Immune-induced fever is mediated by IL-6 receptors on brain endothelial cells coupled to stat3-dependent induction of brain endothelial prostaglandin synthesis

Journal of Neuroscience

Volumn 34, Issue 48, 2014, Pages 15957-15961

  Eskilsson, Anna ^a   Mirrasekhian, Elahe ^a   Dufour, Sylvie ^b   Schwaninger, Markus ^c   Engblom, David ^a   Blomqvist, Anders ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b INSTITUT CURIE   (France)

^c UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Blood brain barrier; Cell specific gene deletions; Fever; Interleukin 6; Prostaglandins; STAT3

Indexed keywords

CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR ALPHA; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; INTERLEUKIN-6, MOUSE; LIPOPOLYSACCHARIDE; PROSTAGLANDIN; STAT3 PROTEIN, MOUSE;

ANAPHYLAXIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; GENE DELETION; GENOTYPE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROVOCATION TEST; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELLULAR IMMUNITY; CHEMICALLY INDUCED; DEFICIENCY; DRUG EFFECTS; FEVER; HUMAN; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; TOXICITY;

ANIMALS; BRAIN; ENDOTHELIAL CELLS; FEMALE; FEVER; HUMANS; IMMUNITY, CELLULAR; INTERLEUKIN-6; INTERLEUKIN-6 RECEPTOR ALPHA SUBUNIT; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROSTAGLANDINS; STAT3 TRANSCRIPTION FACTOR;

EID: 84911893311     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3520-14.2014     Document Type: Article

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