An investigation into the structure-activity relationships associated with the systematic modification of the β2-adrenoceptor agonist indacaterol

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 19, 2012, Pages 6280-6285

  Beattie, David ^a,b   Beer, David ^a,b   Bradley, Michelle E ^a,b   Bruce, Ian ^a,b   Charlton, Steven J ^a,b   Cuenoud, Bernard M ^a,b   Fairhurst, Robin A ^a,b   Farr, David ^a,b   Fozard, John R ^a,b   Janus, Diana ^a,b   Rosethorne, Elizabeth M ^a,b   Sandham, David A ^a,b   Sykes, David A ^a,b   Trifilieff, Alexandre ^a,b   Turner, Katharine L ^a,b   Wissler, Elke ^a,b  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

2 Adrenoceptor agonists; Binding kinetics; Bronchodilator; COPD; Indacaterol

Indexed keywords

3,4 DIHYDROQUINOLINONE; 5 N BUTYLINDANYL DERIVATIVE; ADRENALIN; ALPHA METHYL AMINOINDANE DERIVATIVE; ASPARAGINE; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CATECHOL; DOPAMINE; DOPAMINE 2 RECEPTOR; INDACATEROL; INDANONE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHOSPASM; CHEMICAL MODIFICATION; DIASTEREOISOMER; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FOLLOW UP; HYDROGENOLYSIS; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; NONHUMAN; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TACHYCARDIA;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDANS; MOLECULAR STRUCTURE; QUINOLONES; RECEPTORS, ADRENERGIC, BETA-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84866343951     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.096     Document Type: Article

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