Biological validation that SF3b is a target of the antitumor macrolide pladienolide

FEBS Journal

Volumn 278, Issue 24, 2011, Pages 4870-4880

  Yokoi, Akira ^a   Kotake, Yoshihiko ^a   Takahashi, Kentaro ^a   Kadowaki, Tadashi ^a   Matsumoto, Yoshiko ^a   Minoshima, Yukinori ^a   Sugi, Naoko H ^a   Sagane, Koji ^a   Hamaguchi, Makoto ^a   Iwata, Masao ^a   Mizui, Yoshiharu ^a  

^a EISAI CO LTD   (Japan)

Author keywords

antitumor activity; pladienolide; resistant mutation; SF3b; splicing inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; ARGININE; MACROLIDE; MESSENGER RNA; MUTANT PROTEIN; PLADIENOLIDE; PROTEIN SF3B; PROTEIN SF3B1; PROTEIN SUBUNIT; SMALL NUCLEAR RIBONUCLEOPROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER INHIBITION; CELL CLONE; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN DLD1; CELL STRAIN WIDR; COLORECTAL CANCER; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; GENE MUTATION; GENETIC CODE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; ISOTOPE LABELING; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RNA SEQUENCE; RNA SPLICING; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS;

CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; EPOXY COMPOUNDS; HUMANS; MACROLIDES; PHOSPHOPROTEINS; RIBONUCLEOPROTEIN, U2 SMALL NUCLEAR; RNA SPLICING;

EID: 82755192848     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08387.x     Document Type: Article

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