Leptin plasma concentrations increase during antidepressant treatment with amitriptyline and mirtazapine, but not paroxetine and venlafaxine: Leptin resistance mediated by antihistaminergic activity?

Journal of Clinical Psychopharmacology

Volumn 33, Issue 1, 2013, Pages 99-103

  Schilling, Claudia ^a   Gilles, Maria ^a   Blum, Werner F ^b   Daseking, Emmerich ^a   Colla, Michael ^a,c   Weber Hamann, Bettina ^a,d   Lederbogen, Florian ^a   Krumm, Bertram ^a   Heuser, Isabella ^a,c   Wudy, Stefan A ^e   Kopf, Daniel ^a,f   Deuschle, Michael ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b LILLY DEUTSCHLAND GMBH   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d UNIVERSITY OF WÜRZBURG   (Germany)

^e JUSTUS LIEBIG UNIVERSITY   (Germany)

^f Marienkrankenhaus   (Germany)

Author keywords

amitriptyline; antihistaminergic; leptin; mirtazapine; paroxetine; venlafaxine

Indexed keywords

AMITRIPTYLINE; LEPTIN; MIRTAZAPINE; PAROXETINE; VENLAFAXINE;

ADULT; AGED; ARTICLE; BODY MASS; DEPRESSION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; TREATMENT DURATION; TREATMENT RESPONSE; WEIGHT GAIN;

ADULT; AGED; AGED, 80 AND OVER; AMITRIPTYLINE; ANALYSIS OF VARIANCE; ANTIDEPRESSIVE AGENTS; BIOLOGICAL MARKERS; BODY MASS INDEX; CYCLOHEXANOLS; DEPRESSION; FEMALE; HUMANS; LEPTIN; MALE; MIANSERIN; MIDDLE AGED; PAROXETINE; TIME FACTORS; TREATMENT OUTCOME; UP-REGULATION; WEIGHT GAIN; YOUNG ADULT;

EID: 84873081969     PISSN: 02710749     EISSN: 1533712X     Source Type: Journal    
DOI: 10.1097/JCP.0b013e31827cb179     Document Type: Article

References (29)

1. Elmquist JK, Bjorbaek C, Ahima RS, et al. Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol. 1998;395:535-547.
2. Myers MG, Cowley MA, Münzberg H. Mechanisms of leptin action and leptin resistance. Annu Rev Physiol. 2008;70:537-556.
3. Lu XY. The leptin hypothesis of depression: a potential link between mood disorders and obesity? Curr Opin Pharmacol. 2007;7:648-652.
4. Lu XY, Kim CS, Frazer A, et al. Leptin: a potential novel antidepressant. Proc Natl Acad Sci USA. 2006;103:1593-1598.
5. Newcomer JW, Selke G, Melson AK, et al. Dose-dependent cortisol-induced increases in leptin concentration in healthy humans. Arch Gen Psychiatry. 1998;55:995-1000.
6. Deuschle M, Schweiger U, Weber B, et al. Diurnal activity and pulsatility of the hypothalamus-pituitary-adrenal system in male depressed patients and healthy controls. J Clin Endocrinol Metab. 1997;82:234-238.
7. Antonjievic IA, Murck H, Frieboes RM, et al. Elevated nocturnal profiles of serum leptin in patients with depression. J Psychiatr Res. 1998;32:403-410.
8. Rubin RT, Rhodes ME, Czambel RK. Sexual diergism of baseline plasma leptin and leptin suppression by arginine vasopressin in major depressives and matched controls. Psychiatry Res. 2002;113:255-268.
9. Deuschle M, Blum WF, Englaro P, et al. Plasma leptin in depressed patients and healthy controls. Horm Metab Res. 1996;28:714-717.
10. Jow GM, Yang TT, Chen CL. Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia. J Affect Disord. 2006;90:21-27.
11. Kraus T, Haack M, Schuld A, et al. Low leptin levels but normal body mass indices in patients with depression or schizophrenia. Neuroendocrinology. 2001;73:243-247.
12. Schmid DA, Wichniak A, Uhr M, et al. Changes of sleep architecture, spectral composition of sleep EEG, the nocturnal secretion of cortisol, ACTH, GH, prolactin, melatonin, ghrelin and leptin and the DEX-CRH test in depressed patients during treatment with mirtazapine. Neuropsychopharmacology. 2006;31:832-844.
13. Laimer M, Kramer-Reinstadler K, Rauchenzauner M, et al. Effect of mirtazapine treatment on body composition and metabolism. J Clin Psychiatry. 2006;67:421-424.
14. Kraus T, Haack M, Schuld A, et al. Body weight, the tumor necrosis factor system and leptin production during treatment with mirtazapine and venlafaxine. Pharmacopsychiatry. 2002;35:220-225.
15. Himmerich H, Zimmermann P, Ising M, et al. Changes in the hypothalamic-pituitary-adrenal axis and leptin levels during antidepressant treatment. Neuropsychobiology. 2007;55:28-35.
16. Hinze-Selch D, Schuld A, Kraus T, et al. Effects of antidepressants on weight and on plasma levels of leptin, TNF-> and soluble TNF receptors: a longitudinal study in patients treated with amitriptyline and paroxetine. Neuropsychopharmacology. 2000;23:13-19.
17. Masaki T, Yoshimatsu H. Neuronal histamine and its receptors: implication of the pharmacological treatment of obesity. Curr Med Chem. 2010;17:4587-4592.
18. Morimoto T, Yamamoto Y, Mobarakeh JI, et al. Involvement of the histaminergic system in leptin-induced suppression of food intake. Physiol Behav. 1999;67:679-683.
19. Weber-Hamann B, Gilles M, Schilling C, et al. Improved insulin sensitivity in 51 nondiabetic depressed inpatients remitting during antidepressive treatment with mirtazapine and venlafaxine. J Clin Psychopharmacol. 2008;28(5):581-584.
20. Paslakis G, Kopf D, Westphal S, et al. Treatment with paroxetine, but not amitriptyline, lowers levels of lipoprotein(a) in patients with major depression. J Psychopharmacol. 2011;25:1344-1346.
21. Kauffman RP, Castracane VD, White DL, et al. Impact of the selective serotonin reuptake inhibitor citalopram on insulin sensitivity, leptin and basal cortisol secretion in depressed and non-depressed euglycemic women of reproductive age. Gynecol Endocrinol. 2005; 21:129-137.
22. Jørgensen EA, Knigge U, Warberg J, et al. Histamine and the regulation of body weight. Neuroendocrinology. 2007;86:210-214.
23. Toftegaard CL, Knigge U, Kj&r A, et al. The role of hypothalamic histamine in leptin-induced suppression of short-term food intake in fasted rats. Regul Pept. 2003;111:83-90.
24. Yoshimatsu H, Itateyama E, Kondou S, et al. Hypothalamic neuronal histamine as a target of leptin in feeding behaviour. Diabetes. 1999;48:2286-2291.
25. Münzberg H, Myers MG. Molecular and anatomical determinants of central leptin resistance. Nat Neurosci. 2005;5:566-570.
26. Kim SF, Huang AS, Snowman AM, et al. Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase. Proc Natl Acad USA. 2007;104:3456-3459.
27. Yamada N, Katsura G, Ochi Y, et al. Impaired CNS leptin action is implicated in depression associated with obesity. Endocrinology. 2011;152:2634-2643.
28. Lawson E, Miller KK, Blum JI, et al. Leptin levels are associated with decreased depressive symptoms in women across the weight spectrum, independent of body fat. Clin Endocrinol. 2012;76(4):520-525.
29. Labad J, Price J, Strachan M, et al. Leptin levels and depressive symptoms in people with type 2 diabetes: the Edinburgh type 2 diabetes study. Psychosom Med. 2012;74:39-45.