Tumor suppressor role of notch-1 signaling in neuroendocrine tumors

Oncologist

Volumn 12, Issue 5, 2007, Pages 535-542

  Kunnimalaiyaan, Muthusamy ^a   Chen, Herbert ^a,b  

^a UNIVERSITY OF WISCONSIN   (United States)

^b University of Wisconsin Health   (United States)

Author keywords

Achaete scute complex like 1; Carcinoid; Medullary thyroid cancer; Notch 1 signaling; Notch 1 activating compound

Indexed keywords

NOTCH1 RECEPTOR;

CANCER CELL; CARCINOID; GROWTH INHIBITION; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; T LYMPHOCYTE; THYROID MEDULLARY CARCINOMA; TUMOR GROWTH; UPREGULATION;

ANIMALS; CARCINOID TUMOR; CARCINOMA, MEDULLARY; CARCINOMA, SMALL CELL; HUMANS; LUNG NEOPLASMS; NEUROENDOCRINE TUMORS; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 34548452775     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.12-5-535     Document Type: Review

References (66)

1. Van Gompel JJ, Sippel RS, Warner TF et al. Gastrointestinal carcinoid tumors: Factors that predict outcome. World J Surg 2004;28:387-392.
2. Kunnimalaiyaan M, Traeger K, Chen H. Conservation of the Notch1 signaling pathway in gastrointestinal carcinoid cells. Am J Physiol Gastrointest Liver Physiol 2005;289:G636-G642.
3. Kunnimalaiyaan M, Yan S, Wong F et al. Hairy enhancer of split-1 (HES-1), a Notch1 effector, inhibits the growth of carcinoid tumor cells. Surgery 2005;138:1137-1142.
4. Kunnimalaiyaan M, Chen H. The Raf-1 pathway: A molecular target for treatment of select neuroendocrine tumors? Anticancer Drugs 2006;17:139-142.
5. Nakakura EK, Sriuranpong VR, Kunnimalaiyaan M et al. Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by Notch signaling. J Clin Endocrinol Metab 2005;90:4350-4356.
6. Sippel RS, Carpenter JE, Kunnimalaiyaan M et al. The role of human achaete-scute homolog-1 in medullary thyroid cancer cells. Surgery 2003; 134:866-871; discussion 871-873.
7. Sippel RS, Carpenter JE, Kunnimalaiyaan M et al. Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells. Am J Physiol Gastrointest Liver Physiol 2003;285:G245-G254.
8. Sippel RS, Chen H. Carcinoid tumors. Surg Oncol Clin N Am 2006;15: 463-478.
9. Lal A, Chen H. Treatment of advanced carcinoid tumors. Curr Opin Oncol 2006;18:9-15.
10. Kunnimalaiyaan M, Ndiaye M, Chen H. Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002. Surgery 2006;140:1009-1014; discussion 1014-1015.
11. Kadesch T. Notch signaling: The demise of elegant simplicity. Curr Opin Genet Dev 2004;14:506-512.
12. Maillard I, Pear WS. Notch and cancer: Best to avoid the ups and downs. Cancer Cell 2003;3:203-205.
13. Yoon K, Gaiano N. Notch signaling in the mammalian central nervous system: Insights from mouse mutants. Nat Neurosci 2005;8:709-715.
14. Radtke F, Raj K. The role of Notch in tumorigenesis: Oncogene or tumour suppressor? Nat Rev Cancer 2003;3:756-767.
15. Wilson A, Radtke F. Multiple functions of Notch signaling in self-renewing organs and cancer. FEBS Lett 2006;580:2860-2868.
16. Cabrera CV. Lateral inhibition and cell fate during neurogenesis in Drosophila: The interactions between scute, Notch and Delta. Development 1990;110:733-742.
17. Cabrera CV. The generation of cell diversity during early neurogenesis in Drosophila. Development 1992;115:893-901.
18. Hald J, Hjorth JP, German MS et al. Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol 2003;260:426-437.
19. Jensen J, Heller RS, Funder-Nielsen T et al. Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: A role for the Notch pathway in repression of premature differentiation. Diabetes 2000;49:163-176.
20. Murtaugh LC, Stanger BZ, Kwan KM et al. Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A 2003; 100:14920-14925.
21. Apelqvist A, Li H, Sommer L et al. Notch signalling controls pancreatic cell differentiation. Nature 1999;400:877-881.
22. Allenspach EJ, Maillard I, Aster JC et al. Notch signaling in cancer. Cancer Biol Ther 2002;1:466-476.
23. Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: Cell fate control and signal integration in development. Science 1999;284:770-776.
24. Bray SJ. Notch signalling: A simple pathway becomes complex. Nat Rev Mol Cell Biol 2006;7:678-689.
25. Doglio LE, Kanwar R, Jackson GR et al. gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo. Neuron 2006;50:359-375.
26. Fortini ME. Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling. Nat Rev Mol Cell Biol 2002;3:673-684.
27. Kanwar R, Fortini ME. Notch signaling: A different sort makes the cut. Curr Biol 2004;14:R1043-R1045.
28. Ellisen LW, Bird J, West DC et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991;66:649-661.
29. Jundt F, Anagnostopoulos I, Forster R et al. Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood 2002;99:3398-3403.
30. Jundt F, Probsting KS, Anagnostopoulos I et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood 2004;103: 3511-3515.
31. Miele L. Notch signaling. Clin Cancer Res 2006;12:1074-1079.
32. Nickoloff BJ, Qin JZ, Chaturvedi V et al. Jagged-1 mediated activation of Notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ 2002;9:842-855.
33. Wang Z, Zhang Y, Banerjee S et al. Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. Cancer 2006;106:2503-2513.
34. Wang Z, Zhang Y, Li Y et al. Down-regulation of notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther 2006;5:483-493.
35. Wang Z, Banerjee S, Li Y et al. Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res 2006;66:2778-2784.
36. Balint K, Xiao M, Pinnix CC et al. Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest 2005;115:3166-3176.
37. Liu ZJ, Xiao M, Balint K et al. Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression. Cancer Res 2006;66:4182-4190.
38. Liu ZJ, Xiao M, Balint K et al. Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1. FASEB J 2006;20:1009-1011.
39. Borges M, Linnoila RI, van de Velde HJ et al. An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature 1997;386: 852-855.
40. Ito T, Udaka N, Yazawa T et al. Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium. Development 2000;127:3913-3921.
41. Lanigan TM, DeRaad SK, Russo AF. Requirement of the MASH-1 transcription factor for neuroendocrine differentiation of thyroid C cells. J Neurobiol 1998;34:126-134.
42. Chen H, Udelsman R, Zeiger MA et al. Human achaete-scute homolog-1 is highly expressed in a subset of neuroendocrine tumors. Oncol Rep 1997;4: 775-778.
43. Chen H, Biel MA, Borges MW et al. Tissue-specific expression of human achaete-scute homologue-1 in neuroendocrine tumors: Transcriptional regulation by dual inhibitory regions. Cell Growth Differ 1997;8:677-686.
44. Chen H, Thiagalingam A, Chopra H et al. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: A hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc Natl Acad Sci U S A 1997;94:5355-5360.
45. Ravi RK, Weber E, McMahon M et al. Activated Raf-1 causes growth arrest in human small cell lung cancer cells. J Clin Invest 1998;101:153-159.
46. de la Pompa JL, Wakeham A, Correia KM et al. Conservation of the Notch signalling pathway in mammalian neurogenesis. Development 1997;124:1139-1148.
47. Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA et al. Overexpression of the Notch1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells. J Biol Chem 2006;281:39819-39830.
48. Sriuranpong V, Borges MW, Ravi RK et al. Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res 2001;61:3200-3205.
49. Esni F, Ghosh B, Biankin AV et al. Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Development 2004;131:4213-4224.
50. Jensen J, Pedersen EE, Galante P et al. Control of endodermal endocrine development by Hes-1. Nat Genet 2000;24:36-44.
51. Chen H, Carson-Walter EB, Baylin SB et al. Differentiation of medullary thyroid cancer by C-Raf-1 silences expression of the neural transcription factor human achaete-scute homolog-1. Surgery 1996;120:168-172; discussion 173.
52. Chen H, Roberts JR, Ball DW et al. Effective long-term palliation of symptomatic, incurable metastatic medullary thyroid cancer by operative resection. Ann Surg 1998;227:887-895.
53. Greenblatt DY, Elson D, Mack E et al. Initial lymph node dissection increases cure rates in patients with medullary thyroid cancer. Asian J Surg 2006 (in press).
54. Moley JF, Lairmore TC, Phay JE. Hereditary endocrinopathies. Curr Probl Surg 1999;36:653-762.
55. Park JI, Strock CJ, Ball DW et al. The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway. Mol Cell Biol 2003;23:543-554.
56. Parkin DM, Bray F, Ferlay J et al. Global cancer statistics, 2002. CA Cancer J Clin 2005;55:74-108.
57. Cooper S, Spiro SG. Small cell lung cancer: Treatment review. Respirology 2006;11:241-248.
58. Ganti AK, Mulshine JL. Lung cancer screening: Panacea or pipe dream? Ann Oncol 2005;16(suppl 2):ii215-ii219.
59. Ganti AK, Mulshine JL. Lung cancer screening. The Oncologist 2006;11: 481-487.
60. Spiro SG, Silvestri GA. One hundred years of lung cancer. Am J Respir Crit Care Med 2005;172:523-529.
61. Ravi RK, Thiagalingam A, Weber E et al. Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells. Am J Respir Cell Mol Biol 1999;20:543-549.
62. Osada H, Tatematsu Y, Yatabe Y et al. ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features. Cancer Res 2005;65:10680-10685.
63. Ball DW. Achaete-scute homolog-1 and Notch in lung neuroendocrine development and cancer. Cancer Lett 2004;204:159-169.
64. Collins BJ, Kleeberger W, Ball DW. Notch in lung development and lung cancer. Semin Cancer Biol 2004;14:357-364.
65. Ito T, Udaka N, Okudela K et al. Mechanisms of neuroendocrine differentiation in pulmonary neuroendocrine cells and small cell carcinoma. Endocr Pathol 2003;14:133-139.
66. Sriuranpong V, Borges MW, Strock CL et al. Notch signaling induces rapid degradation of achaete-scute homolog 1. Mol Cell Biol 2002;22:3129-3139.