The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

Genes and Development

Volumn 25, Issue 5, 2011, Pages 440-444

  Folco, Eric G ^a   Coil, Kaitlyn E ^a   Reed, Robin ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

17S U2 snRNP; Anti tumor drug; Branch point binding region; Pladienolide derivative E7107; SF3b; Small molecule splicing inhibitor; Spliceosome assembly

Indexed keywords

ANTINEOPLASTIC AGENT; E 7107; HEPARIN; MESSENGER RNA PRECURSOR; PROTEIN SF3B; SMALL NUCLEAR RIBONUCLEOPROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; DRUG EFFECT; INTRON; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA SPLICING; SPLICEOSOME;

ANTINEOPLASTIC AGENTS; BINDING SITES; EPOXY COMPOUNDS; HELA CELLS; HUMANS; MACROLIDES; PHOSPHOPROTEINS; PROTEIN BINDING; RIBONUCLEOPROTEIN, U2 SMALL NUCLEAR; RNA PRECURSORS; SPLICEOSOMES;

EID: 79952231064     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.2009411     Document Type: Article

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