New antitumor substances, FR901463, FR901464 and FR901465: II. Activities against experimental tumors in mice and mechanism of action

Journal of Antibiotics

Volumn 49, Issue 12, 1996, Pages 1204-1211

  Nakajima, Hidenori ^a   Hori, Yasuhiro ^a   Terano, Hiroshi ^a   Okuhara, Masakuni ^a   Manda, Toshitaka ^a   Matsumoto, Sanae ^a   Shimomura, Kyoichi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DOXORUBICIN; FR 901463; FR 901464; FR 901465; PACLITAXEL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASCITES TUMOR; CELL CYCLE; CHROMATIN; CHROMATIN STRUCTURE; COLON CARCINOMA; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; EXPERIMENTAL NEOPLASM; FEMALE; FIBROSARCOMA; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSCRIPTION; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA P 388; LUNG ADENOCARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ASCITES; CELL CYCLE; CELL DEATH; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; PYRANS; SPIRO COMPOUNDS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0030466895     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.49.1204     Document Type: Article

References (19)

1. EI-DEIRY, W. S.; T. TOKINO, V. E. VELCULESCU, D. B. LEVY, R. PARSONS, J. M. TRENT, D. LIN, W. E. MERCER, K. W. KINZLER & B. VOGELSTEIN: WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825, 1993
2. HAN, J.; P. SABBATINI, D. PEREZ, L. RAO, D. MODHA & E. WHITE: The E1B 19K protein block apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein. Genes & Dev. 10: 461-477, 1996
3. NAKAJIMA, H.; B. SATO, T. FUJITA, S. TAKASE, H. TERANO & M. OKUHARA: New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J. Antibiotics 49: 1196-1203, 1996
4. NAKAJIMA, H.; H. HORI, T. GOTO, S. TAKASE, K. VERHAEGHE, H. TERANO & M. OKUHARA (Fujisawa): Substances WB2663, production thereof and use. Eur. Pat. Appl. 0 591 534 A1, June 12, 1992
5. KINO, T.; H. HATANAKA, M. HASHIMOTO, M. NISHIYAMA, T. GOTO, M. OKUHARA, M. KOHSAKA, H. AOKI & H. IMANAKA: FK-506, a novel immnosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics. J. Antibiotics 40: 1249-1255, 1987
6. KINO, T.; H. HATANAKA, S. MIYATA, N. INAMURA, M. NISHIYAMA, T. YAJIMA, T. GOTO, M. OKUHARA, M. KOHSAKA, H. AOKI & T. OCHIAI: FK-506, a novel immnosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro. J. Antibiotics 40: 1256-1265, 1987
7. BOGDEN, A. E.; D. E. KELTON, W. R. COBB & H. J. ESBER: A rapid screening method for testing chemotherapeutic agents against human tumor xenografts. In Proceeding, Symposium on the Use of Athymic (Nude) Mice in Cancer Research. Eds., D. HOUCHENS & A. OVEJERA, pp. 231-250, Gustav Fischer, New York, 1978
8. BOGDEN, A. E.; P. M. KASKELL, D. L. LEPAGE, D. E. KELTON, W. R. COBB & H. J. ESBER: Growth of human tumor xenografts implanted under the renal capsule of normal immunocompetent mice. Exp. Cell Biol. 47: 281-293, 1979
9. GOLDIN, A.; J. M. VENDITTI, J. S. MACDONALD, F. M. MUGGIA, J. E. HENNEY & V. T. DEVITA: Current results of the screening programmed at the division of cancer treatment. National Cancer Institute. Eur. J. Cancer 17: 129-142, 1981
10. WORKMAN, J. L. & A. R. BUCHMAN: Multiple functions of nucleosomes and regulatory factors in transcription. Trends Biochem. Sci. 18: 90-95, 1993
11. LEVIN, B.: Chromatin and gene expression: constant questions, but changing answers. Cell 79: 397-406, 1994
12. PAZIN, M. J.; P. L. SHERIDAN, K. CANNON, Z. CAO, J. G. KECK, J. T. KADONAGA & K. A. JONES: NF-κB-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro. Genes & Dev. 10: 37-49, 1996
13. CSORDAS, A.: On the biological role of histone acetylation. Biochem. J. 265: 23-38, 1990
14. WOLFEE, A. P. & D. PRUSS: Targeting chromatin disruption: transcription regulators that acetylate histones. Cell 84: 817-819, 1996
15. LINT, C. V.; S. EMILIANI, M. OTT & E. VERDIN: Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. EMBO J. 15: 1112-1120, 1996
16. HARTWELL, L. H. & M. B. KASTAN: Cell cycle control and cancer. Science 266: 1821-1828, 1994
17. DULIĆ, V.; W. K. KAUFMANN, S. J. WILSON, T. D. TLSTY, E. LEES, J. W. HARPER, S. J. ELLEDGE & S. I. REED: p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76: 1013-1023, 1994
18. NAKAJIMA, H.: Transcriptional regulatory activity and cytotoxic effect of trichostatin A. Ann. Rep. Co-ope. Res. (Can.) Minist. Educ., in Japanese: 912, 1991
19. TAUNTON, J.; C. A. HASSIG & S. L. SCHREIBER: A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272: 408-411, 1996