메뉴 건너뛰기




Volumn 58, Issue 10, 2015, Pages 4131-4164

Bronchodilating drugs for chronic obstructive pulmonary disease: Current status and future trends

Author keywords

[No Author keywords available]

Indexed keywords

ABEDITEROL; ACLIDINIUM BROMIDE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; CARMOTEROL; FORMOTEROL; GLYCOPYRRONIUM BROMIDE; INDACATEROL; IPRATROPIUM BROMIDE; LONG ACTING MUSCARINIC ANTAGONIST; MILVETEROL; MUSCARINIC ANTAGONIST BETA 2 AGONIST; MUSCARINIC RECEPTOR BLOCKING AGENT; OLODATEROL; SALBUTAMOL; SALMETEROL; SHORT ACTING MUSCARINIC ANTAGONIST; TIOTROPIUM BROMIDE; UMECLIDINIUM; UNCLASSIFIED DRUG; VILANTEROL; 5-(2-((6-(2,2-DIFLUORO-2-PHENYLETHOXY)HEXYL)AMINO)-1-HYDROXYETHYL)-8-HYDROXYQUINOLIN-2(1H)-ONE; BENZYL ALCOHOL DERIVATIVE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CHLOROBENZENE; INDAN DERIVATIVE; QUINOLONE DERIVATIVE; SCOPOLAMINE DERIVATIVE;

EID: 84930635941     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5013227     Document Type: Review
Times cited : (78)

References (181)
  • 1
    • 69549084350 scopus 로고    scopus 로고
    • Global Strategy for the Diagnosis, Management and Prevention of COPD
    • Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD), 2014. Available from www.goldcopd.org.
    • (2014) Global Initiative for Chronic Obstructive Lung Disease (GOLD)
  • 2
    • 84877966510 scopus 로고    scopus 로고
    • Drugs for chronic obstructive pulmonary disease
    • Montuschi, P. Drugs for chronic obstructive pulmonary disease Curr. Med. Chem. 2013, 20, 1461-1463
    • (2013) Curr. Med. Chem. , vol.20 , pp. 1461-1463
    • Montuschi, P.1
  • 3
    • 84877949046 scopus 로고    scopus 로고
    • Inhaled muscarinic acetylcholine receptor antagonists for treatment of COPD
    • Montuschi, P.; Macagno, F.; Valente, S.; Fuso, L. Inhaled muscarinic acetylcholine receptor antagonists for treatment of COPD Curr. Med. Chem. 2013, 20, 1464-1476
    • (2013) Curr. Med. Chem. , vol.20 , pp. 1464-1476
    • Montuschi, P.1    Macagno, F.2    Valente, S.3    Fuso, L.4
  • 4
    • 84877672552 scopus 로고    scopus 로고
    • Long-acting beta-agonists and their association with inhaled corticosteroids in COPD
    • Fuso, L.; Mores, N.; Valente, S.; Malerba, M.; Montuschi, P. Long-acting beta-agonists and their association with inhaled corticosteroids in COPD Curr. Med. Chem. 2013, 20, 1477-1495
    • (2013) Curr. Med. Chem. , vol.20 , pp. 1477-1495
    • Fuso, L.1    Mores, N.2    Valente, S.3    Malerba, M.4    Montuschi, P.5
  • 5
    • 84880069643 scopus 로고    scopus 로고
    • Aclidinium bromide: An alternative long-acting inhaled anticholinergic in the management of chronic obstructive pulmonary disease
    • Woods, J. A.; Nealy, K. L.; Barrons, R. W. Aclidinium bromide: an alternative long-acting inhaled anticholinergic in the management of chronic obstructive pulmonary disease Ann. Pharmacother. 2013, 47, 1017-1028
    • (2013) Ann. Pharmacother. , vol.47 , pp. 1017-1028
    • Woods, J.A.1    Nealy, K.L.2    Barrons, R.W.3
  • 6
    • 84878632161 scopus 로고    scopus 로고
    • Inhaled glycopyrronium bromide: A review of its use in patients with moderate to severe chronic obstructive pulmonary disease
    • Carter, N. J. Inhaled glycopyrronium bromide: a review of its use in patients with moderate to severe chronic obstructive pulmonary disease Drugs 2013, 73, 741-753
    • (2013) Drugs , vol.73 , pp. 741-753
    • Carter, N.J.1
  • 7
    • 84895816480 scopus 로고    scopus 로고
    • Umeclidinium/vilanterol: First global approval
    • Scott, L. J.; Hair, P. Umeclidinium/vilanterol: first global approval Drugs 2014, 74, 389-395
    • (2014) Drugs , vol.74 , pp. 389-395
    • Scott, L.J.1    Hair, P.2
  • 8
    • 78449291452 scopus 로고    scopus 로고
    • Indacaterol: In chronic obstructive pulmonary disease
    • Moen, M. D. Indacaterol: in chronic obstructive pulmonary disease Drugs 2010, 70, 2269-2280
    • (2010) Drugs , vol.70 , pp. 2269-2280
    • Moen, M.D.1
  • 9
    • 27644530096 scopus 로고    scopus 로고
    • Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease
    • Belmonte, K. E. Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease Proc. Am. Thorac. Soc. 2005, 2, 297-304
    • (2005) Proc. Am. Thorac. Soc. , vol.2 , pp. 297-304
    • Belmonte, K.E.1
  • 10
    • 84916203277 scopus 로고    scopus 로고
    • Pharmacological treatment of chronic obstructive pulmonary disease: From evidence-based medicine to phenotyping
    • Montuschi, P.; Malerba, M.; Santini, G.; Miravitlles, M. Pharmacological treatment of chronic obstructive pulmonary disease: from evidence-based medicine to phenotyping Drug Discovery Today 2014, 19, 1928-1935
    • (2014) Drug Discovery Today , vol.19 , pp. 1928-1935
    • Montuschi, P.1    Malerba, M.2    Santini, G.3    Miravitlles, M.4
  • 11
    • 3042621605 scopus 로고    scopus 로고
    • Identification, localization and function of muscarinic receptor subtypes in the airways
    • Zagsma, J. Meurs, H. Roffel, A. F. Birkhauser Verlag: Basel, Switzerland
    • Roffel, A. F.; Meurs, H.; Zaagsma, J. Identification, localization and function of muscarinic receptor subtypes in the airways. In Muscarinic Receptors in Airways Diseases; Zagsma, J.; Meurs, H.; Roffel, A. F., Ed.; Birkhauser Verlag: Basel, Switzerland, 2001; pp 63-85.
    • (2001) Muscarinic Receptors in Airways Diseases , pp. 63-85
    • Roffel, A.F.1    Meurs, H.2    Zaagsma, J.3
  • 14
    • 79953658881 scopus 로고    scopus 로고
    • The use of long acting β2-agonists, alone or in combination with inhaled corticosteroids, in chronic obstructive pulmonary disease (COPD): A risk-benefit analysis
    • Cave, A. C.; Hurst, M. M. The use of long acting β2-agonists, alone or in combination with inhaled corticosteroids, in chronic obstructive pulmonary disease (COPD): a risk-benefit analysis Pharmacol. Ther. 2011, 130, 114-143
    • (2011) Pharmacol. Ther. , vol.130 , pp. 114-143
    • Cave, A.C.1    Hurst, M.M.2
  • 17
    • 69249205472 scopus 로고    scopus 로고
    • Molecular mechanisms for the persistent bronchodilatory effect of the beta2-adrenoceptor agonist salmeterol
    • Szczuka, A.; Wennerberg, M.; Packeu, A.; Vauquelin, G. Molecular mechanisms for the persistent bronchodilatory effect of the beta2-adrenoceptor agonist salmeterol Br. J. Pharmacol. 2009, 158, 183-194
    • (2009) Br. J. Pharmacol. , vol.158 , pp. 183-194
    • Szczuka, A.1    Wennerberg, M.2    Packeu, A.3    Vauquelin, G.4
  • 18
    • 0027052472 scopus 로고
    • Equilibrium and kinetic studies of the interactions of salmeterol with membrane bilayers
    • Rhodes, D. G.; Newton, R.; Butler, R.; Herbette, L. Equilibrium and kinetic studies of the interactions of salmeterol with membrane bilayers Mol. Pharmacol. 1992, 42, 596-602
    • (1992) Mol. Pharmacol. , vol.42 , pp. 596-602
    • Rhodes, D.G.1    Newton, R.2    Butler, R.3    Herbette, L.4
  • 19
    • 0035005454 scopus 로고    scopus 로고
    • Beta2-adrenoceptors: Mechanisms of action of beta2-agonists
    • Johnson, M. Beta2-adrenoceptors: mechanisms of action of beta2-agonists Paediatr. Respir. Rev. 2001, 2, 57-62
    • (2001) Paediatr. Respir. Rev. , vol.2 , pp. 57-62
    • Johnson, M.1
  • 20
    • 0030247623 scopus 로고    scopus 로고
    • Exosites: Their current status, and their relevance to the duration of action of long-acting beta2-adrenoceptor agonists
    • Coleman, R. A.; Johnson, M.; Nials, A. T.; Vardey, C. J. Exosites: their current status, and their relevance to the duration of action of long-acting beta2-adrenoceptor agonists Trends Pharmacol. Sci. 1996, 17, 324-330
    • (1996) Trends Pharmacol. Sci. , vol.17 , pp. 324-330
    • Coleman, R.A.1    Johnson, M.2    Nials, A.T.3    Vardey, C.J.4
  • 23
    • 0000466265 scopus 로고    scopus 로고
    • Muscarinic receptor agonists and antagonists
    • 9 th ed. Hardman, J. G. Limbird, L. E. Molinoff, P. B. Ruddon, R. W. Gilman, A. G. McGraw-Hill: New York
    • Brown, J. H.; Taylor, P. Muscarinic receptor agonists and antagonists. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9 th ed.; Hardman, J. G.; Limbird, L. E.; Molinoff, P. B.; Ruddon, R. W.; Gilman, A. G., Eds.; McGraw-Hill: New York, 1996; pp 141-160.
    • (1996) Goodman and Gilman's the Pharmacological Basis of Therapeutics , pp. 141-160
    • Brown, J.H.1    Taylor, P.2
  • 24
    • 0024310175 scopus 로고
    • Distance geometry of α-substituted 2,2-diphenylpropionate antimuscarinics
    • Gordon, R. K.; Breuer, E.; Padilla, F. N.; Smejkal, R. M.; Chaing, P. K. Distance geometry of α-substituted 2,2-diphenylpropionate antimuscarinics Mol. Pharmacol. 1989, 36, 766-772
    • (1989) Mol. Pharmacol. , vol.36 , pp. 766-772
    • Gordon, R.K.1    Breuer, E.2    Padilla, F.N.3    Smejkal, R.M.4    Chaing, P.K.5
  • 29
    • 0029007056 scopus 로고
    • Syntheses and biological properties of chiral fluoroalkyl quinuclidinyl benzilates
    • Kiesewetter, D. O.; Silverton, J. V.; Eckelman, W. C. Syntheses and biological properties of chiral fluoroalkyl quinuclidinyl benzilates J. Med. Chem. 1995, 38, 1711-1719
    • (1995) J. Med. Chem. , vol.38 , pp. 1711-1719
    • Kiesewetter, D.O.1    Silverton, J.V.2    Eckelman, W.C.3
  • 30
    • 0026558514 scopus 로고
    • Stereoselective antimuscarinic effects of 3-quinuclidinyl atrolactate and 3-quinuclidinyl xanthene-9-carboxylate
    • Noronha-Blob, L.; Sturm, B.; Lowe, V. Stereoselective antimuscarinic effects of 3-quinuclidinyl atrolactate and 3-quinuclidinyl xanthene-9-carboxylate Eur. J. Pharmacol. 1992, 211, 97-103
    • (1992) Eur. J. Pharmacol. , vol.211 , pp. 97-103
    • Noronha-Blob, L.1    Sturm, B.2    Lowe, V.3
  • 32
    • 0030952907 scopus 로고    scopus 로고
    • Revatropate. Bronchodilator muscarinic M3 antagonist
    • Martel, A. M.; Rabasseda, X.; Castañer, J. Revatropate. Bronchodilator muscarinic M3 antagonist Drugs Future 1997, 22, 135-137
    • (1997) Drugs Future , vol.22 , pp. 135-137
    • Martel, A.M.1    Rabasseda, X.2    Castañer, J.3
  • 33
    • 0022141072 scopus 로고
    • Structure-activity relationship in the series of muscarinic acetylcholine receptor antagonists: Four types of antagonist-receptor binding
    • Tropsha, A. E.; Nizhnii, S. V.; Iaguzhinskii, L. S. Structure-activity relationship in the series of muscarinic acetylcholine receptor antagonists: four types of antagonist-receptor binding Bioorg. Khim. 1985, 11, 1402-1416
    • (1985) Bioorg. Khim. , vol.11 , pp. 1402-1416
    • Tropsha, A.E.1    Nizhnii, S.V.2    Iaguzhinskii, L.S.3
  • 35
    • 84880746971 scopus 로고    scopus 로고
    • Efficacy and safety of aclidinium bromide compared with placebo and tiotropium in patients with moderate-to-severe chronic obstructive pulmonary disease: Results from a 6-week, randomized, controlled phase IIIb study
    • Beier, J.; Kirsten, A. M.; Mróz, R.; Segarra, R.; Chuecos, F.; Caracta, C.; Gil, E. G. Efficacy and safety of aclidinium bromide compared with placebo and tiotropium in patients with moderate-to-severe chronic obstructive pulmonary disease: results from a 6-week, randomized, controlled phase IIIb study COPD 2013, 10, 511-522
    • (2013) COPD , vol.10 , pp. 511-522
    • Beier, J.1    Kirsten, A.M.2    Mróz, R.3    Segarra, R.4    Chuecos, F.5    Caracta, C.6    Gil, E.G.7
  • 44
    • 0027970905 scopus 로고
    • Membrane pathways for drug/ion channel interactions: Molecular basis for pharmacokinetic properties
    • Herbette, L. G. Membrane pathways for drug/ion channel interactions: molecular basis for pharmacokinetic properties Drug Dev. Res. 1994, 33, 214-222
    • (1994) Drug Dev. Res. , vol.33 , pp. 214-222
    • Herbette, L.G.1
  • 46
    • 0003782047 scopus 로고    scopus 로고
    • Computational tools and results in the construction of G protein-coupled receptor models
    • Findlay, J. B. C. Bios Scientific Publishers, Ltd. Oxford, U.K
    • Blaney, F. E.; Tennant, M. Computational tools and results in the construction of G protein-coupled receptor models. In Membrane Protein Models; Findlay, J. B. C., Ed.; Bios Scientific Publishers, Ltd.: Oxford, U.K., 1996; pp 161-176.
    • (1996) Membrane Protein Models , pp. 161-176
    • Blaney, F.E.1    Tennant, M.2
  • 47
    • 0031752778 scopus 로고    scopus 로고
    • Identification of a key amino acid of the β2-adrenergic receptor for high affinity binding of salmeterol
    • Isogaya, M.; Yamagiwa, Y.; Fujita, S.; Sugimoto, Y.; Nagao, T.; Kurose, H. Identification of a key amino acid of the β2-adrenergic receptor for high affinity binding of salmeterol Mol. Pharmacol. 1998, 54, 616-622
    • (1998) Mol. Pharmacol. , vol.54 , pp. 616-622
    • Isogaya, M.1    Yamagiwa, Y.2    Fujita, S.3    Sugimoto, Y.4    Nagao, T.5    Kurose, H.6
  • 49
    • 0029841642 scopus 로고    scopus 로고
    • Sustained activation of a G-protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the β2-adrenergic receptor
    • Green, S. A.; Spasoff, A. P.; Coleman, R. R.; Johnson, M.; Liggett, S. B. Sustained activation of a G-protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the β2-adrenergic receptor J. Biol. Chem. 1996, 271, 24029-24035
    • (1996) J. Biol. Chem. , vol.271 , pp. 24029-24035
    • Green, S.A.1    Spasoff, A.P.2    Coleman, R.R.3    Johnson, M.4    Liggett, S.B.5
  • 50
    • 33344458236 scopus 로고    scopus 로고
    • An efficient and economical synthesis of 5,6-diethyl-2,3-dihydro-1 H -inden-2-amine hydrochloride
    • Prashad, M.; Hu, B.; Har, D.; Repic, O.; Blacklock, T. J. An efficient and economical synthesis of 5,6-diethyl-2,3-dihydro-1 H -inden-2-amine hydrochloride Org. Process Res. Dev. 2006, 10, 135-141
    • (2006) Org. Process Res. Dev. , vol.10 , pp. 135-141
    • Prashad, M.1    Hu, B.2    Har, D.3    Repic, O.4    Blacklock, T.J.5
  • 55
    • 84874563028 scopus 로고    scopus 로고
    • Vilanterol trifenatate, a novel inhaled long-acting β2 adrenoceptor agonist, is well tolerated in healthy subjects and demonstrates prolonged bronchodilation in subjects with asthma and COPD
    • Kempsford, R.; Norris, V.; Siederer, S. Vilanterol trifenatate, a novel inhaled long-acting β2 adrenoceptor agonist, is well tolerated in healthy subjects and demonstrates prolonged bronchodilation in subjects with asthma and COPD Pulm. Pharmacol. Ther. 2013, 26, 256-264
    • (2013) Pulm. Pharmacol. Ther. , vol.26 , pp. 256-264
    • Kempsford, R.1    Norris, V.2    Siederer, S.3
  • 56
    • 84871697898 scopus 로고    scopus 로고
    • In vitro pharmacological characterization of vilanterol, a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action
    • Slack, R. J.; Barrett, V. J.; Morrison, V. S.; Sturton, R. G.; Emmons, A. J.; Ford, A. J.; Knowles, R. G. In vitro pharmacological characterization of vilanterol, a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action J. Pharmacol. Exp. Ther. 2013, 344, 218-230
    • (2013) J. Pharmacol. Exp. Ther. , vol.344 , pp. 218-230
    • Slack, R.J.1    Barrett, V.J.2    Morrison, V.S.3    Sturton, R.G.4    Emmons, A.J.5    Ford, A.J.6    Knowles, R.G.7
  • 63
    • 84888989992 scopus 로고    scopus 로고
    • Olodaterol: First global approval
    • Gibb, A.; Yang, L. P. Olodaterol: first global approval Drugs 2013, 73, 1841-1846
    • (2013) Drugs , vol.73 , pp. 1841-1846
    • Gibb, A.1    Yang, L.P.2
  • 67
    • 0034095929 scopus 로고    scopus 로고
    • Lack of association between ipratropium bromide and mortality in elderly patients with chronic obstructive airway disease
    • Sin, D. D.; Tu, J. V. Lack of association between ipratropium bromide and mortality in elderly patients with chronic obstructive airway disease Thorax 2000, 55, 194-197
    • (2000) Thorax , vol.55 , pp. 194-197
    • Sin, D.D.1    Tu, J.V.2
  • 70
    • 0023048760 scopus 로고
    • Concomitant bronchodilator therapy and ipratropium bromide. A clinical review
    • Chervinsky, P. Concomitant bronchodilator therapy and ipratropium bromide. A clinical review Am. J. Med. 1986, 81, 67-73
    • (1986) Am. J. Med. , vol.81 , pp. 67-73
    • Chervinsky, P.1
  • 72
    • 0030605291 scopus 로고    scopus 로고
    • Nebulized bronchodilators for outpatient management of stable chronic obstructive pulmonary disease
    • Colice, G. L. Nebulized bronchodilators for outpatient management of stable chronic obstructive pulmonary disease Am. J. Med. 1996, 100, 11S-18S
    • (1996) Am. J. Med. , vol.100 , pp. 11S-18S
    • Colice, G.L.1
  • 73
    • 0028318612 scopus 로고
    • In chronic obstructive pulmonary disease, a combination of ipratropium and albuterol is more effective than either agent alone. An 85-day multicenter trial
    • COMBIVENT Inhalation Aerosol Study Group
    • COMBIVENT Inhalation Aerosol Study Group In chronic obstructive pulmonary disease, a combination of ipratropium and albuterol is more effective than either agent alone. An 85-day multicenter trial Chest 1994, 105, 1411-1419
    • (1994) Chest , vol.105 , pp. 1411-1419
  • 74
    • 0031783283 scopus 로고    scopus 로고
    • Inhalation by nebulization of albuterol-ipratropium combination (Dey combination) is superior to either agent alone in the treatment of chronic obstructive pulmonary disease. Dey Combination Solution Study Group
    • Gross, N.; Tashkin, D.; Miller, R.; Oren, J.; Coleman, W.; Linberg, S. Inhalation by nebulization of albuterol-ipratropium combination (Dey combination) is superior to either agent alone in the treatment of chronic obstructive pulmonary disease. Dey Combination Solution Study Group Respiration 1998, 65, 354-362
    • (1998) Respiration , vol.65 , pp. 354-362
    • Gross, N.1    Tashkin, D.2    Miller, R.3    Oren, J.4    Coleman, W.5    Linberg, S.6
  • 75
    • 0033022767 scopus 로고    scopus 로고
    • Pharmacoeconomic evaluation of a combination of ipratropium plus albuterol compared with ipratropium alone and albuterol alone in COPD
    • Friedman, M.; Serby, C. W.; Menjoge, S. S.; Wilson, J. D.; Hilleman, D. E.; Witek, T. J., Jr. Pharmacoeconomic evaluation of a combination of ipratropium plus albuterol compared with ipratropium alone and albuterol alone in COPD Chest 1999, 115, 635-641
    • (1999) Chest , vol.115 , pp. 635-641
    • Friedman, M.1    Serby, C.W.2    Menjoge, S.S.3    Wilson, J.D.4    Hilleman, D.E.5    Witek, T.J.6
  • 76
    • 0033534194 scopus 로고    scopus 로고
    • Tiotropium (Spiriva): Mechanistical considerations and clinical profile in obstructive lung disease
    • Disse, B.; Speck, G. A.; Rominger, K. L.; Witek, T. J., Jr.; Hammer, R. Tiotropium (Spiriva): mechanistical considerations and clinical profile in obstructive lung disease Life Sci. 1999, 64, 457-464
    • (1999) Life Sci. , vol.64 , pp. 457-464
    • Disse, B.1    Speck, G.A.2    Rominger, K.L.3    Witek, T.J.4    Hammer, R.5
  • 77
    • 0141990930 scopus 로고    scopus 로고
    • Effect of tiotropium bromide on circadian variation in airflow limitation in chronic obstructive pulmonary disease
    • Calverley, P. M. A.; Lee, A.; Towse, L.; van Noord, J.; Witek, T. J.; Kelsen, S. Effect of tiotropium bromide on circadian variation in airflow limitation in chronic obstructive pulmonary disease Thorax 2003, 58, 855-860
    • (2003) Thorax , vol.58 , pp. 855-860
    • Calverley, P.M.A.1    Lee, A.2    Towse, L.3    Van Noord, J.4    Witek, T.J.5    Kelsen, S.6
  • 78
    • 33750029372 scopus 로고    scopus 로고
    • Tiotropium for stable chronic obstructive pulmonary disease: A meta-analysis
    • Barr, R. G.; Bourbeau, J.; Camargo, C. A.; Ram, F. S. Tiotropium for stable chronic obstructive pulmonary disease: a meta-analysis Thorax 2006, 61, 854-862
    • (2006) Thorax , vol.61 , pp. 854-862
    • Barr, R.G.1    Bourbeau, J.2    Camargo, C.A.3    Ram, F.S.4
  • 79
    • 0033748430 scopus 로고    scopus 로고
    • The spirometric efficacy of once-daily dosing with tiotropium in stable COPD: A 13-week multicenter trial. The US Tiotropium Study Group
    • Casaburi, R.; Briggs, D. D., Jr.; Donohue, J. F.; Serby, C. W.; Menjoge, S. S.; Witek, T. J., Jr. The spirometric efficacy of once-daily dosing with tiotropium in stable COPD: a 13-week multicenter trial. The US Tiotropium Study Group Chest 2000, 118, 1294-1302
    • (2000) Chest , vol.118 , pp. 1294-1302
    • Casaburi, R.1    Briggs, D.D.2    Donohue, J.F.3    Serby, C.W.4    Menjoge, S.S.5    Witek, T.J.6
  • 80
    • 0034055236 scopus 로고    scopus 로고
    • A randomised controlled comparison of tiotropium and ipratropium in the treatment of chronic obstructive pulmonary disease. The Dutch Tiotropium Study Group
    • van Noord, J. A.; Bantje, T. A.; Eland, M. E.; Korducki, L.; Cornelissen, P. J. A randomised controlled comparison of tiotropium and ipratropium in the treatment of chronic obstructive pulmonary disease. The Dutch Tiotropium Study Group Thorax 2000, 55, 289-294
    • (2000) Thorax , vol.55 , pp. 289-294
    • Van Noord, J.A.1    Bantje, T.A.2    Eland, M.E.3    Korducki, L.4    Cornelissen, P.J.5
  • 81
    • 24644492301 scopus 로고    scopus 로고
    • Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: A randomized trial
    • Niewoehner, D. E.; Rice, K.; Cote, C.; Paulson, D.; Cooper, J. A., Jr.; Korducki, L.; Cassino, C.; Kesten, S. Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: a randomized trial Ann. Intern. Med. 2005, 143, 317-326
    • (2005) Ann. Intern. Med. , vol.143 , pp. 317-326
    • Niewoehner, D.E.1    Rice, K.2    Cote, C.3    Paulson, D.4    Cooper, Jr.J.A.5    Korducki, L.6    Cassino, C.7    Kesten, S.8
  • 84
    • 3042549235 scopus 로고    scopus 로고
    • Long-acting inhaled anticholinergic therapy improves sleeping oxygen saturation in COPD
    • Tiotropium Sleep Study in COPD Investigators
    • McNicholas, W. T.; Calverley, P. M.; Lee, A.; Edwards, J. C.; Tiotropium Sleep Study in COPD Investigators. Long-acting inhaled anticholinergic therapy improves sleeping oxygen saturation in COPD Eur. Respir. J. 2004, 23, 825-831
    • (2004) Eur. Respir. J. , vol.23 , pp. 825-831
    • McNicholas, W.T.1    Calverley, P.M.2    Lee, A.3    Edwards, J.C.4
  • 85
    • 0037879081 scopus 로고    scopus 로고
    • Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responses
    • Tashkin, D.; Kesten, S. Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responses Chest 2003, 123, 1441-1449
    • (2003) Chest , vol.123 , pp. 1441-1449
    • Tashkin, D.1    Kesten, S.2
  • 86
    • 53749102775 scopus 로고    scopus 로고
    • A four-year trial of tiotropium in chronic obstructive pulmonary disease
    • UPLIFT Study Investigators
    • Tashkin, D. P.; Celli, B.; Senn, S.; Burkhart, D.; Kesten, S.; Menjoge, S.; Decramer, M.; UPLIFT Study Investigators. A four-year trial of tiotropium in chronic obstructive pulmonary disease N. Engl. J. Med. 2008, 359, 1543-1554
    • (2008) N. Engl. J. Med. , vol.359 , pp. 1543-1554
    • Tashkin, D.P.1    Celli, B.2    Senn, S.3    Burkhart, D.4    Kesten, S.5    Menjoge, S.6    Decramer, M.7
  • 87
    • 70349547108 scopus 로고    scopus 로고
    • Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): A prespecified subgroup analysis of a randomised controlled trial
    • UPLIFT Investigators
    • Decramer, M.; Celli, B.; Kesten, S.; Lystig, T.; Mehra, S.; Tashkin, D. P.; UPLIFT Investigators. Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial Lancet 2009, 374, 1171-1178
    • (2009) Lancet , vol.374 , pp. 1171-1178
    • Decramer, M.1    Celli, B.2    Kesten, S.3    Lystig, T.4    Mehra, S.5    Tashkin, D.P.6
  • 88
    • 76149098230 scopus 로고    scopus 로고
    • Long-term efficacy of tiotropium in relation to smoking status in the UPLIFT trial
    • Tashkin, D. P.; Celli, B.; Kesten, S.; Lystig, T.; Mehra, S.; Decramer, M. Long-term efficacy of tiotropium in relation to smoking status in the UPLIFT trial Eur. Respir. J. 2010, 35, 287-294
    • (2010) Eur. Respir. J. , vol.35 , pp. 287-294
    • Tashkin, D.P.1    Celli, B.2    Kesten, S.3    Lystig, T.4    Mehra, S.5    Decramer, M.6
  • 89
    • 72849144086 scopus 로고    scopus 로고
    • Mortality in the 4-year trial of tiotropium (UPLIFT) in patients with chronic obstructive pulmonary disease
    • UPLIFT Study Investigators
    • Celli, B.; Decramer, M.; Kesten, S.; Liu, D.; Mehra, S.; Tashkin, D. P.; UPLIFT Study Investigators. Mortality in the 4-year trial of tiotropium (UPLIFT) in patients with chronic obstructive pulmonary disease Am. J. Respir. Crit. Care Med. 2009, 180, 948-955
    • (2009) Am. J. Respir. Crit. Care Med. , vol.180 , pp. 948-955
    • Celli, B.1    Decramer, M.2    Kesten, S.3    Liu, D.4    Mehra, S.5    Tashkin, D.P.6
  • 90
    • 33644859913 scopus 로고    scopus 로고
    • The effect of tiotropium on exacerbations and airflow in patients with COPD
    • Dusser, D.; Bravo, M.-L.; Iacono, P. The effect of tiotropium on exacerbations and airflow in patients with COPD Eur. Respir. J. 2006, 27, 547-555
    • (2006) Eur. Respir. J. , vol.27 , pp. 547-555
    • Dusser, D.1    Bravo, M.-L.2    Iacono, P.3
  • 92
    • 34447570984 scopus 로고    scopus 로고
    • Tiotropium for the treatment of stable chronic obstructive pulmonary disease: A systematic review with meta-analysis
    • Rodrigo, G. J.; Nannini, L. J. Tiotropium for the treatment of stable chronic obstructive pulmonary disease: a systematic review with meta-analysis Pulm. Pharmacol. Ther. 2007, 20, 495-502
    • (2007) Pulm. Pharmacol. Ther. , vol.20 , pp. 495-502
    • Rodrigo, G.J.1    Nannini, L.J.2
  • 94
    • 37849011194 scopus 로고    scopus 로고
    • The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide
    • INSPIRE Investigators
    • Wedzicha, J. A.; Calverley, P. M.; Seemungal, T. A.; Hagan, G.; Ansari, Z.; Stockley, R. A.; INSPIRE Investigators. The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide Am. J. Respir. Crit. Care Med. 2008, 177, 19-26
    • (2008) Am. J. Respir. Crit. Care Med. , vol.177 , pp. 19-26
    • Wedzicha, J.A.1    Calverley, P.M.2    Seemungal, T.A.3    Hagan, G.4    Ansari, Z.5    Stockley, R.A.6
  • 95
    • 39149134323 scopus 로고    scopus 로고
    • A randomized controlled trial to assess the efficacy of tiotropium in Canadian patients with chronic obstructive pulmonary disease
    • SAFE Study Group
    • Chan, C. K. N.; Maltais, R.; Sigouin, C.; Haddon, J. M.; Ford, G. T.; SAFE Study Group. A randomized controlled trial to assess the efficacy of tiotropium in Canadian patients with chronic obstructive pulmonary disease Can. Respir. J. 2007, 14, 465-472
    • (2007) Can. Respir. J. , vol.14 , pp. 465-472
    • Chan, C.K.N.1    Maltais, R.2    Sigouin, C.3    Haddon, J.M.4    Ford, G.T.5
  • 96
  • 97
  • 98
    • 0038366897 scopus 로고    scopus 로고
    • Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD
    • Brusasco, V.; Hodder, R.; Miravitlles, M.; Korducki, L.; Towse, L.; Kesten, S. Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD Thorax 2003, 58, 399-404
    • (2003) Thorax , vol.58 , pp. 399-404
    • Brusasco, V.1    Hodder, R.2    Miravitlles, M.3    Korducki, L.4    Towse, L.5    Kesten, S.6
  • 99
    • 1642493871 scopus 로고    scopus 로고
    • The role of long-acting bronchodilators in the management of stable COPD
    • Tashkin, D. P.; Cooper, C. B. The role of long-acting bronchodilators in the management of stable COPD Chest 2004, 125, 249-259
    • (2004) Chest , vol.125 , pp. 249-259
    • Tashkin, D.P.1    Cooper, C.B.2
  • 101
    • 77956340932 scopus 로고    scopus 로고
    • Sustained 24-h efficacy of NVA237, a once-daily long-acting muscarinic antagonist, in COPD patients
    • Verkindre, C.; Fukuchi, Y.; Flémale, A.; Takeda, A.; Overend, T.; Prasad, N.; Dolker, M. Sustained 24-h efficacy of NVA237, a once-daily long-acting muscarinic antagonist, in COPD patients Respir. Med. 2010, 104, 1482-1489
    • (2010) Respir. Med. , vol.104 , pp. 1482-1489
    • Verkindre, C.1    Fukuchi, Y.2    Flémale, A.3    Takeda, A.4    Overend, T.5    Prasad, N.6    Dolker, M.7
  • 102
    • 67651014864 scopus 로고    scopus 로고
    • Preclinical evaluation of long-acting muscarinic antagonists: Comparison of tiotropium and investigational drugs
    • Casarosa, P.; Bouyssou, T.; Germeyer, S.; Schnapp, A.; Gantner, F.; Pieper, M. Preclinical evaluation of long-acting muscarinic antagonists: comparison of tiotropium and investigational drugs J. Pharmacol. Exp. Ther. 2009, 330, 660-668
    • (2009) J. Pharmacol. Exp. Ther. , vol.330 , pp. 660-668
    • Casarosa, P.1    Bouyssou, T.2    Germeyer, S.3    Schnapp, A.4    Gantner, F.5    Pieper, M.6
  • 104
    • 79151486206 scopus 로고    scopus 로고
    • Bronchodilatory effects of NVA237, a once daily long-acting muscarinic antagonist, in COPD patients
    • Fogarty, C.; Hattersley, H.; Di Scala, L.; Drollmann, A. Bronchodilatory effects of NVA237, a once daily long-acting muscarinic antagonist, in COPD patients Respir. Med. 2011, 105, 337-342
    • (2011) Respir. Med. , vol.105 , pp. 337-342
    • Fogarty, C.1    Hattersley, H.2    Di Scala, L.3    Drollmann, A.4
  • 105
    • 77956309074 scopus 로고    scopus 로고
    • Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action
    • Vauquelin, G.; Charlton, S. J. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action Br. J. Pharmacol. 2010, 161, 488-508
    • (2010) Br. J. Pharmacol. , vol.161 , pp. 488-508
    • Vauquelin, G.1    Charlton, S.J.2
  • 106
    • 79957802503 scopus 로고    scopus 로고
    • NVA237, a long-acting muscarinic antagonist, as an emerging therapy for chronic obstructive pulmonary disease
    • Vogelmeier, C.; Banerji, D. NVA237, a long-acting muscarinic antagonist, as an emerging therapy for chronic obstructive pulmonary disease Ther. Adv. Respir. Dis. 2011, 5, 163-173
    • (2011) Ther. Adv. Respir. Dis. , vol.5 , pp. 163-173
    • Vogelmeier, C.1    Banerji, D.2
  • 109
    • 84868527532 scopus 로고    scopus 로고
    • Once-daily NVA237 improves exercise tolerance from the first dose in patients with COPD: The GLOW3 trial
    • Beeh, K. M.; Singh, D.; Di Scala, L.; Drollmann, A. Once-daily NVA237 improves exercise tolerance from the first dose in patients with COPD: the GLOW3 trial Int. J. Chronic Obstruct. Pulm. Dis. 2012, 7, 503-513
    • (2012) Int. J. Chronic Obstruct. Pulm. Dis. , vol.7 , pp. 503-513
    • Beeh, K.M.1    Singh, D.2    Di Scala, L.3    Drollmann, A.4
  • 110
    • 84892452314 scopus 로고    scopus 로고
    • A blinded evaluation of the efficacy and safety of glycopyrronium, a once-daily long-acting muscarinic antagonist, versus tiotropium, in patients with COPD: The GLOW5 study
    • Chapman, K. R.; Beeh, K. M.; Beier, J.; Bateman, E. D.; D'Urzo, A.; Nutbrown, R.; Henley, M.; Chen, H.; Overend, T.; D'Andrea, P. A blinded evaluation of the efficacy and safety of glycopyrronium, a once-daily long-acting muscarinic antagonist, versus tiotropium, in patients with COPD: the GLOW5 study BMC Pulm. Med. 2014, 14, 4
    • (2014) BMC Pulm. Med. , vol.14 , pp. 4
    • Chapman, K.R.1    Beeh, K.M.2    Beier, J.3    Bateman, E.D.4    D'Urzo, A.5    Nutbrown, R.6    Henley, M.7    Chen, H.8    Overend, T.9    D'Andrea, P.10
  • 111
    • 68949090559 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of single doses of aclidinium bromide, a novel long-acting, inhaled antimuscarinic, in healthy subjects
    • Jansat, J. M.; Lamarca, R.; Garcia Gil, E.; Ferrer, P. Safety and pharmacokinetics of single doses of aclidinium bromide, a novel long-acting, inhaled antimuscarinic, in healthy subjects Int. J. Clin. Pharmacol. Ther. 2009, 47, 460-468
    • (2009) Int. J. Clin. Pharmacol. Ther. , vol.47 , pp. 460-468
    • Jansat, J.M.1    Lamarca, R.2    Garcia Gil, E.3    Ferrer, P.4
  • 113
    • 79952279994 scopus 로고    scopus 로고
    • Aclidinium bromide improves exercise endurance and lung hyperinflation in patients with moderate to severe COPD
    • Maltais, F.; Celli, B.; Casaburi, R.; Porszasz, J.; Jarreta, D.; Seoane, B.; Caracta, C. Aclidinium bromide improves exercise endurance and lung hyperinflation in patients with moderate to severe COPD Respir. Med. 2011, 105, 580-587
    • (2011) Respir. Med. , vol.105 , pp. 580-587
    • Maltais, F.1    Celli, B.2    Casaburi, R.3    Porszasz, J.4    Jarreta, D.5    Seoane, B.6    Caracta, C.7
  • 114
    • 52449106502 scopus 로고    scopus 로고
    • Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis
    • Singh, S.; Loke, Y. K.; Furberg, C. D. Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis JAMA, J. Am. Med. Assoc. 2008, 300, 1439-1450
    • (2008) JAMA, J. Am. Med. Assoc. , vol.300 , pp. 1439-1450
    • Singh, S.1    Loke, Y.K.2    Furberg, C.D.3
  • 115
    • 74949097423 scopus 로고    scopus 로고
    • Cardiovascular events associated with ipratropium bromide in COPD
    • Ogale, S. S.; Lee, T. A.; Au, D. H.; Boudreau, D. M.; Sullivan, S. D. Cardiovascular events associated with ipratropium bromide in COPD Chest 2010, 137, 13-19
    • (2010) Chest , vol.137 , pp. 13-19
    • Ogale, S.S.1    Lee, T.A.2    Au, D.H.3    Boudreau, D.M.4    Sullivan, S.D.5
  • 119
    • 84871396857 scopus 로고    scopus 로고
    • Comparative safety of inhaled medications in patients with chronic obstructive pulmonary disease: Systematic review and mixed treatment comparison meta-analysis of randomised controlled trials
    • Dong, Y. H.; Lin, H. H.; Shau, W. Y.; Wu, Y. C.; Chang, C. H.; Lai, M. S. Comparative safety of inhaled medications in patients with chronic obstructive pulmonary disease: systematic review and mixed treatment comparison meta-analysis of randomised controlled trials Thorax 2013, 68, 48-56
    • (2013) Thorax , vol.68 , pp. 48-56
    • Dong, Y.H.1    Lin, H.H.2    Shau, W.Y.3    Wu, Y.C.4    Chang, C.H.5    Lai, M.S.6
  • 120
    • 84859008802 scopus 로고    scopus 로고
    • Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: Systematic review and meta-analysis of randomised controlled trials
    • Singh, S.; Loke, Y. K.; Enright, P. L.; Furberg, C. D. Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials BMJ 2011, 342, d3215
    • (2011) BMJ , vol.342 , pp. 3215
    • Singh, S.1    Loke, Y.K.2    Enright, P.L.3    Furberg, C.D.4
  • 122
    • 84893090796 scopus 로고    scopus 로고
    • Tiotropium and the risk of death in COPD
    • Loke, Y. K.; Singh, S.; Furberg, C. D. Tiotropium and the risk of death in COPD N. Engl. J. Med. 2014, 370, 480-481
    • (2014) N. Engl. J. Med. , vol.370 , pp. 480-481
    • Loke, Y.K.1    Singh, S.2    Furberg, C.D.3
  • 123
    • 33845938174 scopus 로고    scopus 로고
    • Pooled clinical trial analysis of tiotropium safety
    • Kesten, S.; Jara, M.; Wentworth, C.; Lanes, S. Pooled clinical trial analysis of tiotropium safety Chest 2006, 130, 1695-1703
    • (2006) Chest , vol.130 , pp. 1695-1703
    • Kesten, S.1    Jara, M.2    Wentworth, C.3    Lanes, S.4
  • 125
    • 77953707790 scopus 로고    scopus 로고
    • Efficacy of a new once-daily long-acting inhaled β2-agonist indacaterol versus twice-daily formoterol in COPD
    • INVOLVE (INdacaterol: Value in COPD: Longer Term Validation of Efficacy and Safety) Study Investigators
    • Dahl, R.; Chung, K. F.; Buhl, R.; Magnussen, H.; Nonikov, V.; Jack, D.; Bleasdale, P.; Owen, R.; Higgins, M.; Kramer, B.; INVOLVE (INdacaterol: Value in COPD: Longer Term Validation of Efficacy and Safety) Study Investigators Efficacy of a new once-daily long-acting inhaled β2-agonist indacaterol versus twice-daily formoterol in COPD Thorax 2010, 65, 473-479
    • (2010) Thorax , vol.65 , pp. 473-479
    • Dahl, R.1    Chung, K.F.2    Buhl, R.3    Magnussen, H.4    Nonikov, V.5    Jack, D.6    Bleasdale, P.7    Owen, R.8    Higgins, M.9    Kramer, B.10
  • 126
    • 77951221549 scopus 로고    scopus 로고
    • Efficacy and safety of indacaterol 150 μg once-daily in COPD: A double-blind, randomised, 12-week study
    • INLIGHT 1 Study Group
    • Feldman, G.; Siler, T.; Prasad, N.; Jack, D.; Piggott, S.; Owen, R.; Higgins, M.; Kramer, B.; INLIGHT 1 Study Group. Efficacy and safety of indacaterol 150 μg once-daily in COPD: a double-blind, randomised, 12-week study BMC Pulm. Med. 2010, 10, 11
    • (2010) BMC Pulm. Med. , vol.10 , pp. 11
    • Feldman, G.1    Siler, T.2    Prasad, N.3    Jack, D.4    Piggott, S.5    Owen, R.6    Higgins, M.7    Kramer, B.8
  • 128
    • 79953026850 scopus 로고    scopus 로고
    • Once-daily indacaterol versus twice-daily salmeterol for COPD: A placebo-controlled comparison
    • INLIGHT-2 (Indacaterol Efficacy Evaluation Using 150-μg Doses with COPD Patients) Study Investigators
    • Kornmann, O.; Dahl, R.; Centanni, S.; Dogra, A.; Owen, R.; Lassen, C.; Kramer, B.; INLIGHT-2 (Indacaterol Efficacy Evaluation Using 150-μg Doses with COPD Patients) Study Investigators Once-daily indacaterol versus twice-daily salmeterol for COPD: a placebo-controlled comparison Eur. Respir. J. 2011, 37, 273-279
    • (2011) Eur. Respir. J. , vol.37 , pp. 273-279
    • Kornmann, O.1    Dahl, R.2    Centanni, S.3    Dogra, A.4    Owen, R.5    Lassen, C.6    Kramer, B.7
  • 129
    • 0347473812 scopus 로고    scopus 로고
    • Maintenance therapy with budesonide and formoterol in chronic obstructive pulmonary disease
    • Calverley, P. M.; Boonsawat, W.; Cseke, Z.; Zhong, N.; Peterson, S.; Olsson, H. Maintenance therapy with budesonide and formoterol in chronic obstructive pulmonary disease Eur. Respir. J. 2003, 22, 912-919
    • (2003) Eur. Respir. J. , vol.22 , pp. 912-919
    • Calverley, P.M.1    Boonsawat, W.2    Cseke, Z.3    Zhong, N.4    Peterson, S.5    Olsson, H.6
  • 130
    • 0037425745 scopus 로고    scopus 로고
    • Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: A randomised controlled trial
    • TRial of Inhaled STeroids ANd long-acting β2 agonists study group
    • Calverley, P.; Pauwels, R.; Vestbo, J.; Jones, P.; Pride, N.; Gulsvik, A.; Anderson, J.; Maden, C.; TRial of Inhaled STeroids ANd long-acting β2 agonists study group Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial Lancet 2003, 361, 449-456
    • (2003) Lancet , vol.361 , pp. 449-456
    • Calverley, P.1    Pauwels, R.2    Vestbo, J.3    Jones, P.4    Pride, N.5    Gulsvik, A.6    Anderson, J.7    Maden, C.8
  • 131
    • 37449007559 scopus 로고    scopus 로고
    • Efficacy and safety of formoterol fumarate delivered by nebulisation to COPD patients
    • Formoterol Study Group
    • Gross, N. J.; Nelson, H. S.; Lapidus, R. J.; Dunn, L.; Lynn, L.; Rinehart, M.; Denis-Mize, K.; Formoterol Study Group. Efficacy and safety of formoterol fumarate delivered by nebulisation to COPD patients Respir. Med. 2008, 102, 189-197
    • (2008) Respir. Med. , vol.102 , pp. 189-197
    • Gross, N.J.1    Nelson, H.S.2    Lapidus, R.J.3    Dunn, L.4    Lynn, L.5    Rinehart, M.6    Denis-Mize, K.7
  • 133
    • 3543055330 scopus 로고    scopus 로고
    • Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease
    • O'Donnell, D. E.; Voduc, N.; Fitzpatrick, M.; Webb, K. A. Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease Eur. Respir. J. 2004, 24, 86-94
    • (2004) Eur. Respir. J. , vol.24 , pp. 86-94
    • O'Donnell, D.E.1    Voduc, N.2    Fitzpatrick, M.3    Webb, K.A.4
  • 134
    • 33748902214 scopus 로고    scopus 로고
    • The connection between chronic obstructive pulmonary disease symptoms and hyperinflation and its impact on exercise and function
    • Cooper, C. B. The connection between chronic obstructive pulmonary disease symptoms and hyperinflation and its impact on exercise and function Am. J. Med. 2006, 119, S21-S31
    • (2006) Am. J. Med. , vol.119 , pp. 21-S31
    • Cooper, C.B.1
  • 135
    • 0036305399 scopus 로고    scopus 로고
    • A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol
    • Donohue, J. F.; van Noord, J. A.; Bateman, E. D.; Langley, S. J.; Lee, A.; Witek, T. J., Jr.; Kesten, S.; Towse, L. A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol Chest 2002, 122, 47-55
    • (2002) Chest , vol.122 , pp. 47-55
    • Donohue, J.F.1    Van Noord, J.A.2    Bateman, E.D.3    Langley, S.J.4    Lee, A.5    Witek, T.J.6    Kesten, S.7    Towse, L.8
  • 136
    • 43649089299 scopus 로고    scopus 로고
    • Safety of long-acting β-agonists in stable COPD. A systematic review
    • Rodrigo, G. J.; Nannini, L. J.; Rodríguez-Roisin, R. Safety of long-acting β-agonists in stable COPD. A systematic review Chest 2008, 133, 1079-1087
    • (2008) Chest , vol.133 , pp. 1079-1087
    • Rodrigo, G.J.1    Nannini, L.J.2    Rodríguez-Roisin, R.3
  • 137
    • 68149158110 scopus 로고    scopus 로고
    • Pharmacologic treatments for chronic obstructive pulmonary disease: A mixed treatment comparison meta-analysis
    • Baker, W. L.; Baker, E. L.; Coleman, C. I. Pharmacologic treatments for chronic obstructive pulmonary disease: a mixed treatment comparison meta-analysis Pharmacotherapy 2009, 29, 891-905
    • (2009) Pharmacotherapy , vol.29 , pp. 891-905
    • Baker, W.L.1    Baker, E.L.2    Coleman, C.I.3
  • 138
    • 77954644418 scopus 로고    scopus 로고
    • The effects of long-acting bronchodilators on total mortality in patients with stable chronic obstructive pulmonary disease
    • Kliber, A.; Lynd, L. D.; Sin, D. D. The effects of long-acting bronchodilators on total mortality in patients with stable chronic obstructive pulmonary disease Respir. Res. 2010, 11, 56
    • (2010) Respir. Res. , vol.11 , pp. 56
    • Kliber, A.1    Lynd, L.D.2    Sin, D.D.3
  • 139
    • 84870598137 scopus 로고    scopus 로고
    • Combined corticosteroid and long-acting beta2-agonist in one inhaler versus long-acting beta2-agonists for chronic obstructive pulmonary disease
    • Nannini, L. J.; Lasserson, T. J.; Poole, P. Combined corticosteroid and long-acting beta2-agonist in one inhaler versus long-acting beta2-agonists for chronic obstructive pulmonary disease Cochrane Database Syst. Rev. 2012, 9, CD006829
    • (2012) Cochrane Database Syst. Rev. , vol.9 , pp. 006829
    • Nannini, L.J.1    Lasserson, T.J.2    Poole, P.3
  • 140
    • 33750115861 scopus 로고    scopus 로고
    • Long-acting beta2-agonists or poorly reversible chronic obstructive pulmonary disease
    • Published Online: 19 July 2006
    • Appleton, S.; Poole, P.; Smith, B. J.; Veale, A.; Lasserson, T. J.; Chan, M. M.; Cates, C. J. Long-acting beta2-agonists or poorly reversible chronic obstructive pulmonary disease. Cochrane Libr. Published Online: 19 July 2006. DOI: 10.1002/14651858.CD001104.pub2.
    • Cochrane Libr.
    • Appleton, S.1    Poole, P.2    Smith, B.J.3    Veale, A.4    Lasserson, T.J.5    Chan, M.M.6    Cates, C.J.7
  • 143
    • 40949119305 scopus 로고    scopus 로고
    • Combined corticosteroid and long-acting beta-agonist in one inhaler versus placebo for chronic obstructive pulmonary disease
    • Nannini, L.; Cates, C. J.; Lasserson, T. J.; Poole, P. Combined corticosteroid and long-acting beta-agonist in one inhaler versus placebo for chronic obstructive pulmonary disease Cochrane Database Syst. Rev. 2007, 4, CD003794
    • (2007) Cochrane Database Syst. Rev. , vol.4 , pp. 003794
    • Nannini, L.1    Cates, C.J.2    Lasserson, T.J.3    Poole, P.4
  • 146
    • 33645882522 scopus 로고    scopus 로고
    • In vitro and in vivo pharmacological characterization of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1 H -quinolin-2-one (indacaterol), a novel inhaled beta2 adrenoceptor agonist with a 24-h duration of action
    • Battram, C.; Charlton, S. J.; Cuenoud, B.; Dowling, M. R.; Fairhurst, R. A.; Farr, D.; Fozard, J. R.; Leighton-Davies, J. R.; Lewis, C. A.; McEvoy, L.; Turner, R. J.; Trifilieff, A. In vitro and in vivo pharmacological characterization of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1 H -quinolin-2-one (indacaterol), a novel inhaled beta2 adrenoceptor agonist with a 24-h duration of action J. Pharmacol. Exp. Ther. 2006, 317, 762-770
    • (2006) J. Pharmacol. Exp. Ther. , vol.317 , pp. 762-770
    • Battram, C.1    Charlton, S.J.2    Cuenoud, B.3    Dowling, M.R.4    Fairhurst, R.A.5    Farr, D.6    Fozard, J.R.7    Leighton-Davies, J.R.8    Lewis, C.A.9    McEvoy, L.10    Turner, R.J.11    Trifilieff, A.12
  • 148
    • 58149196474 scopus 로고    scopus 로고
    • Arrhythmias in patients with chronic obstructive pulmonary disease (COPD) occurrence frequency and the effect of treatment with the inhaled long-acting beta2-agonists arformoterol and salmeterol
    • Hanrahan, J. P.; Grogan, D. R.; Baumgartner, R. A.; Wilson, A.; Cheng, H.; Zimetbaum, P. J.; Morganroth, J. Arrhythmias in patients with chronic obstructive pulmonary disease (COPD) occurrence frequency and the effect of treatment with the inhaled long-acting beta2-agonists arformoterol and salmeterol Medicine (Baltimore) 2008, 87, 319-328
    • (2008) Medicine (Baltimore) , vol.87 , pp. 319-328
    • Hanrahan, J.P.1    Grogan, D.R.2    Baumgartner, R.A.3    Wilson, A.4    Cheng, H.5    Zimetbaum, P.J.6    Morganroth, J.7
  • 149
    • 33144476873 scopus 로고    scopus 로고
    • The Salmeterol Multicenter Asthma Research Trial: A comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol
    • SMART Study Group
    • Nelson, H. S.; Weiss, S. T.; Bleecker, E. R.; Yancey, S. W.; Dorinsky, P. M.; SMART Study Group. The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol Chest 2006, 129, 15-26
    • (2006) Chest , vol.129 , pp. 15-26
    • Nelson, H.S.1    Weiss, S.T.2    Bleecker, E.R.3    Yancey, S.W.4    Dorinsky, P.M.5
  • 150
    • 55749112997 scopus 로고    scopus 로고
    • Formoterol mono- and combination therapy with tiotropium in patients with COPD: A 6-month study
    • Vogelmeier, C.; Kardos, P.; Harari, S.; Gans, S. J.; Stenglein, S.; Thirlwell, J. Formoterol mono- and combination therapy with tiotropium in patients with COPD: a 6-month study Respir. Med. 2008, 102, 1511-1520
    • (2008) Respir. Med. , vol.102 , pp. 1511-1520
    • Vogelmeier, C.1    Kardos, P.2    Harari, S.3    Gans, S.J.4    Stenglein, S.5    Thirlwell, J.6
  • 152
    • 49449094831 scopus 로고    scopus 로고
    • Comparison of a combination of tiotropium plus formoterol to salmeterol plus fluticasone in moderate COPD
    • Rabe, K. F.; Timmer, W.; Sagkriotis, A.; Viel, K. Comparison of a combination of tiotropium plus formoterol to salmeterol plus fluticasone in moderate COPD Chest 2008, 134, 255-262
    • (2008) Chest , vol.134 , pp. 255-262
    • Rabe, K.F.1    Timmer, W.2    Sagkriotis, A.3    Viel, K.4
  • 154
    • 42149166529 scopus 로고    scopus 로고
    • Superiority of "triple" therapy with salmeterol/fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD
    • Singh, D.; Brooks, J.; Hagan, G.; Cahn, A.; O'Connor, B. J. Superiority of "triple" therapy with salmeterol/fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD Thorax 2008, 63, 592-598
    • (2008) Thorax , vol.63 , pp. 592-598
    • Singh, D.1    Brooks, J.2    Hagan, G.3    Cahn, A.4    O'Connor, B.J.5
  • 157
    • 84861189477 scopus 로고    scopus 로고
    • A randomized, double-blind dose-ranging study of the novel LAMA GSK573719 in patients with COPD
    • Donohue, J. F.; Anzueto, A.; Brooks, J.; Mehta, R.; Kalberg, C.; Crater, G. A randomized, double-blind dose-ranging study of the novel LAMA GSK573719 in patients with COPD Respir. Med. 2012, 106, 970-979
    • (2012) Respir. Med. , vol.106 , pp. 970-979
    • Donohue, J.F.1    Anzueto, A.2    Brooks, J.3    Mehta, R.4    Kalberg, C.5    Crater, G.6
  • 159
    • 84873377631 scopus 로고    scopus 로고
    • Initial assessment of single and repeat doses of inhaled umeclidinium in patients with chronic obstructive pulmonary disease: Two randomised studies
    • Tal-Singer, R.; Cahn, A.; Mehta, R.; Preece, A.; Crater, G.; Kelleher, D.; Pouliquen, I. J. Initial assessment of single and repeat doses of inhaled umeclidinium in patients with chronic obstructive pulmonary disease: two randomised studies Eur. J. Pharmacol. 2013, 701, 40-48
    • (2013) Eur. J. Pharmacol. , vol.701 , pp. 40-48
    • Tal-Singer, R.1    Cahn, A.2    Mehta, R.3    Preece, A.4    Crater, G.5    Kelleher, D.6    Pouliquen, I.J.7
  • 160
    • 77953799906 scopus 로고    scopus 로고
    • Pharmacological characterization of olodaterol, a novel inhaled beta2-adrenoceptor agonist exerting a 24-hour-long duration of action in preclinical models
    • Bouyssou, T.; Casarosa, P.; Naline, E.; Pestel, S.; Konetzki, I.; Devillier, P.; Schnapp, A. Pharmacological characterization of olodaterol, a novel inhaled beta2-adrenoceptor agonist exerting a 24-hour-long duration of action in preclinical models J. Pharmacol. Exp. Ther. 2010, 334, 53-62
    • (2010) J. Pharmacol. Exp. Ther. , vol.334 , pp. 53-62
    • Bouyssou, T.1    Casarosa, P.2    Naline, E.3    Pestel, S.4    Konetzki, I.5    Devillier, P.6    Schnapp, A.7
  • 164
    • 84964315337 scopus 로고    scopus 로고
    • First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of abediterol (LAS100977), a novel long-acting β2-agonist
    • Timmer, W.; Massana, E.; Jimenez, E.; Seoane, B.; de Miquel, G.; Ruiz, S. First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of abediterol (LAS100977), a novel long-acting β2-agonist J. Clin. Pharmacol. 2014, 54, 1347-1353
    • (2014) J. Clin. Pharmacol. , vol.54 , pp. 1347-1353
    • Timmer, W.1    Massana, E.2    Jimenez, E.3    Seoane, B.4    De Miquel, G.5    Ruiz, S.6
  • 166
    • 84897109639 scopus 로고    scopus 로고
    • QVA149 (indacaterol/glycopyrronium fixed-dose combination): A review of its use in patients with chronic obstructive pulmonary disease
    • Frampton, J. E. QVA149 (indacaterol/glycopyrronium fixed-dose combination): a review of its use in patients with chronic obstructive pulmonary disease Drugs 2014, 74, 465-488
    • (2014) Drugs , vol.74 , pp. 465-488
    • Frampton, J.E.1
  • 169
    • 84884819644 scopus 로고    scopus 로고
    • Safety and efficacy of dual bronchodilation with QVA149 in COPD patients: The ENLIGHTEN study
    • Dahl, R.; Chapman, K. R.; Rudolf, M.; Mehta, R.; Kho, P.; Alagappan, V. K.; Chen, H.; Banerji, D. Safety and efficacy of dual bronchodilation with QVA149 in COPD patients: the ENLIGHTEN study Respir. Med. 2013, 107, 1558-1567
    • (2013) Respir. Med. , vol.107 , pp. 1558-1567
    • Dahl, R.1    Chapman, K.R.2    Rudolf, M.3    Mehta, R.4    Kho, P.5    Alagappan, V.K.6    Chen, H.7    Banerji, D.8
  • 170
    • 84896080720 scopus 로고    scopus 로고
    • Effect of QVA149 on lung volumes and exercise tolerance in COPD patients: The BRIGHT study
    • Beeh, K. M.; Korn, S.; Beier, J.; Jadayel, D.; Henley, M.; D'Andrea, P.; Banerji, D. Effect of QVA149 on lung volumes and exercise tolerance in COPD patients: the BRIGHT study Respir. Med. 2014, 108, 584-592
    • (2014) Respir. Med. , vol.108 , pp. 584-592
    • Beeh, K.M.1    Korn, S.2    Beier, J.3    Jadayel, D.4    Henley, M.5    D'Andrea, P.6    Banerji, D.7
  • 171
    • 84877131237 scopus 로고    scopus 로고
    • Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): A randomised, double-blind, parallel-group study
    • Wedzicha, J. A.; Decramer, M.; Ficker, J. H.; Niewoehner, D. E.; Sandström, T.; Taylor, A. F.; D'Andrea, P.; Arrasate, C.; Chen, H.; Banerji, D. Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomised, double-blind, parallel-group study Lancet Respir. Med. 2013, 1, 199-209
    • (2013) Lancet Respir. Med. , vol.1 , pp. 199-209
    • Wedzicha, J.A.1    Decramer, M.2    Ficker, J.H.3    Niewoehner, D.E.4    Sandström, T.5    Taylor, A.F.6    D'Andrea, P.7    Arrasate, C.8    Chen, H.9    Banerji, D.10
  • 172
    • 84885907768 scopus 로고    scopus 로고
    • Efficacy and safety of QVA149 compared to the concurrent administration of its monocomponents indacaterol and glycopyrronium: The BEACON study
    • Dahl, R.; Jadayel, D.; Alagappan, V. K.; Chen, H.; Banerji, D. Efficacy and safety of QVA149 compared to the concurrent administration of its monocomponents indacaterol and glycopyrronium: the BEACON study Int. J. Chronic Obstruct. Pulm. Dis. 2013, 8, 501-508
    • (2013) Int. J. Chronic Obstruct. Pulm. Dis. , vol.8 , pp. 501-508
    • Dahl, R.1    Jadayel, D.2    Alagappan, V.K.3    Chen, H.4    Banerji, D.5
  • 173
    • 84904535558 scopus 로고    scopus 로고
    • Efficacy and safey of fixed-dose combination of indacaterol and glycopyrronium for the treatment of COPD: A systematic review
    • Rodrigo, G. J.; Plaza, V. Efficacy and safey of fixed-dose combination of indacaterol and glycopyrronium for the treatment of COPD: a systematic review Chest 2014, 146, 309-317
    • (2014) Chest , vol.146 , pp. 309-317
    • Rodrigo, G.J.1    Plaza, V.2
  • 174
    • 84856785850 scopus 로고    scopus 로고
    • Comparison of three combined pharmacological approaches with tiotropium monotherapy in stable moderate to severe COPD: A systematic review
    • Rodrigo, G. J.; Plaza, V.; Castro-Rodríguez, J. A. Comparison of three combined pharmacological approaches with tiotropium monotherapy in stable moderate to severe COPD: a systematic review Pulm. Pharmacol. Ther. 2012, 25, 40-47
    • (2012) Pulm. Pharmacol. Ther. , vol.25 , pp. 40-47
    • Rodrigo, G.J.1    Plaza, V.2    Castro-Rodríguez, J.A.3
  • 175
    • 84877676197 scopus 로고    scopus 로고
    • Efficacy and safety of once-daily QVA149 compared with twice-daily salmeterol-fluticasone in patients with chronic obstructive pulmonary disease (ILLUMINATE): A randomised, double-blind, parallel group study
    • Vogelmeier, C. F.; Bateman, E. D.; Pallante, J.; Alagappan, V. K.; D'Andrea, P.; Chen, H.; Banerji, D. Efficacy and safety of once-daily QVA149 compared with twice-daily salmeterol-fluticasone in patients with chronic obstructive pulmonary disease (ILLUMINATE): a randomised, double-blind, parallel group study Lancet Respir. Med. 2013, 1, 51-60
    • (2013) Lancet Respir. Med. , vol.1 , pp. 51-60
    • Vogelmeier, C.F.1    Bateman, E.D.2    Pallante, J.3    Alagappan, V.K.4    D'Andrea, P.5    Chen, H.6    Banerji, D.7
  • 177
    • 84899863235 scopus 로고    scopus 로고
    • Once-daily umeclidinium/vilanterol 125/25 mcg in COPD: A randomized, controlled study
    • [Online early access]. DOI: Published Online: Jan 2
    • Celli, B.; Crater, G.; Kilbride, S.; Mehta, R.; Tabberer, M.; Kalberg, C. J.; Church, A. Once-daily umeclidinium/vilanterol 125/25 mcg in COPD: a randomized, controlled study. Chest [Online early access]. DOI: 10.1378/chest.13-1579. Published Online: Jan 2, 2014.
    • (2014) Chest
    • Celli, B.1    Crater, G.2    Kilbride, S.3    Mehta, R.4    Tabberer, M.5    Kalberg, C.J.6    Church, A.7
  • 178
    • 84901766003 scopus 로고    scopus 로고
    • Efficacy and safety of umeclidinium plus vilanterol versus tiotropium, vilanterol, or umeclidinium monotherapies over 24 weeks in patients with chronic obstructive pulmonary disease: Results from two multicentre, blinded, randomised controlled trials
    • Decramer, M.; Anzueto, A.; Kerwin, E.; Kaelin, T.; Richard, N.; Crater, G.; Tabberer, M.; Harris, S.; Church, A. Efficacy and safety of umeclidinium plus vilanterol versus tiotropium, vilanterol, or umeclidinium monotherapies over 24 weeks in patients with chronic obstructive pulmonary disease: results from two multicentre, blinded, randomised controlled trials Lancet Respir. Med. 2014, 2, 472-486
    • (2014) Lancet Respir. Med. , vol.2 , pp. 472-486
    • Decramer, M.1    Anzueto, A.2    Kerwin, E.3    Kaelin, T.4    Richard, N.5    Crater, G.6    Tabberer, M.7    Harris, S.8    Church, A.9
  • 179
    • 84907168931 scopus 로고    scopus 로고
    • Pharmacological characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2 adrenoceptor agonist properties
    • Hegde, S. S.; Hughes, A. D.; Chen, Y.; Steinfeld, T.; Jasper, J. R.; Lee, T. W.; McNamara, A.; Martin, W. J.; Pulido-Rios, M. T.; Mammen, M. Pharmacological characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2 adrenoceptor agonist properties J. Pharmacol. Exp. Ther. 2014, 351, 190-199
    • (2014) J. Pharmacol. Exp. Ther. , vol.351 , pp. 190-199
    • Hegde, S.S.1    Hughes, A.D.2    Chen, Y.3    Steinfeld, T.4    Jasper, J.R.5    Lee, T.W.6    McNamara, A.7    Martin, W.J.8    Pulido-Rios, M.T.9    Mammen, M.10
  • 180
    • 84882590787 scopus 로고    scopus 로고
    • Pharmacodynamics of GSK961081, a bi-functional molecule, in patients with COPD
    • Bateman, E. D.; Kornmann, O.; Ambery, C.; Norris, V. Pharmacodynamics of GSK961081, a bi-functional molecule, in patients with COPD Pulm. Pharmacol. Ther. 2013, 26, 581-587
    • (2013) Pulm. Pharmacol. Ther. , vol.26 , pp. 581-587
    • Bateman, E.D.1    Kornmann, O.2    Ambery, C.3    Norris, V.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.