-
1
-
-
3242754448
-
Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity
-
15170211 10.1038/ni1080 1:CAS:528:DC%2BD2cXlt1Wmuro%3D
-
Hope KJ, Jin L, Dick JE. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol. 2004;5:738-43.
-
(2004)
Nat Immunol
, vol.5
, pp. 738-743
-
-
Hope, K.J.1
Jin, L.2
Dick, J.E.3
-
2
-
-
84872176951
-
Clonal evolution of acute leukemia genomes
-
22349821 10.1038/onc.2012.48 1:CAS:528:DC%2BC3sXkvFKlsg%3D%3D
-
Jan M, Majeti R. Clonal evolution of acute leukemia genomes. Oncogene. 2013;32:135-40.
-
(2013)
Oncogene
, vol.32
, pp. 135-140
-
-
Jan, M.1
Majeti, R.2
-
3
-
-
84876511698
-
Concise review: Preleukemic stem cells: Molecular biology and clinical implications of the precursors to leukemia stem cells
-
23349328 10.5966/sctm.2012-0109 1:CAS:528:DC%2BC3sXjvVaks7c%3D
-
Pandolfi A, Barreyro L, Steidl U. Concise review: preleukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cells. Stem Cells Transl Med. 2013;2:143-50.
-
(2013)
Stem Cells Transl Med
, vol.2
, pp. 143-150
-
-
Pandolfi, A.1
Barreyro, L.2
Steidl, U.3
-
4
-
-
84866378702
-
The role of mutations in epigenetic regulators in myeloid malignancies
-
22898539 10.1038/nrc3343 1:CAS:528:DC%2BC38Xht1Wkt7zF
-
Shih AH, Abdel-Wahab O, Patel JP, Levine RL. The role of mutations in epigenetic regulators in myeloid malignancies. Nat Rev Cancer. 2012;12:599-612.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 599-612
-
-
Shih, A.H.1
Abdel-Wahab, O.2
Patel, J.P.3
Levine, R.L.4
-
5
-
-
84879177403
-
The role of chromatin modifiers in normal and malignant hematopoiesis
-
23287864 10.1182/blood-2012-10-451237 1:CAS:528:DC%2BC3sXms1ymsr0%3D
-
Butler JS, Dent SY. The role of chromatin modifiers in normal and malignant hematopoiesis. Blood. 2013;121:3076-84.
-
(2013)
Blood
, vol.121
, pp. 3076-3084
-
-
Butler, J.S.1
Dent, S.Y.2
-
6
-
-
79952053850
-
Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation
-
21163962 10.1126/science.1195380 1:CAS:528:DC%2BC3MXit1eitrk%3D
-
Song J, Rechkoblit O, Bestor TH, Patel DJ. Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science. 2011;331:1036-40.
-
(2011)
Science
, vol.331
, pp. 1036-1040
-
-
Song, J.1
Rechkoblit, O.2
Bestor, T.H.3
Patel, D.J.4
-
7
-
-
0037456636
-
Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers
-
12637155 10.1016/S0304-3835(02)00689-4 1:CAS:528:DC%2BD3sXhvFWqtb8%3D
-
Kanai Y, Ushijima S, Nakanishi Y, Sakamoto M, Hirohashi S. Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers. Cancer Lett. 2003;192:75-82.
-
(2003)
Cancer Lett
, vol.192
, pp. 75-82
-
-
Kanai, Y.1
Ushijima, S.2
Nakanishi, Y.3
Sakamoto, M.4
Hirohashi, S.5
-
8
-
-
84878372012
-
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
-
Cancer Genome Atlas Research Network 10.1056/NEJMoa1301689
-
Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. New Engl J Med. 2013;368:2059-74.
-
(2013)
New Engl J Med
, vol.368
, pp. 2059-2074
-
-
-
9
-
-
78649906060
-
DNMT3A mutations in acute myeloid leukemia
-
21067377 10.1056/NEJMoa1005143 1:CAS:528:DC%2BC3cXhsF2ltb7K
-
Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, et al. DNMT3A mutations in acute myeloid leukemia. New Engl J Med. 2010;363:2424-33.
-
(2010)
New Engl J Med
, vol.363
, pp. 2424-2433
-
-
Ley, T.J.1
Ding, L.2
Walter, M.J.3
McLellan, M.D.4
Lamprecht, T.5
Larson, D.E.6
-
10
-
-
79960255863
-
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
-
21415852 10.1038/leu.2011.44 1:CAS:528:DC%2BC3MXoslOhsr0%3D
-
Walter MJ, Ding L, Shen D, Shao J, Grillot M, McLellan M, et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia. 2011;25:1153-8.
-
(2011)
Leukemia
, vol.25
, pp. 1153-1158
-
-
Walter, M.J.1
Ding, L.2
Shen, D.3
Shao, J.4
Grillot, M.5
McLellan, M.6
-
11
-
-
79960210747
-
DNMT3A mutations in myeloproliferative neoplasms
-
21537334 10.1038/leu.2011.77 1:CAS:528:DC%2BC3MXoslOitLo%3D
-
Stegelmann F, Bullinger L, Schlenk RF, Paschka P, Griesshammer M, Blersch C, et al. DNMT3A mutations in myeloproliferative neoplasms. Leukemia. 2011;25:1217-9.
-
(2011)
Leukemia
, vol.25
, pp. 1217-1219
-
-
Stegelmann, F.1
Bullinger, L.2
Schlenk, R.F.3
Paschka, P.4
Griesshammer, M.5
Blersch, C.6
-
12
-
-
79953176952
-
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
-
21399634 10.1038/ng.788 1:CAS:528:DC%2BC3MXjtVGms7w%3D
-
Yan XJ, Xu J, Gu ZH, Pan CM, Lu G, Shen Y, et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011;43:309-15.
-
(2011)
Nat Genet
, vol.43
, pp. 309-315
-
-
Yan, X.J.1
Xu, J.2
Gu, Z.H.3
Pan, C.M.4
Lu, G.5
Shen, Y.6
-
13
-
-
84555207349
-
Dnmt3a is essential for hematopoietic stem cell differentiation
-
10.1038/ng.1009 1:CAS:528:DC%2BC3MXhsFGktbnL
-
Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet. 2012;44:23-31.
-
(2012)
Nat Genet
, vol.44
, pp. 23-31
-
-
Challen, G.A.1
Sun, D.2
Jeong, M.3
Luo, M.4
Jelinek, J.5
Berg, J.S.6
-
14
-
-
84862909358
-
DNMT3A mutations in acute myeloid leukemia: Stability during disease evolution and clinical implications
-
22077061 10.1182/blood-2011-07-369934 1:CAS:528:DC%2BC38XhsVKltL8%3D
-
Hou HA, Kuo YY, Liu CY, Chou WC, Lee MC, Chen CY, et al. DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications. Blood. 2012;119:559-68.
-
(2012)
Blood
, vol.119
, pp. 559-568
-
-
Hou, H.A.1
Kuo, Y.Y.2
Liu, C.Y.3
Chou, W.C.4
Lee, M.C.5
Chen, C.Y.6
-
15
-
-
84877587361
-
Mutations of the epigenetics-modifying gene (DNMT3a, TET2, IDH1/2) at diagnosis may induce FLT3-ITD at relapse in de novo acute myeloid leukemia
-
23135354 10.1038/leu.2012.317
-
Wakita S, Yamaguchi H, Omori I, Terada K, Ueda T, Manabe E, et al. Mutations of the epigenetics-modifying gene (DNMT3a, TET2, IDH1/2) at diagnosis may induce FLT3-ITD at relapse in de novo acute myeloid leukemia. Leukemia. 2012;27(5):1044-52.
-
(2012)
Leukemia
, vol.27
, Issue.5
, pp. 1044-1052
-
-
Wakita, S.1
Yamaguchi, H.2
Omori, I.3
Terada, K.4
Ueda, T.5
Manabe, E.6
-
16
-
-
84883730914
-
Clonal evolution in relapsed NPM1 mutated acute myeloid leukemia
-
23704090 10.1182/blood-2013-01-479188
-
Kronke J, Bullinger L, Teleanu V, Tschurtz F, Gaidzik VI, Kuhn MW, et al. Clonal evolution in relapsed NPM1 mutated acute myeloid leukemia. Blood. 2013;122(1):100-8.
-
(2013)
Blood
, vol.122
, Issue.1
, pp. 100-108
-
-
Kronke, J.1
Bullinger, L.2
Teleanu, V.3
Tschurtz, F.4
Gaidzik, V.I.5
Kuhn, M.W.6
-
17
-
-
84860772157
-
DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia
-
22124213 10.1038/leu.2011.342 1:CAS:528:DC%2BC38XmvFemsL0%3D
-
Metzeler KH, Walker A, Geyer S, Garzon R, Klisovic RB, Bloomfield CD, et al. DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia. Leukemia. 2012;26:1106-7.
-
(2012)
Leukemia
, vol.26
, pp. 1106-1107
-
-
Metzeler, K.H.1
Walker, A.2
Geyer, S.3
Garzon, R.4
Klisovic, R.B.5
Bloomfield, C.D.6
-
18
-
-
78650175023
-
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
-
21057493 10.1038/nature09586 1:CAS:528:DC%2BC3cXhtl2jtrrP
-
Ko M, Huang Y, Jankowska AM, Pape UJ, Tahiliani M, Bandukwala HS, et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature. 2010;468:839-43.
-
(2010)
Nature
, vol.468
, pp. 839-843
-
-
Ko, M.1
Huang, Y.2
Jankowska, A.M.3
Pape, U.J.4
Tahiliani, M.5
Bandukwala, H.S.6
-
19
-
-
33847055935
-
Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1
-
17283125 10.1158/0008-5472.CAN-06-3123 1:CAS:528:DC%2BD2sXht1yntbw%3D
-
Valinluck V, Sowers LC. Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res. 2007;67:946-50.
-
(2007)
Cancer Res
, vol.67
, pp. 946-950
-
-
Valinluck, V.1
Sowers, L.C.2
-
20
-
-
80052461558
-
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
-
21778364 10.1126/science.1210597 1:CAS:528:DC%2BC3MXhtV2jt7nN
-
Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, et al. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science. 2011;333:1300-3.
-
(2011)
Science
, vol.333
, pp. 1300-1303
-
-
Ito, S.1
Shen, L.2
Dai, Q.3
Wu, S.C.4
Collins, L.B.5
Swenberg, J.A.6
-
21
-
-
80052495940
-
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
-
21817016 10.1126/science.1210944 1:CAS:528:DC%2BC3MXhtV2jt7nO
-
He YF, Li BZ, Li Z, Liu P, Wang Y, Tang Q, et al. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science. 2011;333:1303-7.
-
(2011)
Science
, vol.333
, pp. 1303-1307
-
-
He, Y.F.1
Li, B.Z.2
Li, Z.3
Liu, P.4
Wang, Y.5
Tang, Q.6
-
22
-
-
0037099537
-
LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)
-
12124344 1:CAS:528:DC%2BD38XlsV2lsbs%3D
-
Ono R, Taki T, Taketani T, Taniwaki M, Kobayashi H, Hayashi Y. LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23). Cancer Res. 2002;62:4075-80.
-
(2002)
Cancer Res
, vol.62
, pp. 4075-4080
-
-
Ono, R.1
Taki, T.2
Taketani, T.3
Taniwaki, M.4
Kobayashi, H.5
Hayashi, Y.6
-
23
-
-
66249137734
-
Mutation in TET2 in myeloid cancers
-
19474426 10.1056/NEJMoa0810069
-
Delhommeau F, Dupont S, Della Valle V, James C, Trannoy S, Masse A, et al. Mutation in TET2 in myeloid cancers. New Engl J Med. 2009;360:2289-301.
-
(2009)
New Engl J Med
, vol.360
, pp. 2289-2301
-
-
Delhommeau, F.1
Dupont, S.2
Della Valle, V.3
James, C.4
Trannoy, S.5
Masse, A.6
-
24
-
-
67349145955
-
Frequent TET2 mutations in systemic mastocytosis: Clinical, KITD816V and FIP1L1-PDGFRA correlates
-
19262599 10.1038/leu.2009.37 1:CAS:528:DC%2BD1MXlslCru7g%3D
-
Tefferi A, Levine RL, Lim KH, Abdel-Wahab O, Lasho TL, Patel J, et al. Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates. Leukemia. 2009;23:900-4.
-
(2009)
Leukemia
, vol.23
, pp. 900-904
-
-
Tefferi, A.1
Levine, R.L.2
Lim, K.H.3
Abdel-Wahab, O.4
Lasho, T.L.5
Patel, J.6
-
25
-
-
73149094518
-
TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia
-
19797729 10.3324/haematol.2009.011205 1:CAS:528:DC%2BC3cXhsVSitL0%3D
-
Kosmider O, Gelsi-Boyer V, Ciudad M, Racoeur C, Jooste V, Vey N, et al. TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia. Haematologica. 2009;94:1676-81.
-
(2009)
Haematologica
, vol.94
, pp. 1676-1681
-
-
Kosmider, O.1
Gelsi-Boyer, V.2
Ciudad, M.3
Racoeur, C.4
Jooste, V.5
Vey, N.6
-
26
-
-
79960064353
-
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
-
21723200 10.1016/j.ccr.2011.06.001 1:CAS:528:DC%2BC3MXoslCms7w%3D
-
Moran-Crusio K, Reavie L, Shih A, Abdel-Wahab O, Ndiaye-Lobry D, Lobry C, et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell. 2011;20:11-24.
-
(2011)
Cancer Cell
, vol.20
, pp. 11-24
-
-
Moran-Crusio, K.1
Reavie, L.2
Shih, A.3
Abdel-Wahab, O.4
Ndiaye-Lobry, D.5
Lobry, C.6
-
27
-
-
79960062301
-
TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
-
21723201 10.1016/j.ccr.2011.06.003 1:CAS:528:DC%2BC3MXoslCms7s%3D
-
Quivoron C, Couronne L, Della Valle V, Lopez CK, Plo I, Wagner-Ballon O, et al. TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. Cancer Cell. 2011;20:25-38.
-
(2011)
Cancer Cell
, vol.20
, pp. 25-38
-
-
Quivoron, C.1
Couronne, L.2
Della Valle, V.3
Lopez, C.K.4
Plo, I.5
Wagner-Ballon, O.6
-
28
-
-
80052284526
-
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
-
21873190 10.1073/pnas.1112317108 1:CAS:528:DC%2BC3MXhtFCltbbE
-
Ko M, Bandukwala HS, An J, Lamperti ED, Thompson EC, Hastie R, et al. Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci USA. 2011;108:14566-71.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 14566-14571
-
-
Ko, M.1
Bandukwala, H.S.2
An, J.3
Lamperti, E.D.4
Thompson, E.C.5
Hastie, R.6
-
29
-
-
84859736888
-
Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells
-
22355785
-
Kunimoto H, Fukuchi Y, Sakurai M, Sadahira K, Ikeda Y, Okamoto S, et al. Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells. Sci Rep. 2012;2:273.
-
(2012)
Sci Rep
, vol.2
, pp. 273
-
-
Kunimoto, H.1
Fukuchi, Y.2
Sakurai, M.3
Sadahira, K.4
Ikeda, Y.5
Okamoto, S.6
-
30
-
-
84867403602
-
TET2 is essential for survival and hematopoietic stem cell homeostasis
-
22469782 10.1038/leu.2012.94 1:CAS:528:DC%2BC38XhsFSgurfL
-
Shide K, Kameda T, Shimoda H, Yamaji T, Abe H, Kamiunten A, et al. TET2 is essential for survival and hematopoietic stem cell homeostasis. Leukemia. 2012;26:2216-23.
-
(2012)
Leukemia
, vol.26
, pp. 2216-2223
-
-
Shide, K.1
Kameda, T.2
Shimoda, H.3
Yamaji, T.4
Abe, H.5
Kamiunten, A.6
-
31
-
-
80052285127
-
Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
-
21803851 10.1182/blood-2010-12-325241 1:CAS:528:DC%2BC3MXhsVGqu73F
-
Li Z, Cai X, Cai CL, Wang J, Zhang W, Petersen BE, et al. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood. 2011;118:4509-18.
-
(2011)
Blood
, vol.118
, pp. 4509-4518
-
-
Li, Z.1
Cai, X.2
Cai, C.L.3
Wang, J.4
Zhang, W.5
Petersen, B.E.6
-
32
-
-
79960768558
-
Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors
-
21734233 10.1182/blood-2010-12-324707 1:CAS:528:DC%2BC3MXhtFOjurbL
-
Pronier E, Almire C, Mokrani H, Vasanthakumar A, Simon A, da Costa Reis Monte Mor B, et al. Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors. Blood. 2011;118:2551-5.
-
(2011)
Blood
, vol.118
, pp. 2551-2555
-
-
Pronier, E.1
Almire, C.2
Mokrani, H.3
Vasanthakumar, A.4
Simon, A.5
Da Costa, R.6
Monte Mor, B.7
-
33
-
-
84868208186
-
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
-
23001125 10.1038/ng.2413 1:CAS:528:DC%2BC38XhtlyltrnJ
-
Busque L, Patel JP, Figueroa ME, Vasanthakumar A, Provost S, Hamilou Z, et al. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet. 2012;44:1179-81.
-
(2012)
Nat Genet
, vol.44
, pp. 1179-1181
-
-
Busque, L.1
Patel, J.P.2
Figueroa, M.E.3
Vasanthakumar, A.4
Provost, S.5
Hamilou, Z.6
-
34
-
-
84865827060
-
Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia
-
Jan M, Snyder TM, Corces-Zimmerman MR, Vyas P, Weissman IL, Quake SR, et al. Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci Transl Med. 2012;4:149ra18.
-
(2012)
Sci Transl Med
, vol.4
-
-
Jan, M.1
Snyder, T.M.2
Corces-Zimmerman, M.R.3
Vyas, P.4
Weissman, I.L.5
Quake, S.R.6
-
35
-
-
79953223346
-
Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker
-
21383193 10.1073/pnas.1100551108 1:CAS:528:DC%2BC3MXktVCjsLk%3D
-
Jan M, Chao MP, Cha AC, Alizadeh AA, Gentles AJ, Weissman IL, et al. Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker. Proc Natl Acad Sci USA. 2011;108:5009-14.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 5009-5014
-
-
Jan, M.1
Chao, M.P.2
Cha, A.C.3
Alizadeh, A.A.4
Gentles, A.J.5
Weissman, I.L.6
-
36
-
-
80053620171
-
TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics
-
21828143 10.1182/blood-2011-02-339747 1:CAS:528:DC%2BC3MXhtlCgtb%2FI
-
Chou WC, Chou SC, Liu CY, Chen CY, Hou HA, Kuo YY, et al. TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics. Blood. 2011;118:3803-10.
-
(2011)
Blood
, vol.118
, pp. 3803-3810
-
-
Chou, W.C.1
Chou, S.C.2
Liu, C.Y.3
Chen, C.Y.4
Hou, H.A.5
Kuo, Y.Y.6
-
37
-
-
79960229916
-
Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias
-
21494260 10.1038/leu.2011.71 1:CAS:528:DC%2BC3MXoslOitL0%3D
-
Itzykson R, Kosmider O, Cluzeau T, Mansat-De Mas V, Dreyfus F, Beyne-Rauzy O, et al. Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias. Leukemia. 2011;25:1147-52.
-
(2011)
Leukemia
, vol.25
, pp. 1147-1152
-
-
Itzykson, R.1
Kosmider, O.2
Cluzeau, T.3
Mansat-De Mas, V.4
Dreyfus, F.5
Beyne-Rauzy, O.6
-
38
-
-
70149093912
-
Recurring mutations found by sequencing an acute myeloid leukemia genome
-
19657110 10.1056/NEJMoa0903840 1:CAS:528:DC%2BD1MXhtFaltLvL
-
Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. New Engl J Med. 2009;361:1058-66.
-
(2009)
New Engl J Med
, vol.361
, pp. 1058-1066
-
-
Mardis, E.R.1
Ding, L.2
Dooling, D.J.3
Larson, D.E.4
McLellan, M.D.5
Chen, K.6
-
39
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
19228619 10.1056/NEJMoa0808710 1:CAS:528:DC%2BD1MXitFWru7o%3D
-
Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, et al. IDH1 and IDH2 mutations in gliomas. New Engl J Med. 2009;360:765-73.
-
(2009)
New Engl J Med
, vol.360
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
McLendon, R.4
Rasheed, B.A.5
Yuan, W.6
-
40
-
-
77149134353
-
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
-
20142433 10.1084/jem.20092506 1:CAS:528:DC%2BC3cXitFGqur0%3D
-
Gross S, Cairns RA, Minden MD, Driggers EM, Bittinger MA, Jang HG, et al. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. J Exp Med. 2010;207:339-44.
-
(2010)
J Exp Med
, vol.207
, pp. 339-344
-
-
Gross, S.1
Cairns, R.A.2
Minden, M.D.3
Driggers, E.M.4
Bittinger, M.A.5
Jang, H.G.6
-
41
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
-
20171147 10.1016/j.ccr.2010.01.020 1:CAS:528:DC%2BC3cXlsVWqtLg%3D
-
Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 2010;17:225-34.
-
(2010)
Cancer Cell
, vol.17
, pp. 225-234
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
Abdel-Wahab, O.4
Bennett, B.D.5
Coller, H.A.6
-
42
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
18772396 10.1126/science.1164382 1:CAS:528:DC%2BD1cXhtFCrtLrE
-
Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, et al. An integrated genomic analysis of human glioblastoma multiforme. Science. 2008;321:1807-12.
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
-
43
-
-
84863393263
-
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
-
22417203 10.1056/NEJMoa1112304 1:CAS:528:DC%2BC38XktlCqtLs%3D
-
Patel JP, Gonen M, Figueroa ME, Fernandez H, Sun Z, Racevskis J, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. New Engl J Med. 2012;366:1079-89.
-
(2012)
New Engl J Med
, vol.366
, pp. 1079-1089
-
-
Patel, J.P.1
Gonen, M.2
Figueroa, M.E.3
Fernandez, H.4
Sun, Z.5
Racevskis, J.6
-
44
-
-
84856725273
-
Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: A Mayo Clinic study of 277 patients
-
22033490 10.1038/leu.2011.298 1:CAS:528:DC%2BC38XntF2ltA%3D%3D
-
Patnaik MM, Hanson CA, Hodnefield JM, Lasho TL, Finke CM, Knudson RA, et al. Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients. Leukemia. 2012;26:101-5.
-
(2012)
Leukemia
, vol.26
, pp. 101-105
-
-
Patnaik, M.M.1
Hanson, C.A.2
Hodnefield, J.M.3
Lasho, T.L.4
Finke, C.M.5
Knudson, R.A.6
-
45
-
-
77954658823
-
IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic-or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis
-
20508616 10.1038/leu.2010.113 1:CAS:528:DC%2BC3cXovFKms70%3D
-
Tefferi A, Lasho TL, Abdel-Wahab O, Guglielmelli P, Patel J, Caramazza D, et al. IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic-or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis. Leukemia. 2010;24:1302-9.
-
(2010)
Leukemia
, vol.24
, pp. 1302-1309
-
-
Tefferi, A.1
Lasho, T.L.2
Abdel-Wahab, O.3
Guglielmelli, P.4
Patel, J.5
Caramazza, D.6
-
46
-
-
84856298658
-
Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping
-
22180306 10.1634/theoncologist.2011-0386 1:CAS:528:DC%2BC38XjslGqsLo%3D
-
Borger DR, Tanabe KK, Fan KC, Lopez HU, Fantin VR, Straley KS, et al. Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. Oncologist. 2012;17:72-9.
-
(2012)
Oncologist
, vol.17
, pp. 72-79
-
-
Borger, D.R.1
Tanabe, K.K.2
Fan, K.C.3
Lopez, H.U.4
Fantin, V.R.5
Straley, K.S.6
-
47
-
-
79958226901
-
IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
-
21598255 10.1002/path.2913 1:CAS:528:DC%2BC3MXntVGms7c%3D
-
Amary MF, Bacsi K, Maggiani F, Damato S, Halai D, Berisha F, et al. IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours. J Pathol. 2011;224:334-43.
-
(2011)
J Pathol
, vol.224
, pp. 334-343
-
-
Amary, M.F.1
Bacsi, K.2
Maggiani, F.3
Damato, S.4
Halai, D.5
Berisha, F.6
-
48
-
-
84857575341
-
IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma
-
22215888 10.1182/blood-2011-11-391748 1:CAS:528:DC%2BC38XjsV2lsrk%3D
-
Cairns RA, Iqbal J, Lemonnier F, Kucuk C, de Leval L, Jais JP, et al. IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma. Blood. 2012;119:1901-3.
-
(2012)
Blood
, vol.119
, pp. 1901-1903
-
-
Cairns, R.A.1
Iqbal, J.2
Lemonnier, F.3
Kucuk, C.4
De Leval, L.5
Jais, J.P.6
-
49
-
-
84876889621
-
What a difference a hydroxyl makes: Mutant IDH, (R)-2-hydroxyglutarate, and cancer
-
23630074 10.1101/gad.217406.113 1:CAS:528:DC%2BC3sXnsl2gtro%3D
-
Losman JA, Kaelin WG Jr. What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes Dev. 2013;27:836-52.
-
(2013)
Genes Dev
, vol.27
, pp. 836-852
-
-
Losman, J.A.1
Kaelin, Jr.W.G.2
-
50
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
21130701 10.1016/j.ccr.2010.11.015 1:CAS:528:DC%2BC3cXhsFGhsbvJ
-
Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010;18:553-67.
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
Ward, P.S.4
Patel, J.5
Shih, A.6
-
51
-
-
84862266735
-
TET2 mutations in acute myeloid leukemia (AML): Results from a comprehensive genetic and clinical analysis of the AML study group
-
10.1200/JCO.2011.39.2886 1:CAS:528:DC%2BC38Xos1OgtL8%3D
-
Gaidzik VI, Paschka P, Spath D, Habdank M, Kohne CH, Germing U, et al. TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group. J Clin. 2012;30:1350-7.
-
(2012)
J Clin
, vol.30
, pp. 1350-1357
-
-
Gaidzik, V.I.1
Paschka, P.2
Spath, D.3
Habdank, M.4
Kohne, C.H.5
Germing, U.6
-
52
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
19935646 10.1038/nature08617 1:CAS:528:DC%2BD1MXhsVGlurzE
-
Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009;462:739-44.
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
Bennett, B.D.4
Bittinger, M.A.5
Driggers, E.M.6
-
53
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
-
21251613 10.1016/j.ccr.2010.12.014 1:CAS:528:DC%2BC3MXpvValsQ%3D%3D
-
Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011;19:17-30.
-
(2011)
Cancer Cell
, vol.19
, pp. 17-30
-
-
Xu, W.1
Yang, H.2
Liu, Y.3
Yang, Y.4
Wang, P.5
Kim, S.H.6
-
54
-
-
84875496294
-
(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible
-
23393090 10.1126/science.1231677 1:CAS:528:DC%2BC3sXksFOhsLc%3D
-
Losman JA, Looper RE, Koivunen P, Lee S, Schneider RK, McMahon C, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339:1621-5.
-
(2013)
Science
, vol.339
, pp. 1621-1625
-
-
Losman, J.A.1
Looper, R.E.2
Koivunen, P.3
Lee, S.4
Schneider, R.K.5
McMahon, C.6
-
55
-
-
79955547561
-
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
-
21460794 10.1038/embor.2011.43 1:CAS:528:DC%2BC3MXktFahs74%3D
-
Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep. 2011;12:463-9.
-
(2011)
EMBO Rep
, vol.12
, pp. 463-469
-
-
Chowdhury, R.1
Yeoh, K.K.2
Tian, Y.M.3
Hillringhaus, L.4
Bagg, E.A.5
Rose, N.R.6
-
56
-
-
84858796262
-
IDH mutation impairs histone demethylation and results in a block to cell differentiation
-
22343901 10.1038/nature10860 1:CAS:528:DC%2BC38XisVKks74%3D
-
Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature. 2012;483:474-8.
-
(2012)
Nature
, vol.483
, pp. 474-478
-
-
Lu, C.1
Ward, P.S.2
Kapoor, G.S.3
Rohle, D.4
Turcan, S.5
Abdel-Wahab, O.6
-
57
-
-
84862776918
-
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
-
22343896 10.1038/nature10898 1:CAS:528:DC%2BC38XisVKktb4%3D
-
Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, et al. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature. 2012;483:484-8.
-
(2012)
Nature
, vol.483
, pp. 484-488
-
-
Koivunen, P.1
Lee, S.2
Duncan, C.G.3
Lopez, G.4
Lu, G.5
Ramkissoon, S.6
-
58
-
-
84865520089
-
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
-
22763442 10.1038/nature11323 1:CAS:528:DC%2BC38XhtFWmt7bL
-
Sasaki M, Knobbe CB, Munger JC, Lind EF, Brenner D, Brustle A, et al. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature. 2012;488:656-9.
-
(2012)
Nature
, vol.488
, pp. 656-659
-
-
Sasaki, M.1
Knobbe, C.B.2
Munger, J.C.3
Lind, E.F.4
Brenner, D.5
Brustle, A.6
-
59
-
-
79953287708
-
IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo
-
21446021 10.1002/ana.22390 1:CAS:528:DC%2BC3MXls1Omtbo%3D
-
Bralten LB, Kloosterhof NK, Balvers R, Sacchetti A, Lapre L, Lamfers M, et al. IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo. Ann Neurol. 2011;69:455-63.
-
(2011)
Ann Neurol
, vol.69
, pp. 455-463
-
-
Bralten, L.B.1
Kloosterhof, N.K.2
Balvers, R.3
Sacchetti, A.4
Lapre, L.5
Lamfers, M.6
-
60
-
-
84857995946
-
Persistence of mutant isocitrate dehydrogenase in patients with acute myeloid leukemia in remission
-
21844873 10.1038/leu.2011.215 1:CAS:528:DC%2BC38Xjs1Shtr8%3D
-
Chou WC, Peng KY, Lei WC, Ko BS, Tsay W, Kuo CH, et al. Persistence of mutant isocitrate dehydrogenase in patients with acute myeloid leukemia in remission. Leukemia. 2012;26:527-9.
-
(2012)
Leukemia
, vol.26
, pp. 527-529
-
-
Chou, W.C.1
Peng, K.Y.2
Lei, W.C.3
Ko, B.S.4
Tsay, W.5
Kuo, C.H.6
-
61
-
-
77950968519
-
Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation
-
20097881 10.1182/blood-2009-11-253070 1:CAS:528:DC%2BC3cXkvFKiurY%3D
-
Chou WC, Hou HA, Chen CY, Tang JL, Yao M, Tsay W, et al. Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation. Blood. 2010;115:2749-54.
-
(2010)
Blood
, vol.115
, pp. 2749-2754
-
-
Chou, W.C.1
Hou, H.A.2
Chen, C.Y.3
Tang, J.L.4
Yao, M.5
Tsay, W.6
-
62
-
-
79751530369
-
The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia
-
21079611 10.1038/leu.2010.267 1:CAS:528:DC%2BC3MXhs1amsrY%3D
-
Chou WC, Lei WC, Ko BS, Hou HA, Chen CY, Tang JL, et al. The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia. Leukemia. 2011;25:246-53.
-
(2011)
Leukemia
, vol.25
, pp. 246-253
-
-
Chou, W.C.1
Lei, W.C.2
Ko, B.S.3
Hou, H.A.4
Chen, C.Y.5
Tang, J.L.6
-
63
-
-
84877620952
-
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
-
23558173 10.1126/science.1234769 1:CAS:528:DC%2BC3sXmslWksbs%3D
-
Wang F, Travins J, Delabarre B, Penard-Lacronique V, Schalm S, Hansen E, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013;340(6132):622-6.
-
(2013)
Science
, vol.340
, Issue.6132
, pp. 622-626
-
-
Wang, F.1
Travins, J.2
Delabarre, B.3
Penard-Lacronique, V.4
Schalm, S.5
Hansen, E.6
-
64
-
-
84877632013
-
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
-
23558169 10.1126/science.1236062 1:CAS:528:DC%2BC3sXmslWksbg%3D
-
Rohle D, Popovici-Muller J, Palaskas N, Turcan S, Grommes C, Campos C, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013;340(6132):626-30.
-
(2013)
Science
, vol.340
, Issue.6132
, pp. 626-630
-
-
Rohle, D.1
Popovici-Muller, J.2
Palaskas, N.3
Turcan, S.4
Grommes, C.5
Campos, C.6
|