메뉴 건너뛰기




Volumn 263, Issue 1, 2015, Pages 257-278

Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy

Author keywords

Alternative splicing; Hematopoiesis; Hematopoietic malignancy; Leukemogenesis; Splice factors

Indexed keywords

ALEMTUZUMAB; FLUDARABINE; ISOPROTEIN; MESSENGER RNA; NUCLEAR PROTEIN; PHOSPHOPROTEIN; RIBONUCLEOPROTEIN; RNA SPLICING; SF3B1 PROTEIN, HUMAN; SMALL NUCLEAR RIBONUCLEOPROTEIN; SRSF2 PROTEIN, HUMAN; U2AF1 PROTEIN, HUMAN;

EID: 84930358438     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12241     Document Type: Article
Times cited : (42)

References (184)
  • 1
    • 84865760395 scopus 로고    scopus 로고
    • GENCODE: the reference human genome annotation for The ENCODE Project
    • Harrow J, et al. GENCODE: the reference human genome annotation for The ENCODE Project. Genome Res 2012;22:1760-1774.
    • (2012) Genome Res , vol.22 , pp. 1760-1774
    • Harrow, J.1
  • 2
    • 0036296254 scopus 로고    scopus 로고
    • Identification and characterization of soluble isoform of fibroblast growth factor receptor 3 in human SaOS-2 osteosarcoma cells
    • Jang JH. Identification and characterization of soluble isoform of fibroblast growth factor receptor 3 in human SaOS-2 osteosarcoma cells. Biochem Biophys Res Commun 2002;292:378-382.
    • (2002) Biochem Biophys Res Commun , vol.292 , pp. 378-382
    • Jang, J.H.1
  • 3
    • 0029562180 scopus 로고
    • Receptors for fibroblast growth factors
    • Coutts JC, Gallagher JT. Receptors for fibroblast growth factors. Immunol Cell Biol 1995;73:584-589.
    • (1995) Immunol Cell Biol , vol.73 , pp. 584-589
    • Coutts, J.C.1    Gallagher, J.T.2
  • 4
    • 34248185149 scopus 로고    scopus 로고
    • MDM2 splice variants predominantly localize to the nucleoplasm mediated by a COOH-terminal nuclear localization signal
    • Schuster K, Fan L, Harris LC. MDM2 splice variants predominantly localize to the nucleoplasm mediated by a COOH-terminal nuclear localization signal. Mol Cancer Res 2007;5:403-412.
    • (2007) Mol Cancer Res , vol.5 , pp. 403-412
    • Schuster, K.1    Fan, L.2    Harris, L.C.3
  • 5
    • 48249148310 scopus 로고    scopus 로고
    • Tau exon 10 alternative splicing and tauopathies
    • Liu F, Gong CX. Tau exon 10 alternative splicing and tauopathies. Mol Neurodegener 2008;3:8.
    • (2008) Mol Neurodegener , vol.3 , pp. 8
    • Liu, F.1    Gong, C.X.2
  • 6
    • 84904480109 scopus 로고    scopus 로고
    • Novel Isoforms of Heat Shock Transcription Factor 1, HSF1gammaalpha and HSF1gammabeta, Regulate Chaperone Protein Gene Transcription
    • Neueder A, Achilli F, Moussaoui S, Bates GP. Novel Isoforms of Heat Shock Transcription Factor 1, HSF1gammaalpha and HSF1gammabeta, Regulate Chaperone Protein Gene Transcription. J Biol Chem 2014;289:19894-19906.
    • (2014) J Biol Chem , vol.289 , pp. 19894-19906
    • Neueder, A.1    Achilli, F.2    Moussaoui, S.3    Bates, G.P.4
  • 8
    • 0042671357 scopus 로고    scopus 로고
    • Pre-mRNA splicing: awash in a sea of proteins
    • Jurica MS, Moore MJ. Pre-mRNA splicing: awash in a sea of proteins. Mol Cell 2003;12:5-14.
    • (2003) Mol Cell , vol.12 , pp. 5-14
    • Jurica, M.S.1    Moore, M.J.2
  • 9
    • 84857422448 scopus 로고    scopus 로고
    • Dynamic protein-protein interaction wiring of the human spliceosome
    • Hegele A, et al. Dynamic protein-protein interaction wiring of the human spliceosome. Mol Cell 2012;45:567-580.
    • (2012) Mol Cell , vol.45 , pp. 567-580
    • Hegele, A.1
  • 10
    • 60349104299 scopus 로고    scopus 로고
    • The spliceosome: design principles of a dynamic RNP machine
    • Wahl MC, Will CL, Luhrmann R. The spliceosome: design principles of a dynamic RNP machine. Cell 2009;136:701-718.
    • (2009) Cell , vol.136 , pp. 701-718
    • Wahl, M.C.1    Will, C.L.2    Luhrmann, R.3
  • 11
    • 56549101959 scopus 로고    scopus 로고
    • Alternative isoform regulation in human tissue transcriptomes
    • Wang ET, et al. Alternative isoform regulation in human tissue transcriptomes. Nature 2008;456:470-476.
    • (2008) Nature , vol.456 , pp. 470-476
    • Wang, E.T.1
  • 12
    • 56749098074 scopus 로고    scopus 로고
    • Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
    • Pan Q, Shai O, Lee LJ, Frey BJ, Blencowe BJ. Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet 2008;40:1413-1415.
    • (2008) Nat Genet , vol.40 , pp. 1413-1415
    • Pan, Q.1    Shai, O.2    Lee, L.J.3    Frey, B.J.4    Blencowe, B.J.5
  • 14
    • 0742323558 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics
    • Maquat LE. Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. Nat Rev Mol Cell Biol 2004;5:89-99.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 89-99
    • Maquat, L.E.1
  • 15
    • 84899961614 scopus 로고    scopus 로고
    • Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability
    • Savage KI, et al. Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability. Mol Cell 2014;54:445-459.
    • (2014) Mol Cell , vol.54 , pp. 445-459
    • Savage, K.I.1
  • 16
    • 84895817817 scopus 로고    scopus 로고
    • A genome-wide aberrant RNA splicing in patients with acute myeloid leukemia identifies novel potential disease markers and therapeutic targets
    • Adamia S, et al. A genome-wide aberrant RNA splicing in patients with acute myeloid leukemia identifies novel potential disease markers and therapeutic targets. Clin Cancer Res 2013;20:1135-1145.
    • (2013) Clin Cancer Res , vol.20 , pp. 1135-1145
    • Adamia, S.1
  • 17
    • 84889669175 scopus 로고    scopus 로고
    • Gene and isoform expression signatures associated with tumor stage in kidney renal clear cell carcinoma
    • Liu Q, Zhao S, Su PF, Yu S. Gene and isoform expression signatures associated with tumor stage in kidney renal clear cell carcinoma. BMC Syst Biol 2013;7(Suppl 5):S7.
    • (2013) BMC Syst Biol , vol.7 , pp. S7
    • Liu, Q.1    Zhao, S.2    Su, P.F.3    Yu, S.4
  • 18
    • 85027941046 scopus 로고    scopus 로고
    • Hallmarks of alternative splicing in cancer
    • [Epub ahead of print].
    • Oltean S, Bates DO. Hallmarks of alternative splicing in cancer. Oncogene 2013; doi: 10.1038/onc.2013.533. [Epub ahead of print].
    • (2013) Oncogene
    • Oltean, S.1    Bates, D.O.2
  • 19
    • 78049416081 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged
    • David CJ, Manley JL. Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev 2010;24:2343-2364.
    • (2010) Genes Dev , vol.24 , pp. 2343-2364
    • David, C.J.1    Manley, J.L.2
  • 20
    • 84877768911 scopus 로고    scopus 로고
    • RNA sequencing of cancer reveals novel splicing alterations
    • Eswaran J, et al. RNA sequencing of cancer reveals novel splicing alterations. Sci Rep 2013;3:1689.
    • (2013) Sci Rep , vol.3 , pp. 1689
    • Eswaran, J.1
  • 21
    • 78751700506 scopus 로고    scopus 로고
    • Global profiling and molecular characterization of alternative splicing events misregulated in lung cancer
    • Misquitta-Ali CM, et al. Global profiling and molecular characterization of alternative splicing events misregulated in lung cancer. Mol Cell Biol 2011;31:138-150.
    • (2011) Mol Cell Biol , vol.31 , pp. 138-150
    • Misquitta-Ali, C.M.1
  • 22
    • 84892900538 scopus 로고    scopus 로고
    • A dedicated microarray for in-depth analysis of pre-mRNA splicing events: application to the study of genes involved in the response to targeted anticancer therapies
    • Pesson M, Eymin B, De La Grange P, Simon B, Corcos L. A dedicated microarray for in-depth analysis of pre-mRNA splicing events: application to the study of genes involved in the response to targeted anticancer therapies. Mol Cancer 2014;13:9.
    • (2014) Mol Cancer , vol.13 , pp. 9
    • Pesson, M.1    Eymin, B.2    De La Grange, P.3    Simon, B.4    Corcos, L.5
  • 23
    • 84895551622 scopus 로고    scopus 로고
    • A gene expression and pre-mRNA splicing signature that marks the adenoma-adenocarcinoma progression in colorectal cancer
    • Pesson M, et al. A gene expression and pre-mRNA splicing signature that marks the adenoma-adenocarcinoma progression in colorectal cancer. PLoS ONE 2014;9:e87761.
    • (2014) PLoS ONE , vol.9 , pp. e87761
    • Pesson, M.1
  • 24
    • 84890942102 scopus 로고    scopus 로고
    • Uncovering the role of p53 splice variants in human malignancy: a clinical perspective
    • Surget S, Khoury MP, Bourdon J. Uncovering the role of p53 splice variants in human malignancy: a clinical perspective. Onco Targets Ther 2014;7:57-68.
    • (2014) Onco Targets Ther , vol.7 , pp. 57-68
    • Surget, S.1    Khoury, M.P.2    Bourdon, J.3
  • 25
    • 84874674413 scopus 로고    scopus 로고
    • CD44v6 expression is related to mesenchymal phenotype and poor prognosis in patients with colorectal cancer
    • Saito S, et al. CD44v6 expression is related to mesenchymal phenotype and poor prognosis in patients with colorectal cancer. Oncol Rep 2013;29:1570-1578.
    • (2013) Oncol Rep , vol.29 , pp. 1570-1578
    • Saito, S.1
  • 26
    • 84875873419 scopus 로고    scopus 로고
    • Correlation of CD44v6 expression with ovarian cancer progression and recurrence
    • Shi J, Zhou Z, Di W, Li N. Correlation of CD44v6 expression with ovarian cancer progression and recurrence. BMC Cancer 2013;13:182.
    • (2013) BMC Cancer , vol.13 , pp. 182
    • Shi, J.1    Zhou, Z.2    Di, W.3    Li, N.4
  • 27
    • 40949090037 scopus 로고    scopus 로고
    • Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis
    • Cha JY, Lambert QT, Reuther GW, Der CJ. Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis. Mol Cancer Res 2008;6:435-445.
    • (2008) Mol Cancer Res , vol.6 , pp. 435-445
    • Cha, J.Y.1    Lambert, Q.T.2    Reuther, G.W.3    Der, C.J.4
  • 28
    • 54549123309 scopus 로고    scopus 로고
    • VEGF-A splicing: the key to anti-angiogenic therapeutics?
    • Harper SJ, Bates DO. VEGF-A splicing: the key to anti-angiogenic therapeutics? Nat Rev Cancer 2008;8:880-887.
    • (2008) Nat Rev Cancer , vol.8 , pp. 880-887
    • Harper, S.J.1    Bates, D.O.2
  • 29
    • 84901300422 scopus 로고    scopus 로고
    • The RNA-binding protein QKI suppresses cancer-associated aberrant splicing
    • Zong FY, et al. The RNA-binding protein QKI suppresses cancer-associated aberrant splicing. PLoS Genet 2014;10:e1004289.
    • (2014) PLoS Genet , vol.10 , pp. e1004289
    • Zong, F.Y.1
  • 30
    • 34548452775 scopus 로고    scopus 로고
    • Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors
    • Kunnimalaiyaan M, Chen H. Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors. Oncologist 2007;12:535-542.
    • (2007) Oncologist , vol.12 , pp. 535-542
    • Kunnimalaiyaan, M.1    Chen, H.2
  • 31
    • 80555129351 scopus 로고    scopus 로고
    • Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think
    • Lobry C, Oh P, Aifantis I. Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think. J Exp Med 2011;208:1931-1935.
    • (2011) J Exp Med , vol.208 , pp. 1931-1935
    • Lobry, C.1    Oh, P.2    Aifantis, I.3
  • 32
    • 5044225888 scopus 로고    scopus 로고
    • Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    • Weng AP, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004;306:269-271.
    • (2004) Science , vol.306 , pp. 269-271
    • Weng, A.P.1
  • 33
    • 84857709007 scopus 로고    scopus 로고
    • Activation of the NOTCH1 pathway in chronic lymphocytic leukemia
    • Gianfelici V. Activation of the NOTCH1 pathway in chronic lymphocytic leukemia. Haematologica 2012;97:328-330.
    • (2012) Haematologica , vol.97 , pp. 328-330
    • Gianfelici, V.1
  • 34
    • 84877149088 scopus 로고    scopus 로고
    • Notch signaling in pancreatic cancer: oncogene or tumor suppressor?
    • Avila JL, Kissil JL. Notch signaling in pancreatic cancer: oncogene or tumor suppressor? Trends Mol Med 2013;19:320-327.
    • (2013) Trends Mol Med , vol.19 , pp. 320-327
    • Avila, J.L.1    Kissil, J.L.2
  • 36
    • 0028837972 scopus 로고
    • An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms
    • Tanaka T, et al. An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms. EMBO J 1995;14:341-350.
    • (1995) EMBO J , vol.14 , pp. 341-350
    • Tanaka, T.1
  • 38
    • 0030608376 scopus 로고    scopus 로고
    • Alternative RNA splicing of the MLL gene in normal and malignant cells
    • Nam DK, Honoki K, Yu M, Yunis JJ. Alternative RNA splicing of the MLL gene in normal and malignant cells. Gene 1996;178:169-175.
    • (1996) Gene , vol.178 , pp. 169-175
    • Nam, D.K.1    Honoki, K.2    Yu, M.3    Yunis, J.J.4
  • 39
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: class discovery and class prediction by gene expression monitoring
    • Golub TR, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999;286:531-537.
    • (1999) Science , vol.286 , pp. 531-537
    • Golub, T.R.1
  • 40
    • 84908301087 scopus 로고    scopus 로고
    • The leukemogenicity of Hoxa9 depends on alternative splicing
    • Stadler CR, et al. The leukemogenicity of Hoxa9 depends on alternative splicing. Leukemia 2014;28:1838-1843.
    • (2014) Leukemia , vol.28 , pp. 1838-1843
    • Stadler, C.R.1
  • 41
    • 35748975645 scopus 로고    scopus 로고
    • PU.1: a crucial and versatile player in hematopoiesis and leukemia
    • Kastner P, Chan S. PU.1: a crucial and versatile player in hematopoiesis and leukemia. Int J Biochem Cell Biol 2008;40:22-27.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 22-27
    • Kastner, P.1    Chan, S.2
  • 42
    • 0033587755 scopus 로고    scopus 로고
    • Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1
    • Zhang P, et al. Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. Proc Natl Acad Sci USA 1999;96:8705-8710.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8705-8710
    • Zhang, P.1
  • 43
    • 0032570707 scopus 로고    scopus 로고
    • The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS
    • Hallier M, Lerga A, Barnache S, Tavitian A, Moreau-Gachelin F. The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS. J Biol Chem 1996;273:4838-4842.
    • (1996) J Biol Chem , vol.273 , pp. 4838-4842
    • Hallier, M.1    Lerga, A.2    Barnache, S.3    Tavitian, A.4    Moreau-Gachelin, F.5
  • 44
    • 0029991768 scopus 로고    scopus 로고
    • The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb
    • Hallier M, Tavitian A, Moreau-Gachelin F. The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb. J Biol Chem 1998;271:11177-11181.
    • (1998) J Biol Chem , vol.271 , pp. 11177-11181
    • Hallier, M.1    Tavitian, A.2    Moreau-Gachelin, F.3
  • 45
    • 3042581034 scopus 로고    scopus 로고
    • Multiple functional domains of the oncoproteins Spi-1/PU.1 and TLS are involved in their opposite splicing effects in erythroleukemic cells
    • Delva L, Gallais I, Guillouf C, Denis N, Orvain C, Moreau-Gachelin F. Multiple functional domains of the oncoproteins Spi-1/PU.1 and TLS are involved in their opposite splicing effects in erythroleukemic cells. Oncogene 2004;23:4389-4399.
    • (2004) Oncogene , vol.23 , pp. 4389-4399
    • Delva, L.1    Gallais, I.2    Guillouf, C.3    Denis, N.4    Orvain, C.5    Moreau-Gachelin, F.6
  • 46
    • 33745845831 scopus 로고    scopus 로고
    • Spi-1/PU.1 oncoprotein affects splicing decisions in a promoter binding-dependent manner
    • Guillouf C, Gallais I, Moreau-Gachelin F. Spi-1/PU.1 oncoprotein affects splicing decisions in a promoter binding-dependent manner. J Biol Chem 2006;281:19145-19155.
    • (2006) J Biol Chem , vol.281 , pp. 19145-19155
    • Guillouf, C.1    Gallais, I.2    Moreau-Gachelin, F.3
  • 47
    • 65449117656 scopus 로고    scopus 로고
    • Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML
    • Zhou J, et al. Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML. Blood 2009;113:4052-4062.
    • (2009) Blood , vol.113 , pp. 4052-4062
    • Zhou, J.1
  • 48
    • 37549036729 scopus 로고    scopus 로고
    • Survivin, cancer networks and pathway-directed drug discovery
    • Altieri DC. Survivin, cancer networks and pathway-directed drug discovery. Nat Rev Cancer 2008;8:61-70.
    • (2008) Nat Rev Cancer , vol.8 , pp. 61-70
    • Altieri, D.C.1
  • 49
    • 33747516350 scopus 로고    scopus 로고
    • In vivo expression of survivin and its splice variant survivin-2B: impact on clinical outcome in acute myeloid leukemia
    • Wagner M, Schmelz K, Wuchter C, Ludwig WD, Dorken B, Tamm I. In vivo expression of survivin and its splice variant survivin-2B: impact on clinical outcome in acute myeloid leukemia. Int J Cancer 2006;119:1291-1297.
    • (2006) Int J Cancer , vol.119 , pp. 1291-1297
    • Wagner, M.1    Schmelz, K.2    Wuchter, C.3    Ludwig, W.D.4    Dorken, B.5    Tamm, I.6
  • 50
    • 84863574448 scopus 로고    scopus 로고
    • Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML
    • Carter BZ, et al. Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML. Blood 2012;120:173-180.
    • (2012) Blood , vol.120 , pp. 173-180
    • Carter, B.Z.1
  • 51
    • 67651108920 scopus 로고    scopus 로고
    • Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3
    • Fukuda S, et al. Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3. Blood 2009;114:394-403.
    • (2009) Blood , vol.114 , pp. 394-403
    • Fukuda, S.1
  • 52
    • 84893434231 scopus 로고    scopus 로고
    • BIRC5 (survivin) splice variant expression correlates with refractory disease and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group
    • Moore AS, et al. BIRC5 (survivin) splice variant expression correlates with refractory disease and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group. Pediatr Blood Cancer 2014;61:647-652.
    • (2014) Pediatr Blood Cancer , vol.61 , pp. 647-652
    • Moore, A.S.1
  • 53
    • 84865866410 scopus 로고    scopus 로고
    • Real-time PCR quantification of major Wilms' tumor gene 1 (WT1) isoforms in acute myeloid leukemia, their characteristic expression patterns and possible functional consequences
    • Kramarzova K, et al. Real-time PCR quantification of major Wilms' tumor gene 1 (WT1) isoforms in acute myeloid leukemia, their characteristic expression patterns and possible functional consequences. Leukemia 2012;26:2086-2095.
    • (2012) Leukemia , vol.26 , pp. 2086-2095
    • Kramarzova, K.1
  • 54
    • 84885967382 scopus 로고    scopus 로고
    • Acquired mutations that affect pre-mRNA splicing in hematologic malignancies and solid tumors
    • Scott LM, Rebel VI. Acquired mutations that affect pre-mRNA splicing in hematologic malignancies and solid tumors. J Natl Cancer Inst 2013;105:1540-1549.
    • (2013) J Natl Cancer Inst , vol.105 , pp. 1540-1549
    • Scott, L.M.1    Rebel, V.I.2
  • 55
    • 84886683522 scopus 로고    scopus 로고
    • Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle
    • Risso G, et al. Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle. Cell Cycle 2013;12:3165-3174.
    • (2013) Cell Cycle , vol.12 , pp. 3165-3174
    • Risso, G.1
  • 56
    • 84862777672 scopus 로고    scopus 로고
    • A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
    • Ng KP, et al. A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer. Nat Med 2012;18:521-528.
    • (2012) Nat Med , vol.18 , pp. 521-528
    • Ng, K.P.1
  • 57
    • 84863393843 scopus 로고    scopus 로고
    • The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation
    • Anczukow O, et al. The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nat Struct Mol Biol 2012;19:220-228.
    • (2012) Nat Struct Mol Biol , vol.19 , pp. 220-228
    • Anczukow, O.1
  • 58
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 59
    • 0036277787 scopus 로고    scopus 로고
    • BCR/ABL p210, p190 and p230 fusion genes in 250 Mexican patients with chronic myeloid leukaemia (CML)
    • Arana-Trejo RM, et al. BCR/ABL p210, p190 and p230 fusion genes in 250 Mexican patients with chronic myeloid leukaemia (CML). Clin Lab Haematol 2002;24:145-150.
    • (2002) Clin Lab Haematol , vol.24 , pp. 145-150
    • Arana-Trejo, R.M.1
  • 60
    • 33746064087 scopus 로고    scopus 로고
    • A distinct p53 protein isoform signature reflects the onset of induction chemotherapy for acute myeloid leukemia
    • Anensen N, Oyan AM, Bourdon JC, Kalland KH, Bruserud O, Gjertsen BT. A distinct p53 protein isoform signature reflects the onset of induction chemotherapy for acute myeloid leukemia. Clin Cancer Res 2006;12:3985-3992.
    • (2006) Clin Cancer Res , vol.12 , pp. 3985-3992
    • Anensen, N.1    Oyan, A.M.2    Bourdon, J.C.3    Kalland, K.H.4    Bruserud, O.5    Gjertsen, B.T.6
  • 61
    • 0033104708 scopus 로고    scopus 로고
    • Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-apoptotic activities
    • Konopleva M, et al. Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-apoptotic activities. Blood 1999;93:1668-1676.
    • (1999) Blood , vol.93 , pp. 1668-1676
    • Konopleva, M.1
  • 62
    • 84878900540 scopus 로고    scopus 로고
    • Clonal diversity of recurrently mutated genes in myelodysplastic syndromes
    • Walter MJ, et al. Clonal diversity of recurrently mutated genes in myelodysplastic syndromes. Leukemia 2013;27:1275-1282.
    • (2013) Leukemia , vol.27 , pp. 1275-1282
    • Walter, M.J.1
  • 63
    • 80053900941 scopus 로고    scopus 로고
    • Frequent pathway mutations of splicing machinery in myelodysplasia
    • Yoshida K, et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 2011;478:64-69.
    • (2011) Nature , vol.478 , pp. 64-69
    • Yoshida, K.1
  • 64
    • 80054010617 scopus 로고    scopus 로고
    • Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts
    • Papaemmanuil E, et al. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med 2011;365:1384-1395.
    • (2011) N Engl J Med , vol.365 , pp. 1384-1395
    • Papaemmanuil, E.1
  • 65
    • 34848855566 scopus 로고    scopus 로고
    • The U1 snRNP-associated factor Luc7p affects 5′ splice site selection in yeast and human
    • Puig O, Bragado-Nilsson E, Koski T, Seraphin B. The U1 snRNP-associated factor Luc7p affects 5′ splice site selection in yeast and human. Nucleic Acids Res 2007;35:5874-5885.
    • (2007) Nucleic Acids Res , vol.35 , pp. 5874-5885
    • Puig, O.1    Bragado-Nilsson, E.2    Koski, T.3    Seraphin, B.4
  • 66
    • 84868208186 scopus 로고    scopus 로고
    • Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
    • Busque L, et al. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet 2012;44:1179-1181.
    • (2012) Nat Genet , vol.44 , pp. 1179-1181
    • Busque, L.1
  • 67
    • 84891159388 scopus 로고    scopus 로고
    • Role of DNMT3A, TET2, and IDH1/2 mutations in pre-leukemic stem cells in acute myeloid leukemia
    • Chan SM, Majeti R. Role of DNMT3A, TET2, and IDH1/2 mutations in pre-leukemic stem cells in acute myeloid leukemia. Int J Hematol 2013;98:648-657.
    • (2013) Int J Hematol , vol.98 , pp. 648-657
    • Chan, S.M.1    Majeti, R.2
  • 68
    • 84888219405 scopus 로고    scopus 로고
    • Clinical and biological implications of driver mutations in myelodysplastic syndromes
    • quiz 3699.
    • Papaemmanuil E, et al. Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood 2013;122:3616-3627; quiz 3699.
    • (2013) Blood , vol.122 , pp. 3616-3627
    • Papaemmanuil, E.1
  • 69
    • 84863337617 scopus 로고    scopus 로고
    • Clonal architecture of secondary acute myeloid leukemia
    • Walter MJ, et al. Clonal architecture of secondary acute myeloid leukemia. N Engl J Med 2012;366:1090-1098.
    • (2012) N Engl J Med , vol.366 , pp. 1090-1098
    • Walter, M.J.1
  • 70
    • 84904405761 scopus 로고    scopus 로고
    • SF3B1 mutations in patients with myelodysplastic syndromes: the mutation is stable during disease evolution
    • Lin CC, et al. SF3B1 mutations in patients with myelodysplastic syndromes: the mutation is stable during disease evolution. Am J Hematol 2014;89:E109-E115.
    • (2014) Am J Hematol , vol.89 , pp. E109-E115
    • Lin, C.C.1
  • 71
    • 84886257256 scopus 로고    scopus 로고
    • Clinical implications of U2AF1 mutation in patients with myelodysplastic syndrome and its stability during disease progression
    • Wu SJ, et al. Clinical implications of U2AF1 mutation in patients with myelodysplastic syndrome and its stability during disease progression. Am J Hematol 2013;88:E277-E282.
    • (2013) Am J Hematol , vol.88 , pp. E277-E282
    • Wu, S.J.1
  • 72
    • 84879692782 scopus 로고    scopus 로고
    • In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation
    • Keightley MC, et al. In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation. FEBS Lett 2013;587:2150-2157.
    • (2013) FEBS Lett , vol.587 , pp. 2150-2157
    • Keightley, M.C.1
  • 73
    • 84879565619 scopus 로고    scopus 로고
    • Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome
    • Mian SA, et al. Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome. Haematologica 2013;98:1058-1066.
    • (2013) Haematologica , vol.98 , pp. 1058-1066
    • Mian, S.A.1
  • 74
    • 0032880119 scopus 로고    scopus 로고
    • Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155
    • Das BK, Xia L, Palandjian L, Gozani O, Chyung Y, Reed R. Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155. Mol Cell Biol 1999;19:6796-6802.
    • (1999) Mol Cell Biol , vol.19 , pp. 6796-6802
    • Das, B.K.1    Xia, L.2    Palandjian, L.3    Gozani, O.4    Chyung, Y.5    Reed, R.6
  • 75
    • 84903169674 scopus 로고    scopus 로고
    • Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia
    • Wang C, et al. Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia. Blood 2014;123:3336-3343.
    • (2014) Blood , vol.123 , pp. 3336-3343
    • Wang, C.1
  • 76
    • 84908299112 scopus 로고    scopus 로고
    • Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia
    • Matsunawa M, et al. Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia. Leukemia 2014;28:1844-1850.
    • (2014) Leukemia , vol.28 , pp. 1844-1850
    • Matsunawa, M.1
  • 77
    • 15244359121 scopus 로고    scopus 로고
    • Major conformational change in the complex SF3b upon integration into the spliceosomal U11/U12 di-snRNP as revealed by electron cryomicroscopy
    • Golas MM, Sander B, Will CL, Luhrmann R, Stark H. Major conformational change in the complex SF3b upon integration into the spliceosomal U11/U12 di-snRNP as revealed by electron cryomicroscopy. Mol Cell 2005;17:869-883.
    • (2005) Mol Cell , vol.17 , pp. 869-883
    • Golas, M.M.1    Sander, B.2    Will, C.L.3    Luhrmann, R.4    Stark, H.5
  • 78
    • 84555191727 scopus 로고    scopus 로고
    • Spliceosome mutations in hematopoietic malignancies
    • Hahn CN, Scott HS. Spliceosome mutations in hematopoietic malignancies. Nat Genet 2011;44:9-10.
    • (2011) Nat Genet , vol.44 , pp. 9-10
    • Hahn, C.N.1    Scott, H.S.2
  • 79
    • 84862854953 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia with SF3B1 mutation
    • Quesada V, Ramsay AJ, Lopez-Otin C. Chronic lymphocytic leukemia with SF3B1 mutation. N Engl J Med 2012;366:2530.
    • (2012) N Engl J Med , vol.366 , pp. 2530
    • Quesada, V.1    Ramsay, A.J.2    Lopez-Otin, C.3
  • 80
    • 84857994411 scopus 로고    scopus 로고
    • SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts
    • Visconte V, et al. SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts. Leukemia 2012a;26:542-545.
    • (2012) Leukemia , vol.26 , pp. 542-545
    • Visconte, V.1
  • 81
    • 84855370035 scopus 로고    scopus 로고
    • SF3B1 and other novel cancer genes in chronic lymphocytic leukemia
    • Wang L, et al. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med 2011;365:2497-2506.
    • (2011) N Engl J Med , vol.365 , pp. 2497-2506
    • Wang, L.1
  • 82
    • 84869091997 scopus 로고    scopus 로고
    • Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
    • Biankin AV, et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 2012;491:399-405.
    • (2012) Nature , vol.491 , pp. 399-405
    • Biankin, A.V.1
  • 83
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Network CGA. Comprehensive molecular portraits of human breast tumours. Nature 2012;490:61-70.
    • (2012) Nature , vol.490 , pp. 61-70
    • Network, C.G.A.1
  • 84
    • 84885615233 scopus 로고    scopus 로고
    • SF3B1 mutations are associated with alternative splicing in uveal melanoma
    • Furney SJ, et al. SF3B1 mutations are associated with alternative splicing in uveal melanoma. Cancer Discov 2013;3:1122-1129.
    • (2013) Cancer Discov , vol.3 , pp. 1122-1129
    • Furney, S.J.1
  • 86
    • 84904051768 scopus 로고    scopus 로고
    • Rare SF3B1 R625 mutations in cutaneous melanoma
    • Kong Y, Krauthammer M, Halaban R. Rare SF3B1 R625 mutations in cutaneous melanoma. Melanoma Res 2014;24:332-334.
    • (2014) Melanoma Res , vol.24 , pp. 332-334
    • Kong, Y.1    Krauthammer, M.2    Halaban, R.3
  • 87
    • 84877926730 scopus 로고    scopus 로고
    • The significance of spliceosome mutations in chronic lymphocytic leukemia
    • Rozovski U, Keating M, Estrov Z. The significance of spliceosome mutations in chronic lymphocytic leukemia. Leuk Lymphoma 2012;54:1364-1366.
    • (2012) Leuk Lymphoma , vol.54 , pp. 1364-1366
    • Rozovski, U.1    Keating, M.2    Estrov, Z.3
  • 88
    • 84859595800 scopus 로고    scopus 로고
    • Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes
    • Damm F, et al. Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes. Blood 2012;119:3211-3218.
    • (2012) Blood , vol.119 , pp. 3211-3218
    • Damm, F.1
  • 89
    • 83455234787 scopus 로고    scopus 로고
    • Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms
    • Malcovati L, et al. Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms. Blood 2011;118:6239-6246.
    • (2011) Blood , vol.118 , pp. 6239-6246
    • Malcovati, L.1
  • 90
    • 84868091622 scopus 로고    scopus 로고
    • SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes
    • Visconte V, et al. SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes. Blood 2012b;120:3173-3186.
    • (2012) Blood , vol.120 , pp. 3173-3186
    • Visconte, V.1
  • 91
    • 84920663583 scopus 로고    scopus 로고
    • Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron
    • Visconte V, et al. Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron. Leukemia 2014; doi: 10.1038/leu.2014.170. [Epub ahead of print].
    • (2014) Leukemia
    • Visconte, V.1
  • 92
    • 84859597590 scopus 로고    scopus 로고
    • Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis
    • Makishima H, et al. Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis. Blood 2012;119:3203-3210.
    • (2012) Blood , vol.119 , pp. 3203-3210
    • Makishima, H.1
  • 93
    • 0033576626 scopus 로고    scopus 로고
    • Functional recognition of the 3′ splice site AG by the splicing factor U2AF35
    • Wu S, Romfo CM, Nilsen TW, Green MR. Functional recognition of the 3′ splice site AG by the splicing factor U2AF35. Nature 1999;402:832-835.
    • (1999) Nature , vol.402 , pp. 832-835
    • Wu, S.1    Romfo, C.M.2    Nilsen, T.W.3    Green, M.R.4
  • 95
    • 84555192302 scopus 로고    scopus 로고
    • Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
    • Graubert TA, et al. Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat Genet 2011;44:53-57.
    • (2011) Nat Genet , vol.44 , pp. 53-57
    • Graubert, T.A.1
  • 96
    • 84899748605 scopus 로고    scopus 로고
    • A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events
    • Brooks AN, et al. A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events. PLoS ONE 2014;9:e87361.
    • (2014) PLoS ONE , vol.9 , pp. e87361
    • Brooks, A.N.1
  • 97
    • 84886905271 scopus 로고    scopus 로고
    • Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms
    • Przychodzen B, et al. Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms. Blood 2013;122:999-1006.
    • (2013) Blood , vol.122 , pp. 999-1006
    • Przychodzen, B.1
  • 98
    • 84920688391 scopus 로고    scopus 로고
    • U2AF1 mutations alter splice site recognition in hematological malignancies
    • Ilagan JO, et al. U2AF1 mutations alter splice site recognition in hematological malignancies. Genome Res 2014; doi: 10.1101/gr.181016.114. [Epub ahead of print].
    • (2014) Genome Res
    • Ilagan, J.O.1
  • 99
    • 84855841586 scopus 로고    scopus 로고
    • SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value
    • Patnaik MM, et al. SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value. Blood 2012;119:569-572.
    • (2012) Blood , vol.119 , pp. 569-572
    • Patnaik, M.M.1
  • 101
    • 17844395704 scopus 로고    scopus 로고
    • Prp8 protein: at the heart of the spliceosome
    • Grainger RJ, Beggs JD. Prp8 protein: at the heart of the spliceosome. RNA 2005;11:533-557.
    • (2005) RNA , vol.11 , pp. 533-557
    • Grainger, R.J.1    Beggs, J.D.2
  • 102
    • 84873629024 scopus 로고    scopus 로고
    • Crystal structure of Prp8 reveals active site cavity of the spliceosome
    • Galej WP, Oubridge C, Newman AJ, Nagai K. Crystal structure of Prp8 reveals active site cavity of the spliceosome. Nature 2013;493:638-643.
    • (2013) Nature , vol.493 , pp. 638-643
    • Galej, W.P.1    Oubridge, C.2    Newman, A.J.3    Nagai, K.4
  • 103
    • 0028016354 scopus 로고
    • U4/U5/U6 snRNP recognizes the 5′ splice site in the absence of U2 snRNP
    • Konforti BB, Konarska MM. U4/U5/U6 snRNP recognizes the 5′ splice site in the absence of U2 snRNP. Genes Dev 1994;8:1962-1973.
    • (1994) Genes Dev , vol.8 , pp. 1962-1973
    • Konforti, B.B.1    Konarska, M.M.2
  • 104
    • 84920675692 scopus 로고    scopus 로고
    • PRPF8 defects cause missplicing in myeloid malignancies
    • Kurtovic-Kozaric A, et al. PRPF8 defects cause missplicing in myeloid malignancies. Leukemia 2014; doi: 10.1038/leu.2014.144. [Epub ahead of print].
    • (2014) Leukemia
    • Kurtovic-Kozaric, A.1
  • 105
    • 14644431836 scopus 로고    scopus 로고
    • Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1
    • Isono K, Mizutani-Koseki Y, Komori T, Schmidt-Zachmann MS, Koseki H. Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes Dev 2005;19:536-541.
    • (2005) Genes Dev , vol.19 , pp. 536-541
    • Isono, K.1    Mizutani-Koseki, Y.2    Komori, T.3    Schmidt-Zachmann, M.S.4    Koseki, H.5
  • 106
    • 34547190674 scopus 로고    scopus 로고
    • Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis
    • Xiao R, et al. Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis. Mol Cell Biol 2007;27:5393-5402.
    • (2007) Mol Cell Biol , vol.27 , pp. 5393-5402
    • Xiao, R.1
  • 107
    • 79551602983 scopus 로고    scopus 로고
    • Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin
    • Edmond V, et al. Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin. EMBO J 2011;30:510-523.
    • (2011) EMBO J , vol.30 , pp. 510-523
    • Edmond, V.1
  • 108
    • 79959215165 scopus 로고    scopus 로고
    • SRSF2 is required for sodium butyrate-mediated p21(WAF1) induction and premature senescence in human lung carcinoma cell lines
    • Edmond V, Brambilla C, Brambilla E, Gazzeri S, Eymin B. SRSF2 is required for sodium butyrate-mediated p21(WAF1) induction and premature senescence in human lung carcinoma cell lines. Cell Cycle 2011;10:1968-1977.
    • (2011) Cell Cycle , vol.10 , pp. 1968-1977
    • Edmond, V.1    Brambilla, C.2    Brambilla, E.3    Gazzeri, S.4    Eymin, B.5
  • 109
    • 84859856420 scopus 로고    scopus 로고
    • Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes
    • Thol F, et al. Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes. Blood 2012;119:3578-3584.
    • (2012) Blood , vol.119 , pp. 3578-3584
    • Thol, F.1
  • 110
    • 84887374002 scopus 로고    scopus 로고
    • Unique role of SRSF2 in transcription activation and diverse functions of the SR and hnRNP proteins in gene expression regulation
    • Mo S, Ji X, Fu XD. Unique role of SRSF2 in transcription activation and diverse functions of the SR and hnRNP proteins in gene expression regulation. Transcription 2013;4:251-259.
    • (2013) Transcription , vol.4 , pp. 251-259
    • Mo, S.1    Ji, X.2    Fu, X.D.3
  • 111
    • 84866749552 scopus 로고    scopus 로고
    • Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes
    • Bejar R, et al. Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes. J Clin Oncol 2012;30:3376-3382.
    • (2012) J Clin Oncol , vol.30 , pp. 3376-3382
    • Bejar, R.1
  • 112
    • 84902147114 scopus 로고    scopus 로고
    • Genomic landscape of CD34+ hematopoietic cells in myelodysplastic syndrome and gene mutation profiles as prognostic markers
    • Xu L, et al. Genomic landscape of CD34+ hematopoietic cells in myelodysplastic syndrome and gene mutation profiles as prognostic markers. Proc Natl Acad Sci USA 2014;111:8589-8594.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 8589-8594
    • Xu, L.1
  • 113
    • 84864054209 scopus 로고    scopus 로고
    • GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia
    • Greif PA, et al. GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia. Blood 2012;120:395-403.
    • (2012) Blood , vol.120 , pp. 395-403
    • Greif, P.A.1
  • 114
    • 34247172535 scopus 로고    scopus 로고
    • Myelodysplastic syndromes: incidence and survival in the United States
    • Ma X, Does M, Raza A, Mayne ST. Myelodysplastic syndromes: incidence and survival in the United States. Cancer 2007;109:1536-1542.
    • (2007) Cancer , vol.109 , pp. 1536-1542
    • Ma, X.1    Does, M.2    Raza, A.3    Mayne, S.T.4
  • 116
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
    • Vardiman JW, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009;114:937-951.
    • (2009) Blood , vol.114 , pp. 937-951
    • Vardiman, J.W.1
  • 117
    • 0030897009 scopus 로고    scopus 로고
    • International scoring system for evaluating prognosis in myelodysplastic syndromes
    • Greenberg P, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997;89:2079-2088.
    • (1997) Blood , vol.89 , pp. 2079-2088
    • Greenberg, P.1
  • 118
    • 84866621729 scopus 로고    scopus 로고
    • Revised international prognostic scoring system for myelodysplastic syndromes
    • Greenberg PL, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood 2012;120:2454-2465.
    • (2012) Blood , vol.120 , pp. 2454-2465
    • Greenberg, P.L.1
  • 119
    • 39649094569 scopus 로고    scopus 로고
    • New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients
    • Haase D, et al. New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients. Blood 2007;110:4385-4395.
    • (2007) Blood , vol.110 , pp. 4385-4395
    • Haase, D.1
  • 120
    • 84878328784 scopus 로고    scopus 로고
    • Interpreting new molecular genetics in myelodysplastic syndromes
    • Abdel-Wahab O, Figueroa ME. Interpreting new molecular genetics in myelodysplastic syndromes. Hematology 2012;2012:56-64.
    • (2012) Hematology , vol.2012 , pp. 56-64
    • Abdel-Wahab, O.1    Figueroa, M.E.2
  • 121
    • 84893772765 scopus 로고    scopus 로고
    • Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
    • Haferlach T, et al. Landscape of genetic lesions in 944 patients with myelodysplastic syndromes. Leukemia 2014;28:241-247.
    • (2014) Leukemia , vol.28 , pp. 241-247
    • Haferlach, T.1
  • 122
    • 79959794787 scopus 로고    scopus 로고
    • Clinical effect of point mutations in myelodysplastic syndromes
    • Bejar R, et al. Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med 2011;364:2496-2506.
    • (2011) N Engl J Med , vol.364 , pp. 2496-2506
    • Bejar, R.1
  • 123
    • 84907346397 scopus 로고    scopus 로고
    • Driver somatic mutations identify distinct disease entities within myeloid neoplasms with myelodysplasia
    • Malcovati L, et al. Driver somatic mutations identify distinct disease entities within myeloid neoplasms with myelodysplasia. Blood 2014;124:1513-1521.
    • (2014) Blood , vol.124 , pp. 1513-1521
    • Malcovati, L.1
  • 124
    • 84883637783 scopus 로고    scopus 로고
    • SF3B1 mutations are infrequently found in non-myelodysplastic bone marrow failure syndromes and mast cell diseases but, if present, are associated with the ring sideroblast phenotype
    • Visconte V, et al. SF3B1 mutations are infrequently found in non-myelodysplastic bone marrow failure syndromes and mast cell diseases but, if present, are associated with the ring sideroblast phenotype. Haematologica 2013;98:e105-e107.
    • (2013) Haematologica , vol.98 , pp. e105-e107
    • Visconte, V.1
  • 125
    • 84860767817 scopus 로고    scopus 로고
    • SF3B1 mutations in myelodysplastic syndromes: clinical associations and prognostic implications
    • Damm F, et al. SF3B1 mutations in myelodysplastic syndromes: clinical associations and prognostic implications. Leukemia 2012;26:1137-1140.
    • (2012) Leukemia , vol.26 , pp. 1137-1140
    • Damm, F.1
  • 126
    • 84860782819 scopus 로고    scopus 로고
    • SF3B1 mutations in primary myelofibrosis: clinical, histopathology and genetic correlates among 155 patients
    • Lasho TL, et al. SF3B1 mutations in primary myelofibrosis: clinical, histopathology and genetic correlates among 155 patients. Leukemia 2012a;26:1135-1137.
    • (2012) Leukemia , vol.26 , pp. 1135-1137
    • Lasho, T.L.1
  • 127
    • 84555171449 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
    • Quesada V, et al. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet 2012;44:47-52.
    • (2012) Nat Genet , vol.44 , pp. 47-52
    • Quesada, V.1
  • 128
    • 84255160977 scopus 로고    scopus 로고
    • Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness
    • Rossi D, et al. Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness. Blood 2011;118:6904-6908.
    • (2011) Blood , vol.118 , pp. 6904-6908
    • Rossi, D.1
  • 129
    • 84555192302 scopus 로고    scopus 로고
    • Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
    • Graubert TA, et al. Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat Genet 2012;44:53-57.
    • (2012) Nat Genet , vol.44 , pp. 53-57
    • Graubert, T.A.1
  • 130
    • 0033117879 scopus 로고    scopus 로고
    • Structure and assembly of the spliceosomal small nuclear ribonucleoprotein particles
    • Kambach C, Walke S, Nagai K. Structure and assembly of the spliceosomal small nuclear ribonucleoprotein particles. Curr Opin Struct Biol 1999;9:222-230.
    • (1999) Curr Opin Struct Biol , vol.9 , pp. 222-230
    • Kambach, C.1    Walke, S.2    Nagai, K.3
  • 131
    • 84922336738 scopus 로고    scopus 로고
    • Prognostic score including gene mutations in chronic myelomonocytic leukemia
    • Itzykson R, et al. Prognostic score including gene mutations in chronic myelomonocytic leukemia. J Clin Oncol 2013;31:2428-2436.
    • (2013) J Clin Oncol , vol.31 , pp. 2428-2436
    • Itzykson, R.1
  • 132
    • 84861082246 scopus 로고    scopus 로고
    • Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome
    • Zhang SJ, et al. Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome. Blood 2012;119:4480-4485.
    • (2012) Blood , vol.119 , pp. 4480-4485
    • Zhang, S.J.1
  • 133
    • 33745615399 scopus 로고    scopus 로고
    • Gene expression profiles of CD34+ cells in myelodysplastic syndromes: involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype
    • Pellagatti A, et al. Gene expression profiles of CD34+ cells in myelodysplastic syndromes: involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype. Blood 2006;108:337-345.
    • (2006) Blood , vol.108 , pp. 337-345
    • Pellagatti, A.1
  • 134
    • 44849143798 scopus 로고    scopus 로고
    • The role of the iron transporter ABCB7 in refractory anemia with ring sideroblasts
    • Boultwood J, et al. The role of the iron transporter ABCB7 in refractory anemia with ring sideroblasts. PLoS ONE 2008;3:e1970.
    • (2008) PLoS ONE , vol.3 , pp. e1970
    • Boultwood, J.1
  • 135
    • 77952682066 scopus 로고    scopus 로고
    • Gene expression profiling of erythroblasts from refractory anaemia with ring sideroblasts (RARS) and effects of G-CSF
    • Nikpour M, et al. Gene expression profiling of erythroblasts from refractory anaemia with ring sideroblasts (RARS) and effects of G-CSF. Br J Haematol 2010;149:844-854.
    • (2010) Br J Haematol , vol.149 , pp. 844-854
    • Nikpour, M.1
  • 136
    • 84876107840 scopus 로고    scopus 로고
    • The transporter ABCB7 is a mediator of the phenotype of acquired refractory anemia with ring sideroblasts
    • Nikpour M, et al. The transporter ABCB7 is a mediator of the phenotype of acquired refractory anemia with ring sideroblasts. Leukemia 2013;27:889-896.
    • (2013) Leukemia , vol.27 , pp. 889-896
    • Nikpour, M.1
  • 137
    • 79953074952 scopus 로고    scopus 로고
    • Recent advances in diagnosis, molecular pathology and therapy of chronic myelomonocytic leukaemia
    • Bacher U, Haferlach T, Schnittger S, Kreipe H, Kroger N. Recent advances in diagnosis, molecular pathology and therapy of chronic myelomonocytic leukaemia. Br J Haematol 2011;153:149-167.
    • (2011) Br J Haematol , vol.153 , pp. 149-167
    • Bacher, U.1    Haferlach, T.2    Schnittger, S.3    Kreipe, H.4    Kroger, N.5
  • 138
    • 2542537480 scopus 로고    scopus 로고
    • Risk assessment in chronic myelomonocytic leukemia (CMML)
    • Germing U, Kundgen A, Gattermann N. Risk assessment in chronic myelomonocytic leukemia (CMML). Leuk Lymphoma 2004;45:1311-1318.
    • (2004) Leuk Lymphoma , vol.45 , pp. 1311-1318
    • Germing, U.1    Kundgen, A.2    Gattermann, N.3
  • 139
    • 0036464647 scopus 로고    scopus 로고
    • Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients
    • Onida F, et al. Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients. Blood 2002;99:840-849.
    • (2002) Blood , vol.99 , pp. 840-849
    • Onida, F.1
  • 140
    • 53149113768 scopus 로고    scopus 로고
    • Proposal for a new risk model in myelodysplastic syndrome that accounts for events not considered in the original International Prognostic Scoring System
    • Kantarjian H, et al. Proposal for a new risk model in myelodysplastic syndrome that accounts for events not considered in the original International Prognostic Scoring System. Cancer 2008;113:1351-1361.
    • (2008) Cancer , vol.113 , pp. 1351-1361
    • Kantarjian, H.1
  • 141
    • 0023881235 scopus 로고
    • Prognostic features of chronic myelomonocytic leukaemia: a modified Bournemouth score gives the best prediction of survival
    • Worsley A, et al. Prognostic features of chronic myelomonocytic leukaemia: a modified Bournemouth score gives the best prediction of survival. Br J Haematol 1988;68:17-21.
    • (1988) Br J Haematol , vol.68 , pp. 17-21
    • Worsley, A.1
  • 142
    • 84872085802 scopus 로고    scopus 로고
    • Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia
    • Kar SA, et al. Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia. Haematologica 2013;98:107-113.
    • (2013) Haematologica , vol.98 , pp. 107-113
    • Kar, S.A.1
  • 143
    • 84874303759 scopus 로고    scopus 로고
    • Spliceosome mutations involving SRSF2, SF3B1, and U2AF35 in chronic myelomonocytic leukemia: prevalence, clinical correlates, and prognostic relevance
    • Patnaik MM, et al. Spliceosome mutations involving SRSF2, SF3B1, and U2AF35 in chronic myelomonocytic leukemia: prevalence, clinical correlates, and prognostic relevance. Am J Hematol 2013a;88:201-206.
    • (2013) Am J Hematol , vol.88 , pp. 201-206
    • Patnaik, M.M.1
  • 144
    • 84867253750 scopus 로고    scopus 로고
    • SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)
    • Meggendorfer M, et al. SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML). Blood 2012;120:3080-3088.
    • (2012) Blood , vol.120 , pp. 3080-3088
    • Meggendorfer, M.1
  • 145
    • 84922332658 scopus 로고    scopus 로고
    • ASXL1 and SETBP1 mutations and their prognostic contribution in chronic myelomonocytic leukemia: a two-center study of 466 patients
    • [Eoub ahead of print].
    • Patnaik MM, et al. ASXL1 and SETBP1 mutations and their prognostic contribution in chronic myelomonocytic leukemia: a two-center study of 466 patients. Leukemia 2014;10.1038/leu.2014.125. [Eoub ahead of print].
    • (2014) Leukemia
    • Patnaik, M.M.1
  • 146
    • 84880263477 scopus 로고    scopus 로고
    • Mayo prognostic model for WHO-defined chronic myelomonocytic leukemia: ASXL1 and spliceosome component mutations and outcomes
    • Patnaik MM, et al. Mayo prognostic model for WHO-defined chronic myelomonocytic leukemia: ASXL1 and spliceosome component mutations and outcomes. Leukemia 2013b;27:1504-1510.
    • (2013) Leukemia , vol.27 , pp. 1504-1510
    • Patnaik, M.M.1
  • 147
    • 84858672060 scopus 로고    scopus 로고
    • Spliceosomal gene aberrations are rare, coexist with oncogenic mutations, and are unlikely to exert a driver effect in childhood MDS and JMML
    • Hirabayashi S, et al. Spliceosomal gene aberrations are rare, coexist with oncogenic mutations, and are unlikely to exert a driver effect in childhood MDS and JMML. Blood 2012;119:e96-e99.
    • (2012) Blood , vol.119 , pp. e96-e99
    • Hirabayashi, S.1
  • 148
    • 84875670242 scopus 로고    scopus 로고
    • Molecular similarity between myelodysplastic form of chronic myelomonocytic leukemia and refractory anemia with ring sideroblasts
    • Gelsi-Boyer V, et al. Molecular similarity between myelodysplastic form of chronic myelomonocytic leukemia and refractory anemia with ring sideroblasts. Haematologica 2013;98:576-583.
    • (2013) Haematologica , vol.98 , pp. 576-583
    • Gelsi-Boyer, V.1
  • 149
    • 33750299561 scopus 로고    scopus 로고
    • The JAK2 V617F mutation is rare in RARS but common in RARS-T
    • Ceesay MM, et al. The JAK2 V617F mutation is rare in RARS but common in RARS-T. Leukemia 2006;20:2060-2061.
    • (2006) Leukemia , vol.20 , pp. 2060-2061
    • Ceesay, M.M.1
  • 150
    • 84875283054 scopus 로고    scopus 로고
    • High frequencies of SF3B1 and JAK2 mutations in refractory anemia with ring sideroblasts associated with marked thrombocytosis strengthen the assignment to the category of myelodysplastic/myeloproliferative neoplasms
    • Jeromin S, et al. High frequencies of SF3B1 and JAK2 mutations in refractory anemia with ring sideroblasts associated with marked thrombocytosis strengthen the assignment to the category of myelodysplastic/myeloproliferative neoplasms. Haematologica 2013;98:e15-e17.
    • (2013) Haematologica , vol.98 , pp. e15-e17
    • Jeromin, S.1
  • 151
    • 84883741044 scopus 로고    scopus 로고
    • Age, JAK2(V617F) and SF3B1 mutations are the main predicting factors for survival in refractory anaemia with ring sideroblasts and marked thrombocytosis
    • Broseus J, et al. Age, JAK2(V617F) and SF3B1 mutations are the main predicting factors for survival in refractory anaemia with ring sideroblasts and marked thrombocytosis. Leukemia 2013;27:1826-1831.
    • (2013) Leukemia , vol.27 , pp. 1826-1831
    • Broseus, J.1
  • 152
    • 84890328032 scopus 로고    scopus 로고
    • Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2
    • Nangalia J, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med 2013;369:2391-2405.
    • (2013) N Engl J Med , vol.369 , pp. 2391-2405
    • Nangalia, J.1
  • 153
    • 84893717057 scopus 로고    scopus 로고
    • U2AF1 mutations in primary myelofibrosis are strongly associated with anemia and thrombocytopenia despite clustering with JAK2V617F and normal karyotype
    • Tefferi A, et al. U2AF1 mutations in primary myelofibrosis are strongly associated with anemia and thrombocytopenia despite clustering with JAK2V617F and normal karyotype. Leukemia 2014a;28:431-433.
    • (2014) Leukemia , vol.28 , pp. 431-433
    • Tefferi, A.1
  • 154
    • 84869786872 scopus 로고    scopus 로고
    • SRSF2 mutations in primary myelofibrosis: significant clustering with IDH mutations and independent association with inferior overall and leukemia-free survival
    • Lasho TL, et al. SRSF2 mutations in primary myelofibrosis: significant clustering with IDH mutations and independent association with inferior overall and leukemia-free survival. Blood 2012b;120:4168-4171.
    • (2012) Blood , vol.120 , pp. 4168-4171
    • Lasho, T.L.1
  • 155
    • 84904042955 scopus 로고    scopus 로고
    • CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons
    • Tefferi A, et al. CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons. Leukemia 2014b;28:1472-1477.
    • (2014) Leukemia , vol.28 , pp. 1472-1477
    • Tefferi, A.1
  • 156
    • 84876131053 scopus 로고    scopus 로고
    • Mutations of epigenetic regulators and of the spliceosome machinery in therapy-related myeloid neoplasms and in acute leukemias evolved from chronic myeloproliferative diseases
    • Voso MT, et al. Mutations of epigenetic regulators and of the spliceosome machinery in therapy-related myeloid neoplasms and in acute leukemias evolved from chronic myeloproliferative diseases. Leukemia 2013;27:982-985.
    • (2013) Leukemia , vol.27 , pp. 982-985
    • Voso, M.T.1
  • 157
    • 84891866590 scopus 로고    scopus 로고
    • SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients
    • Jeromin S, et al. SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients. Leukemia 2014;28:108-117.
    • (2014) Leukemia , vol.28 , pp. 108-117
    • Jeromin, S.1
  • 158
    • 84873567287 scopus 로고    scopus 로고
    • NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia
    • Mansouri L, et al. NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia. Leukemia 2013;27:512-514.
    • (2013) Leukemia , vol.27 , pp. 512-514
    • Mansouri, L.1
  • 159
    • 84901408966 scopus 로고    scopus 로고
    • Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial
    • Stilgenbauer S, et al. Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial. Blood 2014;123:3247-3254.
    • (2014) Blood , vol.123 , pp. 3247-3254
    • Stilgenbauer, S.1
  • 160
    • 84874929638 scopus 로고    scopus 로고
    • Analysis of SF3B1 mutations in monoclonal B-cell lymphocytosis
    • Greco M, et al. Analysis of SF3B1 mutations in monoclonal B-cell lymphocytosis. Hematol Oncol 2013;31:54-55.
    • (2013) Hematol Oncol , vol.31 , pp. 54-55
    • Greco, M.1
  • 161
    • 84872469222 scopus 로고    scopus 로고
    • The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial
    • Oscier DG, et al. The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial. Blood 2013;121:468-475.
    • (2013) Blood , vol.121 , pp. 468-475
    • Oscier, D.G.1
  • 162
    • 84887204270 scopus 로고    scopus 로고
    • NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG
    • Schnaiter A, et al. NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG. Blood 2013;122:1266-1270.
    • (2013) Blood , vol.122 , pp. 1266-1270
    • Schnaiter, A.1
  • 163
    • 84884741125 scopus 로고    scopus 로고
    • SF3B1 mutation is a rare event in Chinese patients with acute and chronic myeloid leukemia
    • Yang J, et al. SF3B1 mutation is a rare event in Chinese patients with acute and chronic myeloid leukemia. Clin Biochem 2013;46:701-703.
    • (2013) Clin Biochem , vol.46 , pp. 701-703
    • Yang, J.1
  • 164
    • 84922529491 scopus 로고    scopus 로고
    • Recurrent mutations refine prognosis in chronic lymphocytic leukemia
    • [Epub ahead of print].
    • Baliakas P, et al. Recurrent mutations refine prognosis in chronic lymphocytic leukemia. Leukemia 2014; doi:10.1038/leu.2014.196. [Epub ahead of print].
    • (2014) Leukemia
    • Baliakas, P.1
  • 165
    • 84874428346 scopus 로고    scopus 로고
    • Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia
    • Rossi D, et al. Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia. Blood 2013;121:1403-1412.
    • (2013) Blood , vol.121 , pp. 1403-1412
    • Rossi, D.1
  • 166
    • 84879173666 scopus 로고    scopus 로고
    • TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia: six-year follow-up of the GCLLSG CLL3X trial
    • Dreger P, et al. TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia: six-year follow-up of the GCLLSG CLL3X trial. Blood 2013;121:3284-3288.
    • (2013) Blood , vol.121 , pp. 3284-3288
    • Dreger, P.1
  • 167
    • 84869753284 scopus 로고    scopus 로고
    • Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns
    • Schuh A, et al. Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns. Blood 2012;120:4191-4196.
    • (2012) Blood , vol.120 , pp. 4191-4196
    • Schuh, A.1
  • 168
    • 36349025291 scopus 로고    scopus 로고
    • Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival
    • Stilgenbauer S, et al. Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival. Haematologica 2007;92:1242-1245.
    • (2007) Haematologica , vol.92 , pp. 1242-1245
    • Stilgenbauer, S.1
  • 169
    • 84874102335 scopus 로고    scopus 로고
    • Evolution and impact of subclonal mutations in chronic lymphocytic leukemia
    • Landau DA, et al. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell 2013;152:714-726.
    • (2013) Cell , vol.152 , pp. 714-726
    • Landau, D.A.1
  • 170
    • 33749438404 scopus 로고    scopus 로고
    • Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion
    • List A, et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med 2006;355:1456-1465.
    • (2006) N Engl J Med , vol.355 , pp. 1456-1465
    • List, A.1
  • 171
    • 1842865015 scopus 로고    scopus 로고
    • Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. II. Physico-chemical properties and structure elucidation
    • Sakai T, Asai N, Okuda A, Kawamura N, Mizui Y. Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. II. Physico-chemical properties and structure elucidation. J Antibiot 2004a;57:180-187.
    • (2004) J Antibiot , vol.57 , pp. 180-187
    • Sakai, T.1    Asai, N.2    Okuda, A.3    Kawamura, N.4    Mizui, Y.5
  • 172
    • 1842832148 scopus 로고    scopus 로고
    • Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening
    • Sakai T, Sameshima T, Matsufuji M, Kawamura N, Dobashi K, Mizui Y. Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening. J Antibiot 2004b;57:173-179.
    • (2004) J Antibiot , vol.57 , pp. 173-179
    • Sakai, T.1    Sameshima, T.2    Matsufuji, M.3    Kawamura, N.4    Dobashi, K.5    Mizui, Y.6
  • 173
    • 34548104659 scopus 로고    scopus 로고
    • Splicing factor SF3b as a target of the antitumor natural product pladienolide
    • Kotake Y, et al. Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat Chem Biol 2007;3:570-575.
    • (2007) Nat Chem Biol , vol.3 , pp. 570-575
    • Kotake, Y.1
  • 174
    • 82755192848 scopus 로고    scopus 로고
    • Biological validation that SF3b is a target of the antitumor macrolide pladienolide
    • Yokoi A, et al. Biological validation that SF3b is a target of the antitumor macrolide pladienolide. FEBS J 2011;278:4870-4880.
    • (2011) FEBS J , vol.278 , pp. 4870-4880
    • Yokoi, A.1
  • 175
    • 79952231064 scopus 로고    scopus 로고
    • The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region
    • Folco EG, Coil KE, Reed R. The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region. Genes Dev 2011;25:440-444.
    • (2011) Genes Dev , vol.25 , pp. 440-444
    • Folco, E.G.1    Coil, K.E.2    Reed, R.3
  • 176
    • 0030466895 scopus 로고    scopus 로고
    • New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action
    • Nakajima H, et al. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot 1996;49:1204-1211.
    • (1996) J Antibiot , vol.49 , pp. 1204-1211
    • Nakajima, H.1
  • 177
    • 0030461311 scopus 로고    scopus 로고
    • New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities
    • Nakajima H, Sato B, Fujita T, Takase S, Terano H, Okuhara M. New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J Antibiot 1996;49:1196-1203.
    • (1996) J Antibiot , vol.49 , pp. 1196-1203
    • Nakajima, H.1    Sato, B.2    Fujita, T.3    Takase, S.4    Terano, H.5    Okuhara, M.6
  • 178
    • 33847668813 scopus 로고    scopus 로고
    • Total syntheses, fragmentation studies, and antitumor/antiproliferative activities of FR901464 and its low picomolar analogue
    • Albert BJ, Sivaramakrishnan A, Naka T, Czaicki NL, Koide K. Total syntheses, fragmentation studies, and antitumor/antiproliferative activities of FR901464 and its low picomolar analogue. J Am Chem Soc 2007;129:2648-2659.
    • (2007) J Am Chem Soc , vol.129 , pp. 2648-2659
    • Albert, B.J.1    Sivaramakrishnan, A.2    Naka, T.3    Czaicki, N.L.4    Koide, K.5
  • 179
    • 78651417715 scopus 로고    scopus 로고
    • Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464
    • Osman S, Albert BJ, Wang Y, Li M, Czaicki NL, Koide K. Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464. Chemistry 2011;17:895-904.
    • (2011) Chemistry , vol.17 , pp. 895-904
    • Osman, S.1    Albert, B.J.2    Wang, Y.3    Li, M.4    Czaicki, N.L.5    Koide, K.6
  • 180
    • 34548095157 scopus 로고    scopus 로고
    • Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
    • Kaida D, et al. Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nat Chem Biol 2007;3:576-583.
    • (2007) Nat Chem Biol , vol.3 , pp. 576-583
    • Kaida, D.1
  • 181
    • 79961049732 scopus 로고    scopus 로고
    • Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing
    • Fan L, Lagisetti C, Edwards CC, Webb TR, Potter PM. Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing. ACS Chem Biol 2011;6:582-589.
    • (2011) ACS Chem Biol , vol.6 , pp. 582-589
    • Fan, L.1    Lagisetti, C.2    Edwards, C.C.3    Webb, T.R.4    Potter, P.M.5
  • 182
    • 70949100953 scopus 로고    scopus 로고
    • Synthetic mRNA splicing modulator compounds with in vivo antitumor activity
    • Lagisetti C, et al. Synthetic mRNA splicing modulator compounds with in vivo antitumor activity. J Med Chem 2009;52:6979-6990.
    • (2009) J Med Chem , vol.52 , pp. 6979-6990
    • Lagisetti, C.1
  • 183
    • 79955589140 scopus 로고    scopus 로고
    • Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms
    • Woolard J, et al. Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Chem Sci 2011;2011:273-278.
    • (2011) Chem Sci , vol.2011 , pp. 273-278
    • Woolard, J.1
  • 184
    • 80055072546 scopus 로고    scopus 로고
    • Antitumorigenic potential of STAT3 alternative splicing modulation
    • Zammarchi F, et al. Antitumorigenic potential of STAT3 alternative splicing modulation. Proc Natl Acad Sci USA 2011;108:17779-17784.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 17779-17784
    • Zammarchi, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.