-
3
-
-
0348222671
-
Inflammation: The link between insulin resistance, obesity and diabetes
-
Dandona P, Aljada A, Bandyopadhyay A. Inflammation: The link between insulin resistance, obesity and diabetes. Trends Immunol. 2004;25:4-7.
-
(2004)
Trends Immunol.
, vol.25
, pp. 4-7
-
-
Dandona, P.1
Aljada, A.2
Bandyopadhyay, A.3
-
4
-
-
33644856005
-
Obesity and the role of adipose tissue in inflammation and metabolism
-
Greenberg AS, Obin MS. Obesity and the role of adipose tissue in inflammation and metabolism. Am J Clin Nutr. 2006;83:461S-465S.
-
(2006)
Am J Clin Nutr.
, vol.83
-
-
Greenberg, A.S.1
Obin, M.S.2
-
5
-
-
33748992313
-
Adipocytokines: Mediators linking adipose tissue, inflammation and immunity
-
Tilg H, Moschen AR. Adipocytokines: Mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. 2006;6: 772-783.
-
(2006)
Nat Rev Immunol.
, vol.6
, pp. 772-783
-
-
Tilg, H.1
Moschen, A.R.2
-
6
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112:1796-1808.
-
(2003)
J Clin Invest.
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante Jr., A.W.6
-
7
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003;112:1821-1830.
-
(2003)
J Clin Invest.
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
-
8
-
-
33846026712
-
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
-
Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007;117:175-184.
-
(2007)
J Clin Invest.
, vol.117
, pp. 175-184
-
-
Lumeng, C.N.1
Bodzin, J.L.2
Saltiel, A.R.3
-
9
-
-
58149347227
-
Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes
-
Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes. 2008;57:3239-3246.
-
(2008)
Diabetes.
, vol.57
, pp. 3239-3246
-
-
Lumeng, C.N.1
DelProposto, J.B.2
Westcott, D.J.3
Saltiel, A.R.4
-
10
-
-
27444437321
-
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
-
Cinti S, Mitchell G, Barbatelli G, et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res. 2005;46:2347-2355.
-
(2005)
J Lipid Res.
, vol.46
, pp. 2347-2355
-
-
Cinti, S.1
Mitchell, G.2
Barbatelli, G.3
-
11
-
-
33847073149
-
Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
-
Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes. 2007;56:16-23.
-
(2007)
Diabetes.
, vol.56
, pp. 16-23
-
-
Lumeng, C.N.1
Deyoung, S.M.2
Bodzin, J.L.3
Saltiel, A.R.4
-
12
-
-
73949125691
-
MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity
-
Westcott DJ, Delproposto JB, Geletka LM, et al. MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. J Exp Med. 2009;206:3143-3156.
-
(2009)
J Exp Med.
, vol.206
, pp. 3143-3156
-
-
Westcott, D.J.1
Delproposto, J.B.2
Geletka, L.M.3
-
13
-
-
84877841706
-
Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice
-
Aouadi M, Tencerova M, Vangala P, et al. Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice. Proc Natl Acad Sci U S A. 2013;110:8278-8283.
-
(2013)
Proc Natl Acad Sci U S A.
, vol.110
, pp. 8278-8283
-
-
Aouadi, M.1
Tencerova, M.2
Vangala, P.3
-
14
-
-
2442618838
-
The weight of leptin in immunity
-
La Cava A, Matarese G. The weight of leptin in immunity. Nat Rev Immunol. 2004;4:371-379.
-
(2004)
Nat Rev Immunol.
, vol.4
, pp. 371-379
-
-
La Cava, A.1
Matarese, G.2
-
15
-
-
2442654859
-
Identification and expression cloning of a leptin receptor OB-R
-
Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell. 1995;83:1263-1271.
-
(1995)
Cell.
, vol.83
, pp. 1263-1271
-
-
Tartaglia, L.A.1
Dembski, M.2
Weng, X.3
-
16
-
-
73649112416
-
Leptin: A critical regulator of CD4+ T-cell polarization in vitro and in vivo
-
Batra A, Okur B, Glauben R, et al. Leptin: A critical regulator of CD4+ T-cell polarization in vitro and in vivo. Endocrinology. 2010; 151:56-62.
-
(2010)
Endocrinology.
, vol.151
, pp. 56-62
-
-
Batra, A.1
Okur, B.2
Glauben, R.3
-
17
-
-
33744946045
-
Leptin receptor expression and signaling in lymphocytes: Kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice
-
Papathanassoglou E, El-Haschimi K, Li XC, Matarese G, Strom T, Mantzoros C. Leptin receptor expression and signaling in lymphocytes: Kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol. 2006;176: 7745-7752.
-
(2006)
J Immunol.
, vol.176
, pp. 7745-7752
-
-
Papathanassoglou, E.1
El-Haschimi, K.2
Li, X.C.3
Matarese, G.4
Strom, T.5
Mantzoros, C.6
-
18
-
-
0036854487
-
Leptin potentiates IFN-γ-induced expression of nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A.1
-
Raso GM, Pacilio M, Esposito E, Coppola A, Di Carlo R, Meli R. Leptin potentiates IFN-γ-induced expression of nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A.1. Br J Pharmacol. 2002;137:799-804.
-
(2002)
Br J Pharmacol.
, vol.137
, pp. 799-804
-
-
Raso, G.M.1
Pacilio, M.2
Esposito, E.3
Coppola, A.4
Di Carlo, R.5
Meli, R.6
-
19
-
-
18944364947
-
Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming
-
Mattioli B, Straface E, Quaranta MG, Giordani L, Viora M. Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming. J Immunol. 2005;174:6820-6828.
-
(2005)
J Immunol.
, vol.174
, pp. 6820-6828
-
-
Mattioli, B.1
Straface, E.2
Quaranta, M.G.3
Giordani, L.4
Viora, M.5
-
20
-
-
13344295079
-
Serum immunoreactive- leptin concentrations in normal-weight and obese humans
-
Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive- leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292-295.
-
(1996)
N Engl J Med.
, vol.334
, pp. 292-295
-
-
Considine, R.V.1
Sinha, M.K.2
Heiman, M.L.3
-
21
-
-
39449103260
-
Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo
-
Lim WS, Timmins JM, Seimon TA, et al. Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo. Circulation. 2008;117:940-951.
-
(2008)
Circulation.
, vol.117
, pp. 940-951
-
-
Lim, W.S.1
Timmins, J.M.2
Seimon, T.A.3
-
22
-
-
38949125499
-
Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice
-
Lee S, Muniyappa R, Yan X, et al. Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice. Am J Physiol Endocrinol Metab. 2008;294:E261-E270.
-
(2008)
Am J Physiol Endocrinol Metab.
, vol.294
-
-
Lee, S.1
Muniyappa, R.2
Yan, X.3
-
23
-
-
80052373417
-
Evaluation of macrophage plasticity in brown and white adipose tissue
-
Ortega MT, Xie L, Mora S, Chapes SK. Evaluation of macrophage plasticity in brown and white adipose tissue. Cell Immunol. 2011; 271:124-133.
-
(2011)
Cell Immunol.
, vol.271
, pp. 124-133
-
-
Ortega, M.T.1
Xie, L.2
Mora, S.3
Chapes, S.K.4
-
24
-
-
34547182426
-
Reduced adiposity in ob/ob mice following total body irradiation and bone marrow transplantation
-
Ablamunits V, Weisberg SP, Lemieux JE, Combs TP, Klebanov S. Reduced adiposity in ob/ob mice following total body irradiation and bone marrow transplantation. Obesity. 2007;15:1419-1429.
-
(2007)
Obesity.
, vol.15
, pp. 1419-1429
-
-
Ablamunits, V.1
Weisberg, S.P.2
Lemieux, J.E.3
Combs, T.P.4
Klebanov, S.5
-
25
-
-
58249111473
-
Adipose tissue sensitivity to radiation exposure
-
Poglio S, Galvani S, Bour S, et al. Adipose tissue sensitivity to radiation exposure. Am J Pathol. 2009;174:44-53.
-
(2009)
Am J Pathol.
, vol.174
, pp. 44-53
-
-
Poglio, S.1
Galvani, S.2
Bour, S.3
-
26
-
-
69449097633
-
The protein kinase IKKε regulates energy balance in obese mice
-
Chiang SH, Bazuine M, Lumeng CN, et al. The protein kinase IKKε regulates energy balance in obese mice. Cell. 2009;138:961-975.
-
(2009)
Cell.
, vol.138
, pp. 961-975
-
-
Chiang, S.H.1
Bazuine, M.2
Lumeng, C.N.3
-
27
-
-
44449110675
-
Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
-
Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME. Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity. 2008;16:1248-1255.
-
(2008)
Obesity.
, vol.16
, pp. 1248-1255
-
-
Davis, J.E.1
Gabler, N.K.2
Walker-Daniels, J.3
Spurlock, M.E.4
-
28
-
-
31044456529
-
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
-
Weisberg SP, Hunter D, Huber R, et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest. 2006; 116:115-124.
-
(2006)
J Clin Invest.
, vol.116
, pp. 115-124
-
-
Weisberg, S.P.1
Hunter, D.2
Huber, R.3
-
29
-
-
33745216724
-
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
-
Kanda H, Tateya S, Tamori Y, et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest. 2006;116:1494-1505.
-
(2006)
J Clin Invest.
, vol.116
, pp. 1494-1505
-
-
Kanda, H.1
Tateya, S.2
Tamori, Y.3
-
30
-
-
34147122535
-
Bone marrow-specificCap gene deletion protects against high-fat diet-induced insulin resistance
-
Lesniewski LA, Hosch SE, Neels JG, et al. Bone marrow-specificCap gene deletion protects against high-fat diet-induced insulin resistance. Nat Med. 2007;13:455-462.
-
(2007)
Nat Med.
, vol.13
, pp. 455-462
-
-
Lesniewski, L.A.1
Hosch, S.E.2
Neels, J.G.3
-
31
-
-
59149093623
-
Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: Cross talk with the osteoblastogenic program
-
Muruganandan S,RomanAA, Sinal CJ. Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: Cross talk with the osteoblastogenic program. Cell Mol Life Sci. 2009;66:236-253.
-
(2009)
Cell Mol Life Sci.
, vol.66
, pp. 236-253
-
-
Muruganandan, S.1
Roman, A.A.2
Sinal, C.J.3
-
33
-
-
78649972071
-
Generation of leptin receptor bone marrow chimeras: Recovery from irradiation, immune cellularity, cytokine expression, and metabolic parameters
-
Gove ME, Sherry CL, Pini M, Fantuzzi G. Generation of leptin receptor bone marrow chimeras: Recovery from irradiation, immune cellularity, cytokine expression, and metabolic parameters. Obesity. 2010;18:2274-2281.
-
(2010)
Obesity.
, vol.18
, pp. 2274-2281
-
-
Gove, M.E.1
Sherry, C.L.2
Pini, M.3
Fantuzzi, G.4
-
34
-
-
0030955949
-
Leptin induces mitogenactivated protein kinase-dependent proliferation of C3H10T1/2 cells
-
Takahashi Y, Okimura Y, Mizuno I, et al. Leptin induces mitogenactivated protein kinase-dependent proliferation of C3H10T1/2 cells. J Biol Chem. 1997;272:12897-12900.
-
(1997)
J Biol Chem.
, vol.272
, pp. 12897-12900
-
-
Takahashi, Y.1
Okimura, Y.2
Mizuno, I.3
-
35
-
-
82555186955
-
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
-
Nguyen KD, Qiu Y, Cui X, et al. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature. 2011;480:104-108.
-
(2011)
Nature.
, vol.480
, pp. 104-108
-
-
Nguyen, K.D.1
Qiu, Y.2
Cui, X.3
-
36
-
-
50949108719
-
Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice
-
Murano I, Barbatelli G, Parisani V, et al. Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice. J Lipid Res. 2008;49:1562-1568.
-
(2008)
J Lipid Res.
, vol.49
, pp. 1562-1568
-
-
Murano, I.1
Barbatelli, G.2
Parisani, V.3
-
37
-
-
36049051889
-
Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis
-
Gruen ML, Hao M, Piston DW, Hasty AH. Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis. Am J Physiol Cell Physiol. 2007;293: C1481-C1488.
-
(2007)
Am J Physiol Cell Physiol
, vol.293
-
-
Gruen, M.L.1
Hao, M.2
Piston, D.W.3
Hasty, A.H.4
-
38
-
-
2342537773
-
From blood monocytes to adipose tissue-resident macrophages: Induction of diapedesis by human mature adipocytes
-
Curat CA, Miranville A, Sengenès C, et al. From blood monocytes to adipose tissue-resident macrophages: Induction of diapedesis by human mature adipocytes. Diabetes. 2004;53:1285-1292.
-
(2004)
Diabetes.
, vol.53
, pp. 1285-1292
-
-
Curat, C.A.1
Miranville, A.2
Sengenès, C.3
-
39
-
-
0032572722
-
Leptin modulates the T-cell immune response and reverses starvation- induced immunosuppression
-
Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation- induced immunosuppression. Nature. 1998;394:897-901.
-
(1998)
Nature.
, vol.394
, pp. 897-901
-
-
Lord, G.M.1
Matarese, G.2
Howard, J.K.3
Baker, R.J.4
Bloom, S.R.5
Lechler, R.I.6
-
40
-
-
77956202073
-
Leptin exacerbates sepsis-mediated morbidity and mortality
-
Shapiro NI, Khankin EV, Van Meurs M, et al. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol. 2010;185: 517-524.
-
(2010)
J Immunol.
, vol.185
, pp. 517-524
-
-
Shapiro, N.I.1
Khankin, E.V.2
Van Meurs, M.3
-
42
-
-
0030061922
-
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF- and obesity-induced insulin resistance
-
Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF- and obesity-induced insulin resistance. Science. 1996;271:665-668.
-
(1996)
Science.
, vol.271
, pp. 665-668
-
-
Hotamisligil, G.S.1
Peraldi, P.2
Budavari, A.3
Ellis, R.4
White, M.F.5
Spiegelman, B.M.6
-
43
-
-
84872142459
-
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation
-
Han MS, Jung DY, Morel C, et al. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science. 2013;339:218-222.
-
(2013)
Science.
, vol.339
, pp. 218-222
-
-
Han, M.S.1
Jung, D.Y.2
Morel, C.3
-
44
-
-
0038809142
-
Monocyte chemoattractant protein 1 in obesity and insulin resistance
-
Sartipy P, Loskutoff DJ. Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci U S A. 2003;100: 7265-7270.
-
(2003)
Proc Natl Acad Sci U S A.
, vol.100
, pp. 7265-7270
-
-
Sartipy, P.1
Loskutoff, D.J.2
-
45
-
-
77956396699
-
Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: Implications for systemic inflammation and insulin resistance
-
Yang H, Youm YH, Vandanmagsar B, et al. Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: Implications for systemic inflammation and insulin resistance. JImmunol. 2010;185: 1836-1845.
-
(2010)
JImmunol.
, vol.185
, pp. 1836-1845
-
-
Yang, H.1
Youm, Y.H.2
Vandanmagsar, B.3
|