Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 291, Issue 5, 2006, Pages

  Rummel, Christoph ^a   Sachot, Christelle ^a   Poole, Stephen ^b   Luheshi, Giamal N ^a  

^a MCGILL UNIVERSITY   (Canada)

^b NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

Circumventricular organs; Cytokines; Local inflammation; Nuclear factor B; Prostaglandins

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROSTAGLANDIN E2; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; ENDOTHELIUM CELL; FEVER; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFLAMMATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; BODY TEMPERATURE; BRAIN; CYCLOOXYGENASE 2; ENDOTHELIAL CELLS; FEVER; GENE EXPRESSION REGULATION; IMMUNE SERA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; NF-KAPPA B; PYROGENS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 33751192075     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00301.2006     Document Type: Article

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