The identification of indacaterol as an ultralong-acting inhaled β2-adrenoceptor agonist

Journal of Medicinal Chemistry

Volumn 53, Issue 9, 2010, Pages 3675-3684

  Baur, François ^a,b   Beattie, David ^a,b   Beer, David ^a,b   Bentley, David ^a,b   Bradley, Michelle ^a,b   Bruce, Ian ^a,b   Charlton, Steven J ^a,b   Cuenoud, Bernard ^a,b   Ernst, Roland ^a,b   Fairhurst, Robin A ^a,b   Faller, Bernard ^c   Farr, David ^a,b   Keller, Thomas ^a,b   Fozard, John R ^a,b   Fullerton, Joe ^a,b   Garman, Sheila ^a,b   Hatto, Julia ^a,b   Hayden, Claire ^a,b   He, Handan ^a   Howes, Colin ^a,b   Janus, Diana ^a,b   Jiang, Zhengjin ^a,b   Lewis, Christine ^a,b   Loeuillet Ritzler, Frederique ^c   Moser, Heinz ^a,b   Reilly, John ^a,b   Steward, Alan ^b   Sykes, David ^a,b   Tedaldi, Lauren ^a,b   Trifilieff, Alexandre ^a,b   Tweed, Morris ^a,b   Watson, Simon ^a,b   Wissler, Elke ^a,b   Wyss, Daniel ^a,b   more..

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b Novartis Campus ^*

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXY 5 [ 1 HYDROXY 2 ( 4,7 DIETHYLINDAN 2 YLAMINO)ETHYL] 1H QUINOLIN 2 ONE; 8 HYDROXY 5 [ 1 HYDROXY 2 ( 5,6 DI N BUTYLINDAN 2 YLAMINO)ETHL] 1H QUINOLIN 2 ONE; 8 HYDROXY 5 [ 1 HYDROXY 2 ( 5,6 DI N PROPYLINDAN 2 YLAMINO)ETHYL] 1H QUINOLIN 2 ONE; 8 HYDROXY 5 [ 1 HYDROXY 2 ( 5,6 DIETHYLINDAN 2 YLAMINO)ETHYL] 1H QUINOLIN 2 ONE; 8 HYDROXY 5 [ 1 HYDROXY 2 ( 5,6 DIMETHOXYINDAN 2 YLAMINO)ETHYL] 1H QUINOLIN 2 ONE; 8 HYDROXY 5 [ 1 HYDROXY 2 ( 5,6 DIMETHYLINDAN 2 YLAMINO)ETHYL] 1H QUINOLIN 2 ONE; 8 HYDROXY 5 [ 1 HYDROXY 2 (INDAN 2 YLAMINO)ETHYL] 1H QUINOLIN 2 ONE; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; CARMOTEROL; FORMOTEROL; INDACATEROL; INDAN DERIVATIVE; QUINOLINE DERIVATIVE; SALBUTAMOL; SALMETEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRONCHODILATATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; ELECTROSTIMULATION; GUINEA PIG; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; NONHUMAN; SUBSTITUTION REACTION; TRACHEA;

ADMINISTRATION, INHALATION; ANIMALS; BRONCHODILATOR AGENTS; GUINEA PIGS; HUMANS; HYDROPHOBICITY; INDANS; QUINOLONES; RECEPTORS, ADRENERGIC, BETA-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77952054496     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100068m     Document Type: Article

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