메뉴 건너뛰기




Volumn 26, Issue 4, 2015, Pages 201-209

Cellular innate immunity and restriction of viral infection: Implications for lentiviral gene therapy in human hematopoietic cells

Author keywords

[No Author keywords available]

Indexed keywords

HOST FACTOR; LENTIVIRUS VECTOR; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR;

EID: 84928468984     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2015.036     Document Type: Review
Times cited : (29)

References (121)
  • 1
    • 78650735673 scopus 로고    scopus 로고
    • Human hematopoietic stem/ progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
    • Holt N, Wang J, Kim K, et al. Human hematopoietic stem/ progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol 2010; 28:839-847.
    • (2010) Nat Biotechnol , vol.28 , pp. 839-847
    • Holt, N.1    Wang, J.2    Kim, K.3
  • 2
    • 35948946526 scopus 로고    scopus 로고
    • Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
    • Lombardo A, Genovese P, Beausejour CM, et al. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nat Biotechnol 2007;25:1298-1306.
    • (2007) Nat Biotechnol , vol.25 , pp. 1298-1306
    • Lombardo, A.1    Genovese, P.2    Beausejour, C.M.3
  • 3
    • 84902315464 scopus 로고    scopus 로고
    • Targeted genome editing in human repopulating haematopoietic stem cells
    • Genovese P, Schiroli G, Escobar G, et al. Targeted genome editing in human repopulating haematopoietic stem cells. Nature 2014;510:235-240.
    • (2014) Nature , vol.510 , pp. 235-240
    • Genovese, P.1    Schiroli, G.2    Escobar, G.3
  • 4
    • 70449427834 scopus 로고    scopus 로고
    • Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy
    • Cartier N, Hacein-Bey-Abina S, Bartholomae CC, et al. Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. Science 2009; 326:818-823.
    • (2009) Science , vol.326 , pp. 818-823
    • Cartier, N.1    Hacein-Bey-Abina, S.2    Bartholomae, C.C.3
  • 5
    • 77955564990 scopus 로고    scopus 로고
    • Gene therapy of x-linked adrenoleukodystrophy using hematopoietic stem cells and a lentiviral vector
    • discussion 264-268
    • Cartier N, Hacein-Bey-Abina S, Von Kalle C, et al. [Gene therapy of x-linked adrenoleukodystrophy using hematopoietic stem cells and a lentiviral vector]. Bull Acad Natl Med 2010;194:255-264; discussion 264-268.
    • (2010) Bull Acad Natl Med , vol.194 , pp. 255-264
    • Cartier, N.1    Hacein-Bey-Abina, S.2    Von Kalle, C.3
  • 6
    • 84879873039 scopus 로고    scopus 로고
    • Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy
    • Biffi A, Montini E, Lorioli L, et al. Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy. Science 2013;341:1233158.
    • (2013) Science , vol.341 , pp. 1233158
    • Biffi, A.1    Montini, E.2    Lorioli, L.3
  • 7
    • 84879867061 scopus 로고    scopus 로고
    • Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott- Aldrich syndrome
    • Aiuti A, Biasco L, Scaramuzza S, et al. Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott- Aldrich syndrome. Science 2013;341:1233151.
    • (2013) Science , vol.341 , pp. 1233151
    • Aiuti, A.1    Biasco, L.2    Scaramuzza, S.3
  • 8
    • 77953611002 scopus 로고    scopus 로고
    • Restriction factors of retroviral replication: The example oftripartite motif (TRIM) protein 5 alpha and 22
    • Kajaste-Rudnitski A, Pultrone C, Marzetta F, et al. Restriction factors of retroviral replication: the example oftripartite motif (TRIM) protein 5 alpha and 22. Amino Acids 2010;39:1-9.
    • (2010) Amino Acids , vol.39 , pp. 1-9
    • Kajaste-Rudnitski, A.1    Pultrone, C.2    Marzetta, F.3
  • 9
    • 84863115198 scopus 로고    scopus 로고
    • Intrinsic antiviral immunity
    • Yan N, Chen ZJ. Intrinsic antiviral immunity. Nat Immunol 2012;13:214-222.
    • (2012) Nat Immunol , vol.13 , pp. 214-222
    • Yan, N.1    Chen, Z.J.2
  • 10
    • 84904200114 scopus 로고    scopus 로고
    • Interactions between HIV-1 and the cell-autonomous innate immune system
    • Towers GJ, Noursadeghi M. Interactions between HIV-1 and the cell-autonomous innate immune system. Cell Host Microbe 2014;16:10-18.
    • (2014) Cell Host Microbe , vol.16 , pp. 10-18
    • Towers, G.J.1    Noursadeghi, M.2
  • 11
    • 9244260598 scopus 로고    scopus 로고
    • Intrinsic immunity: A front-line defense against viral attack
    • Bieniasz PD. Intrinsic immunity: a front-line defense against viral attack. Nat Immunol 2004;5:1109-1115.
    • (2004) Nat Immunol , vol.5 , pp. 1109-1115
    • Bieniasz, P.D.1
  • 12
    • 70350738592 scopus 로고    scopus 로고
    • Human cellular restriction factors that target HIV-1 replication
    • Strebel K, Luban J, Jeang KT. Human cellular restriction factors that target HIV-1 replication. BMC Med 2009; 7:48.
    • (2009) BMC Med , vol.7 , pp. 48
    • Strebel, K.1    Luban, J.2    Jeang, K.T.3
  • 13
    • 80053133049 scopus 로고    scopus 로고
    • Inflammatory modulation of HSCs: Viewing the HSC as a foundation for the immune response
    • King KY, Goodell MA. Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nat Rev Immunol 2011;11:685-692.
    • (2011) Nat Rev Immunol , vol.11 , pp. 685-692
    • King, K.Y.1    Goodell, M.A.2
  • 14
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006;124:783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 15
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NFkappaB by Toll-like receptor 3
    • Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NFkappaB by Toll-like receptor 3. Nature 2001;413:732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 16
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold SS, Kaisho T, Hemmi H, et al. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004;303:1529-1531.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3
  • 17
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    • Heil F, Hemmi H, Hochrein H, et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 2004;303:1526-1529.
    • (2004) Science , vol.303 , pp. 1526-1529
    • Heil, F.1    Hemmi, H.2    Hochrein, H.3
  • 18
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9- mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    • Lund J, Sato A, Akira S, et al. Toll-like receptor 9- mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 2003;198:513-520.
    • (2003) J Exp Med , vol.198 , pp. 513-520
    • Lund, J.1    Sato, A.2    Akira, S.3
  • 19
    • 11144273976 scopus 로고    scopus 로고
    • Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
    • Wang T, Town T, Alexopoulou L, et al. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med 2004;10:1366-1373.
    • (2004) Nat Med , vol.10 , pp. 1366-1373
    • Wang, T.1    Town, T.2    Alexopoulou, L.3
  • 20
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell 2010;140:805-820.
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 21
    • 33646342149 scopus 로고    scopus 로고
    • Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    • Kato H, Takeuchi O, Sato S, et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006;441:101-105.
    • (2006) Nature , vol.441 , pp. 101-105
    • Kato, H.1    Takeuchi, O.2    Sato, S.3
  • 22
    • 3242813113 scopus 로고    scopus 로고
    • The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
    • Yoneyama M, Kikuchi M, Natsukawa T, et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 2004;5:730-737.
    • (2004) Nat Immunol , vol.5 , pp. 730-737
    • Yoneyama, M.1    Kikuchi, M.2    Natsukawa, T.3
  • 23
    • 70349459734 scopus 로고    scopus 로고
    • RIG-Idependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
    • Ablasser A, Bauernfeind F, Hartmann G, et al. RIG-Idependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol 2009;10:1065-1072.
    • (2009) Nat Immunol , vol.10 , pp. 1065-1072
    • Ablasser, A.1    Bauernfeind, F.2    Hartmann, G.3
  • 24
    • 68049092912 scopus 로고    scopus 로고
    • RNA polymerase III detects cytosolic DNA and induces type i interferons through the RIG-I pathway
    • Chiu YH, Macmillan JB, Chen ZJ. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 2009;138:576-591.
    • (2009) Cell , vol.138 , pp. 576-591
    • Chiu, Y.H.1    Macmillan, J.B.2    Chen, Z.J.3
  • 25
    • 34547143110 scopus 로고    scopus 로고
    • DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
    • Takaoka A, Wang Z, Choi MK, et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007;448:501-505.
    • (2007) Nature , vol.448 , pp. 501-505
    • Takaoka, A.1    Wang, Z.2    Choi, M.K.3
  • 26
    • 84866488122 scopus 로고    scopus 로고
    • Innate immune recognition of HIV-1
    • Iwasaki A. Innate immune recognition of HIV-1. Immunity 2012;37:389-398.
    • (2012) Immunity , vol.37 , pp. 389-398
    • Iwasaki, A.1
  • 28
    • 0142150948 scopus 로고    scopus 로고
    • Global analysis of cellular transcription following infection with an HIV-based vector
    • Mitchell R, Chiang CY, Berry C, Bushman F. Global analysis of cellular transcription following infection with an HIV-based vector. Mol Ther 2003;8:674-687.
    • (2003) Mol Ther , vol.8 , pp. 674-687
    • Mitchell, R.1    Chiang, C.Y.2    Berry, C.3    Bushman, F.4
  • 29
    • 77951993592 scopus 로고    scopus 로고
    • HIV-1 lentiviral vector immunogenicity is mediated by Toll-like receptor 3 (TLR3) and TLR7
    • Breckpot K, Escors D, Arce F, et al. HIV-1 lentiviral vector immunogenicity is mediated by Toll-like receptor 3 (TLR3) and TLR7. J Virol 2010;84:5627-5636.
    • (2010) J Virol , vol.84 , pp. 5627-5636
    • Breckpot, K.1    Escors, D.2    Arce, F.3
  • 30
    • 79951840580 scopus 로고    scopus 로고
    • HIV-1-derived lentiviral vectors directly activate plasmacytoid dendritic cells, which in turn induce the maturation of myeloid dendritic cells
    • Rossetti M, Gregori S, Hauben E, et al. HIV-1-derived lentiviral vectors directly activate plasmacytoid dendritic cells, which in turn induce the maturation of myeloid dendritic cells. Hum Gene Ther 2011;22:177-188.
    • (2011) Hum Gene Ther , vol.22 , pp. 177-188
    • Rossetti, M.1    Gregori, S.2    Hauben, E.3
  • 31
    • 84870594961 scopus 로고    scopus 로고
    • A TLR and non-TLR mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade
    • Agudo J, Ruzo A, Kitur K, et al. A TLR and non-TLR mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade. Mol Ther 2012;20:2257-2267.
    • (2012) Mol Ther , vol.20 , pp. 2257-2267
    • Agudo, J.1    Ruzo, A.2    Kitur, K.3
  • 32
    • 84872865451 scopus 로고    scopus 로고
    • Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: Implications for gene therapy
    • Sutlu T, Nystrom S, Gilljam M, et al. Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: implications for gene therapy. Hum Gene Ther 2012;23: 1090-1100.
    • (2012) Hum Gene Ther , vol.23 , pp. 1090-1100
    • Sutlu, T.1    Nystrom, S.2    Gilljam, M.3
  • 33
    • 68049085518 scopus 로고    scopus 로고
    • HIV-1 RNA dimerization: It takes two to tango
    • Moore MD, Hu WS. HIV-1 RNA dimerization: it takes two to tango. AIDS Rev 2009;11:91-102.
    • (2009) AIDS Rev , vol.11 , pp. 91-102
    • Moore, M.D.1    Hu, W.S.2
  • 34
    • 0000829669 scopus 로고    scopus 로고
    • HIVs and their replication
    • 5th edition. DM Knipe, PM Howley, eds. (Lippincot, Williams & Wilkins, Philadelphia, PA)
    • Freed EO, Martin MA. HIVs and their replication. In: Field's Virology, 5th edition. DM Knipe, PM Howley, eds. (Lippincot, Williams & Wilkins, Philadelphia, PA). 2007; pp. 2107-2186.
    • (2007) Field's Virology , pp. 2107-2186
    • Freed, E.O.1    Martin, M.A.2
  • 35
    • 84855301478 scopus 로고    scopus 로고
    • Genomic HIV RNA induces innate immune responses through RIG-Idependent sensing of secondary-structured RNA
    • Berg RK, Melchjorsen J, Rintahaka J, et al. Genomic HIV RNA induces innate immune responses through RIG-Idependent sensing of secondary-structured RNA. PLoS One 2012;7:e29291.
    • (2012) PLoS One , vol.7 , pp. e29291
    • Berg, R.K.1    Melchjorsen, J.2    Rintahaka, J.3
  • 37
    • 77958114725 scopus 로고    scopus 로고
    • The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
    • Yan N, Regalado-Magdos AD, Stiggelbout B, et al. The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol 2010;11:1005-1013.
    • (2010) Nat Immunol , vol.11 , pp. 1005-1013
    • Yan, N.1    Regalado-Magdos, A.D.2    Stiggelbout, B.3
  • 38
    • 84882896267 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses
    • Gao D, Wu J, Wu YT, et al. Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 2013;341:903-906.
    • (2013) Science , vol.341 , pp. 903-906
    • Gao, D.1    Wu, J.2    Wu, Y.T.3
  • 39
    • 49549100511 scopus 로고    scopus 로고
    • Trex1 prevents cell-intrinsic initiation of autoimmunity
    • Stetson DB, Ko JS, Heidmann T, Medzhitov R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 2008;134:587-598.
    • (2008) Cell , vol.134 , pp. 587-598
    • Stetson, D.B.1    Ko, J.S.2    Heidmann, T.3    Medzhitov, R.4
  • 40
    • 84902197435 scopus 로고    scopus 로고
    • TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner
    • Ablasser A, Hemmerling I, Schmid-Burgk JL, et al. TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner. J Immunol 2014;192:5993-5997.
    • (2014) J Immunol , vol.192 , pp. 5993-5997
    • Ablasser, A.1    Hemmerling, I.2    Schmid-Burgk, J.L.3
  • 41
    • 84918823623 scopus 로고    scopus 로고
    • Cytosolic RNA:DNA hybrids activate the cGAS-STING axis
    • Mankan AK, Schmidt T, Chauhan D, et al. Cytosolic RNA:DNA hybrids activate the cGAS-STING axis. EMBO J 2014;33:2937-2946.
    • (2014) EMBO J , vol.33 , pp. 2937-2946
    • Mankan, A.K.1    Schmidt, T.2    Chauhan, D.3
  • 42
    • 84255177502 scopus 로고    scopus 로고
    • RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability
    • Wahba L, Amon JD, Koshland D, Vuica-Ross M. RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability. Mol Cell 2011;44:978-988.
    • (2011) Mol Cell , vol.44 , pp. 978-988
    • Wahba, L.1    Amon, J.D.2    Koshland, D.3    Vuica-Ross, M.4
  • 43
    • 84920413492 scopus 로고    scopus 로고
    • Defective removal of ribonucleotides from DNA promotes systemic autoimmunity
    • Gunther C, Kind B, Reijns MA, et al. Defective removal of ribonucleotides from DNA promotes systemic autoimmunity. J Clin Invest 2015;125:413-424.
    • (2015) J Clin Invest , vol.125 , pp. 413-424
    • Gunther, C.1    Kind, B.2    Reijns, M.A.3
  • 44
    • 84892946076 scopus 로고    scopus 로고
    • IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV
    • Monroe KM, Yang Z, Johnson JR, et al. IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science 2014;343:428-432.
    • (2014) Science , vol.343 , pp. 428-432
    • Monroe, K.M.1    Yang, Z.2    Johnson, J.R.3
  • 45
    • 84892739389 scopus 로고    scopus 로고
    • Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
    • Doitsh G, Galloway NL, Geng X, et al. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature 2014;505:509-514.
    • (2014) Nature , vol.505 , pp. 509-514
    • Doitsh, G.1    Galloway, N.L.2    Geng, X.3
  • 46
    • 79952688973 scopus 로고    scopus 로고
    • Large-scale manufacture and characterization of a lentiviral vector produced for clinical ex vivo gene therapy application
    • Merten OW, Charrier S, Laroudie N, et al. Large-scale manufacture and characterization of a lentiviral vector produced for clinical ex vivo gene therapy application. Hum Gene Ther 2011;22:343-356.
    • (2011) Hum Gene Ther , vol.22 , pp. 343-356
    • Merten, O.W.1    Charrier, S.2    Laroudie, N.3
  • 47
    • 84890926341 scopus 로고    scopus 로고
    • A model for cofactor use during HIV-1 reverse transcription and nuclear entry
    • Hilditch L, Towers GJ. A model for cofactor use during HIV-1 reverse transcription and nuclear entry. Curr Opin Virol 2014;4C:32-36.
    • (2014) Curr Opin Virol , vol.4 C , pp. 32-36
    • Hilditch, L.1    Towers, G.J.2
  • 48
    • 84890215093 scopus 로고    scopus 로고
    • The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNAby the innate sensor cGAS in dendritic cells
    • Lahaye X, Satoh T, Gentili M, et al. The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNAby the innate sensor cGAS in dendritic cells. Immunity 2013;39:1132-1142.
    • (2013) Immunity , vol.39 , pp. 1132-1142
    • Lahaye, X.1    Satoh, T.2    Gentili, M.3
  • 49
    • 84888054227 scopus 로고    scopus 로고
    • HIV-1 evades innate immune recognition through specific cofactor recruitment
    • Rasaiyaah J, Tan CP, Fletcher AJ, et al. HIV-1 evades innate immune recognition through specific cofactor recruitment. Nature 2013;503:402-405.
    • (2013) Nature , vol.503 , pp. 402-405
    • Rasaiyaah, J.1    Tan, C.P.2    Fletcher, A.J.3
  • 50
    • 79955377543 scopus 로고    scopus 로고
    • TRIM5 is an innate immune sensor for the retrovirus capsid lattice
    • Pertel T, Hausmann S, Morger D, et al. TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature 2011;472:361-365.
    • (2011) Nature , vol.472 , pp. 361-365
    • Pertel, T.1    Hausmann, S.2    Morger, D.3
  • 51
    • 84859496523 scopus 로고    scopus 로고
    • TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling
    • Grutter MG, Luban J. TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling. Curr Opin Virol 2012;2:142-150.
    • (2012) Curr Opin Virol , vol.2 , pp. 142-150
    • Grutter, M.G.1    Luban, J.2
  • 52
    • 1542288934 scopus 로고    scopus 로고
    • The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys
    • Stremlau M, Owens CM, Perron MJ, et al. The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys. Nature 2004;427:848-853.
    • (2004) Nature , vol.427 , pp. 848-853
    • Stremlau, M.1    Owens, C.M.2    Perron, M.J.3
  • 53
    • 84895906595 scopus 로고    scopus 로고
    • TRIM5alpha variations influence transduction efficiency with lentiviral vectors in both human and rhesus CD34 cells in vitro and in vivo
    • Evans ME, Kumkhaek C, Hsieh MM, et al. TRIM5alpha variations influence transduction efficiency with lentiviral vectors in both human and rhesus CD34 cells in vitro and in vivo. Mol Ther 2013;22:348-358.
    • (2013) Mol Ther , vol.22 , pp. 348-358
    • Evans, M.E.1    Kumkhaek, C.2    Hsieh, M.M.3
  • 54
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • Naldini L, Blomer U, Gallay P, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996;272:263-267.
    • (1996) Science , vol.272 , pp. 263-267
    • Naldini, L.1    Blomer, U.2    Gallay, P.3
  • 55
    • 84892171421 scopus 로고    scopus 로고
    • Structural basis of lentiviral subversion of a cellular protein degradation pathway
    • Schwefel D, Groom HC, Boucherit VC, et al. Structural basis of lentiviral subversion of a cellular protein degradation pathway. Nature 2014;505:234-238.
    • (2014) Nature , vol.505 , pp. 234-238
    • Schwefel, D.1    Groom, H.C.2    Boucherit, V.C.3
  • 56
    • 84892799863 scopus 로고    scopus 로고
    • Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing
    • Laguette N, Bregnard C,Hue P, et al. Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing. Cell 2014;156:134-145.
    • (2014) Cell , vol.156 , pp. 134-145
    • Laguette, N.1    Bregnard Chue, P.2
  • 57
    • 33744978765 scopus 로고    scopus 로고
    • Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment
    • Nagai Y, Garrett KP, Ohta S, et al. Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity 2006;24:801-812.
    • (2006) Immunity , vol.24 , pp. 801-812
    • Nagai, Y.1    Garrett, K.P.2    Ohta, S.3
  • 58
    • 66149115277 scopus 로고    scopus 로고
    • IFNalpha activates dormant haematopoietic stem cells in vivo
    • Essers MA, Offner S, Blanco-Bose WE, et al. IFNalpha activates dormant haematopoietic stem cells in vivo. Nature 2009;458:904-908.
    • (2009) Nature , vol.458 , pp. 904-908
    • Essers, M.A.1    Offner, S.2    Blanco-Bose, W.E.3
  • 59
    • 79955530513 scopus 로고    scopus 로고
    • Chronic exposure to a TLR ligand injures hematopoietic stem cells
    • Esplin BL, Shimazu T, Welner RS, et al. Chronic exposure to a TLR ligand injures hematopoietic stem cells. J Immunol 2011;186:5367-5375.
    • (2011) J Immunol , vol.186 , pp. 5367-5375
    • Esplin, B.L.1    Shimazu, T.2    Welner, R.S.3
  • 60
    • 84859181084 scopus 로고    scopus 로고
    • Demand-adapted regulation of early hematopoiesis in infection and inflammation
    • Takizawa H, Boettcher S, Manz MG. Demand-adapted regulation of early hematopoiesis in infection and inflammation. Blood 2012;119:2991-3002.
    • (2012) Blood , vol.119 , pp. 2991-3002
    • Takizawa, H.1    Boettcher, S.2    Manz, M.G.3
  • 61
    • 33751315780 scopus 로고    scopus 로고
    • Signaling through toll-like receptor 7/8 induces the differentiation of human bone marrow CD34 + progenitor cells along the myeloid lineage
    • Sioud M, Floisand Y, Forfang L, Lund-Johansen F. Signaling through toll-like receptor 7/8 induces the differentiation of human bone marrow CD34 + progenitor cells along the myeloid lineage. J Mol Biol 2006;364:945-954.
    • (2006) J Mol Biol , vol.364 , pp. 945-954
    • Sioud, M.1    Floisand, Y.2    Forfang, L.3    Lund-Johansen, F.4
  • 62
    • 77953935525 scopus 로고    scopus 로고
    • CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells
    • Guo YM, Ishii K, Hirokawa M, et al. CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells. Blood 2010;115:4569-4579.
    • (2010) Blood , vol.115 , pp. 4569-4579
    • Guo, Y.M.1    Ishii, K.2    Hirokawa, M.3
  • 63
    • 84862831148 scopus 로고    scopus 로고
    • A synthetic doublestranded RNA, poly I:C, induces a rapid apoptosis of human CD34( + ) cells
    • Liu J, Guo YM, Hirokawa M, et al. A synthetic doublestranded RNA, poly I:C, induces a rapid apoptosis of human CD34( + ) cells. Exp Hematol 2012;40:330-341.
    • (2012) Exp Hematol , vol.40 , pp. 330-341
    • Liu, J.1    Guo, Y.M.2    Hirokawa, M.3
  • 64
    • 70450237721 scopus 로고    scopus 로고
    • The TLR1/2 agonist PAM(3)CSK(4) instructs commitment of human hematopoietic stem cells to a myeloid cell fate
    • De Luca K, Frances-Duvert V, Asensio MJ, et al. The TLR1/2 agonist PAM(3)CSK(4) instructs commitment of human hematopoietic stem cells to a myeloid cell fate. Leukemia 2009;23:2063-2074.
    • (2009) Leukemia , vol.23 , pp. 2063-2074
    • De Luca, K.1    Frances-Duvert, V.2    Asensio, M.J.3
  • 65
    • 80052823309 scopus 로고    scopus 로고
    • Candida albicans induces selective development of macrophages and monocyte derived dendritic cells by a TLR2 dependent signalling
    • Yanez A, Megias J, O'Connor JE, et al. Candida albicans induces selective development of macrophages and monocyte derived dendritic cells by a TLR2 dependent signalling. PLoS One 2011;6:e24761.
    • (2011) PLoS One , vol.6 , pp. e24761
    • Yanez, A.1    Megias, J.2    O'connor, J.E.3
  • 66
    • 0037043699 scopus 로고    scopus 로고
    • Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein
    • Sheehy AM, Gaddis NC, Choi JD, Malim MH. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 2002;418:646-650.
    • (2002) Nature , vol.418 , pp. 646-650
    • Sheehy, A.M.1    Gaddis, N.C.2    Choi, J.D.3    Malim, M.H.4
  • 67
    • 38549095979 scopus 로고    scopus 로고
    • Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
    • Neil SJ, Zang T, Bieniasz PD. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature 2008;451:425-430.
    • (2008) Nature , vol.451 , pp. 425-430
    • Neil, S.J.1    Zang, T.2    Bieniasz, P.D.3
  • 68
    • 41849116366 scopus 로고    scopus 로고
    • The interferoninduced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein
    • Van Damme N, Goff D, Katsura C, et al. The interferoninduced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe 2008;3:245-252.
    • (2008) Cell Host Microbe , vol.3 , pp. 245-252
    • Van Damme, N.1    Goff, D.2    Katsura, C.3
  • 69
    • 79959858243 scopus 로고    scopus 로고
    • Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
    • Hrecka K, Hao C, Gierszewska M, et al. Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature 2011;474:658-661.
    • (2011) Nature , vol.474 , pp. 658-661
    • Hrecka, K.1    Hao, C.2    Gierszewska, M.3
  • 70
    • 79959843617 scopus 로고    scopus 로고
    • SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
    • Laguette N, Sobhian B, Casartelli N, et al. SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature 2011;474:654-657.
    • (2011) Nature , vol.474 , pp. 654-657
    • Laguette, N.1    Sobhian, B.2    Casartelli, N.3
  • 71
    • 84886953102 scopus 로고    scopus 로고
    • Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection
    • Goujon C, Moncorge O, Bauby H, et al. Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection. Nature 2013;502:559-562.
    • (2013) Nature , vol.502 , pp. 559-562
    • Goujon, C.1    Moncorge, O.2    Bauby, H.3
  • 72
    • 84886949134 scopus 로고    scopus 로고
    • MX2 is an interferon- induced inhibitor of HIV-1 infection
    • Kane M, Yadav SS, Bitzegeio J, et al. MX2 is an interferon- induced inhibitor of HIV-1 infection. Nature 2013;502:563-566.
    • (2013) Nature , vol.502 , pp. 563-566
    • Kane, M.1    Yadav, S.S.2    Bitzegeio, J.3
  • 73
    • 84885987626 scopus 로고    scopus 로고
    • The interferon-inducible MxB protein inhibits HIV-1 infection
    • Liu Z, Pan Q, Ding S, et al. The interferon-inducible MxB protein inhibits HIV-1 infection. Cell Host Microbe 2013;14:398-410.
    • (2013) Cell Host Microbe , vol.14 , pp. 398-410
    • Liu, Z.1    Pan, Q.2    Ding, S.3
  • 74
    • 47549109070 scopus 로고    scopus 로고
    • Tissue-specific restriction of cyclophilin A-independent HIV-1- and SIVderived lentiviral vectors
    • Kahl CA, Cannon PM, Oldenburg J, et al. Tissue-specific restriction of cyclophilin A-independent HIV-1- and SIVderived lentiviral vectors. Gene Ther 2008;15:1079-1089.
    • (2008) Gene Ther , vol.15 , pp. 1079-1089
    • Kahl, C.A.1    Cannon, P.M.2    Oldenburg, J.3
  • 75
    • 84869170593 scopus 로고    scopus 로고
    • SAMHD1 restricts HIV-1 infection in resting CD4( + ) T cells
    • Baldauf HM, Pan X, Erikson E, et al. SAMHD1 restricts HIV-1 infection in resting CD4( + ) T cells. Nat Med 2012;18:1682-1687.
    • (2012) Nat Med , vol.18 , pp. 1682-1687
    • Baldauf, H.M.1    Pan, X.2    Erikson, E.3
  • 76
    • 83555164881 scopus 로고    scopus 로고
    • HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
    • Goldstone DC, Ennis-Adeniran V, Hedden JJ, et al. HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature 2011;480:379-382.
    • (2011) Nature , vol.480 , pp. 379-382
    • Goldstone, D.C.1    Ennis-Adeniran, V.2    Hedden, J.J.3
  • 77
    • 84862777555 scopus 로고    scopus 로고
    • SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
    • Lahouassa H, Daddacha W, Hofmann H, et al. SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nat Immunol 2012;13:223-228.
    • (2012) Nat Immunol , vol.13 , pp. 223-228
    • Lahouassa, H.1    Daddacha, W.2    Hofmann, H.3
  • 78
    • 33644758276 scopus 로고    scopus 로고
    • Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells
    • Sokolskaja E, Berthoux L, Luban J. Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells. J Virol 2006;80:2855-2862.
    • (2006) J Virol , vol.80 , pp. 2855-2862
    • Sokolskaja, E.1    Berthoux, L.2    Luban, J.3
  • 79
    • 34447317534 scopus 로고    scopus 로고
    • The control of viral infection by tripartite motif proteins and cyclophilin A
    • Towers GJ. The control of viral infection by tripartite motif proteins and cyclophilin A. Retrovirology 2007;4:40.
    • (2007) Retrovirology , vol.4 , pp. 40
    • Towers, G.J.1
  • 80
    • 84930486755 scopus 로고    scopus 로고
    • Cyclosporin a and rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cells
    • Petrillo C, Cesana D, Piras F, et al. Cyclosporin a and rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cells. Mol Ther 2015;23:352-362.
    • (2015) Mol Ther , vol.23 , pp. 352-362
    • Petrillo, C.1    Cesana, D.2    Piras, F.3
  • 81
    • 84904684665 scopus 로고    scopus 로고
    • Host and viral determinants of mx2 antiretroviral activity
    • Busnadiego I, Kane M, Rihn SJ, et al. Host and viral determinants of mx2 antiretroviral activity. J Virol 2014; 88:7738-7752.
    • (2014) J Virol , vol.88 , pp. 7738-7752
    • Busnadiego, I.1    Kane, M.2    Rihn, S.J.3
  • 82
    • 77956036847 scopus 로고    scopus 로고
    • Characterization of the alpha interferon- induced postentry block to HIV-1 infection in primary human macrophages and T cells
    • Goujon C, Malim MH. Characterization of the alpha interferon- induced postentry block to HIV-1 infection in primary human macrophages and T cells. J Virol 2010; 84:9254-9266.
    • (2010) J Virol , vol.84 , pp. 9254-9266
    • Goujon, C.1    Malim, M.H.2
  • 83
    • 79958723079 scopus 로고    scopus 로고
    • The TRIM family protein KAP1 inhibits HIV-1 integration
    • Allouch A, Di Primio C, Alpi E, et al. The TRIM family protein KAP1 inhibits HIV-1 integration. Cell HostMicrobe 2011;9:484-495.
    • (2011) Cell HostMicrobe , vol.9 , pp. 484-495
    • Allouch, A.1    Di Primio, C.2    Alpi, E.3
  • 84
    • 33846809447 scopus 로고    scopus 로고
    • Primitive hematopoietic cells resist HIV-1 infection via p21
    • Zhang J, Scadden DT, Crumpacker CS. Primitive hematopoietic cells resist HIV-1 infection via p21. J Clin Invest 2007;117:473-481.
    • (2007) J Clin Invest , vol.117 , pp. 473-481
    • Zhang, J.1    Scadden, D.T.2    Crumpacker, C.S.3
  • 85
    • 34848819391 scopus 로고    scopus 로고
    • TRIM28 mediates primer binding sitetargeted silencing of murine leukemia virus in embryonic cells
    • Wolf D, Goff SP. TRIM28 mediates primer binding sitetargeted silencing of murine leukemia virus in embryonic cells. Cell 2007;131:46-57.
    • (2007) Cell , vol.131 , pp. 46-57
    • Wolf, D.1    Goff, S.P.2
  • 86
    • 74549116659 scopus 로고    scopus 로고
    • KAP1 controls endogenous retroviruses in embryonic stem cells
    • Rowe HM, Jakobsson J, Mesnard D, et al. KAP1 controls endogenous retroviruses in embryonic stem cells. Nature 2010;463:237-240.
    • (2010) Nature , vol.463 , pp. 237-240
    • Rowe, H.M.1    Jakobsson, J.2    Mesnard, D.3
  • 87
    • 84885761187 scopus 로고    scopus 로고
    • P21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway
    • Allouch A, David A, Amie SM, et al. p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway. Proc Natl Acad Sci USA 2013;110: E3997-E4006.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. E3997-E4006
    • Allouch, A.1    David, A.2    Amie, S.M.3
  • 88
    • 84898027657 scopus 로고    scopus 로고
    • P21 regulates the HIV-1 restriction factor SAMHD1
    • Pauls E, Ruiz A, Riveira-Munoz E, et al. p21 regulates the HIV-1 restriction factor SAMHD1. Proc Natl Acad Sci USA 2014;111:E1322-E1324.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. E1322-E1324
    • Pauls, E.1    Ruiz, A.2    Riveira-Munoz, E.3
  • 89
    • 34547152610 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells and the quest for transplant tolerance
    • Morelli AE, Thomson AW. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 2007;7:610-621.
    • (2007) Nat Rev Immunol , vol.7 , pp. 610-621
    • Morelli, A.E.1    Thomson, A.W.2
  • 90
    • 0030026776 scopus 로고    scopus 로고
    • Vaccination of patients with B-cell lymphoma using autologous antigenpulsed dendritic cells
    • Hsu FJ, Benike C, Fagnoni F, et al. Vaccination of patients with B-cell lymphoma using autologous antigenpulsed dendritic cells. Nat Med 1996;2:52-58.
    • (1996) Nat Med , vol.2 , pp. 52-58
    • Hsu, F.J.1    Benike, C.2    Fagnoni, F.3
  • 91
    • 84255197842 scopus 로고    scopus 로고
    • Cancer immunotherapy comes of age
    • Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature 2011;480:480-489.
    • (2011) Nature , vol.480 , pp. 480-489
    • Mellman, I.1    Coukos, G.2    Dranoff, G.3
  • 92
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: Mechanism and functions
    • Gordon S, Martinez FO. Alternative activation of macrophages: mechanism and functions. Immunity 2010;32: 593-604.
    • (2010) Immunity , vol.32 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 93
    • 80355131976 scopus 로고    scopus 로고
    • Protective and pathogenic functions of macrophage subsets
    • Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 2011;11:723-737.
    • (2011) Nat Rev Immunol , vol.11 , pp. 723-737
    • Murray, P.J.1    Wynn, T.A.2
  • 94
    • 84871076444 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization in tissue repair and remodelling
    • Mantovani A, Biswas SK, Galdiero MR, et al. Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol 2013;229:176-185.
    • (2013) J Pathol , vol.229 , pp. 176-185
    • Mantovani, A.1    Biswas, S.K.2    Galdiero, M.R.3
  • 95
    • 63149088164 scopus 로고    scopus 로고
    • Trophic macrophages in development and disease
    • Pollard JW. Trophic macrophages in development and disease. Nat Rev Immunol 2009;9:259-270.
    • (2009) Nat Rev Immunol , vol.9 , pp. 259-270
    • Pollard, J.W.1
  • 96
    • 84876424760 scopus 로고    scopus 로고
    • Macrophage regulation of tumor responses to anticancer therapies
    • De Palma M, Lewis CE. Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell 2013;23:277-286.
    • (2013) Cancer Cell , vol.23 , pp. 277-286
    • De Palma, M.1    Lewis, C.E.2
  • 97
    • 84877779587 scopus 로고    scopus 로고
    • Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein
    • Bobadilla S, Sunseri N, Landau NR. Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein. Gene Ther 2012.
    • (2012) Gene Ther
    • Bobadilla, S.1    Sunseri, N.2    Landau, N.R.3
  • 98
    • 79952149658 scopus 로고    scopus 로고
    • The inside out of lentiviral vectors
    • Durand S, Cimarelli A. The inside out of lentiviral vectors. Viruses 2011;3:132-159.
    • (2011) Viruses , vol.3 , pp. 132-159
    • Durand, S.1    Cimarelli, A.2
  • 99
    • 84895464998 scopus 로고    scopus 로고
    • Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells
    • Tareen SU, Kelley-Clarke B, Nicolai CJ, et al. Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells. Mol Ther 2013;22:575-587.
    • (2013) Mol Ther , vol.22 , pp. 575-587
    • Tareen, S.U.1    Kelley-Clarke, B.2    Nicolai, C.J.3
  • 100
    • 79958172300 scopus 로고    scopus 로고
    • A simple, versatile and efficient method to genetically modify human monocyte-derived dendritic cells with HIV-1-derived lentiviral vectors
    • Berger G, Durand S, Goujon C, et al. A simple, versatile and efficient method to genetically modify human monocyte-derived dendritic cells with HIV-1-derived lentiviral vectors. Nat Protoc 2011;6:806-816.
    • (2011) Nat Protoc , vol.6 , pp. 806-816
    • Berger, G.1    Durand, S.2    Goujon, C.3
  • 101
    • 44449129551 scopus 로고    scopus 로고
    • Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction
    • Sharova N, Wu Y, Zhu X, et al. Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction. PLoS Pathogens 2008;4:e1000057.
    • (2008) PLoS Pathogens , vol.4 , pp. e1000057
    • Sharova, N.1    Wu, Y.2    Zhu, X.3
  • 102
    • 84892497056 scopus 로고    scopus 로고
    • Genetic engineering of hematopoiesis for targeted IFN-alpha delivery inhibits breast cancer progression
    • EscobarG,Moi D, RanghettiA, et al. Genetic engineering of hematopoiesis for targeted IFN-alpha delivery inhibits breast cancer progression. Sci Transl Med 2014;6:217ra213.
    • (2014) Sci Transl Med , vol.6 , pp. 217ra213
    • Ranghettia, E.D.1
  • 103
    • 84905451458 scopus 로고    scopus 로고
    • Dual-regulated lentiviral vector for gene therapy of X-linked chronic granulomatosis
    • Chiriaco M, Farinelli G, Capo V, et al. Dual-regulated lentiviral vector for gene therapy of X-linked chronic granulomatosis. Mol Ther 2014;22:1472-1483.
    • (2014) Mol Ther , vol.22 , pp. 1472-1483
    • Chiriaco, M.1    Farinelli, G.2    Capo, V.3
  • 104
    • 84884291057 scopus 로고    scopus 로고
    • SAMHD1- dependent retroviral control and escape in mice
    • Rehwinkel J, Maelfait J, Bridgeman A, et al. SAMHD1- dependent retroviral control and escape in mice. EMBO J 2013;11;32:2454-2462.
    • (2013) EMBO J , vol.11 , Issue.32 , pp. 2454-2462
    • Rehwinkel, J.1    Maelfait, J.2    Bridgeman, A.3
  • 105
    • 84862777555 scopus 로고    scopus 로고
    • SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
    • Lahouassa H, Daddacha W, Hofmann H, et al. SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nat Immunol 2012;12;13:223-228.
    • (2012) Nat Immunol , vol.12 , Issue.13 , pp. 223-228
    • Lahouassa, H.1    Daddacha, W.2    Hofmann, H.3
  • 106
    • 77956497003 scopus 로고    scopus 로고
    • A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
    • Manel N, Hogstad B, Wang Y, et al. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 2010;467:214-217.
    • (2010) Nature , vol.467 , pp. 214-217
    • Manel, N.1    Hogstad, B.2    Wang, Y.3
  • 107
    • 55049091782 scopus 로고    scopus 로고
    • Lentiviral vector gene transfer is limited by the proteasome at postentry steps in various types of stem cells
    • Santoni de Sio FR, Gritti A, Cascio P, et al. Lentiviral vector gene transfer is limited by the proteasome at postentry steps in various types of stem cells. Stem Cells 2008; 26:2142-2152.
    • (2008) Stem Cells , vol.26 , pp. 2142-2152
    • Santoni De Sio, F.R.1    Gritti, A.2    Cascio, P.3
  • 108
    • 84883556680 scopus 로고    scopus 로고
    • Efficient transduction of human hematopoietic repopulating cells with a chimeric HIV1-based vector including SIV capsid
    • Uchida N, Hsieh MM, Washington KN, Tisdale JF. Efficient transduction of human hematopoietic repopulating cells with a chimeric HIV1-based vector including SIV capsid. Exp Hematol 2013;41:779-788.e771.
    • (2013) Exp Hematol , vol.41 , pp. 779e771-788e771
    • Uchida, N.1    Hsieh, M.M.2    Washington, K.N.3    Tisdale, J.F.4
  • 109
    • 33744496523 scopus 로고    scopus 로고
    • Proteasome activity restricts lentiviral gene transfer into hematopoietic stem cells and is down-regulated by cytokines that enhance transduction
    • Santoni de Sio FR, Cascio P, Zingale A, et al. Proteasome activity restricts lentiviral gene transfer into hematopoietic stem cells and is down-regulated by cytokines that enhance transduction. Blood 2006;107:4257-4265.
    • (2006) Blood , vol.107 , pp. 4257-4265
    • Santoni De Sio, F.R.1    Cascio, P.2    Zingale, A.3
  • 110
    • 84905745710 scopus 로고    scopus 로고
    • Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells
    • Wang CX, Sather BD, Wang X, et al. Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells. Blood 2014;124:913-923.
    • (2014) Blood , vol.124 , pp. 913-923
    • Wang, C.X.1    Sather, B.D.2    Wang, X.3
  • 111
    • 84908054283 scopus 로고    scopus 로고
    • Enhanced genetic modification of adult growth factor mobilized peripheral blood hematopoietic stem and progenitor cells with rapamycin
    • Li, L, Torres-Coronado M, Gu A, et al. Enhanced genetic modification of adult growth factor mobilized peripheral blood hematopoietic stem and progenitor cells with rapamycin. Stem Cells Trans Med 2014;3:1199-1208.
    • (2014) Stem Cells Trans Med , vol.3 , pp. 1199-1208
    • Li, L.1    Torres-Coronado, M.2    Gu, A.3
  • 112
    • 79954692758 scopus 로고    scopus 로고
    • Ex vivo gene transfer and correction for cellbased therapies
    • Naldini L. Ex vivo gene transfer and correction for cellbased therapies. Nat Rev Genet 2011;12:301-315.
    • (2011) Nat Rev Genet , vol.12 , pp. 301-315
    • Naldini, L.1
  • 113
    • 84899683375 scopus 로고    scopus 로고
    • Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor
    • Amirache F, Levy C, Costa C, et al. Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor. Blood 2014;123:1422-1424.
    • (2014) Blood , vol.123 , pp. 1422-1424
    • Amirache, F.1    Levy, C.2    Costa, C.3
  • 114
    • 84876926824 scopus 로고    scopus 로고
    • LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus
    • Finkelshtein D, Werman A, Novick D, et al. LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus. Proc Natl Acad Sci USA 2013; 110:7306-7311.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 7306-7311
    • Finkelshtein, D.1    Werman, A.2    Novick, D.3
  • 115
    • 84907303748 scopus 로고    scopus 로고
    • Baboon envelope pseudotyped LVs outperform VSV-G-LVs for gene transfer into early-cytokine-stimulated and resting HSCs
    • Girard-Gagnepain A, Amirache F, Costa C, et al. Baboon envelope pseudotyped LVs outperform VSV-G-LVs for gene transfer into early-cytokine-stimulated and resting HSCs. Blood 2014;124:1221-1231.
    • (2014) Blood , vol.124 , pp. 1221-1231
    • Girard-Gagnepain, A.1    Amirache, F.2    Costa, C.3
  • 116
    • 84860298517 scopus 로고    scopus 로고
    • Measles virus glycoprotein-pseudotyped lentiviral vectors are highly superior to vesicular stomatitis virus G pseudotypes for genetic modification of monocyte-derived dendritic cells
    • Humbert JM, Frecha C, Amirache Bouafia F, et al. Measles virus glycoprotein-pseudotyped lentiviral vectors are highly superior to vesicular stomatitis virus G pseudotypes for genetic modification of monocyte-derived dendritic cells. J Virol 2012;86:5192-5203.
    • (2012) J Virol , vol.86 , pp. 5192-5203
    • Humbert, J.M.1    Frecha, C.2    Amirache Bouafia, F.3
  • 117
    • 84920553698 scopus 로고    scopus 로고
    • CD133-targeted gene transfer into long-term repopulating hematopoietic stem cells
    • Brendel C, Goebel B, Daniela A, et al. CD133-targeted gene transfer into long-term repopulating hematopoietic stem cells. Mol Ther 2015;23:63-70.
    • (2015) Mol Ther , vol.23 , pp. 63-70
    • Brendel, C.1    Goebel, B.2    Daniela, A.3
  • 118
    • 84924346983 scopus 로고    scopus 로고
    • CD105 is a surface marker for receptor-targeted gene transfer into human long-term repopulating hematopoietic stem cells
    • Kays SK, Kaufmann KB, Abel T, et al. CD105 is a surface marker for receptor-targeted gene transfer into human long-term repopulating hematopoietic stem cells. Stem Cells Dev 2015;24:714-723.
    • (2015) Stem Cells Dev , vol.24 , pp. 714-723
    • Kays, S.K.1    Kaufmann, K.B.2    Abel, T.3
  • 119
    • 84871929094 scopus 로고    scopus 로고
    • Preclinical safety and efficacy of human CD34( + ) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome
    • Scaramuzza S, Biasco L, Ripamonti A, et al. Preclinical safety and efficacy of human CD34( + ) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome. Mol Ther 2013;21:175-184.
    • (2013) Mol Ther , vol.21 , pp. 175-184
    • Scaramuzza, S.1    Biasco, L.2    Ripamonti, A.3
  • 120
    • 84891832674 scopus 로고    scopus 로고
    • No impact of lentiviral transduction on hematopoietic stem/progenitor cell telomere length or gene expression in the rhesus macaque model
    • Sellers SE, Dumitriu B, Morgan MJ, et al. No impact of lentiviral transduction on hematopoietic stem/progenitor cell telomere length or gene expression in the rhesus macaque model. Mol Ther 2014;22:52-58.
    • (2014) Mol Ther , vol.22 , pp. 52-58
    • Sellers, S.E.1    Dumitriu, B.2    Morgan, M.J.3
  • 121
    • 70449370351 scopus 로고    scopus 로고
    • HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation
    • Tsang J, Chain BM, Miller RF, et al. HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation. Aids 2009;23:2255-2263.
    • (2009) Aids , vol.23 , pp. 2255-2263
    • Tsang, J.1    Chain, B.M.2    Miller, R.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.