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Volumn 418, Issue , 2015, Pages 55-65

Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?

Author keywords

Ectopic lipids; Inflammation; Insulin resistance; Metabolic syndrome; NAFLD

Indexed keywords

4 PHENYLBUTYRIC ACID; ANOREXIGENIC AGENT; ATORVASTATIN; C REACTIVE PROTEIN; ETANERCEPT; INTERLEUKIN 6; METFORMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; SALSALATE; TAUROURSODEOXYCHOLIC ACID; TETRAHYDROLIPSTATIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 84930675030     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2015.02.018     Document Type: Review
Times cited : (267)

References (154)
  • 1
    • 0034708832 scopus 로고    scopus 로고
    • The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
    • Aguirre V., Uchida T., Yenush L., Davis R., White M.F. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J. Biol. Chem 2000, 275:9047-9054.
    • (2000) J. Biol. Chem , vol.275 , pp. 9047-9054
    • Aguirre, V.1    Uchida, T.2    Yenush, L.3    Davis, R.4    White, M.F.5
  • 2
    • 33645978121 scopus 로고    scopus 로고
    • Metabolic syndrome-a new world-wide definition. A consensus statement from the International Diabetes Federation
    • Alberti K.G., Zimmet P., Shaw J. Metabolic syndrome-a new world-wide definition. A consensus statement from the International Diabetes Federation. Diabet. Med 2006, 23:469-480.
    • (2006) Diabet. Med , vol.23 , pp. 469-480
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 3
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N. Engl. J. Med 2002, 346:1221-1231.
    • (2002) N. Engl. J. Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 5
    • 84884176199 scopus 로고    scopus 로고
    • Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance
    • Asrih M., Jornayvaz F.R. Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance. J. Endocrinol 2013, 218:R25-R36.
    • (2013) J. Endocrinol , vol.218 , pp. R25-R36
    • Asrih, M.1    Jornayvaz, F.R.2
  • 6
    • 84895508097 scopus 로고    scopus 로고
    • Diets and nonalcoholic fatty liver disease: the good and the bad
    • Asrih M., Jornayvaz F.R. Diets and nonalcoholic fatty liver disease: the good and the bad. Clin. Nutr 2014, 33:186-190.
    • (2014) Clin. Nutr , vol.33 , pp. 186-190
    • Asrih, M.1    Jornayvaz, F.R.2
  • 8
    • 0030747895 scopus 로고    scopus 로고
    • Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients
    • Auboeuf D., Rieusset J., Fajas L., Vallier P., Frering V., Riou J.P., et al. Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes 1997, 46:1319-1327.
    • (1997) Diabetes , vol.46 , pp. 1319-1327
    • Auboeuf, D.1    Rieusset, J.2    Fajas, L.3    Vallier, P.4    Frering, V.5    Riou, J.P.6
  • 9
    • 84864954849 scopus 로고    scopus 로고
    • Obesity in Arabic-speaking countries
    • Badran M., Laher I. Obesity in Arabic-speaking countries. J. Obes 2011, 2011:686430.
    • (2011) J. Obes , vol.2011 , pp. 686430
    • Badran, M.1    Laher, I.2
  • 10
    • 79960969204 scopus 로고    scopus 로고
    • Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice
    • Birkenfeld A.L., Lee H.Y., Guebre-Egziabher F., Alves T.C., Jurczak M.J., Jornayvaz F.R., et al. Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metab 2011, 14:184-195.
    • (2011) Cell Metab , vol.14 , pp. 184-195
    • Birkenfeld, A.L.1    Lee, H.Y.2    Guebre-Egziabher, F.3    Alves, T.C.4    Jurczak, M.J.5    Jornayvaz, F.R.6
  • 11
    • 80054712654 scopus 로고    scopus 로고
    • Influence of the hepatic Eukaryotic Initiation Factor 2 alpha (eIF2 alpha) Endoplasmic Reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism
    • Birkenfeld A.L., Lee H.Y., Majumdar S., Jurczak M.J., Camporez J.P., Jornayvaz F.R., et al. Influence of the hepatic Eukaryotic Initiation Factor 2 alpha (eIF2 alpha) Endoplasmic Reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism. J. Biol. Chem 2011, 286:36163-36170.
    • (2011) J. Biol. Chem , vol.286 , pp. 36163-36170
    • Birkenfeld, A.L.1    Lee, H.Y.2    Majumdar, S.3    Jurczak, M.J.4    Camporez, J.P.5    Jornayvaz, F.R.6
  • 12
    • 0032214652 scopus 로고    scopus 로고
    • A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    • Bruning J.C., Michael M.D., Winnay J.N., Hayashi T., Horsch D., Accili D., et al. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol. Cell 1998, 2:559-569.
    • (1998) Mol. Cell , vol.2 , pp. 559-569
    • Bruning, J.C.1    Michael, M.D.2    Winnay, J.N.3    Hayashi, T.4    Horsch, D.5    Accili, D.6
  • 13
    • 30944455145 scopus 로고    scopus 로고
    • Insulin resistance: a metabolic pathway to chronic liver disease
    • Bugianesi E., McCullough A.J., Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 2005, 42:987-1000.
    • (2005) Hepatology , vol.42 , pp. 987-1000
    • Bugianesi, E.1    McCullough, A.J.2    Marchesini, G.3
  • 14
    • 84880798525 scopus 로고    scopus 로고
    • The effect of etanercept on hepatic fibrosis risk in patients with non-alcoholic fatty liver disease, metabolic syndrome, and psoriasis
    • Campanati A., Ganzetti G., Di Sario A., Damiani A., Sandroni L., Rosa L., et al. The effect of etanercept on hepatic fibrosis risk in patients with non-alcoholic fatty liver disease, metabolic syndrome, and psoriasis. J. Gastroenterol 2013, 48:839-846.
    • (2013) J. Gastroenterol , vol.48 , pp. 839-846
    • Campanati, A.1    Ganzetti, G.2    Di Sario, A.3    Damiani, A.4    Sandroni, L.5    Rosa, L.6
  • 15
    • 84874607649 scopus 로고    scopus 로고
    • Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance
    • Camporez J.P., Jornayvaz F.R., Lee H.Y., Kanda S., Guigni B.A., Kahn M., et al. Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance. Endocrinology 2013, 154:1021-1028.
    • (2013) Endocrinology , vol.154 , pp. 1021-1028
    • Camporez, J.P.1    Jornayvaz, F.R.2    Lee, H.Y.3    Kanda, S.4    Guigni, B.A.5    Kahn, M.6
  • 17
    • 84873178604 scopus 로고    scopus 로고
    • CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance
    • Cantley J.L., Yoshimura T., Camporez J.P., Zhang D., Jornayvaz F.R., Kumashiro N., et al. CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:1869-1874.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 1869-1874
    • Cantley, J.L.1    Yoshimura, T.2    Camporez, J.P.3    Zhang, D.4    Jornayvaz, F.R.5    Kumashiro, N.6
  • 18
    • 33747032339 scopus 로고    scopus 로고
    • Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice
    • Cao H., Maeda K., Gorgun C.Z., Kim H.J., Park S.Y., Shulman G.I., et al. Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice. Diabetes 2006, 55:1915-1922.
    • (2006) Diabetes , vol.55 , pp. 1915-1922
    • Cao, H.1    Maeda, K.2    Gorgun, C.Z.3    Kim, H.J.4    Park, S.Y.5    Shulman, G.I.6
  • 19
    • 84885405205 scopus 로고    scopus 로고
    • Dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects
    • Cariou B., Hanf R., Lambert-Porcheron S., Zair Y., Sauvinet V., Noel B., et al. Dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. Diabetes Care 2013, 36:2923-2930.
    • (2013) Diabetes Care , vol.36 , pp. 2923-2930
    • Cariou, B.1    Hanf, R.2    Lambert-Porcheron, S.3    Zair, Y.4    Sauvinet, V.5    Noel, B.6
  • 21
    • 68149091653 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance
    • Chavez A.O., Molina-Carrion M., Abdul-Ghani M.A., Folli F., Defronzo R.A., Tripathy D. Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance. Diabetes Care 2009, 32:1542-1546.
    • (2009) Diabetes Care , vol.32 , pp. 1542-1546
    • Chavez, A.O.1    Molina-Carrion, M.2    Abdul-Ghani, M.A.3    Folli, F.4    Defronzo, R.A.5    Tripathy, D.6
  • 22
    • 43249092409 scopus 로고    scopus 로고
    • Hepatic triglyceride synthesis and nonalcoholic fatty liver disease
    • Choi S.S., Diehl A.M. Hepatic triglyceride synthesis and nonalcoholic fatty liver disease. Curr. Opin. Lipidol 2008, 19:295-300.
    • (2008) Curr. Opin. Lipidol , vol.19 , pp. 295-300
    • Choi, S.S.1    Diehl, A.M.2
  • 23
    • 84865864614 scopus 로고    scopus 로고
    • Recent advances in the pathophysiology and pharmacological treatment of obesity
    • Chugh P.K., Sharma S. Recent advances in the pathophysiology and pharmacological treatment of obesity. J. Clin. Pharm. Ther 2012, 37:525-535.
    • (2012) J. Clin. Pharm. Ther , vol.37 , pp. 525-535
    • Chugh, P.K.1    Sharma, S.2
  • 24
    • 4344581329 scopus 로고    scopus 로고
    • The histologic spectrum of nonalcoholic fatty liver disease
    • vii
    • Contos M.J., Choudhury J., Mills A.S., Sanyal A.J. The histologic spectrum of nonalcoholic fatty liver disease. Clin. Liver Dis 2004, 8:481-500. vii.
    • (2004) Clin. Liver Dis , vol.8 , pp. 481-500
    • Contos, M.J.1    Choudhury, J.2    Mills, A.S.3    Sanyal, A.J.4
  • 26
    • 0019838759 scopus 로고
    • Short chain fatty acids in the human colon
    • Cummings J.H. Short chain fatty acids in the human colon. Gut 1981, 22:763-779.
    • (1981) Gut , vol.22 , pp. 763-779
    • Cummings, J.H.1
  • 27
    • 78650280416 scopus 로고    scopus 로고
    • JNK regulation of hepatic manifestations of the metabolic syndrome
    • Czaja M.J. JNK regulation of hepatic manifestations of the metabolic syndrome. Trends Endocrinol. Metab 2010, 21:707-713.
    • (2010) Trends Endocrinol. Metab , vol.21 , pp. 707-713
    • Czaja, M.J.1
  • 28
    • 37549022688 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • de Luca C., Olefsky J.M. Inflammation and insulin resistance. FEBS Lett 2008, 582:97-105.
    • (2008) FEBS Lett , vol.582 , pp. 97-105
    • de Luca, C.1    Olefsky, J.M.2
  • 29
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: a tale of two "hits"?
    • Day C.P., James O.F. Steatohepatitis: a tale of two "hits"?. Gastroenterology 1998, 114:842-845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 30
    • 27344441019 scopus 로고    scopus 로고
    • Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes
    • Dominguez H., Storgaard H., Rask-Madsen C., Steffen Hermann T., Ihlemann N., Baunbjerg Nielsen D., et al. Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes. J. Vasc. Res 2005, 42:517-525.
    • (2005) J. Vasc. Res , vol.42 , pp. 517-525
    • Dominguez, H.1    Storgaard, H.2    Rask-Madsen, C.3    Steffen Hermann, T.4    Ihlemann, N.5    Baunbjerg Nielsen, D.6
  • 31
    • 79151478555 scopus 로고    scopus 로고
    • Type 2 diabetes as an inflammatory disease
    • Donath M.Y., Shoelson S.E. Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol 2011, 11:98-107.
    • (2011) Nat. Rev. Immunol , vol.11 , pp. 98-107
    • Donath, M.Y.1    Shoelson, S.E.2
  • 32
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly K.L., Smith C.I., Schwarzenberg S.J., Jessurun J., Boldt M.D., Parks E.J. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest 2005, 115:1343-1351.
    • (2005) J. Clin. Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 34
    • 33745401989 scopus 로고    scopus 로고
    • Visceral fat accumulation and insulin resistance are important factors in nonalcoholic fatty liver disease
    • Eguchi Y., Eguchi T., Mizuta T., Ide Y., Yasutake T., Iwakiri R., et al. Visceral fat accumulation and insulin resistance are important factors in nonalcoholic fatty liver disease. J. Gastroenterol 2006, 41:462-469.
    • (2006) J. Gastroenterol , vol.41 , pp. 462-469
    • Eguchi, Y.1    Eguchi, T.2    Mizuta, T.3    Ide, Y.4    Yasutake, T.5    Iwakiri, R.6
  • 36
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • Farazi P.A., DePinho R.A. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer 2006, 6:674-687.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 37
    • 73349117487 scopus 로고    scopus 로고
    • Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome
    • Fessler M.B., Rudel L.L., Brown J.M. Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome. Curr. Opin. Lipidol 2009, 20:379-385.
    • (2009) Curr. Opin. Lipidol , vol.20 , pp. 379-385
    • Fessler, M.B.1    Rudel, L.L.2    Brown, J.M.3
  • 39
    • 84870359606 scopus 로고    scopus 로고
    • Treating diabetes and obesity with an FGF21-mimetic antibody activating the betaKlotho/FGFR1c receptor complex
    • 162ra153
    • Foltz I.N., Hu S., King C., Wu X., Yang C., Wang W., et al. Treating diabetes and obesity with an FGF21-mimetic antibody activating the betaKlotho/FGFR1c receptor complex. Sci. Transl. Med 2012, 4:162ra153.
    • (2012) Sci. Transl. Med , vol.4
    • Foltz, I.N.1    Hu, S.2    King, C.3    Wu, X.4    Yang, C.5    Wang, W.6
  • 40
    • 78650971903 scopus 로고    scopus 로고
    • Atorvastatin and antioxidants for the treatment of nonalcoholic fatty liver disease: the St Francis Heart Study randomized clinical trial
    • Foster T., Budoff M.J., Saab S., Ahmadi N., Gordon C., Guerci A.D. Atorvastatin and antioxidants for the treatment of nonalcoholic fatty liver disease: the St Francis Heart Study randomized clinical trial. Am. J. Gastroenterol 2011, 106:71-77.
    • (2011) Am. J. Gastroenterol , vol.106 , pp. 71-77
    • Foster, T.1    Budoff, M.J.2    Saab, S.3    Ahmadi, N.4    Gordon, C.5    Guerci, A.D.6
  • 41
    • 79959267977 scopus 로고    scopus 로고
    • Toll-like receptors, inflammation, metabolism and obesity
    • Fresno M., Alvarez R., Cuesta N. Toll-like receptors, inflammation, metabolism and obesity. Arch. Physiol. Biochem 2011, 117:151-164.
    • (2011) Arch. Physiol. Biochem , vol.117 , pp. 151-164
    • Fresno, M.1    Alvarez, R.2    Cuesta, N.3
  • 42
    • 84878349086 scopus 로고    scopus 로고
    • Selective peroxisome proliferator-activated receptor alpha modulators (SPPARMalpha): the next generation of peroxisome proliferator-activated receptor alpha-agonists
    • Fruchart J.C. Selective peroxisome proliferator-activated receptor alpha modulators (SPPARMalpha): the next generation of peroxisome proliferator-activated receptor alpha-agonists. Cardiovasc. Diabetol 2013, 12:82.
    • (2013) Cardiovasc. Diabetol , vol.12 , pp. 82
    • Fruchart, J.C.1
  • 43
    • 84889887123 scopus 로고    scopus 로고
    • Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
    • Fullerton M.D., Galic S., Marcinko K., Sikkema S., Pulinilkunnil T., Chen Z.P., et al. Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nat. Med 2013, 19:1649-1654.
    • (2013) Nat. Med , vol.19 , pp. 1649-1654
    • Fullerton, M.D.1    Galic, S.2    Marcinko, K.3    Sikkema, S.4    Pulinilkunnil, T.5    Chen, Z.P.6
  • 44
    • 84875053195 scopus 로고    scopus 로고
    • Portal, but not lobular, macrophages express matrix metalloproteinase-9: association with the ductular reaction and fibrosis in chronic hepatitis C
    • Gadd V.L., Melino M., Roy S., Horsfall L., O'Rourke P., Williams M.R., et al. Portal, but not lobular, macrophages express matrix metalloproteinase-9: association with the ductular reaction and fibrosis in chronic hepatitis C. Liver Int 2013, 33:569-579.
    • (2013) Liver Int , vol.33 , pp. 569-579
    • Gadd, V.L.1    Melino, M.2    Roy, S.3    Horsfall, L.4    O'Rourke, P.5    Williams, M.R.6
  • 45
    • 84883481988 scopus 로고    scopus 로고
    • The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
    • Gaich G., Chien J.Y., Fu H., Glass L.C., Deeg M.A., Holland W.L., et al. The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. Cell Metab 2013, 18:333-340.
    • (2013) Cell Metab , vol.18 , pp. 333-340
    • Gaich, G.1    Chien, J.Y.2    Fu, H.3    Glass, L.C.4    Deeg, M.A.5    Holland, W.L.6
  • 46
    • 67649238355 scopus 로고    scopus 로고
    • Butyrate improves insulin sensitivity and increases energy expenditure in mice
    • Gao Z., Yin J., Zhang J., Ward R.E., Martin R.J., Lefevre M., et al. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 2009, 58:1509-1517.
    • (2009) Diabetes , vol.58 , pp. 1509-1517
    • Gao, Z.1    Yin, J.2    Zhang, J.3    Ward, R.E.4    Martin, R.J.5    Lefevre, M.6
  • 47
    • 84874289874 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and insulin resistance: from bench to bedside
    • Gariani K., Philippe J., Jornayvaz F.R. Non-alcoholic fatty liver disease and insulin resistance: from bench to bedside. Diabetes Metab 2013, 39:16-26.
    • (2013) Diabetes Metab , vol.39 , pp. 16-26
    • Gariani, K.1    Philippe, J.2    Jornayvaz, F.R.3
  • 48
    • 64149121817 scopus 로고    scopus 로고
    • Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes
    • Goldfine A.B., Silver R., Aldhahi W., Cai D., Tatro E., Lee J., et al. Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin. Transl. Sci 2008, 1:36-43.
    • (2008) Clin. Transl. Sci , vol.1 , pp. 36-43
    • Goldfine, A.B.1    Silver, R.2    Aldhahi, W.3    Cai, D.4    Tatro, E.5    Lee, J.6
  • 49
    • 84878549605 scopus 로고    scopus 로고
    • The role of adipocyte XBP1 in metabolic regulation during lactation
    • Gregor M.F., Misch E.S., Yang L., Hummasti S., Inouye K.E., Lee A.H., et al. The role of adipocyte XBP1 in metabolic regulation during lactation. Cell Rep 2013, 3:1430-1439.
    • (2013) Cell Rep , vol.3 , pp. 1430-1439
    • Gregor, M.F.1    Misch, E.S.2    Yang, L.3    Hummasti, S.4    Inouye, K.E.5    Lee, A.H.6
  • 50
    • 0141835015 scopus 로고    scopus 로고
    • Insulin resistance, inflammation, and the prediabetic state
    • Haffner S.M. Insulin resistance, inflammation, and the prediabetic state. Am. J. Cardiol 2003, 92:18J-26J.
    • (2003) Am. J. Cardiol , vol.92 , pp. 18J-26J
    • Haffner, S.M.1
  • 53
    • 0029366188 scopus 로고
    • Prevalence and secular trends in obesity in Pacific and Indian Ocean island populations
    • Hodge A.M., Dowse G.K., Zimmet P.Z., Collins V.R. Prevalence and secular trends in obesity in Pacific and Indian Ocean island populations. Obes. Res 1995, 3(Suppl. 2):77s-87s.
    • (1995) Obes. Res , vol.3 , pp. 77s-87s
    • Hodge, A.M.1    Dowse, G.K.2    Zimmet, P.Z.3    Collins, V.R.4
  • 54
    • 84905026699 scopus 로고    scopus 로고
    • Prevalence of overweight and obesity among children and adolescents of the Indian subcontinent: a meta-analysis
    • Hoque M.E., Doi S.A.R., Mannan M., Long K., Niessen L.W., Mamun A.A. Prevalence of overweight and obesity among children and adolescents of the Indian subcontinent: a meta-analysis. Nutr. Rev 2014, 72:541-550.
    • (2014) Nutr. Rev , vol.72 , pp. 541-550
    • Hoque, M.E.1    Doi, S.A.R.2    Mannan, M.3    Long, K.4    Niessen, L.W.5    Mamun, A.A.6
  • 55
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil G.S., Shargill N.S., Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 57
    • 84880426480 scopus 로고    scopus 로고
    • Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody
    • Huang J., Ishino T., Chen G., Rolzin P., Osothprarop T.F., Retting K., et al. Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody. J. Pharmacol. Exp. Ther 2013, 346:270-280.
    • (2013) J. Pharmacol. Exp. Ther , vol.346 , pp. 270-280
    • Huang, J.1    Ishino, T.2    Chen, G.3    Rolzin, P.4    Osothprarop, T.F.5    Retting, K.6
  • 58
    • 55649083505 scopus 로고    scopus 로고
    • Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia
    • Hyogo H., Tazuma S., Arihiro K., Iwamoto K., Nabeshima Y., Inoue M., et al. Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia. Metabolism 2008, 57:1711-1718.
    • (2008) Metabolism , vol.57 , pp. 1711-1718
    • Hyogo, H.1    Tazuma, S.2    Arihiro, K.3    Iwamoto, K.4    Nabeshima, Y.5    Inoue, M.6
  • 59
    • 56049098214 scopus 로고    scopus 로고
    • Impact of visceral fat on the metabolic syndrome and nonalcoholic fatty liver disease
    • Jeong S.K., Kim Y.K., Park J.W., Shin Y.J., Kim D.S. Impact of visceral fat on the metabolic syndrome and nonalcoholic fatty liver disease. J. Korean Med. Sci 2008, 23:789-795.
    • (2008) J. Korean Med. Sci , vol.23 , pp. 789-795
    • Jeong, S.K.1    Kim, Y.K.2    Park, J.W.3    Shin, Y.J.4    Kim, D.S.5
  • 60
    • 84908200877 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 is regulated by the IRE1alpha-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis
    • Jiang S., Yan C., Fang Q.C., Shao M.L., Zhang Y.L., Liu Y., et al. Fibroblast growth factor 21 is regulated by the IRE1alpha-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis. J. Biol. Chem 2014, 289:29751-29765.
    • (2014) J. Biol. Chem , vol.289 , pp. 29751-29765
    • Jiang, S.1    Yan, C.2    Fang, Q.C.3    Shao, M.L.4    Zhang, Y.L.5    Liu, Y.6
  • 61
    • 84860497397 scopus 로고    scopus 로고
    • Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance
    • Jornayvaz F.R., Shulman G.I. Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance. Cell Metab 2012, 15:574-584.
    • (2012) Cell Metab , vol.15 , pp. 574-584
    • Jornayvaz, F.R.1    Shulman, G.I.2
  • 62
    • 78349242167 scopus 로고    scopus 로고
    • A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain
    • Jornayvaz F.R., Jurczak M.J., Lee H.Y., Birkenfeld A.L., Frederick D.W., Zhang D.Y., et al. A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain. Am. J. Physiol. Endocrinol. Metab 2010, 299:E808-E815.
    • (2010) Am. J. Physiol. Endocrinol. Metab , vol.299 , pp. E808-E815
    • Jornayvaz, F.R.1    Jurczak, M.J.2    Lee, H.Y.3    Birkenfeld, A.L.4    Frederick, D.W.5    Zhang, D.Y.6
  • 63
    • 77955642542 scopus 로고    scopus 로고
    • The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome
    • Jornayvaz F.R., Samuel V.T., Shulman G.I. The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome. Annu. Rev. Nutr 2010, 30:273-290.
    • (2010) Annu. Rev. Nutr , vol.30 , pp. 273-290
    • Jornayvaz, F.R.1    Samuel, V.T.2    Shulman, G.I.3
  • 65
    • 84862907611 scopus 로고    scopus 로고
    • Thyroid hormone receptor-alpha gene knockout mice are protected from diet-induced hepatic insulin resistance
    • Jornayvaz F.R., Lee H.Y., Jurczak M.J., Alves T.C., Guebre-Egziabher F., Guigni B.A., et al. Thyroid hormone receptor-alpha gene knockout mice are protected from diet-induced hepatic insulin resistance. Endocrinology 2012, 153:583-591.
    • (2012) Endocrinology , vol.153 , pp. 583-591
    • Jornayvaz, F.R.1    Lee, H.Y.2    Jurczak, M.J.3    Alves, T.C.4    Guebre-Egziabher, F.5    Guigni, B.A.6
  • 66
    • 84879161441 scopus 로고    scopus 로고
    • Salsalate and adiponectin improve palmitate-induced insulin resistance via inhibition of selenoprotein P through the AMPK-FOXO1alpha pathway
    • Jung T.W., Choi H.Y., Lee S.Y., Hong H.C., Yang S.J., Yoo H.J., et al. Salsalate and adiponectin improve palmitate-induced insulin resistance via inhibition of selenoprotein P through the AMPK-FOXO1alpha pathway. PLoS ONE 2013, 8:e66529.
    • (2013) PLoS ONE , vol.8 , pp. e66529
    • Jung, T.W.1    Choi, H.Y.2    Lee, S.Y.3    Hong, H.C.4    Yang, S.J.5    Yoo, H.J.6
  • 67
    • 84862908245 scopus 로고    scopus 로고
    • Dissociation of inositol-requiring enzyme (IRE1alpha)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice
    • Jurczak M.J., Lee A.H., Jornayvaz F.R., Lee H.Y., Birkenfeld A.L., Guigni B.A., et al. Dissociation of inositol-requiring enzyme (IRE1alpha)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice. J. Biol. Chem 2012, 287:2558-2567.
    • (2012) J. Biol. Chem , vol.287 , pp. 2558-2567
    • Jurczak, M.J.1    Lee, A.H.2    Jornayvaz, F.R.3    Lee, H.Y.4    Birkenfeld, A.L.5    Guigni, B.A.6
  • 68
    • 11144280457 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease-a common and benign finding in octogenarian patients
    • Kagansky N., Levy S., Keter D., Rimon E., Taiba Z., Fridman Z., et al. Non-alcoholic fatty liver disease-a common and benign finding in octogenarian patients. Liver Int 2004, 24:588-594.
    • (2004) Liver Int , vol.24 , pp. 588-594
    • Kagansky, N.1    Levy, S.2    Keter, D.3    Rimon, E.4    Taiba, Z.5    Fridman, Z.6
  • 70
    • 70350550096 scopus 로고    scopus 로고
    • Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene
    • Kantartzis K., Peter A., Machicao F., Machann J., Wagner S., Konigsrainer I., et al. Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes 2009, 58:2616-2623.
    • (2009) Diabetes , vol.58 , pp. 2616-2623
    • Kantartzis, K.1    Peter, A.2    Machicao, F.3    Machann, J.4    Wagner, S.5    Konigsrainer, I.6
  • 71
    • 84878709716 scopus 로고    scopus 로고
    • Gut metagenome in European women with normal, impaired and diabetic glucose control
    • Karlsson F.H., Tremaroli V., Nookaew I., Bergstrom G., Behre C.J., Fagerberg B., et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 2013, 498:99-103.
    • (2013) Nature , vol.498 , pp. 99-103
    • Karlsson, F.H.1    Tremaroli, V.2    Nookaew, I.3    Bergstrom, G.4    Behre, C.J.5    Fagerberg, B.6
  • 72
    • 6944227798 scopus 로고    scopus 로고
    • Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults
    • Kim H.J., Kim H.J., Lee K.E., Kim D.J., Kim S.K., Ahn C.W., et al. Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults. Arch. Intern. Med 2004, 164:2169-2175.
    • (2004) Arch. Intern. Med , vol.164 , pp. 2169-2175
    • Kim, H.J.1    Kim, H.J.2    Lee, K.E.3    Kim, D.J.4    Kim, S.K.5    Ahn, C.W.6
  • 74
    • 0033917321 scopus 로고    scopus 로고
    • Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle
    • Kim J.K., Michael M.D., Previs S.F., Peroni O.D., Mauvais-Jarvis F., Neschen S., et al. Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. J. Clin. Invest 2000, 105:1791-1797.
    • (2000) J. Clin. Invest , vol.105 , pp. 1791-1797
    • Kim, J.K.1    Michael, M.D.2    Previs, S.F.3    Peroni, O.D.4    Mauvais-Jarvis, F.5    Neschen, S.6
  • 75
    • 0035912744 scopus 로고    scopus 로고
    • Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
    • Kim J.K., Fillmore J.J., Chen Y., Yu C., Moore I.K., Pypaert M., et al. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:7522-7527.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 7522-7527
    • Kim, J.K.1    Fillmore, J.J.2    Chen, Y.3    Yu, C.4    Moore, I.K.5    Pypaert, M.6
  • 76
    • 78650472774 scopus 로고    scopus 로고
    • Toll-like receptors: linking inflammation to metabolism
    • Konner A.C., Bruning J.C. Toll-like receptors: linking inflammation to metabolism. Trends Endocrinol. Metab 2011, 22:16-23.
    • (2011) Trends Endocrinol. Metab , vol.22 , pp. 16-23
    • Konner, A.C.1    Bruning, J.C.2
  • 78
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman P.G. Obesity as a medical problem. Nature 2000, 404:635-643.
    • (2000) Nature , vol.404 , pp. 635-643
    • Kopelman, P.G.1
  • 79
    • 15244358817 scopus 로고    scopus 로고
    • GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization
    • Kotani K., Peroni O.D., Minokoshi Y., Boss O., Kahn B.B. GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization. J. Clin. Invest 2004, 114:1666-1675.
    • (2004) J. Clin. Invest , vol.114 , pp. 1666-1675
    • Kotani, K.1    Peroni, O.D.2    Minokoshi, Y.3    Boss, O.4    Kahn, B.B.5
  • 81
    • 84876718085 scopus 로고    scopus 로고
    • Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats
    • Kumashiro N., Yoshimura T., Cantley J.L., Majumdar S.K., Guebre-Egziabher F., Kursawe R., et al. Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats. Hepatology 2013, 57:1763-1772.
    • (2013) Hepatology , vol.57 , pp. 1763-1772
    • Kumashiro, N.1    Yoshimura, T.2    Cantley, J.L.3    Majumdar, S.K.4    Guebre-Egziabher, F.5    Kursawe, R.6
  • 82
    • 84870855668 scopus 로고    scopus 로고
    • Association of nonalcoholic fatty liver disease with components of metabolic syndrome according to body mass index in Korean adults
    • Kwon Y.M., Oh S.W., Hwang S.S., Lee C., Kwon H., Chung G.E. Association of nonalcoholic fatty liver disease with components of metabolic syndrome according to body mass index in Korean adults. Am. J. Gastroenterol 2012, 107:1852-1858.
    • (2012) Am. J. Gastroenterol , vol.107 , pp. 1852-1858
    • Kwon, Y.M.1    Oh, S.W.2    Hwang, S.S.3    Lee, C.4    Kwon, H.5    Chung, G.E.6
  • 84
    • 80055057797 scopus 로고    scopus 로고
    • Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance
    • Lee H.Y., Birkenfeld A.L., Jornayvaz F.R., Jurczak M.J., Kanda S., Popov V., et al. Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance. Hepatology 2011, 54:1650-1660.
    • (2011) Hepatology , vol.54 , pp. 1650-1660
    • Lee, H.Y.1    Birkenfeld, A.L.2    Jornayvaz, F.R.3    Jurczak, M.J.4    Kanda, S.5    Popov, V.6
  • 85
    • 78650647326 scopus 로고    scopus 로고
    • Has the microbiota played a critical role in the evolution of the adaptive immune system?
    • Lee Y.K., Mazmanian S.K. Has the microbiota played a critical role in the evolution of the adaptive immune system?. Science 2010, 330:1768-1773.
    • (2010) Science , vol.330 , pp. 1768-1773
    • Lee, Y.K.1    Mazmanian, S.K.2
  • 87
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: human gut microbes associated with obesity
    • Ley R.E., Turnbaugh P.J., Klein S., Gordon J.I. Microbial ecology: human gut microbes associated with obesity. Nature 2006, 444:1022-1023.
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 88
    • 77957359658 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride
    • Li H., Fang Q., Gao F., Fan J., Zhou J., Wang X., et al. Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. J. Hepatol 2010, 53:934-940.
    • (2010) J. Hepatol , vol.53 , pp. 934-940
    • Li, H.1    Fang, Q.2    Gao, F.3    Fan, J.4    Zhou, J.5    Wang, X.6
  • 89
    • 57649229536 scopus 로고    scopus 로고
    • Clinical trial: pilot study of metformin for the treatment of non-alcoholic steatohepatitis
    • Loomba R., Lutchman G., Kleiner D.E., Ricks M., Feld J.J., Borg B.B., et al. Clinical trial: pilot study of metformin for the treatment of non-alcoholic steatohepatitis. Aliment. Pharmacol. Ther 2009, 29:172-182.
    • (2009) Aliment. Pharmacol. Ther , vol.29 , pp. 172-182
    • Loomba, R.1    Lutchman, G.2    Kleiner, D.E.3    Ricks, M.4    Feld, J.J.5    Borg, B.B.6
  • 90
    • 58149347227 scopus 로고    scopus 로고
    • Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes
    • Lumeng C.N., DelProposto J.B., Westcott D.J., Saltiel A.R. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 2008, 57:3239-3246.
    • (2008) Diabetes , vol.57 , pp. 3239-3246
    • Lumeng, C.N.1    DelProposto, J.B.2    Westcott, D.J.3    Saltiel, A.R.4
  • 92
    • 84879830881 scopus 로고    scopus 로고
    • Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet
    • Mattace Raso G., Simeoli R., Russo R., Iacono A., Santoro A., Paciello O., et al. Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet. PLoS ONE 2013, 8:e68626.
    • (2013) PLoS ONE , vol.8 , pp. e68626
    • Mattace Raso, G.1    Simeoli, R.2    Russo, R.3    Iacono, A.4    Santoro, A.5    Paciello, O.6
  • 93
    • 80455176656 scopus 로고    scopus 로고
    • Tipping the balance: the pathophysiology of obesity and type 2 diabetes mellitus
    • vii
    • McKenney R.L., Short D.K. Tipping the balance: the pathophysiology of obesity and type 2 diabetes mellitus. Surg. Clin. North Am 2011, 91:1139-1148. vii.
    • (2011) Surg. Clin. North Am , vol.91 , pp. 1139-1148
    • McKenney, R.L.1    Short, D.K.2
  • 94
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • Michael M.D., Kulkarni R.N., Postic C., Previs S.F., Shulman G.I., Magnuson M.A., et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell 2000, 6:87-97.
    • (2000) Mol. Cell , vol.6 , pp. 87-97
    • Michael, M.D.1    Kulkarni, R.N.2    Postic, C.3    Previs, S.F.4    Shulman, G.I.5    Magnuson, M.A.6
  • 96
    • 79952230506 scopus 로고    scopus 로고
    • Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease
    • Miura K., Seki E., Ohnishi H., Brenner D.A. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. Gastroenterol. Res. Pract 2010, 2010:362847.
    • (2010) Gastroenterol. Res. Pract , vol.2010 , pp. 362847
    • Miura, K.1    Seki, E.2    Ohnishi, H.3    Brenner, D.A.4
  • 97
    • 0029863074 scopus 로고    scopus 로고
    • Nutritional status of infants and young children in the Arabian Gulf countries
    • Musaiger A.O. Nutritional status of infants and young children in the Arabian Gulf countries. J. Trop. Pediatr 1996, 42:121-124.
    • (1996) J. Trop. Pediatr , vol.42 , pp. 121-124
    • Musaiger, A.O.1
  • 98
    • 44449129581 scopus 로고    scopus 로고
    • Should nonalcoholic fatty liver disease be included in the definition of metabolic syndrome? A cross-sectional comparison with Adult Treatment Panel III criteria in nonobese nondiabetic subjects
    • Musso G., Gambino R., Bo S., Uberti B., Biroli G., Pagano G., et al. Should nonalcoholic fatty liver disease be included in the definition of metabolic syndrome? A cross-sectional comparison with Adult Treatment Panel III criteria in nonobese nondiabetic subjects. Diabetes Care 2008, 31:562-568.
    • (2008) Diabetes Care , vol.31 , pp. 562-568
    • Musso, G.1    Gambino, R.2    Bo, S.3    Uberti, B.4    Biroli, G.5    Pagano, G.6
  • 99
    • 80555136061 scopus 로고    scopus 로고
    • Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity
    • Musso G., Gambino R., Cassader M., Pagano G. Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity. Ann. Med 2011, 43:617-649.
    • (2011) Ann. Med , vol.43 , pp. 617-649
    • Musso, G.1    Gambino, R.2    Cassader, M.3    Pagano, G.4
  • 101
    • 79960452600 scopus 로고    scopus 로고
    • Metabolic syndrome: nature, therapeutic solutions and options
    • Onat A. Metabolic syndrome: nature, therapeutic solutions and options. Expert Opin. Pharmacother 2011, 12:1887-1900.
    • (2011) Expert Opin. Pharmacother , vol.12 , pp. 1887-1900
    • Onat, A.1
  • 102
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Ozcan U., Cao Q., Yilmaz E., Lee A.H., Iwakoshi N.N., Ozdelen E., et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004, 306:457-461.
    • (2004) Science , vol.306 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3    Lee, A.H.4    Iwakoshi, N.N.5    Ozdelen, E.6
  • 103
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    • Ozcan U., Yilmaz E., Ozcan L., Furuhashi M., Vaillancourt E., Smith R.O., et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006, 313:1137-1140.
    • (2006) Science , vol.313 , pp. 1137-1140
    • Ozcan, U.1    Yilmaz, E.2    Ozcan, L.3    Furuhashi, M.4    Vaillancourt, E.5    Smith, R.O.6
  • 104
    • 0035836770 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
    • Ozes O.N., Akca H., Mayo L.D., Gustin J.A., Maehama T., Dixon J.E., et al. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:4640-4645.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 4640-4645
    • Ozes, O.N.1    Akca, H.2    Mayo, L.D.3    Gustin, J.A.4    Maehama, T.5    Dixon, J.E.6
  • 106
    • 67349268828 scopus 로고    scopus 로고
    • Increased expression and activity of hepatic lipase in the liver of morbidly obese adult patients in relation to lipid content
    • Pardina E., Baena-Fustegueras J.A., Catalan R., Galard R., Lecube A., Fort J.M., et al. Increased expression and activity of hepatic lipase in the liver of morbidly obese adult patients in relation to lipid content. Obes. Surg 2009, 19:894-904.
    • (2009) Obes. Surg , vol.19 , pp. 894-904
    • Pardina, E.1    Baena-Fustegueras, J.A.2    Catalan, R.3    Galard, R.4    Lecube, A.5    Fort, J.M.6
  • 107
    • 2342480355 scopus 로고    scopus 로고
    • Effect of weight reduction on metabolic syndrome in Korean obese patients
    • Park H.S., Sim S.J., Park J.Y. Effect of weight reduction on metabolic syndrome in Korean obese patients. J. Korean Med. Sci 2004, 19:202-208.
    • (2004) J. Korean Med. Sci , vol.19 , pp. 202-208
    • Park, H.S.1    Sim, S.J.2    Park, J.Y.3
  • 108
    • 84922248122 scopus 로고    scopus 로고
    • The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice
    • Pawlak M., Bauge E., Bourguet W., De Bosscher K., Lalloyer F., Tailleux A., et al. The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice. Hepatology 2014, 60:1593-1606.
    • (2014) Hepatology , vol.60 , pp. 1593-1606
    • Pawlak, M.1    Bauge, E.2    Bourguet, W.3    De Bosscher, K.4    Lalloyer, F.5    Tailleux, A.6
  • 109
    • 84901944641 scopus 로고    scopus 로고
    • The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
    • Perry R.J., Samuel V.T., Petersen K.F., Shulman G.I. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 2014, 510:84-91.
    • (2014) Nature , vol.510 , pp. 84-91
    • Perry, R.J.1    Samuel, V.T.2    Petersen, K.F.3    Shulman, G.I.4
  • 110
    • 0036114844 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
    • Petersen K.F., Oral E.A., Dufour S., Befroy D., Ariyan C., Yu C., et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J. Clin. Invest 2002, 109:1345-1350.
    • (2002) J. Clin. Invest , vol.109 , pp. 1345-1350
    • Petersen, K.F.1    Oral, E.A.2    Dufour, S.3    Befroy, D.4    Ariyan, C.5    Yu, C.6
  • 111
    • 0038025371 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in the elderly: possible role in insulin resistance
    • Petersen K.F., Befroy D., Dufour S., Dziura J., Ariyan C., Rothman D.L., et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 2003, 300:1140-1142.
    • (2003) Science , vol.300 , pp. 1140-1142
    • Petersen, K.F.1    Befroy, D.2    Dufour, S.3    Dziura, J.4    Ariyan, C.5    Rothman, D.L.6
  • 112
    • 33845315534 scopus 로고    scopus 로고
    • Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men
    • Petersen K.F., Dufour S., Feng J., Befroy D., Dziura J., Dalla Man C., et al. Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:18273-18277.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 18273-18277
    • Petersen, K.F.1    Dufour, S.2    Feng, J.3    Befroy, D.4    Dziura, J.5    Dalla Man, C.6
  • 115
    • 78049516225 scopus 로고    scopus 로고
    • Visceral adiposity index is associated with histological findings and high viral load in patients with chronic hepatitis C due to genotype 1
    • Petta S., Amato M., Cabibi D., Camma C., Di Marco V., Giordano C., et al. Visceral adiposity index is associated with histological findings and high viral load in patients with chronic hepatitis C due to genotype 1. Hepatology 2010, 52:1543-1552.
    • (2010) Hepatology , vol.52 , pp. 1543-1552
    • Petta, S.1    Amato, M.2    Cabibi, D.3    Camma, C.4    Di Marco, V.5    Giordano, C.6
  • 116
    • 0027973036 scopus 로고
    • The nutrition transition in low-income countries: an emerging crisis
    • Popkin B.M. The nutrition transition in low-income countries: an emerging crisis. Nutr. Rev 1994, 52:285-298.
    • (1994) Nutr. Rev , vol.52 , pp. 285-298
    • Popkin, B.M.1
  • 118
    • 84867074831 scopus 로고    scopus 로고
    • A metagenome-wide association study of gut microbiota in type 2 diabetes
    • Qin J., Li Y., Cai Z., Li S., Zhu J., Zhang F., et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 2012, 490:55-60.
    • (2012) Nature , vol.490 , pp. 55-60
    • Qin, J.1    Li, Y.2    Cai, Z.3    Li, S.4    Zhu, J.5    Zhang, F.6
  • 119
    • 0037118703 scopus 로고    scopus 로고
    • Metabolic syndrome: pathophysiology and implications for management of cardiovascular disease
    • Reaven G. Metabolic syndrome: pathophysiology and implications for management of cardiovascular disease. Circulation 2002, 106:286-288.
    • (2002) Circulation , vol.106 , pp. 286-288
    • Reaven, G.1
  • 120
    • 62549122501 scopus 로고    scopus 로고
    • Update on the metabolic syndrome: hypertension
    • Reynolds K., Wildman R.P. Update on the metabolic syndrome: hypertension. Curr. Hypertens. Rep 2009, 11:150-155.
    • (2009) Curr. Hypertens. Rep , vol.11 , pp. 150-155
    • Reynolds, K.1    Wildman, R.P.2
  • 121
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S., Kozlitina J., Xing C., Pertsemlidis A., Cox D., Pennacchio L.A., et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet 2008, 40:1461-1465.
    • (2008) Nat. Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3    Pertsemlidis, A.4    Cox, D.5    Pennacchio, L.A.6
  • 122
    • 4444341881 scopus 로고    scopus 로고
    • Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation
    • Sabapathy K., Hochedlinger K., Nam S.Y., Bauer A., Karin M., Wagner E.F. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol. Cell 2004, 15:713-725.
    • (2004) Mol. Cell , vol.15 , pp. 713-725
    • Sabapathy, K.1    Hochedlinger, K.2    Nam, S.Y.3    Bauer, A.4    Karin, M.5    Wagner, E.F.6
  • 123
    • 3543029821 scopus 로고    scopus 로고
    • Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    • Samuel V.T., Liu Z.X., Qu X., Elder B.D., Bilz S., Befroy D., et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J. Biol. Chem 2004, 279:32345-32353.
    • (2004) J. Biol. Chem , vol.279 , pp. 32345-32353
    • Samuel, V.T.1    Liu, Z.X.2    Qu, X.3    Elder, B.D.4    Bilz, S.5    Befroy, D.6
  • 124
    • 33847404482 scopus 로고    scopus 로고
    • Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease
    • Samuel V.T., Liu Z.X., Wang A., Beddow S.A., Geisler J.G., Kahn M., et al. Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease. J. Clin. Invest 2007, 117:739-745.
    • (2007) J. Clin. Invest , vol.117 , pp. 739-745
    • Samuel, V.T.1    Liu, Z.X.2    Wang, A.3    Beddow, S.A.4    Geisler, J.G.5    Kahn, M.6
  • 126
    • 15944364442 scopus 로고    scopus 로고
    • Energy expenditure and adaptive responses to an acute hypercaloric fat load in humans with lipodystrophy
    • Savage D.B., Murgatroyd P.R., Chatterjee V.K., O'Rahilly S. Energy expenditure and adaptive responses to an acute hypercaloric fat load in humans with lipodystrophy. J. Clin. Endocrinol. Metab 2005, 90:1446-1452.
    • (2005) J. Clin. Endocrinol. Metab , vol.90 , pp. 1446-1452
    • Savage, D.B.1    Murgatroyd, P.R.2    Chatterjee, V.K.3    O'Rahilly, S.4
  • 130
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • Shimomura I., Hammer R.E., Ikemoto S., Brown M.S., Goldstein J.L. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 1999, 401:73-76.
    • (1999) Nature , vol.401 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3    Brown, M.S.4    Goldstein, J.L.5
  • 131
    • 33644919989 scopus 로고    scopus 로고
    • Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates
    • Shiri-Sverdlov R., Wouters K., van Gorp P.J., Gijbels M.J., Noel B., Buffat L., et al. Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates. J. Hepatol 2006, 44:732-741.
    • (2006) J. Hepatol , vol.44 , pp. 732-741
    • Shiri-Sverdlov, R.1    Wouters, K.2    van Gorp, P.J.3    Gijbels, M.J.4    Noel, B.5    Buffat, L.6
  • 132
    • 79952855868 scopus 로고    scopus 로고
    • Is prediction of cardiovascular disease and all-cause mortality genuinely driven by the metabolic syndrome, and independently from its component variables? The Dubbo study
    • Simons L.A., Simons J., Friedlander Y., McCallum J. Is prediction of cardiovascular disease and all-cause mortality genuinely driven by the metabolic syndrome, and independently from its component variables? The Dubbo study. Heart Lung Circ 2011, 20:214-219.
    • (2011) Heart Lung Circ , vol.20 , pp. 214-219
    • Simons, L.A.1    Simons, J.2    Friedlander, Y.3    McCallum, J.4
  • 133
    • 58949093454 scopus 로고    scopus 로고
    • Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance
    • Singh R., Wang Y., Xiang Y., Tanaka K.E., Gaarde W.A., Czaja M.J. Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology 2009, 49:87-96.
    • (2009) Hepatology , vol.49 , pp. 87-96
    • Singh, R.1    Wang, Y.2    Xiang, Y.3    Tanaka, K.E.4    Gaarde, W.A.5    Czaja, M.J.6
  • 134
    • 84859611672 scopus 로고    scopus 로고
    • Ultrasonographically detected non-alcoholic fatty liver disease is an independent predictor for identifying patients with insulin resistance in non-obese, non-diabetic middle-aged Asian adults
    • Sinn D.H., Gwak G.Y., Park H.N., Kim J.E., Min Y.W., Kim K.M., et al. Ultrasonographically detected non-alcoholic fatty liver disease is an independent predictor for identifying patients with insulin resistance in non-obese, non-diabetic middle-aged Asian adults. Am. J. Gastroenterol 2012, 107:561-567.
    • (2012) Am. J. Gastroenterol , vol.107 , pp. 561-567
    • Sinn, D.H.1    Gwak, G.Y.2    Park, H.N.3    Kim, J.E.4    Min, Y.W.5    Kim, K.M.6
  • 136
    • 84867038186 scopus 로고    scopus 로고
    • Silencing of lipid metabolism genes through IRE1alpha-mediated mRNA decay lowers plasma lipids in mice
    • So J.S., Hur K.Y., Tarrio M., Ruda V., Frank-Kamenetsky M., Fitzgerald K., et al. Silencing of lipid metabolism genes through IRE1alpha-mediated mRNA decay lowers plasma lipids in mice. Cell Metab 2012, 16:487-499.
    • (2012) Cell Metab , vol.16 , pp. 487-499
    • So, J.S.1    Hur, K.Y.2    Tarrio, M.3    Ruda, V.4    Frank-Kamenetsky, M.5    Fitzgerald, K.6
  • 137
    • 77955806634 scopus 로고    scopus 로고
    • JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction
    • Solinas G., Karin M. JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. FASEB J. 2010, 24:2596-2611.
    • (2010) FASEB J. , vol.24 , pp. 2596-2611
    • Solinas, G.1    Karin, M.2
  • 138
    • 0345700727 scopus 로고    scopus 로고
    • Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    • Spranger J., Kroke A., Mohlig M., Hoffmann K., Bergmann M.M., Ristow M., et al. Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 2003, 52:812-817.
    • (2003) Diabetes , vol.52 , pp. 812-817
    • Spranger, J.1    Kroke, A.2    Mohlig, M.3    Hoffmann, K.4    Bergmann, M.M.5    Ristow, M.6
  • 139
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: insights into insulin action
    • Taniguchi C.M., Emanuelli B., Kahn C.R. Critical nodes in signalling pathways: insights into insulin action. Nat. Rev. Mol. Cell Biol 2006, 7:85-96.
    • (2006) Nat. Rev. Mol. Cell Biol , vol.7 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 140
    • 84858174466 scopus 로고    scopus 로고
    • Are hepatic steatosis and carotid intima media thickness associated in obese patients with normal or slightly elevated gamma-glutamyl-transferase?
    • Tarantino G., Finelli C., Colao A., Capone D., Tarantino M., Grimaldi E., et al. Are hepatic steatosis and carotid intima media thickness associated in obese patients with normal or slightly elevated gamma-glutamyl-transferase?. J. Transl. Med 2012, 10:50.
    • (2012) J. Transl. Med , vol.10 , pp. 50
    • Tarantino, G.1    Finelli, C.2    Colao, A.3    Capone, D.4    Tarantino, M.5    Grimaldi, E.6
  • 142
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis
    • Tilg H., Moschen A.R. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 2010, 52:1836-1846.
    • (2010) Hepatology , vol.52 , pp. 1836-1846
    • Tilg, H.1    Moschen, A.R.2
  • 143
    • 42649144463 scopus 로고    scopus 로고
    • Beneficial effects of subcutaneous fat transplantation on metabolism
    • Tran T.T., Yamamoto Y., Gesta S., Kahn C.R. Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab 2008, 7:410-420.
    • (2008) Cell Metab , vol.7 , pp. 410-420
    • Tran, T.T.1    Yamamoto, Y.2    Gesta, S.3    Kahn, C.R.4
  • 146
    • 84865442538 scopus 로고    scopus 로고
    • Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys
    • Veniant M.M., Komorowski R., Chen P., Stanislaus S., Winters K., Hager T., et al. Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys. Endocrinology 2012, 153:4192-4203.
    • (2012) Endocrinology , vol.153 , pp. 4192-4203
    • Veniant, M.M.1    Komorowski, R.2    Chen, P.3    Stanislaus, S.4    Winters, K.5    Hager, T.6
  • 147
    • 84866738529 scopus 로고    scopus 로고
    • Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
    • e917
    • Vrieze A., Van Nood E., Holleman F., Salojarvi J., Kootte R.S., Bartelsman J.F., et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 2012, 143:913-916. e917.
    • (2012) Gastroenterology , vol.143 , pp. 913-916
    • Vrieze, A.1    Van Nood, E.2    Holleman, F.3    Salojarvi, J.4    Kootte, R.S.5    Bartelsman, J.F.6
  • 148
    • 84905061754 scopus 로고    scopus 로고
    • The future burden of obesity-related diseases in the 53 WHO European-Region countries and the impact of effective interventions: a modelling study
    • Webber L., Divajeva D., Marsh T., McPherson K., Brown M., Galea G., et al. The future burden of obesity-related diseases in the 53 WHO European-Region countries and the impact of effective interventions: a modelling study. BMJ Open 2014, 4:e004787.
    • (2014) BMJ Open , vol.4 , pp. e004787
    • Webber, L.1    Divajeva, D.2    Marsh, T.3    McPherson, K.4    Brown, M.5    Galea, G.6
  • 150
    • 83655165300 scopus 로고    scopus 로고
    • Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1
    • Wu A.L., Kolumam G., Stawicki S., Chen Y., Li J., Zavala-Solorio J., et al. Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Sci. Transl. Med 2011, 3:113ra126.
    • (2011) Sci. Transl. Med , vol.3 , pp. 113ra126
    • Wu, A.L.1    Kolumam, G.2    Stawicki, S.3    Chen, Y.4    Li, J.5    Zavala-Solorio, J.6
  • 152
    • 26444442450 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress: cell life and death decisions
    • Xu C., Bailly-Maitre B., Reed J.C. Endoplasmic reticulum stress: cell life and death decisions. J. Clin. Invest 2005, 115:2656-2664.
    • (2005) J. Clin. Invest , vol.115 , pp. 2656-2664
    • Xu, C.1    Bailly-Maitre, B.2    Reed, J.C.3
  • 153
    • 61649127208 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
    • Xu J., Lloyd D.J., Hale C., Stanislaus S., Chen M., Sivits G., et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 2009, 58:250-259.
    • (2009) Diabetes , vol.58 , pp. 250-259
    • Xu, J.1    Lloyd, D.J.2    Hale, C.3    Stanislaus, S.4    Chen, M.5    Sivits, G.6
  • 154
    • 48349146527 scopus 로고    scopus 로고
    • Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
    • Zhang X., Yeung D.C., Karpisek M., Stejskal D., Zhou Z.G., Liu F., et al. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes 2008, 57:1246-1253.
    • (2008) Diabetes , vol.57 , pp. 1246-1253
    • Zhang, X.1    Yeung, D.C.2    Karpisek, M.3    Stejskal, D.4    Zhou, Z.G.5    Liu, F.6


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