Aclidinium inhibits cigarette smoke-induced lung fibroblast-to- myofibroblast transition

European Respiratory Journal

Volumn 41, Issue 6, 2013, Pages 1264-1274

  Milara, Javier ^a,b,c   Serrano, Adela ^a   Peiró, Teresa ^a   Artigues, Enrique ^a   Gavaldà, Amadeu ^e   Miralpeix, Montse ^e   Morcillo, Esteban J ^b,d   Cortijo, Julio ^a,b,d  

^a HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

^d UNIVERSITY OF VALENCIA   (Spain)

^e Dept of Pharmacology Faculty of Medicine University of Valencia ^*  (Spain)

Author keywords

Anticholinergic; Chronic obstructive pulmonary disease; Cigarette smoke; Non neuronal cholinergic system

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ACLIDINIUM BROMIDE; ALPHA SMOOTH MUSCLE ACTIN; CHOLINE ACETYLTRANSFERASE; CIGARETTE SMOKE; COLLAGEN TYPE 1; CYCLIC AMP; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; REACTIVE OXYGEN METABOLITE; 2',7'-DICHLORODIHYDROFLUORESCEIN; ACTA2 PROTEIN, HUMAN; ACTIN; CHOLINERGIC RECEPTOR BLOCKING AGENT; FLUORESCEIN DERIVATIVE; SMALL INTERFERING RNA; SMOKE; TROPANE DERIVATIVE;

ARTICLE; CELL DIFFERENTIATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG FIBROBLAST; LUNG FIBROSIS; MYOFIBROBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; BRONCHUS; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; FIBROSIS; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; INFLAMMATION; LUNG; METABOLISM; SMOKE; SMOKING; TIME;

ACTINS; BRONCHI; CELLS, CULTURED; CHOLINERGIC ANTAGONISTS; COLLAGEN TYPE I; CYCLIC AMP; FIBROBLASTS; FIBROSIS; FLUORESCEINS; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; LUNG; MICROSCOPY, FLUORESCENCE; MYOFIBROBLASTS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SMOKE; SMOKING; TIME FACTORS; TROPANES;

EID: 84878802677     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00017712     Document Type: Article

References (36)

1. Hogg JC, Chu F, Utokaparch S, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004; 350: 2645-2653. (Pubitemid 38787999)
2. Jeffery PK. Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc 2004; 1: 176-183.
3. Singh SR, Hall IP. Airway myofibroblasts and their relationship with airway myocytes and fibroblasts. Proc Am Thorac Soc 2008; 5: 127-132.
4. Undem BJ, Kollarik M. The role of vagal afferent nerves in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2005; 2: 355-360. (Pubitemid 41699696)
5. Gross NJ. Anticholinergic agents in asthma and COPD. Eur J Pharmacol 2006; 533: 36-39. (Pubitemid 43340003)
6. Bos IS, Gosens R, Zuidhof AB, et al. Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison. Eur Respir J 2007; 30: 653-661. (Pubitemid 351194824)
7. Gosens R, Zaagsma J, Meurs H, et al. Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir Res 2006; 7: 73.
8. Cortijo J, Mata M, Milara J, et al. Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways. Eur Respir J 2011; 37: 244-254.
9. Profita M, Bonanno A, Siena L, et al. Smoke, choline acetyltransferase, muscarinic receptors, and fibroblast proliferation in chronic obstructive pulmonary disease. J Pharmacol Exp Ther 2009; 329: 753-763.
10. Prat M, Gavalda A, Fonquerna S, et al. Inhaled muscarinic antagonists for respiratory diseases: a review of patents and current developments (2006-2010). Expert Opin Ther Pat 2011; 21: 1543-1573.
11. Gavalda A, Miralpeix M, Ramos I, et al. Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile. J Pharmacol Exp Ther 2009; 331: 740-751.
12. Matthiesen S, Bahulayan A, Kempkens S, et al. Muscarinic receptors mediate stimulation of human lung fibroblast proliferation. Am J Respir Cell Mol Biol 2006; 35: 621-627. (Pubitemid 44901851)
13. Ortiz JL, Milara J, Juan G, et al. Direct effect of cigarette smoke on human pulmonary artery tension. Pulm Pharmacol Ther 2010; 23: 222-228.
14. Su Y, Han W, Giraldo C, et al. Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells. Am J Respir Cell Mol Biol 1998; 19: 819-825. (Pubitemid 128353682)
15. Petry A, Weitnauer M, Gorlach A. Receptor activation of NADPH oxidases. Antioxid Redox Signal 2010; 13: 467-487.
16. Huang S, Wettlaufer SH, Hogaboam C, et al. Prostaglandin E2 inhibits collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2 receptor and cAMP signaling. Am J Physiol Lung Cell Mol Physiol 2007; 292: L405-L413.
17. Burgel PR, Bourdin A, Chanez P, et al. Update on the roles of distal airways in COPD. Eur Respir Rev 2011; 20: 7-22.
18. Scotton CJ, Chambers RC. Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest 2007; 132: 1311-1321. (Pubitemid 47621009)
19. Baglole CJ, Bushinsky SM, Garcia TM, et al. Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema. Am J Physiol Lung Cell Mol Physiol 2006; 291: L19-L29.
20. Dasari V, Gallup M, Lemjabbar H, et al. Epithelial-mesenchymal transition in lung cancer: is tobacco the ''smoking gun''? Am J Respir Cell Mol Biol 2006; 35: 3-9. (Pubitemid 43993148)
21. Dhaunsi GS, Paintlia MK, Kaur J, et al. NADPH oxidase in human lung fibroblasts. J Biomed Sci 2004; 11: 617-622. (Pubitemid 39179126)
22. Hecker L, Vittal R, Jones T, et al. NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury. Nat Med 2009; 15: 1077-1081.
23. Milara J, Cortijo J. Tobacco, Inflammation, and Respiratory Tract Cancer. Curr Pharm Des 2012; 18: 3901-3938.
24. Krimmer DI, Burgess JK, Wooi TK, et al. Matrix proteins from smoke-exposed fibroblasts are pro-proliferative. Am J Respir Cell Mol Biol 2012; 46: 34-39.
25. Liu Y, Gao W, Zhang D. Effects of cigarette smoke extract on A549 cells and human lung fibroblasts treated with transforming growth factor-b1 in a coculture system. Clin Exp Med 2010; 10: 159-167.
26. Wang Q, Fan J, Liu S. [Effects of cigarette smoke solution and chrysotile on proliferation activity of human embryo lung cells]. Zhonghua Yu Fang Yi Xue Za Zhi 1999; 33: 231-233.
27. Miglino N, Roth M, Lardinois D, et al. Cigarette smoke inhibits lung fibroblast proliferation by translational mechanisms. Eur Respir J 2012; 39: 705-711.
28. Milara J, Serrano A, Peiro T, et al. Aclidinium inhibits human lung fibroblast to myofibroblast transition. Thorax 2012; 67: 229-237.
29. 2 inhibits specific lung fibroblast functions via selective actions of PKA and Epac-1. Am J Respir Cell Mol Biol 2008; 39: 482-489.
30. Kolosionek E, Savai R, Ghofrani HA, et al. Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4. Mol Biol Cell 2009; 20: 4751-4765.
31. Hill EV, Sheppard CL, Cheung YF, et al. Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multisite phosphorylation at Ser239 and Ser579. Cell Signal 2006; 18: 2056-2069. (Pubitemid 44488666)
32. Racke K, Haag S, Bahulayan A, et al. Pulmonary fibroblasts, an emerging target for anti-obstructive drugs. Naunyn Schmiedebergs Arch Pharmacol 2008; 378: 193-201.
33. 2 inhibits fibroblast to myofibroblast transition via E prostanoid receptor 2 signaling and cyclic adenosine monophosphate elevation. Am J Respir Cell Mol Biol 2003; 29: 537-544.
34. 2 inhibition of TGF-b 1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling. Am J Physiol Lung Cell Mol Physiol 2007; 293: L417-L428.
35. Caraci F, Gili E, Calafiore M, et al. TGF-β1 targets the GSK-3β/β-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts. Pharmacol Res 2008; 57: 274-282.
36. Caulfield MP, Birdsall NJ. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 1998; 50: 279-290. (Pubitemid 28304029)