-
1
-
-
84877970605
-
-
Global initiative for chronic obstructive lung disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (revised 2013). Available at
-
Global initiative for chronic obstructive lung disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (revised 2013). Available at: Www.goldcopd.org.
-
-
-
-
2
-
-
84856118942
-
Tiotropium bromide inhalation powder: A review of its use in the management of chronic obstructive pulmonary disease
-
Keating, G. M. Tiotropium bromide inhalation powder: A review of its use in the management of chronic obstructive pulmonary disease. Drugs, 2012, 72, 273-300
-
(2012)
Drugs
, vol.72
, pp. 273-300
-
-
Keating, G.M.1
-
3
-
-
84871396857
-
Comparative safety of inhaled medications in patients with chronic obstructive pulmonary disease: Systematic review and mixed treatment comparison meta-analysis of randomised controlled trials
-
Dong, Y. H.; Lin, H. H.; Shau, W. Y.; Wu, Y. C.; Chang, C. H.; Lai, M. S. Comparative safety of inhaled medications in patients with chronic obstructive pulmonary disease: Systematic review and mixed treatment comparison meta-analysis of randomised controlled trials. Thorax, 2013, 68, 48-56
-
(2013)
Thorax
, vol.68
, pp. 48-56
-
-
Dong, Y.H.1
Lin, H.H.2
Shau, W.Y.3
Wu, Y.C.4
Chang, C.H.5
Lai, M.S.6
-
4
-
-
78751667795
-
An update on the efficacy and safety of aclidinium bromide in patients with COPD
-
Alagha, K.; Bourdin, A.; Tummino, C.; Chanez, P. An update on the efficacy and safety of aclidinium bromide in patients with COPD. Ther. Adv. Respir. Dis., 2011, 5, 19-28
-
(2011)
Ther. Adv. Respir. Dis.
, vol.5
, pp. 19-28
-
-
Alagha, K.1
Bourdin, A.2
Tummino, C.3
Chanez, P.4
-
5
-
-
79957802503
-
NVA237, a long-acting muscarinic antagonist, as an emerging therapy for chronic obstructive pulmonary disease
-
Vogelmeier, C.; Banerji, D. NVA237, a long-acting muscarinic antagonist, as an emerging therapy for chronic obstructive pulmonary disease. Ther. Adv. Respir. Dis., 2011, 5, 163-173
-
(2011)
Ther. Adv. Respir. Dis.
, vol.5
, pp. 163-173
-
-
Vogelmeier, C.1
Banerji, D.2
-
6
-
-
84857283681
-
Indacaterol: A review of its use as maintenance therapy in patients with chronic obstructive pulmonary disease
-
McKeage, K. Indacaterol: A review of its use as maintenance therapy in patients with chronic obstructive pulmonary disease. Drugs, 2012, 72, 543-563
-
(2012)
Drugs
, vol.72
, pp. 543-563
-
-
McKeage, K.1
-
7
-
-
78649635656
-
QVA149 demonstrates superior bronchodilation compared with indacaterol or placebo in patients with chronic obstructive pulmonary disease
-
van Noord, J. A.; Buhl, R.; Laforce, C.; Martin, C.; Jones, F.; Dolker, M.; Overend, T. QVA149 demonstrates superior bronchodilation compared with indacaterol or placebo in patients with chronic obstructive pulmonary disease. Thorax, 2010, 65, 1086-1091
-
(2010)
Thorax
, vol.65
, pp. 1086-1091
-
-
Van Noord, J.A.1
Buhl, R.2
Laforce, C.3
Martin, C.4
Jones, F.5
Dolker, M.6
Overend, T.7
-
8
-
-
33847172367
-
Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
-
for the TORCH investigators
-
Calverley, P. M. A.; Anderson, J. A.; Celli, B.; Ferguson, G. T.; Jenkins, C.; Jones, P. W.; Yates, J. C.; Vestbo, J. for the TORCH investigators. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. New. Eng. J. Med., 2007, 356, 775-789
-
(2007)
New. Eng. J. Med.
, vol.356
, pp. 775-789
-
-
Calverley, P.M.A.1
Anderson, J.A.2
Celli, B.3
Ferguson, G.T.4
Jenkins, C.5
Jones, P.W.6
Yates, J.C.7
Vestbo, J.8
-
9
-
-
84870598137
-
Combined corticosteroid and long-acting-2-agonist in one inhaler versus long-acting beta2-agonists for chronic obstructive pulmonary disease
-
Nannini, L. J.; Lasserson, T. J.; Poole, P. Combined corticosteroid and long-acting-2-agonist in one inhaler versus long-acting beta2-agonists for chronic obstructive pulmonary disease. Cochrane Database Syst. Rev., 2012, 9, CD006829
-
(2012)
Cochrane Database Syst. Rev.
, vol.9
-
-
Nannini, L.J.1
Lasserson, T.J.2
Poole, P.3
-
10
-
-
84862290893
-
Selective PDE inhibitors as novel treatments for respiratory diseases
-
Page, C. P.; Spina, D. Selective PDE inhibitors as novel treatments for respiratory diseases. Curr. Opin. Pharmacol., 2012, 12, 275-286
-
(2012)
Curr. Opin. Pharmacol.
, vol.12
, pp. 275-286
-
-
Page, C.P.1
Spina, D.2
-
11
-
-
69149103642
-
M2-124 and M2-125 study groups. Roflumilast in symptomatic chronic obstructive pulmonary disease: Two randomised clinical trials
-
Calverley, P. M.; Rabe, K. F.; Goehring, U. M.; Kristiansen, S.; Fabbri, L. M.; Martinez, F. J.; M2-124 and M2-125 study groups. Roflumilast in symptomatic chronic obstructive pulmonary disease: Two randomised clinical trials. Lancet, 2009, 374, 685-694
-
(2009)
Lancet
, vol.374
, pp. 685-694
-
-
Calverley, P.M.1
Rabe, K.F.2
Goehring, U.M.3
Kristiansen, S.4
Fabbri, L.M.5
Martinez, F.J.6
-
12
-
-
66749187721
-
A Controlled Trial Of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD
-
UK-500001 Global Study Team
-
Vestbo, J.; Tan, L.; Atkinson, G.; Ward, J.; UK-500,001 Global Study Team. A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD. Eur. Respir. J., 2009, 33, 1039-1044
-
(2009)
Eur. Respir. J.
, vol.33
, pp. 1039-1044
-
-
Vestbo, J.1
Tan, L.2
Atkinson, G.3
Ward, J.4
-
13
-
-
70249093993
-
A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice
-
Fortin, M.; D'Anjou, H.; Higgins, M. E.; Gougeon, J.; Aubé, P.; Moktefi, K.; Mouissi, S.; Séguin, S.; Séguin, R.; Renzi, P. M.; Parquet, L;, Ferrari, N. A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice. Respir. Res., 2009, 10, 39.
-
(2009)
Respir. Res.
, vol.10
, pp. 39
-
-
Fortin, M.1
D'Anjou, H.2
Higgins, M.E.3
Gougeon, J.4
Aubé, P.5
Moktefi, K.6
Mouissi, S.7
Séguin, S.8
Séguin, R.9
Renzi, P.M.10
Parquet, L.11
Ferrari, N.12
-
14
-
-
74049158987
-
Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety
-
Burgin, A. B.; Magnusson, O. T.; Singh, J.; Witte, P.; Staker, B. L.; Bjornsson, J. M.; Thorsteinsdottir, M.; Hrafnsdottir, S.; Hagen, T.; Kiselyov, A. S.; Stewart, L. J.; Gurney, M. E. Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat. Biotechnol., 2010, 28, 63-70
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 63-70
-
-
Burgin, A.B.1
Magnusson, O.T.2
Singh, J.3
Witte, P.4
Staker, B.L.5
Bjornsson, J.M.6
Thorsteinsdottir, M.7
Hrafnsdottir, S.8
Hagen, T.9
Kiselyov, A.S.10
Stewart, L.J.11
Gurney, M.E.12
-
15
-
-
79952587807
-
Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages
-
Milara, J.; Navarro, A.; Almudéver, P.; Lluch, J.; Morbillo, E.J.; Cortijo, J. Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages. Clin. Exp. Allergy, 2011, 41, 535-546
-
(2011)
Clin. Exp. Allergy
, vol.41
, pp. 535-546
-
-
Milara, J.1
Navarro, A.2
Almudéver, P.3
Lluch, J.4
Morbillo, E.J.5
Cortijo, J.6
-
16
-
-
33745939122
-
The pharmacology of two novel long-acting phosphodiesterase 34 inhibitors RPL554 [910-dimethoxy-2(246-trimethylphenylimino)-3-(n-carbamoyl-2-aminoethyl)- 3,4,6,7-tetrahydro-2H-pyrimido[6,1-A]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diisopropylphenoxy)-9,10-dimethoxy-4H-pyrimido[61-A] isoquinolin-4-one]
-
Boswell-Smith, V.; Spina, D.; Oxford, A.W.; Comer, M.B.: Seeds, E.A.; Page, C.P. The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(n-carbamoyl- 2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diisopropylphenoxy)-9,10-dimethoxy-4H-pyrimido[6,1-a] isoquinolin-4-one]. J. Pharmacol. Exp. Ther., 2006, 318, 840-848
-
(2006)
J Pharmacol Exp Ther
, vol.318
, pp. 840-848
-
-
Boswell-Smith, V.1
Spina, D.2
Oxford, A.W.3
Comer, M.B.4
Seeds, E.A.5
Page, C.P.6
-
17
-
-
84868623633
-
Novel antiinflammatory therapies for COPD
-
Gross, N.J. Novel antiinflammatory therapies for COPD. Chest, 2012, 142, 1300-1307
-
(2012)
Chest
, vol.142
, pp. 1300-1307
-
-
Gross, N.J.1
-
18
-
-
9444228283
-
Discovery of BRL 50481 [3-(NN-dimethylsulfonamido)-4-methyl-nitrobenzene] , a selective inhibitor of phosphodiesterase 7: In vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes
-
Smith, S.J.; Cieslinski, L.B.; Newton, R.; Donnelly, L.E.; Fenwick, P.S.; Nicholson, A.G.; Barnes, P.J.; Barnette, M.S.; Giembycz, M.A. Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: In vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol. Pharmacol., 2004, 6, 1679-1689
-
(2004)
Mol. Pharmacol.
, vol.6
, pp. 1679-1689
-
-
Smith, S.J.1
Cieslinski, L.B.2
Newton, R.3
Donnelly, L.E.4
Fenwick, P.S.5
Nicholson, A.G.6
Barnes, P.J.7
Barnette, M.S.8
Giembycz, M.A.9
-
19
-
-
84859915668
-
Multivalent dual pharmacology muscarinic antagonist and-2 agonist (MABA) molecules for the treatment of COPD
-
Hughes, A.D.; McNamara, A.; Steinfeld, T. Multivalent dual pharmacology muscarinic antagonist and-2 agonist (MABA) molecules for the treatment of COPD. Prog. Med. Chem., 2012, 51, 71-95
-
(2012)
Prog. Med. Chem.
, vol.51
, pp. 71-95
-
-
Hughes, A.D.1
McNamara, A.2
Steinfeld, T.3
|