Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile

Journal of Pharmacology and Experimental Therapeutics

Volumn 331, Issue 2, 2009, Pages 740-751

  Gavaldà, Amadeu ^a   Miralpeix, Montserrat ^a   Ramos, Israel ^a   Otal, Raquel ^a   Carreño, Cristina ^a   Viñals, Marisa ^a   Doménech, Teresa ^a   Carcasona, Carla ^a   Reyes, Blanca ^a   Vilella, Dolors ^a   Gras, Jordi ^a   Cortijo, Julio ^b,c,d   Morcillo, Esteban ^b,c,e   Llenas, Jesús ^a   Ryder, Hamish ^a,f   Beleta, Jorge ^a  

^a R and D Center ^*  (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA   (Spain)

^e HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^f Cancer Research Technology Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ACLIDINIUM BROMIDE; CARBACHOL; IPRATROPIUM BROMIDE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; TIOTROPIUM BROMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHODILATATION; BRONCHOSPASM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION; DOG; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SAFETY; DRUG SELECTIVITY; GUINEA PIG; HEART RATE; ISOTOPE LABELING; MALE; NEBULIZATION; NONHUMAN; PRIORITY JOURNAL; REACTION TIME; RECEPTOR AFFINITY; TRACHEA;

ADMINISTRATION, INHALATION; ANESTHESIA; ANIMALS; BRONCHI; BRONCHOCONSTRICTION; CARBACHOL; CHO CELLS; CRICETINAE; CRICETULUS; DOGS; GUINEA PIGS; HEART RATE; HUMANS; IPRATROPIUM; MALE; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; RECEPTORS, MUSCARINIC; SCOPOLAMINE DERIVATIVES; STIMULATION, CHEMICAL; TRACHEA; TROPANES;

EID: 70350462573     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.151639     Document Type: Article

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