahashi T., Matsuzawa Y., Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 2001 103 8 1057 1063 10.1161/01.CIR.103.8.1057 2-s2.0-0035957040 (Pubitemid 32200177)
92. Chen Z., Peng I., Sun W., Su M., Hsu P., Fu Y., Zhu Y., Defea K., Pan S., Tsai M., Shyy J. Y., AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase ser633. Circulation Research 2009 104 4 496 505 10.1161/CIRCRESAHA.108.187567 2-s2.0-61949165795
93. Mathew A. V., Okada S., Sharma K., Obesity related kidney disease. Current Diabetes Reviews 2011 7 1 41 49 10.2174/157339911794273928 2-s2.0-79952748617
94. Tesauro M., Mascali A., Franzese O., Cipriani S., Cardillo C., di Daniele N., Chronic kidney disease, obesity, and hypertension: the role of leptin and adiponectin. International Journal of Hypertension 2012 2012 7 943605 10.1155/2012/943605 2-s2.0-84872774057
95. Menon V., Li L., Wang X., Greene T., Balakrishnan V., Madero M., Pereira A. A., Beck G. J., Kusek J. W., Collins A. J., Levey A. S., Sarnak M. J., Adiponectin and mortality in patients with chronic kidney disease. Journal of the American Society of Nephrology 2006 17 9 2599 2606 10.1681/ASN.2006040331 2-s2.0-33748050124 (Pubitemid 44300977)
96. Bakkaloglu S. A., Soylemezoglu O., Buyan N., Funahashi T., Elhan A. H., Peru H., Fidan K., Yilmaz S., Hasanoglu E., High serum adiponectin levels during steroid-responsive nephrotic syndrome relapse. Pediatric Nephrology 2005 20 4 474 477 10.1007/s00467-004-1770-z 2-s2.0-15344343045 (Pubitemid 40392621)
97. Komura N., Kihara S., Sonoda M., Maeda N., Tochino Y., Funahashi T., Shimomura I., Increment and impairment of adiponectin in renal failure. Cardiovascular Research 2010 86 3 471 477 10.1093/cvr/cvp415 2-s2.0-77952357751
98. Sharma K., RamachandraRao S., Qiu G., Usui H. K., Zhu Y., Dunn S. R., Ouedraogo R., Hough K., McCue P., Chan L., Falkner B., Goldstein B. J., Adiponectin regulates albuminuria and podocyte function in mice. The Journal of Clinical Investigation 2008 118 5 1645 1656 10.1172/JCI32691 2-s2.0-43049095682 (Pubitemid 351632369)
99. Shimamoto Y., Mizukoshi M., Kuroi A., Is visceral fat really a coronary risk factor? International Heart Journal 2013 54 5 273 278
100. Choi S. H., Hong E. S., Lim S., Clinical implications of adipocytokines and newly emerging metabolic factors with relation to insulin resistance and cardiovascular health. Frontiers in Endocrinology 2013 4, article 97 10.3389/fendo.2013.00097
101. Sattar N., Watt P., Cherry L., Ebrahim S., Smith G. D., Lawlor D. A., High molecular weight adiponectin is not associated with incident coronary heart disease in older women: a nested prospective case-control study. The Journal of Clinical Endocrinology and Metabolism 2008 93 5 1846 1849 10.1210/jc.2007-2603 2-s2.0-43249100007 (Pubitemid 351656528)
102. Matsuda M., Shimomura I., Sata M., Arita Y., Nishida M., Maeda N., Kumada M., Okamoto Y., Nagaretani H., Nishizawa H., Kishida K., Komuro R., Ouchi N., Kihara S., Nagai R., Funahashi T., Matsuzawa Y., Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. Journal of Biological Chemistry 2002 277 40 37487 37491 10.1074/jbc.M206083200 2-s2.0-0037020170
103. Ouchi N., Walsh K., Cardiovascular and metabolic regulation by the adiponectin/C1q/tumor necrosis factor-related protein family of proteins. Circulation 2012 125 25 3066 3068 10.1161/CIRCULATIONAHA.112.114181 2-s2.0-84863211730
104. Mazzarella G., Esposito V., Bianco A., Ferraraccio F., Prati M. V., Lucariello A., Manente L., Mezzogiorno A., De Luca A., Inflammatory effects on human lung epithelial cells after exposure to diesel exhaust micron sub particles (PM1.0) and pollen allergens. Environmental Pollution 2012 161 64 69 10.1016/j.envpol.2011.09.046 2-s2.0-80055043648
105. Esposito V., Lucariello A., Savarese L., Cinelli M. P., Ferraraccio F., Bianco A., De Luca A., Mazzarella G., Morphology changes in human lung epithelial cells after exposure to diesel exhaust micron sub particles (PM1.0) and pollen allergens. Environmental Pollution 2012 171 162 167 10.1016/j.envpol.2012.07.006 2-s2.0-84865331283
106. Mazzarella G., Ferraraccio F., Prati M. V., Annunziata S., Bianco A., Mezzogiorno A., Liguori G., Angelillo I. F., Cazzola M., Effects of diesel exhaust particles on human lung epithelial cells: an in vitro study. Respiratory Medicine 2007 101 6 1155 1162 10.1016/j.rmed.2006.11.011 2-s2.0-34247586649 (Pubitemid 46667679)
107. Grella E., Paciocco G., Caterino U., Mazzarella G., Respiratory function and atmospheric pollution. Monaldi Archives for Chest Disease 2002 57 3-4 196 199 2-s2.0-0036626920 (Pubitemid 36356000)
108. de Laurentiis G., Paris D., Melck D., Montuschi P., Maniscalco M., Bianco A., Sofia M., Motta A., Separating smoking-related diseases using NMR-based metabolomics of exhaled breath condensate. Journal of Proteome Research 2013 12 3 1502 1511 10.1021/pr301171p 2-s2.0-84874625331
109. Corbi G., Bianco A., Turchiarelli V., Cellurale M., Fatica F., Daniele A., Mazzarella G., Ferrara N., Potential mechanisms linking atherosclerosis and increased cardiovascular risk in COPD: focus on sirtuins. International Journal of Molecular Sciences 2013 14 6 12696 12713 10.3390/ijms140612696 2-s2.0-84879330179
110. Cecere L. M., Littman A. J., Slatore C. G., Udris E. M., Bryson C. L., Boyko E. J., Pierson D. J., Au D. H., Obesity and COPD: associated symptoms, health-related quality of life, and medication use. Journal of Chronic Obstructive Pulmonary Disease 2011 8 4 275 284 10.3109/15412555.2011.586660 2-s2.0-80052053931
111. Franssen F. M. E., O'Donnell D. E., Goossens G. H., Blaak E. E., Schols A. M. W. J., Obesity and the lung: 5·Obesity and COPD. Thorax 2008 63 12 1110 1117 10.1136/thx.2007.086827 2-s2.0-57149096723
112. Bianco A., Mazzarella G., Turchiarelli V., Adiponectin: an attractive marker for metabolic disorders in Chronic Obstructive Pulmonary Disease (COPD). Nutrients 2013 5 10 4115 4125
113. Chan K. H., Yeung S. C., Yao T. J., Ip M. S. M., Cheung A. H. K., Chan-Yeung M. M. W., Mak J. C. W., Lam W. K., Yew W. W., Wong P. C., Chau C. H., Liu R., Lam C. W., So L., Yee W., Chan K. K., Chan K. S., Chan J. W. M., Chu C. M., Ho A. S. S., Sit K. M., Choo K., Lam W. K., Ko F. W. S., Yu W. C., Wong M., Elevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease. International Journal of Tuberculosis and Lung Disease 2010 14 9 1193 1200 2-s2.0-77956594638
114. Liu H., Liu J. S., Huang J., Zhong L. W., Xu J. Y., Unique association of adiponectin isoforms with serum cytokines and redox molecules in patients with chronic obstructive pulmonary disease. Chinese Medical Journal (English Edition) 2013 126 17 3383 3384
115. Summer R., Fiack C. A., Ikeda Y., Sato K., Dwyer D., Ouchi N., Fine A., Farber H. W., Walshe K., Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease. American Journal of Physiology-Lung Cellular and Molecular Physiology 2009 297 3 L432 L438 10.1152/ajplung.90599.2008 2-s2.0-68949149049
116. Mathew J. L., Narang I., Sleeping too close together: obesity and obstructive sleep apnea in childhood and adolescence. Paediatric Respiratory Reviews 2013 10.1016/j.prrv.2013.09.001
117. Hargens T. A., Guill S. G., Kaleth A. S., Nickols-Richardson S. M., Miller L. E., Zedalis D., Gregg J. M., Gwazdauskas F., Herbert W. G., Insulin resistance and adipose-derived hormones in young men with untreated obstructive sleep apnea. Sleep and Breathing 2013 17 1 403 409 10.1007/s11325-012-0708-0 2-s2.0-84874194551
118. Nakagawa Y., Kishida K., Kihara S., Yoshida R., Funahashi T., Shimomura I., Nocturnal falls of adiponectin levels in sleep apnea with abdominal obesity and impact of hypoxia-induced dysregulated adiponectin production in obese murine mesenteric adipose tissue. Journal of Atherosclerosis and Thrombosis 2011 18 3 240 247 10.5551/jat.6593 2-s2.0-79953294011
119. Magalang U. J., Cruff J. P., Rajappan R., Hunter M. G., Patel T., Marsh C. B., Raman S. V., Parinandi N. L., Intermittent hypoxia suppresses adiponectin secretion by adipocytes. Experimental and Clinical Endocrinology and Diabetes 2009 117 3 129 134 10.1055/s-2008-1078738 2-s2.0-62749109694
120. Klein B. E. K., Overview of epidemiologic studies of diabetic retinopathy. Ophthalmic Epidemiology 2007 14 4 179 183 10.1080/09286580701396720 2-s2.0-34848907420 (Pubitemid 47493723)
121. Yilmaz M. I., Sonmez A., Acikel C., Celik T., Bingol N., Pinar M., Bayraktar Z., Ozata M., Adiponectin may play a part in the pathogenesis of diabetic retinopathy. European Journal of Endocrinology 2004 151 1 135 140 10.1530/eje.0.1510135 2-s2.0-4344673661 (Pubitemid 39117376)
122. Misu H., Ishikura K., Kurita S., Takeshita Y., Ota T., Saito Y., Takahashi K., Kaneko S., Takamura T., Inverse correlation between serum levels of selenoprotein p and adiponectin in patients with type 2 diabetes. PLoS ONE 2012 7 4 e34952 10.1371/journal.pone.0034952 2-s2.0-84859327136
123. Costagliola C., Daniele A., dell'Omo R., Romano M. R., Aceto F., Agnifili L., Semeraro F., Porcellini A., Aqueous humor levels of vascular endothelial growth factor and adiponectin in patients with type 2 diabetes before and after intravitreal bevacizumab injection. Experimental Eye Research 2013 110 50 54 10.1016/j.exer.2013.02.004 2-s2.0-84875660152
124. Mao D., Peng H., Li Q., Wang J., Li P., Hu K., Zhang X., Lei B., Aqueous humor and plasma adiponectin levels in proliferative diabetic retinopathy patients. Current Eye Research 2012 37 9 803 808 10.3109/02713683.2012.676700 2-s2.0-84864838967
125. Cunha-Vaz J., De Abreu J. R. F., Campos A. J., Figo G. M., Early breakdown of the blood retinal barrier in diabetes. British Journal of Ophthalmology 1975 59 11 649 656 10.1136/bjo.59.11.649 2-s2.0-0016715526
126. Chen H., Montagnani M., Funahashi T., Shimomura I., Quon M. J., Adiponectin stimulates production of nitric oxide in vascular endothelial cells. Journal of Biological Chemistry 2003 278 45 45021 45026 10.1074/jbc.M307878200 2-s2.0-0242581695 (Pubitemid 37377262)
127. Fukumura D., Ushiyama A., Duda D. G., Xu L., Tam J., Krishna V., Chatterjee K., Garkavtsev I., Jain R. K., Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. Circulation Research 2003 93 9 e88 e97 10.1161/01.RES.0000099243.20096.FA 2-s2.0-0345900899
128. Iskander K., Farhour R., Ficek M., Ray A., Obesity-related complications: Few biochemical phenomena with reference to tumorigenesis. Malaysian Journal of Pathology 2013 35 1 1 15 2-s2.0-84879594882
129. Kwan M. L., John E. M., Caan B. J., Obesity and mortality after Breast Cancer by Race/Ethnicity: the California Breast Cancer Survivorship Consortium. American Journal of Epidemiology 2013 179 1 95 111
130. Surmacz E., Mammary J., Leptin and adiponectin: emerging therapeutic targets in breast cancer. Journal of Mammar Gland Biology and Neoplasia 2013 18 3-4 321 332 10.1007/s10911-013-9302-8
131. Ohbuchi Y., Suzuki Y., Hatakeyama I., Nakao Y., Fujito A., Iwasaka T., Isaka K., A lower serum level of middle-molecular-weight adiponectin is a risk factor for endometrial cancer. International Journal of Clinical Oncology 2014 10.1007/s10147-013-0603-0 2-s2.0-84881525382
132. Kerenidi T., Lada M., Tsaroucha A., Georgoulias P., Mystridou P., Gourgoulianis K. I., Clinical significance of serum adipokines levels in lung cancer. Medical Oncology 2013 30 2, article 507 10.1007/s12032-013-0507-x 2-s2.0-84873980370
133. Kosova F., Coskun T., Kaya Y., Kara E., Ari Z., Adipocytokine levels of colon cancer patients before and after treatment. Bratislava Medical Journal 2013 114 7 394 397 10.4149/BLL-2013-083 2-s2.0-84880945541
134. Liao L. M., Schwartz K., Pollak M., Graubard B. I., Li Z., Ruterbusch J., Rothman N., Davis F., Wacholder S., Colt J., Chow W., Purdue M. P., Serum leptin and adiponectin levels and risk of renal cell carcinoma. Obesity 2013 21 7 1478 1485 10.1002/oby.20138 2-s2.0-84881549679
135. Petridou E. T., Mitsiades N., Gialamas S., Angelopoulos M., Skalkidou A., Dessypris N., Hsi A., Lazaris N., Polyzos A., Syrigos C., Brennan A. M., Tseleni-Balafouta S., Mantzoros C. S., Circulating adiponectin levels and expression of adiponectin receptors in relation to lung cancer: two case-control studies. Oncology 2007 73 3-4 261 269 10.1159/000127424 2-s2.0-43049123827 (Pubitemid 351630059)
136. Grossmann M. E., Nkhata K. J., Mizuno N. K., Ray A., Cleary M. P., Effects of adiponectin on breast cancer cell growth and signaling. British Journal of Cancer 2008 98 2 370 379 10.1038/sj.bjc.6604166 2-s2.0-38549160793 (Pubitemid 351161253)
137. Nakayama S., Miyoshi Y., Ishihara H., Noguchi S., Growth-inhibitory effect of adiponectin via adiponectin receptor 1 on human breast cancer cells through inhibition of S-phase entry without inducing apoptosis. Breast Cancer Research and Treatment 2008 112 3 405 410 10.1007/s10549-007-9874-3 2-s2.0-56549085580
138. Courcoulas A. P., Christian N. J., Belle S. H., Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity. The Journal of the American Medical Association 2013 310 22 2416 2425
139. Noria S. F., Grantcharov T., Biological effects of bariatric surgery on obesity-related comorbidities. Canadian Journal of Surgery 2013 56 1 47 57 10.1503/cjs.036111 2-s2.0-84875048426
140. Salas-Salvadó J., Bulló M., García-Lorda P., Figueredo R., Del Castillo D., Bonada A., Balanzà R., Subcutaneous adipose tissue cytokine production is not responsible for the restoration of systemic inflammation markers during weight loss. International Journal of Obesity 2006 30 12 1714 1720 10.1038/sj.ijo.0803348 2-s2.0-33845271942 (Pubitemid 44863402)
141. Weiss E. P., Racette S. B., Villareal D. T., Fontana L., Steger-May K., Schechtman K. B., Klein S., Holloszy J. O., Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. The American Journal of Clinical Nutrition 2006 84 5 1033 1042 2-s2.0-33750908045 (Pubitemid 44730373)
142. Simpson K. A., Singh M. A. F., Effects of exercise on adiponectin: a systematic review. Obesity 2008 16 2 241 256 10.1038/oby.2007.53 2-s2.0-39449135967 (Pubitemid 351271902)
143. Rokling-Andersen M. H., Reseland J. E., Veierød M. B., Anderssen S. A., Jacobs D. R. Jr., Urdal P., Jansson J., Drevon C. A., Effects of long-term exercise and diet intervention on plasma adipokine concentrations. The American Journal of Clinical Nutrition 2007 86 5 1293 1301 2-s2.0-36248988657 (Pubitemid 350126230)
144. Christiansen T., Paulsen S. K., Bruun J. M., Ploug T., Pedersen S. B., Richelsen B., Diet-induced weight loss and exercise alone and in combination enhance the expression of adiponectin receptors in adipose tissue and skeletal muscle, but only diet-induced weight loss enhanced circulating adiponectin. The Journal of Clinical Endocrinology & Metabolism 2010 95 2 911 919 10.1210/jc.2008-2505 2-s2.0-76149126091
145. Yamazaki Y., Kawano Y., Uebayasi M., Induction of adiponectin by natural and synthetic phenolamides in mouse and human preadipocytes and its enhancement by docosahexaenoic acid. Life Sciences 2008 82 5-6 290 300 10.1016/j.lfs.2007. 11.016 2-s2.0-38349075791
146. Tsuda T., Ueno Y., Aoki H., Koda T., Horio F., Takahashi N., Kawada T., Osawa T., Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. Biochemical and Biophysical Research Communications 2004 316 1 149 157 10.1016/j.bbrc.2004.02.031 2-s2.0-1542319262 (Pubitemid 38304941)
147. Nozawa H., Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-Ay mice. Biochemical and Biophysical Research Communications 2005 336 3 754 761 10.1016/j.bbrc.2005.08.159 2-s2.0-25144446897 (Pubitemid 41338333)
148. Moriuchi A., Yamasaki H., Shimamura M., Kita A., Kuwahara H., Fujishima K., Satoh T., Fukushima K., Fukushima T., Hayakawa T., Mizuguchi H., Nagayama Y., Abiru N., Kawasaki E., Eguchi K., Induction of human adiponectin gene transcription by telmisartan, angiotensin receptor blocker, independently on PPAR- γ activation. Biochemical and Biophysical Research Communications 2007 356 4 1024 1030 10.1016/j.bbrc.2007.03.084 2-s2.0-34047170834 (Pubitemid 46529394)
149. Hiuge A., Tenenbaum A., Maeda N., Benderly M., Kumada M., Fisman E. Z., Tanne D., Matas Z., Hibuse T., Fujita K., Nishizawa H., Adler Y., Motro M., Kihara S., Shimomura I., Behar S., Funahashi T., Effects of peroxisome proliferator-activated receptor ligands, bezafibrate and fenofibrate, on adiponectin level. Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27 3 635 641 10.1161/01.ATV.0000256469.06782.d5 2-s2.0-33847021451
150. Bruun J. M., Roeske-Nielsen A., Richelsen B., Fredman P., Buschard K., Sulfatide increases adiponectin and decreases TNF- α IL-6, and IL-8 in human adipose tissue in vitro. Molecular and Cellular Endocrinology 2007 263 1-2 142 148 10.1016/j.mce.2006.09.008 2-s2.0-34248376872 (Pubitemid 44828239)
151. Adamia N., Virsaladze D., Charkviani N., Skhirtladze M., Khutsishvili M., Effect of metformin therapy on plasma adiponectin and leptin levels in obese and insulin resistant postmenopausal females with type 2 diabetes. Georgian Medical News 2007 145 52 55 2-s2.0-34547729921
152. Sahebkar A., Head-to-head comparison of fibrates versus statins for elevation of circulating adiponectin concentrations: a systematic review and meta-analysis. Metabolism 2013 62 12 1876 1885
153. Tsuchida A., Yamauchi T., Takekawa S., Hada Y., Ito Y., Maki T., Kadowaki T., Peroxisome proliferator-activated receptor (PPAR) α activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPAR α PPAR γ and their combination. Diabetes 2005 54 12 3358 3370 10.2337/diabetes.54.12.3358 2-s2.0-33644664433 (Pubitemid 43334324)
154. Phillips S. A., Ciaraldi T. P., Oh D. K., Savu M. K., Henry R. R., Adiponectin secretion and response to pioglitazone is depot dependent in cultured human adipose tissue. The American Journal of Physiology: Endocrinology and Metabolism 2008 295 4 E842 E850 10.1152/ajpendo.90359.2008 2-s2.0-56049087969
155. Liu M., Liu F., Transcriptional and post-translational regulation of adiponectin. Biochemical Journal 2009 425 1 41 52 10.1042/BJ20091045 2-s2.0-72449141637
156. Liu Y., Turdi S., Park T., Morris N. J., Deshaies Y., Xu A., Sweeney G., Adiponectin corrects high-fat diet-induced disturbances in muscle metabolomic profile and whole-body glucose homeostasis. Diabetes 2013 62 3 743 752 10.2337/db12-0687 2-s2.0-84874406268
157. Kondo K., Shibata R., Unno K., Shimano M., Ishii M., Kito T., Shintani S., Walsh K., Ouchi N., Murohara T., Impact of a single intracoronary administration of adiponectin on myocardial ischemia/reperfusion injury in a pig model. Circulation: Cardiovascular Interventions 2010 3 2 166 173 10.1161/CIRCINTERVENTIONS.109.872044 2-s2.0-77953681258
158. Yamauchi T., Kamon J., Waki H., Imai Y., Shimozawa N., Hioki K., Uchida S., Ito Y., Takakuwa K., Matsui J., Takata M., Eto K., Terauchi Y., Komeda K., Tsunoda M., Murakami K., Ohnishi Y., Naitoh T., Yamamura K., Ueyama Y., Froguel P., Kimura S., Nagai R., Kadowaki T., Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. Journal of Biological Chemistry 2003 278 4 2461 2468 10.1074/jbc.M209033200 2-s2.0-0037462684 (Pubitemid 36801322)
159. Otvos L., Haspinger E., LaRussa F., Maspero F., Graziano P., Kovalszky I., Lovas S., Nama K., Hoffmann R., Knappe D., Cassone M., Wade J., Surmacz E., Design and development of a peptide-based adiponectin receptor agonist for cancer treatment. BMC Biotechnology 2011 11 article 90 10.1186/1472-6750-11-90 2-s2.0-80053478017
160. Sun Y., Zang Z., Zhong L., Wu M., Su Q., Gao X., Zan W., Lin D., Zhao Y., Zhang Z., Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS ONE 2013 8 5 e63354 10.1371/journal.pone.0063354 2-s2.0-84877771919
161. Okada-Iwabu M., Yamauchi T., Iwabu M., A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 2013 503 7477 493 499
162. Kasim-Karakas S. E., Tsodikov A., Singh U., Jialal I., Responses of inflammatory markers to a low-fat, high-carbohydrate diet: effects of energy intake. The American Journal of Clinical Nutrition 2006 83 4 774 779 2-s2.0-33646684051 (Pubitemid 44713139)
163. He K., Hu F. B., Colditz G. A., Manson J. E., Willett W. C., Liu S., Changes in intake of fruits and vegetables in relation to risk of obesity and weight gain among middle-aged women. International Journal of Obesity 2004 28 12 1569 1574 10.1038/sj.ijo.0802795 2-s2.0-9444263725 (Pubitemid 39564335)
164. Nelson T. L., Stevens J. R., Hickey M. S., Adiponectin levels are reduced, independent of polymorphisms in the adiponectin gene, after supplementation with α -linolenic acid among healthy adults. Metabolism: Clinical and Experimental 2007 56 9 1209 1215 10.1016/j.metabol.2007.04.017 2-s2.0-34547687656 (Pubitemid 47223260)
165. Micallef M. A., Garg M. L., Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals. Atherosclerosis 2009 204 2 476 482 10.1016/j.atherosclerosis.2008. 09.020 2-s2.0-67349086951
166. Grunberger G., Jen K. L., Artiss J. D., The benefits of early intervention in obese diabetic patients with FBCx: a new dietary fibre. Diabetes/Metabolism Research and Reviews 2007 23 1 56 62 10.1002/dmrr.687 2-s2.0-33846511731 (Pubitemid 46152487)
167. Hulver M. W., Zheng D., Tanner C. J., Houmard J. A., Kraus W. E., Slentz C. A., Sinha M. K., Pories W. J., MacDonald K. G., Lynis Dohm G., Adiponectin is not altered with exercise training despite enhanced insulin action. American Journal of Physiology: Endocrinology and Metabolism 2002 283 4 E861 E865 2-s2.0-0036785619
168. Blüher M., Bullen J. W. Jr., Lee J. H., Kralisch S., Fasshauer M., Klöting N., Niebauer J., Schön M. R., Williams C. J., Mantzoros C. S., Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training. The Journal of Clinical Endocrinology & Metabolism 2006 91 6 2310 2316 10.1210/jc.2005-2556 2-s2.0-33744949934 (Pubitemid 43855022)
169. Zhu M., Miura J., Lu L. X., Bernier M., DeCabo R., Lane M. A., Roth G. S., Ingram D. K., Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization. Experimental Gerontology 2004 39 7 1049 1059 10.1016/j.exger.2004.03.024 2-s2.0-3242720519 (Pubitemid 38952885)