Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: Proliferative and anti-apoptotic activities

Blood

Volumn 93, Issue 5, 1999, Pages 1668-1676

  Konopleva, Marina ^b   Mikhail, Adel ^b   Estrov, Zeev ^b   Zhao, Shourong ^b   Harris, David ^b   Sanchez Williams, Gisela ^b   Kornblau, Steven M ^b   Dong, Joan ^b   Kliche, Kay Oliver ^b   Jiang, Shuwei ^b   Snodgrass, H Ralph ^b   Estey, Elihu H ^b   Andreeff, Michael ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD33 ANTIGEN; CD34 ANTIGEN; GENE PRODUCT; INTERLEUKIN 3; LEPTIN; LEPTIN RECEPTOR; MICROSOMAL AMINOPEPTIDASE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; STEM CELL FACTOR;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0033104708     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.5.1668     Document Type: Article

References (35)

1. Metcalf D: Hematopoietic regulators: Redundancy or subtlety? Blood 82:3515, 1993
2. Löwenberg B, Touw IP: Hematopoietic growth factors and their receptors in acute leukemia. Blood 81:281, 1993
3. Benett BD, Solar GP, Yuan JQ, Mathias J, Thomas GR, Matthews W: A role for leptin and its cognate receptor in hematopoiesis. Curr Biol 6:1170, 1996
4. Cioffi J, Shafer A, Zupanic T, Smith-Gbuf J, Mikhail A, Platika D, Snodgrass H: Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction. Nat Med 2:585, 1996
5. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA, Tepper RI: Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263, 1995
6. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425, 1994
7. Lee G, Proenca R, Montez J, Carroll K, Darvishzadeh J, Lee J: Abnormal splicing of the leptin receptor in diabetic mice. Nature 379:632, 1996
8. Maffei M, Hallas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM: Leptin levels in human and rodent: Measurement of plasma leptin and ob mRNA in obese and weight reduced subjects. Nat Med 1:1155, 1995
9. Considine RV, Sinha MK, Heiman MR, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF: Serum immunoreactive leptin concentrations in normal weight and obese humans. N Engl J Med 334:292, 1996
10. Winik JD, Stoffel M, Friedman JM: Identification of microsatellite markers linked to the human leptin receptor gene on chromosome 1. Genomics 36:221, 1996
11. Chen H, Charlat O, Tartaglia LA, Woolf EA, Wen X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP: Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491, 1996
12. Gainsford T, Willson TA, Metcalf D, Handman E, McFarlane C, Ng A, Nicola NA, Alexander WS, Hilton DJ: Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA 93:14564, 1996
13. Mikhail AA, Beck EX, Shafer A, Barut B, Gbur JS, Zupancic TJ, Schweitzer AC, Cioffi JA, Lacaud G, Ouyang B, Keller G, Snodgrass HR: Leptin stimulates fetal and adult erythroid and myeloid development. Blood 89:1507, 1997
14. Matsuda J, Yokota I, Iida M, Murakami T, Naito E, Ito M, Shima K, Kuroda Y: Serum leptin concentration in cord blood: Relationship to birth weight and gender. J Clin Endocr Met 82:1642, 1997
15. Laharrague P, Larrouy D, Fontanilles AM, Truel N, Campfield A, Tenenbaum R, Galitzky J, Corberand JX, Penicaud L, Casteilla L: High expression of leptin by human bone marrow adipocytes in primary culture. FASEB J 12:747, 1998
16. Wang C, Curtis JE, Minden MD, McCulloch EA: Expression of retinoic acid receptor gene in myeloid leukemia cells. Leukemia 3:264, 1989
17. Lanotte M, Martin-Thouvenin V, Najman S, Balerini P, Valensi F, Berger R: NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood 77:1080, 1991
18. McGrath T, Center MS: Mechanisms of MDR in HL60 cells: Evidence that a surface membrane protein distinct from a p-glycoprotein contributes to reduced cellular accumulation of drugs. Cancer Res 48:3959, 1988
19. Lisovsky M, Estrov Z, Zhang X, Consoli U, Sanchez-Williams G, Snell V, Munker R, Goodacre A, Savchenko V, Andreeff M: Flt3 ligand stimulates proliferation and inhibits apoptosis of acute myeloid leukemia cells: Regulation of Bcl-2 and Bax. Blood 88:3987, 1996
20. Estrov Z, Cohen A, Gelfand EW, Freedman MH: Synergistic antiproliferative effects on HL-60 cells: Deferoxamine enhances cytosine arabinoside, methotrexate, and daunorubicin cytotoxicity. Am J Pediatr Hematol Oncol 10:288, 1988
21. Buick RN, Till JE, McCulloch EA: A colony assay for proliferative blast cells circulating in myeloblastic leukemia. Lancet 1:862, 1977
22. Estrov Z, Black RA, Sleath PR, Harris D, Van Q, LaPushin R, Estey EH, Talpaz M: Effect of interleukin-1 beta converting enzyme inhibitor on acute myelogenous leukemia progenitor proliferation. Blood 86:4594, 1995
23. Freedman MH, Chan HSL, Chang L: Childhood erythroleukemia: Studies on pathogenesis using colony assays. Am J Pediatr Hematol Oncol 8:2, 1986
24. Andreeff M, Darzynkiewicz Z, Sharpless TK, Clarkson BD, Melamed MR: Discrimination of human leukemia subtypes by flow cytometric analysis of cellular DNA and RNA. Blood 55:282, 1980
25. Chomocyznski P, Sacchi N: Single-step method for RNA isolation by acid guanidinium thiocyonate-phenol-chloroform extraction. Anal Biochem 162:156, 1987
26. Zhao S, Consoli U, Arceci R, Pfeifer J, Dalton WS, Andreeff M: Semi-automated PCR method for quantitating MDR1 expression. BioTechniques 21:726, 1996
27. Drach D, Zhao S, Drach J, Mahadevia R, Gattringer C, Huber H, Andreeff M: Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype. Blood 80:2729, 1992
28. Ma Z, Gingerich RL, Santiago JV, Klein S, Smith CH, Landt M: RIA of leptin in human plasma. Clin Chem 42:942, 1996
29. Berdanier C: Obesity, in Munson PL, Mueller RA, Breese GR (eds): Principles of Pharmacology: Basic Concepts and Clinical Applications. New York, Chapman and Hall, 1995, p 1045
30. Umenoto Y, Tsuji K, Yang F, Ebihara Y, Kaneko A, Furukawa S, Nakahata T: Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells. Blood 90:3438, 1997
31. Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, Lai C, Tartaglia L: The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 93:8374, 1996
32. Masuzaki H, Ogawa Y, Isse N, Satoh N, Okazaki T, Shigemoto M, Mori K, Tamura N, Hosoda K, Yoshimasa Y, Jingami H, Kawada T, Nakao K: Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44:855, 1995
33. Chilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH, Skoda RC: Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA 93:6231, 1996
34. Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, Nishimura H, Yoshimasa Y, Tanaka I, Mori T, Nakao K: Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans. Nature Med 3:1029, 1997
35. Estey E, Thall P, Kantarjian H, Pierce S, Kornblau S, Keating M: Association between increased body mass index and a diagnosis of acute promyelocytic leukemia in patients with acute myeloid leukemia. Leukemia 11:1661, 1997