Pharmacological assessment of the duration of action of glycopyrrolate vs tiotropium and ipratropium in guinea-pig and human airways

British Journal of Pharmacology

Volumn 148, Issue 3, 2006, Pages 291-298

  Villetti, Gino ^a   Bergamaschi, Marco ^a   Bassani, Franco ^a   Bolzoni, Pier Tonino ^a   Harrison, Selena ^b   Gigli, Paolo M ^b   Janni, Alberto ^b   Geppetti, Pierangelo ^b   Civelli, Maurizio ^a   Patacchini, Riccardo ^a  

^a CHIESI FARMACEUTICI S P A   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Antimuscarinic drugs; Bronchodilation; COPD; Glycopyrrolate; Human bronchus; Ipratropium; Tiotropium

Indexed keywords

ACETYLCHOLINE; CARBACHOL; GLYCOPYRRONIUM BROMIDE; IPRATROPIUM BROMIDE; MUSCARINIC RECEPTOR BLOCKING AGENT; TIOTROPIUM BROMIDE;

ADULT; AGED; AIRWAY; ANIMAL TISSUE; ARTICLE; BRONCHODILATATION; BRONCHOSPASM; BRONCHUS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG RESPONSE; FEMALE; GUINEA PIG; HUMAN; HUMAN TISSUE; INHIBITION KINETICS; MALE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTILITY; TRACHEA;

ACETYLCHOLINE; ANIMALS; BRONCHODILATOR AGENTS; GLYCOPYRROLATE; GUINEA PIGS; HUMANS; IPRATROPIUM; MUSCARINIC ANTAGONISTS; PHARMACOKINETICS; RESPIRATORY SYSTEM; SCOPOLAMINE DERIVATIVES; TIME FACTORS; TREATMENT OUTCOME;

EID: 33744490604     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706724     Document Type: Article

References (24)

1. BARNES, P.J. (2004a). New drugs for asthma. Nat. Rev. Drug Discov., 10, 831-844.
2. BARNES, P.J. (2004b). The role of anticholinergics in chronic obstructive pulmonary disease. Am. J. Med., 117 (Suppl 12A), 24S-32S.
3. BELVISI, M.G., HELE, D.J. & BIRRELL, M.A. (2004). New anti-inflammatory therapies and targets for asthma and chronic obstructive pulmonary disease. Expert Opin. Ther. Targets, 8, 265-285.
4. DISSE, B., REICHL, R., SPECK, G., TRAUNECKER, W., ROMINGER, K.L. & HAMMER, R. (1993). Ba 679 BR, a novel long-acting anticholinergic bronchodilator. Life Sci., 52, 537-544.
5. GROSS, N.J. & SKORODIN, M.S. (1984). Role of the parasympathetic system in airway obstruction due to emphysema. N. Engl. J. Med., 311, 421-425.
6. GROSS, N.J. (1988). Ipratropium bromide. N. Engl. J. Med., 319, 486-494.
7. GROSS, N.J. (2004). Tiotropium bromide. Chest, 126, 1946-1953.
8. 2 muscarinic receptor. Trends Pharmacol. Sci., 19, 322-327.
9. 3H]Ba 679 BR, a slowly dissociating muscarinic antagonist, in human lung: radioligand binding and autoradiographic mapping. Mol. Pharmacol., 45, 899-907.
10. HADDAD, E.B., PATEL, H., KEELING, J.E., YACOUB, M.H., BARNES, P.J. & BELVISI, M.G. (1999). Pharmacological characterization of the muscarinic receptor antagonist, glycopyrrolate, in human and guinea-pig airways. Br. J. Pharmacol., 127, 413-420.
11. HANSEL, T.T., NEIGHBOUR, H., ERIN, E.M., TAN, A.J., TENNANT, R.C., MAUS, J.G. & BARNES, P.J. (2005). Glycopyrrolate causes prolonged bronchoprotection and bronchodilatation in patients with asthma. Chest, 128, 1974-1979.
12. KONZETT, H. & ROESSLER, R. (1940). Versuchanornungzu untersuchungen an der bronchialmuskulatur. Arch. Exp. Path. Pharmak., 195, 71-74.
13. KRISHNA, G., SANKARANARAYANAN, V. & CHITKARA, R.K. (2004). New therapies for chronic obstructive pulmonary disease. Expert Opin. Invest. Drugs, 13, 255-267.
14. LITTNER, M.R., ILOWITE, J.S., TASHKIN, D.P., FIEDMAN, M., SERBY, C.W., MENJOGE, S.S. & WITEK JR, T.J. (2000). Long-acting bronchodilation with once-daily dosing of tiotropium (Spiriva) in stable chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med., 161, 1136-1142.
15. LUNDBERG, J.M. & SARIA, A. (1983). Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants. Nature, 302, 251-253.
16. MIRAKHUR, R.K. & DUNDEE, J.W. (1981). Glycopyrrolate. Gen. Pharmacol., 12, 423-427.
17. MUIR, J.C. & VON GUNTEN, C.F. (2000). Antisecretory agents in gastrointestinal obstruction. Clin. Geriatr. Med., 16, 327-334.
18. RENNARD, S.I., SERBY, C.W., GHAFOURI, M., JOHNSON, P.A. & FRIEDMAN, M. (1996). Extended therapy with ipratropium is associated with improved lung function in patients with COPD. A retrospective analysis of data from seven clinical trials. Chest, 110, 62-70.
19. SCHROECKENSTEIN, D.C., BUSH, R.K., CHERVINSKY, P. & BUSSE, W.W. (1988). Twelve-hour bronchodilation in asthma with a single aerosol dose of the anticholinergic compound glycopyrrolate. J. Allergy Clin. Immunol., 82, 115-119.
20. SKORODIN, M.S., GROSS, N.J., MORITZ, T., KING, F.W., ARMSTRONG, W., WELLS, D., GALAVAN, E. & SLUTSKY, L. (1986). Oxitropium bromide, a new anticholinergic bronchodilator. Ann. Allergy, 56, 229-232.
21. TAKAHASHI, T., BELVISI, M.G., PATEL, H., WARD, J.K., TADJKARIMI, S., YACOUB, M.H. & BARNES, P.J. (1994). Effect of Ba 679 BR, a novel long-acting anticholinergic agent, on cholinergic neurotransmission in guinea pig and human airways. Am. J. Respir. Crit. Care Med., 150, 1640-1645.
22. TSCHENG, D.Z. (2002). Sialorrhea - therapeutic drug options. Ann. Pharmacother., 36, 1785-1790.
23. TZELEPIS, G., KOMANAPOLLI, S., TYLER, D., VEGA, D. & FULAMBARKER, A. (1996). Comparison of nebulized glycopyrrolate and metaproterenol in chronic obstructive pulmonary disease. Eur. Respir. J., 9, 100-103.
24. WALKER IV, F.B., KAISER, D.L., KOWAL, M.B. & SURATT, P.M. (1987). Prolonged effect of inhaled glycopyrrolate in asthma. Chest, 91, 49-51.