메뉴 건너뛰기




Volumn 57, Issue 5, 2013, Pages 1763-1772

Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats

Author keywords

[No Author keywords available]

Indexed keywords

1 ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE; ACYL COENZYME A; ACYL COENZYME A: 1 ACYLGLYCEROL SN 3 PHOSPHATE ACYLTRANSFERASE; ANTISENSE OLIGONUCLEOTIDE; DIACYLGLYCEROL; FATTY ACID; GLUCOSE; INSULIN; LIPID; LONG CHAIN FATTY ACYL COENZYME A; LYSOPHOSPHATIDIC ACID; MESSENGER RNA; PALMITIC ACID C 13; PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3; PHOSPHATIDIC ACID; PHOSPHOLIPASE; PROTEIN KINASE C EPSILON; RADIOISOTOPE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84876718085     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26170     Document Type: Article
Times cited : (74)

References (46)
  • 1
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: common threads and missing links
    • Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell 2012; 148: 852-871.
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 2
    • 77951286204 scopus 로고    scopus 로고
    • Recent advances in nonalcoholic fatty liver disease
    • Cheung O, Sanyal AJ. Recent advances in nonalcoholic fatty liver disease. Curr Opin Gastroenterol 2010; 26: 202-208.
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 202-208
    • Cheung, O.1    Sanyal, A.J.2
  • 3
    • 70350550096 scopus 로고    scopus 로고
    • Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene
    • Kantartzis K, Peter A, Machicao F, Machann J, Wagner S, Konigsrainer I, et al. Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes 2009; 58: 2616-2623.
    • (2009) Diabetes , vol.58 , pp. 2616-2623
    • Kantartzis, K.1    Peter, A.2    Machicao, F.3    Machann, J.4    Wagner, S.5    Konigsrainer, I.6
  • 4
    • 80052534977 scopus 로고    scopus 로고
    • Understanding the relationship between PNPLA3, NAFLD and insulin resistance: do ethnic differences bring more questions or more answers?
    • Chang CY. Understanding the relationship between PNPLA3, NAFLD and insulin resistance: do ethnic differences bring more questions or more answers? Liver Int 2011; 31: 1246-1249.
    • (2011) Liver Int , vol.31 , pp. 1246-1249
    • Chang, C.Y.1
  • 5
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008; 40: 1461-1465.
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3    Pertsemlidis, A.4    Cox, D.5    Pennacchio, L.A.6
  • 6
    • 77956636268 scopus 로고    scopus 로고
    • The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease
    • Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. HEPATOLOGY 2010; 52: 894-903.
    • (2010) HEPATOLOGY , vol.52 , pp. 894-903
    • Rotman, Y.1    Koh, C.2    Zmuda, J.M.3    Kleiner, D.E.4    Liang, T.J.5
  • 7
    • 69249111667 scopus 로고    scopus 로고
    • A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity
    • Sookoian S, Castano GO, Burgueno AL, Gianotti TF, Rosselli MS, Pirola CJ. A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity. J Lipid Res 2009; 50: 2111-2116.
    • (2009) J Lipid Res , vol.50 , pp. 2111-2116
    • Sookoian, S.1    Castano, G.O.2    Burgueno, A.L.3    Gianotti, T.F.4    Rosselli, M.S.5    Pirola, C.J.6
  • 8
    • 80052552852 scopus 로고    scopus 로고
    • The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population
    • Wang CW, Lin HY, Shin SJ, Yu ML, Lin ZY, Dai CY, et al. The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population. Liver Int 2011; 31: 1326-1331.
    • (2011) Liver Int , vol.31 , pp. 1326-1331
    • Wang, C.W.1    Lin, H.Y.2    Shin, S.J.3    Yu, M.L.4    Lin, Z.Y.5    Dai, C.Y.6
  • 10
    • 84860465005 scopus 로고    scopus 로고
    • Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase
    • Kumari M, Schoiswohl G, Chitraju C, Paar M, Cornaciu I, Rangrez AY, et al. Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell Metab 2012; 15: 691-702.
    • (2012) Cell Metab , vol.15 , pp. 691-702
    • Kumari, M.1    Schoiswohl, G.2    Chitraju, C.3    Paar, M.4    Cornaciu, I.5    Rangrez, A.Y.6
  • 11
    • 77949895032 scopus 로고    scopus 로고
    • A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis
    • He S, McPhaul C, Li JZ, Garuti R, Kinch L, Grishin NV, et al. A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J Biol Chem 2010; 285: 6706-6715.
    • (2010) J Biol Chem , vol.285 , pp. 6706-6715
    • He, S.1    McPhaul, C.2    Li, J.Z.3    Garuti, R.4    Kinch, L.5    Grishin, N.V.6
  • 12
    • 80054806707 scopus 로고    scopus 로고
    • Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease
    • Huang Y, Cohen JC, Hobbs HH. Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease. J Biol Chem 2011; 286: 37085-37093.
    • (2011) J Biol Chem , vol.286 , pp. 37085-37093
    • Huang, Y.1    Cohen, J.C.2    Hobbs, H.H.3
  • 14
    • 10344262633 scopus 로고    scopus 로고
    • Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
    • Jenkins CM, Mancuso DJ, Yan W, Sims HF, Gibson B, Gross RW. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 2004; 279: 48968-48975.
    • (2004) J Biol Chem , vol.279 , pp. 48968-48975
    • Jenkins, C.M.1    Mancuso, D.J.2    Yan, W.3    Sims, H.F.4    Gibson, B.5    Gross, R.W.6
  • 15
    • 79960729651 scopus 로고    scopus 로고
    • Mouse patatin-like phospholipase domain-containing 3 influences systemic lipid and glucose homeostasis
    • Qiao A, Liang J, Ke Y, Li C, Cui Y, Shen L, et al. Mouse patatin-like phospholipase domain-containing 3 influences systemic lipid and glucose homeostasis. HEPATOLOGY 2011; 54: 509-521.
    • (2011) HEPATOLOGY , vol.54 , pp. 509-521
    • Qiao, A.1    Liang, J.2    Ke, Y.3    Li, C.4    Cui, Y.5    Shen, L.6
  • 16
    • 78751489992 scopus 로고    scopus 로고
    • Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome
    • Basantani MK, Sitnick MT, Cai L, Brenner DS, Gardner NP, Li JZ, et al. Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome. J Lipid Res 2011; 52: 318-329.
    • (2011) J Lipid Res , vol.52 , pp. 318-329
    • Basantani, M.K.1    Sitnick, M.T.2    Cai, L.3    Brenner, D.S.4    Gardner, N.P.5    Li, J.Z.6
  • 17
    • 77956625538 scopus 로고    scopus 로고
    • Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease
    • Chen W, Chang B, Li L, Chan L. Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease. HEPATOLOGY 2010; 52: 1134-1142.
    • (2010) HEPATOLOGY , vol.52 , pp. 1134-1142
    • Chen, W.1    Chang, B.2    Li, L.3    Chan, L.4
  • 18
    • 84862491622 scopus 로고    scopus 로고
    • Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant
    • Palmer CN, Maglio C, Pirazzi C, Burza MA, Adiels M, Burch L, et al. Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant. PLoS One 2012; 7: e39362.
    • (2012) PLoS One , vol.7
    • Palmer, C.N.1    Maglio, C.2    Pirazzi, C.3    Burza, M.A.4    Adiels, M.5    Burch, L.6
  • 19
    • 0026087478 scopus 로고
    • Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid
    • Storlien LH, Jenkins AB, Chisholm DJ, Pascoe WS, Khouri S, Kraegen EW. Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes 1991; 40: 280-289.
    • (1991) Diabetes , vol.40 , pp. 280-289
    • Storlien, L.H.1    Jenkins, A.B.2    Chisholm, D.J.3    Pascoe, W.S.4    Khouri, S.5    Kraegen, E.W.6
  • 20
    • 58149401189 scopus 로고    scopus 로고
    • Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
    • Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, et al. Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc Natl Acad Sci U S A 2008; 105: 19926-19931.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 19926-19931
    • Choi, C.S.1    Befroy, D.E.2    Codella, R.3    Kim, S.4    Reznick, R.M.5    Hwang, Y.J.6
  • 21
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 2002; 277: 50230-50236.
    • (2002) J Biol Chem , vol.277 , pp. 50230-50236
    • Yu, C.1    Chen, Y.2    Cline, G.W.3    Zhang, D.4    Zong, H.5    Wang, Y.6
  • 23
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959; 37: 911-917.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 24
    • 0034961514 scopus 로고    scopus 로고
    • Insulin-responsive compartments containing GLUT4 in 3T3-L1 and CHO cells: regulation by amino acid concentrations
    • Bogan JS, McKee AE, Lodish HF. Insulin-responsive compartments containing GLUT4 in 3T3-L1 and CHO cells: regulation by amino acid concentrations. Mol Cell Biol 2001; 21: 4785-4806.
    • (2001) Mol Cell Biol , vol.21 , pp. 4785-4806
    • Bogan, J.S.1    McKee, A.E.2    Lodish, H.F.3
  • 25
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29: e45.
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 27
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
    • Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 1999; 48: 1270-1274.
    • (1999) Diabetes , vol.48 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3    Bell, K.4    Barucci, N.5    Lee, D.6
  • 28
    • 33847404482 scopus 로고    scopus 로고
    • Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease
    • Samuel VT, Liu ZX, Wang A, Beddow SA, Geisler JG, Kahn M, et al. Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease. J Clin Invest 2007; 117: 739-745.
    • (2007) J Clin Invest , vol.117 , pp. 739-745
    • Samuel, V.T.1    Liu, Z.X.2    Wang, A.3    Beddow, S.A.4    Geisler, J.G.5    Kahn, M.6
  • 29
    • 60649109153 scopus 로고    scopus 로고
    • The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance
    • Nagai Y, Yonemitsu S, Erion DM, Iwasaki T, Stark R, Weismann D, et al. The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. Cell Metab 2009; 9: 252-264.
    • (2009) Cell Metab , vol.9 , pp. 252-264
    • Nagai, Y.1    Yonemitsu, S.2    Erion, D.M.3    Iwasaki, T.4    Stark, R.5    Weismann, D.6
  • 30
    • 0028318737 scopus 로고
    • In vivo measurement of fatty acids and cholesterol synthesis using D2O and mass isotopomer analysis
    • Lee WN, Bassilian S, Ajie HO, Schoeller DA, Edmond J, Bergner EA, et al. In vivo measurement of fatty acids and cholesterol synthesis using D2O and mass isotopomer analysis. Am J Physiol 1994; 266: E699-708.
    • (1994) Am J Physiol , vol.266
    • Lee, W.N.1    Bassilian, S.2    Ajie, H.O.3    Schoeller, D.A.4    Edmond, J.5    Bergner, E.A.6
  • 32
    • 27244440736 scopus 로고    scopus 로고
    • Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice
    • Neschen S, Morino K, Hammond LE, Zhang D, Liu ZX, Romanelli AJ, et al. Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice. Cell Metab 2005; 2: 55-65.
    • (2005) Cell Metab , vol.2 , pp. 55-65
    • Neschen, S.1    Morino, K.2    Hammond, L.E.3    Zhang, D.4    Liu, Z.X.5    Romanelli, A.J.6
  • 33
    • 41149167132 scopus 로고    scopus 로고
    • Association of morbid obesity with FTO and INSIG2 allelic variants
    • discussion 241.
    • Chu X, Erdman R, Susek M, Gerst H, Derr K, Al-Agha M, et al. Association of morbid obesity with FTO and INSIG2 allelic variants. Arch Surg 2008; 143: 235-240; discussion 241.
    • (2008) Arch Surg , vol.143 , pp. 235-240
    • Chu, X.1    Erdman, R.2    Susek, M.3    Gerst, H.4    Derr, K.5    Al-Agha, M.6
  • 34
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. HEPATOLOGY 2005; 41: 1313-1321.
    • (2005) HEPATOLOGY , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 35
    • 0036903132 scopus 로고    scopus 로고
    • Systemically delivered antisense oligomers upregulate gene expression in mouse tissues
    • Sazani P, Gemignani F, Kang SH, Maier MA, Manoharan M, Persmark M, et al. Systemically delivered antisense oligomers upregulate gene expression in mouse tissues. Nat Biotechnol 2002; 20: 1228-1233.
    • (2002) Nat Biotechnol , vol.20 , pp. 1228-1233
    • Sazani, P.1    Gemignani, F.2    Kang, S.H.3    Maier, M.A.4    Manoharan, M.5    Persmark, M.6
  • 36
    • 75349111467 scopus 로고    scopus 로고
    • The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status
    • Hoekstra M, Li Z, Kruijt JK, Van Eck M, Van Berkel TJ, Kuiper J. The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status. J Hepatol 2010; 52: 244-251.
    • (2010) J Hepatol , vol.52 , pp. 244-251
    • Hoekstra, M.1    Li, Z.2    Kruijt, J.K.3    Van Eck, M.4    Van Berkel, T.J.5    Kuiper, J.6
  • 38
    • 33644764922 scopus 로고    scopus 로고
    • Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin
    • Kershaw EE, Hamm JK, Verhagen LA, Peroni O, Katic M, Flier JS. Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin. Diabetes 2006; 55: 148-157.
    • (2006) Diabetes , vol.55 , pp. 148-157
    • Kershaw, E.E.1    Hamm, J.K.2    Verhagen, L.A.3    Peroni, O.4    Katic, M.5    Flier, J.S.6
  • 39
    • 34247384681 scopus 로고    scopus 로고
    • Regulation of adiponutrin expression by feeding conditions in rats is altered in the obese state
    • Caimari A, Oliver P, Palou A. Regulation of adiponutrin expression by feeding conditions in rats is altered in the obese state. Obesity 2007; 15: 591-599.
    • (2007) Obesity , vol.15 , pp. 591-599
    • Caimari, A.1    Oliver, P.2    Palou, A.3
  • 40
    • 77957970113 scopus 로고    scopus 로고
    • A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents
    • Santoro N, Kursawe R, D'Adamo E, Dykas DJ, Zhang CK, Bale AE, et al. A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents. HEPATOLOGY 2010; 52: 1281-1290.
    • (2010) HEPATOLOGY , vol.52 , pp. 1281-1290
    • Santoro, N.1    Kursawe, R.2    D'Adamo, E.3    Dykas, D.J.4    Zhang, C.K.5    Bale, A.E.6
  • 41
    • 84860497397 scopus 로고    scopus 로고
    • Diacylglycerol activation of protein kinase cepsilon and hepatic insulin resistance
    • Jornayvaz FR, Shulman GI. Diacylglycerol activation of protein kinase cepsilon and hepatic insulin resistance. Cell Metab 2012; 15: 574-584.
    • (2012) Cell Metab , vol.15 , pp. 574-584
    • Jornayvaz, F.R.1    Shulman, G.I.2
  • 42
    • 78649448446 scopus 로고    scopus 로고
    • Regulation of the promoter region of the human adiponutrin/PNPLA3 gene by glucose and insulin
    • Rae-Whitcombe SM, Kennedy D, Voyles M, Thompson MP. Regulation of the promoter region of the human adiponutrin/PNPLA3 gene by glucose and insulin. Biochem Biophys Res Commun 2010; 402: 767-772.
    • (2010) Biochem Biophys Res Commun , vol.402 , pp. 767-772
    • Rae-Whitcombe, S.M.1    Kennedy, D.2    Voyles, M.3    Thompson, M.P.4
  • 43
    • 77957302090 scopus 로고    scopus 로고
    • Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c
    • Ferre P, Foufelle F. Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes Obes Metab 2010; 12( Suppl 2): 83-92.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.SUPPL 2 , pp. 83-92
    • Ferre, P.1    Foufelle, F.2
  • 44
    • 14544289119 scopus 로고    scopus 로고
    • Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver
    • Dentin R, Girard J, Postic C. Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver. Biochimie 2005; 87: 81-86.
    • (2005) Biochimie , vol.87 , pp. 81-86
    • Dentin, R.1    Girard, J.2    Postic, C.3
  • 45
    • 84869224701 scopus 로고    scopus 로고
    • Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro
    • Pirazzi C, Adiels M, Burza MA, Mancina RM, Levin M, Stahlman M, et al. Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro. J Hepatol 2012; 57: 1276-1282.
    • (2012) J Hepatol , vol.57 , pp. 1276-1282
    • Pirazzi, C.1    Adiels, M.2    Burza, M.A.3    Mancina, R.M.4    Levin, M.5    Stahlman, M.6
  • 46
    • 84868609657 scopus 로고    scopus 로고
    • Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis
    • Epub ahead of print.
    • Li JZ, Huang Y, Karaman R, Ivanova PT, Brown HA, Roddy T, et al. Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis. J Clin Invest 2012 [Epub ahead of print].
    • (2012) J Clin Invest
    • Li, J.Z.1    Huang, Y.2    Karaman, R.3    Ivanova, P.T.4    Brown, H.A.5    Roddy, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.