Bronchodilator activity of (3R)-3-[[[(3-fluorophenyl) [(3,4,5- trifluorophenyl)methyl]amino] carbonyl] oxy]-1-[2-oxo-2-(2-thienyl)ethyl]-1- azoniabicyclo[2.2.2]octane bromide (CHF5407), a potent, long-acting, and selective muscarinic M3 receptor antagonist

Journal of Pharmacology and Experimental Therapeutics

Volumn 335, Issue 3, 2010, Pages 622-635

  Villetti, G ^a   Pastore, F ^a   Bergamaschi, M ^a   Bassani, F ^a   Bolzoni, P T ^a   Battipaglia, L ^a   Amari, G ^a   Rizzi, A ^a   Delcanale, M ^a   Volta, R ^a   Cenacchi, V ^a   Cacciani, F ^d   Zaniboni, M ^d   Berti, F ^e   Rossoni, G ^e   Harrison, S ^b   Petrillo, P ^c   Santoro, E ^c   Scudellaro, R ^c   Mannini, F ^b   Geppetti, P A ^b   Razzetti, R ^a   Patacchini, R ^a   Civelli, Maurizio ^a   more..

^a CHIESI FARMACEUTICI S P A   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c NiKem Research   (Italy)

^d UNIVERSITY OF PARMA   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 [[[(3 FLUOROPHENYL)[(3,4,5 TRIFLUOROPHENYL)METHYL]AMINO] CARBONYL]OXY] 1 [2 OXO 2 (2 THIENYL)ETHYL] 1 AZONIABICYCLO[2.2.2]OCTANE BROMIDE; MUSCARINIC M3 RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; CLINICAL ARTICLE; CONTROLLED STUDY; DISSOCIATION; DRUG ACTIVITY; DRUG STRUCTURE; FEMALE; GUINEA PIG; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; PRIORITY JOURNAL;

ACETYLCHOLINE; AGED; ANESTHESIA; ANIMALS; BLOOD PRESSURE; BRONCHI; BRONCHIAL SPASM; BRONCHOCONSTRICTION; BRONCHOCONSTRICTOR AGENTS; BRONCHODILATOR AGENTS; CARBACHOL; CARBAMATES; CHO CELLS; CRICETINAE; CRICETULUS; DIAMINES; GUINEA PIGS; HEART ATRIA; HEART RATE; HUMANS; KINETICS; MALE; MIDDLE AGED; MOLECULAR STRUCTURE; MUSCARINIC ANTAGONISTS; MYOCARDIAL CONTRACTION; QUINUCLIDINES; RECEPTOR, MUSCARINIC M1; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; SCOPOLAMINE DERIVATIVES; TRACHEA; TRANSFECTION; VENTRICULAR FUNCTION, LEFT;

EID: 78649547027     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.170035     Document Type: Article

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