Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 13, 2014, Pages 3478-3487

  Nagashima, Shinya ^a   Matsushima, Yuji ^a   Hamaguchi, Hisao ^a   Nagata, Hiroshi ^a   Kontani, Toru ^a   Moritomo, Ayako ^a   Koshika, Tadatsura ^a   Takeuchi, Makoto ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

ASP9133; COPD; In vivo selectivity; Long acting muscarinic receptor antagonist

Indexed keywords

1 AZABICYCLO[2.2.2]OCT 3 YL (2 PHENYL 3 THIENYL)CARBAMATE; 1 AZABICYCLO[2.2.2]OCT 3 YL (4 PHENYL 1,3 THIAZOL 5 YL)CARBAMATE; 1 AZABICYCLO[2.2.2]OCT 3 YL (5 PHENYL 1,3 THIAZOL 4 YL)CARBAMATE; 1 AZABICYCLO[2.2.2]OCT 3 YL (5 PHENYL 1,3 THIAZOL 5 YL)CARBAMATE; 1 AZABICYCLO[2.2.2]OCT 4 YL (2 PHENYL 3 THIENYL)CARBAMATE; 1 AZABICYCLO[2.2.2]OCT 4 YL (3 PHENYL 2 THIENYL)CARBAMATE; 1 AZABICYCLO[2.2.2]OCT 4 YL (4 PHENYL 3 THIENYL)CARBAMATE; 1 AZABICYCLO[2.2.2]OCT 4 YL (5 PHENYL 1,3 THIAZOL 4 YL)CARBAMATE; 1 METHYL 3 [[(5 PHENYL 1,3 THIAZOL 4 YL)CARBAMOYL]OXY] 1 AZONIABICYCLO[2.2.2]OCTANE IODIDE; 1 METHYL 4 [[(2 PHENYL 3 THIENYL)CARBAMOYL]OXY] 1 AZONIABICYCLO[2.2.2]OCTANE IODIDE; 1 METHYL 4 [[(5 PHENYL 1,3 THIAZOL 4 YL)CARBAMOYL]OXY] 1 AZONIABICYCLO[2.2.2]OCTANE IODIDE; 1 METHYL 4 [[[5 [3 (TRIFLUOROMETHYL)PHENYL] 1,3 THIAZOL 4 YL]CARBAMOYL]OXY] 1 METHYL 1 AZONIABICYCLO[2.2.2]OCTANE IODIDE; 3 [[[5 (3 CHLOROPHENYL) 1,3 THIAZOL 4 YL]CARBAMOYL]OXY] 1 METHYL 1 AZONIABICYCLO[2.2.2]OCTANE IODIDE; 4 [[[5 (3 CHLOROPHENYL) 1,3 THIAZOL 4 YL]CARBAMOYL]OXY] 1 METHYL 1 AZONIABICYCLO[2.2.2]OCTANE IODIDE; 4 [[[5 (3,5 CHLOROPHENYL) 1,3 THIAZOL 4 YL]CARBAMOYL]OXY] 1 METHYL 1 AZONIABICYCLO[2.2.2]OCTANE IODIDE; 4 [[[5 (3,5 DICHLOROPHENYL) 1,3 THIAZOL 4 YL]CARBAMOYL]OXY] 1 METHYL 1 AZONIABICYCLO[2.2.2]OCTANE IODIDE; 4 [[[5 (4 FLUOROPHENYL) 1,3 THIAZOL 4 YL]CARBAMOYL]OXY] 1 METHYL 1 AZONIABICYCLO[2.2.2]OCTANE IODIDE; ASP 9133; BRONCHODILATING AGENT; GLYCOPYRRONIUM BROMIDE; IPRATROPIUM BROMIDE; LONG ACTING DRUG; MUSCARINIC RECEPTOR BLOCKING AGENT; QUINUCLIDIN 4 YL THIAZOLYLCARBAMATE DERIVATIVE; QUINUCLIDINYL HETEROARYLCARBAMATE DERIVATIVE; TIOTROPIUM BROMIDE; UNCLASSIFIED DRUG; YM 46303; CARBAMIC ACID DERIVATIVE; MUSCARINIC M3 RECEPTOR; QUINUCLIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BRONCHODILATING ACTIVITY; BRONCHOSPASM; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; NONHUMAN; RAT; SALIVATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

RATTUS;

ANIMALS; CARBAMATES; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUINUCLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MUSCARINIC M3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84901921763     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.04.031     Document Type: Article

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