Synthetic mRNA splicing modulator compounds with in vivo antitumor activity

Journal of Medicinal Chemistry

Volumn 52, Issue 22, 2009, Pages 6979-6990

  Lagisetti, Chandraiah ^a   Pourpak, Alan ^a   Goronga, Tinopiwa ^a   Jiang, Qin ^a   Cui, Xiaoli ^a   Hyle, Judith ^a   Lahti, Jill M ^a   Morris, Stephan W ^a   Webb, Thomas R ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DIOXANE DERIVATIVE; 2 [4 (5 AZIDO 1,3 DIOXAN 2 YL) 2 METHYLBUT 2 ENYLSULFONYL]BENZO[D]THIAZOLE; 2 [4 (5 AZIDO 1,3 DIOXAN 2 YL) 2 METHYLBUT 2 ENYLTHIO]BENZO[D]THIAZOLE; 4 (5 AZIDO 1,3 DIOXAN 2 YL) 2 METHYLBUT 2 EN 1 OL; 4 (TERT BUTYLDIMETHYSILYLOXY) N [2 [5 [7,7 DIMETHYL 1,6 DIOXASPIRO(2.5)OCTAN 5 YL] 3 METHYLPENTA 2,4 DIENYL] 1,3 DIOXAN 5 YL]PENT 2 ENAMIDE; 5 [2 [5 [7,7 DIMETHYL 1,6 DIOXASPIRO(2.5)OCTAN 5 YL] 3 METHYLPENTA 2,4 DIENYL] 1,3 DIOXAN 5 YLAMINO] 5 OXOPENT 3 EN 2 YL ISOBUTYRATE; 5 [4 [5 [7,7 DIMETHYL 1,6 DIOXASPIRO(2.5)OCTAN 5 YL] 3 METHYLPENTA 2,4 DIENYL]CYCLOHEXYLAMINO] 5 OXOPENT 3 EN 2 YL 1 METHYLPIPERIDINE 4 CARBOXYLATE; 5 [4 [5 [7,7 DIMETHYL 1,6 DIOXASPIRO(2.5)OCTAN 5 YL] 3 METHYLPENTA 2,4 DIENYL]CYCLOHEXYLAMINO] 5 OXOPENT 3 EN 2 YL 4 CYCLOHEPTYLPIPERAZINE 1 CARBOXYLATE; 5 [4 [5 [7,7 DIMETHYL 1,6 DIOXASPIRO(2.5)OCTAN 5 YL] 3 METHYLPENTA 2,4 DIENYL]CYCLOHEXYLAMINO] 5 OXOPENT 3 EN 2 YL 4 NITROPHENYLCARBONATE; 5 [4 [5 [7,7 DIMETHYL 1,6 DIOXASPIRO(2.5)OCTAN 5 YL] 3 METHYLPENTA 2,4 DIENYL]CYCLOHEXYLAMINO] 5 OXOPENT 3 EN 2 YL ISOBUTYRATE; 5 [4 [5 [7,7 DIMETHYL 1,6 DIOXASPIRO(2.5)OCTAN 5 YL] 3 METHYLPENTA 2,4 DIENYL]CYCLOHEXYLAMINO] 5 OXOPENT 3 EN 2 YL TETRAHYDRO 2H PYRAN 4 CARBOXYLATE; 5 AZIDO 2 (2,2 DIMETHOXYETHYL) 1,3 DIOXANE; 7 [5 (5 AZIDO 1,3 DIOXAN 2 YL) 2 METHYLPENTA 1,3 DIENYL] 5,5 DIMETHYL 1,6 DIOXASPIRO[2.5]OCTANE; ANTINEOPLASTIC AGENT; CARBAMIC ACID DERIVATIVE; CELL EXTRACT; ESTER DERIVATIVE; ETHYL 4 (5 AZIDO 1,3 DIOXAN 2 YL) 2 METHYLBUT 2 ENOATE; MESSENGER RNA; N [2 [5 [7,7 DIMETHYL 1,6 DIOXASPIRO(2.5)OCTAN 5 YL] 3 METHYLPENTA 2,4 DIENYL] 1,3 DIOXAN 5 YL] 4 HYDROXYPENT 2 ENAMIDE; N [2 [5 [7,7 DIMETHYL 1,6 DIOXASPIRO(2.5)OCTAN 5 YL] 3 METHYLPENTA 2,4 DIENYL] 1,3 DIOXAN 5 YL]ACETAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL FREE SYSTEM; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFICACY; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; REPORTER GENE; RNA SPLICING; RNA TRANSLATION; SPLICEOSOME; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CARBAMATES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; ESTERS; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RNA SPLICING; RNA, MESSENGER; SOLUBILITY; STEREOISOMERISM;

EID: 70949100953     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm901215m     Document Type: Article

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