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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 9, 2012, Pages 3366-3369

Design, synthesis and structure-activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists

(21) Lainé, Dramane I a,b Yan, Hongxing a Xie, Haibo a Davis, Roderick S a Dufour, Jeremy a Widdowson, Katherine L a Palovich, Michael R a Wan, Zehong a Foley, James J a Schmidt, Dulcie B a Hunsberger, Gerald E a Burman, Miriam a Bacon, Alicia M a Webb, Edward F a Luttmann, Mark A a Salmon, Michael a,c Sarau, Henry M a Umbrecht, Sandra T a Landis, Philip S a Peck, Brian J a Busch Petersen, Jakob a more..

a GLAXOSMITHKLINE (United States)

b HOFFMANN LA ROCHE INC (United States)

c MERCK RESEARCH LABORATORIES (United States)

Author keywords

COPD; Inhaled; Muscarinic antagonist; Quaternary ammonium salts; Tropane

Indexed keywords

BRONCHODILATING AGENT; DAROTROPIUM BROMIDE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M3 RECEPTOR ANTAGONIST; TROPANE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BRONCHOSPASM; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; IC 50; MOUSE; NONHUMAN; PLASMA CLEARANCE; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BRONCHIAL DISEASES; DRUG DESIGN; MICE; MUSCARINIC ANTAGONISTS; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP; TROPANES;

EID: 84859846464 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.02.015 Document Type: Article

Times cited : (7)

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