CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells

Blood

Volumn 115, Issue 22, 2010, Pages 4569-4579

  Guo, Yong Mei ^a,b   Ishii, Keiko ^c   Hirokawa, Makoto ^a   Tagawa, Hiroyuki ^a   Ohyagi, Hideaki ^a   Michishita, Yoshihiro ^a   Ubukawa, Kumi ^a   Yamashita, Junsuke ^d   Ohteki, Toshiaki ^e,f   Onai, Nobuyuki ^e,f   Kawakami, Kazuyoshi ^c   Xiao, Weiguo ^b   Sawada, Kenichi ^a  

^a AKITA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b CHINA MEDICAL UNIVERSITY   (China)

^c TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^f JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; CPG OLIGODEOXYNUCLEOTIDE 2006; ERYTHROPOIETIN RECEPTOR; GLYCOPHORIN A; MESSENGER RNA; PHOSPHODIESTERASE; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; CPG ODN 2006; ERYTHROID KRUPPEL LIKE FACTOR; ERYTHROID KRUPPEL-LIKE FACTOR; KRUPPEL LIKE FACTOR; LIGAND; OLIGODEOXYRIBONUCLEOTIDE; PRIMER DNA; TLR9 PROTEIN, HUMAN;

ANEMIA; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL GROWTH; CELL MATURATION; CELL SIZE; CONSENSUS SEQUENCE; CONTROLLED STUDY; DOWN REGULATION; ERYTHROCYTE APLASIA; ERYTHROID PRECURSOR CELL; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN PARVOVIRUS B19; NONHUMAN; PRIORITY JOURNAL; VIRUS GENOME; BLOOD; CYTOLOGY; DRUG EFFECT; ERYTHROPOIESIS; GENETICS; IN VITRO STUDY; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOGENICITY;

ANEMIA; BASE SEQUENCE; CONSENSUS SEQUENCE; DNA PRIMERS; DOWN-REGULATION; ERYTHROID PRECURSOR CELLS; ERYTHROPOIESIS; GENOME, VIRAL; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LIGANDS; OLIGODEOXYRIBONUCLEOTIDES; PARVOVIRUS B19, HUMAN; RECEPTORS, ERYTHROPOIETIN; RNA, MESSENGER; TOLL-LIKE RECEPTOR 9;

EID: 77953935525     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-08-239202     Document Type: Article

References (48)

1. Bafica A, Scanga CA, Feng CG, Leifer C, Cheever A, Sher A. TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis. J Exp Med. 2005;202(12):1715-1724.
2. Kalis C, Gumenscheimer M, Freudenberg N, et al. Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes. J Immunol. 2005;174(7):4295-4300.
3. Coban C, Ishii KJ, Kawai T, et al. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J Exp Med. 2005;201(1):19-25.
4. Chang KH, Stevenson MM. Malarial anaemia: mechanisms and implications of insufficient erythropoiesis during blood-stage malaria. Int J Parasitol. 2004;34(13):1501-1516.
5. Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol. 2002;20:709-760.
6. Yamamoto S, Yamamoto T, Kataoka T, Kuramoto E, Yano O, Tokunaga T. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity. J Immunol. 1992;148(12):4072-4076.
7. Sun S, Zhang X, Tough DF, Sprent J. Type I interferon-mediated stimulation of T cells by CpG DNA. J Exp Med. 1998;188(12):2335-2342.
8. Lipford GB, Bendigs S, Heeg K, Wagner H. Poly-guanosine motifs costimulate antigen-reactive CD8 T cells while bacterial CpG-DNA affect T-cell activation via antigen-presenting cell-derived cytokines. Immunology. 2000;101(1):46-52.
9. Verthelyi D, Ishii KJ, Gursel M, Takeshita F, Klinman DM. Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J Immunol. 2001;166(4):2372-2377.
10. Kadowaki N, Antonenko S, Liu YJ. Distinct CpG DNA and polyinosinic-polycytidylic acid double-stranded RNA, respectively, stimulate CD11c- type 2 dendritic cell precursors and CD11c+ dendritic cells to produce type I IFN. J Immunol. 2001;166(4):2291-2295.
11. Sester DP, Naik S, Beasley SJ, Hume DA, Stacey KJ. Phosphorothioate backbone modification modulates macrophage activation by CpG DNA. J Immunol. 2000;165(8):4165-4173.
12. Haas T, Metzger J, Schmitz F, et al. The DNA sugar backbone 2′ deoxyribose determines toll-like receptor 9 activation. Immunity. 2008;28(3):315-323.
13. Nagai Y, Garrett KP, Ohta S, et al. Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity. 2006;24(6):801-812.
14. Sioud M, Floisand Y, Forfang L, Lund-Johansen F. Signaling through toll-like receptor 7/8 induces the differentiation of human bone marrow CD34+ progenitor cells along the myeloid lineage. J Mol Biol. 2006;364(5):945-954.
15. Sparwasser T, Hultner L, Koch ES, Luz A, Lipford GB, Wagner H. Immunostimulatory CpG-oligodeoxynucleotides cause extramedullary murine hemopoiesis. J Immunol. 1999;162(4):2368-2374.
16. Thawani N, Tam M, Chang KH, Stevenson MM. Interferon-gamma mediates suppression of erythropoiesis but not reduced red cell survival following CpG-ODN administration in vivo. Exp Hematol. 2006;34(11):1451-1461.
17. Brown KE, Anderson SM, Young NS. Erythrocyte P antigen: cellular receptor for B19 parvovirus. Science. 1993;262:114-117.
18. Brown KE, Hibbs JR, Gallinella G, et al. Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen). N Engl J Med. 1994;330(17):1192-1196.
19. Cooling LL, Zhang DS, Walker KE, Koerner TA. Detection in human blood platelets of sialyl Lewis X gangliosides, potential ligands for CD62 and other selectins. Glycobiology. 1995;5(6):571-581.
20. Morita E, Tada K, Chisaka H, et al. Human parvovirus B19 induces cell cycle arrest at G(2) phase with accumulation of mitotic cyclins. J Virol. 2001;75(16):7555-7563.
21. Ozawa K, Ayub J, Kajigaya S, Shimada T, Young N. The gene encoding the nonstructural protein of B19 (human) parvovirus may be lethal in transfected cells. J Virol. 1988;62(8):2884-2889.
22. Moffatt S, Yaegashi N, Tada K, Tanaka N, Sugamura K. Human parvovirus B19 nonstructural (NS1) protein induces apoptosis in erythroid lineage cells. J Virol. 1998;72(4):3018-3028.
23. Saito K, Hirokawa M, Inaba K, et al. Phagocytosis of codeveloping megakaryocytic progenitors by dendritic cells in culture with thrombopoietin and tumor necrosis factor-alpha and its possible role in hemophagocytic syndrome. Blood. 2006;107(1):1366-1374.
24. Oda A, Sawada K, Druker BJ, et al. Erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B in primary cultured human erythroid precursors. Blood. 1998;92(2):443-451.
25. Saito Y, Guo YM, Hirokawa M, et al. Phagocytosis of co-developing neutrophil progenitors by dendritic cells in a culture of human CD34(+) cells with granulocyte colony-stimulating factor and tumor necrosis factor-alpha. Int J Hematol. 2008;88(1):64-72.
26. Sato N, Sawada K, Kannonji M, et al. Purification of human marrow progenitor cells and demonstration of the direct action of macrophage colony-stimulating factor on colony-forming unit-macrophage. Blood. 1991;78(4):967-974.
27. Sawada K, Krantz SB, Kans JS, et al. Purification of human erythroid colony-forming units and demonstration of specific binding of erythropoietin. J Clin Invest. 1987;80(2):357-366.
28. Sawada K, Krantz SB, Dai CH, et al. Purification of human blood burst-forming units-erythroid and demonstration of the evolution of erythropoietin receptors. J Cell Physiol. 1990;142(2):219-230.
29. Kadowaki N, Ho S, Antonenko S, et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med. 2001;194(6):863-869.
30. Zhao Q, Waldschmidt T, Fisher E, Herrera CJ, Krieg AM. Stage-specific oligonucleotide uptake in murine bone marrow B-cell precursors. Blood. 1994;84(11):3660-3666.
31. Dozmorov I, Eisenbraun MD, Lefkovits I. Limiting dilution analysis: from frequencies to cellular interactions. Immunol Today. 2000;21(1):15-18.
32. Cantor AB, Orkin SH. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene. 2002;21(21):3368-3376.
33. Tsai SF, Martin DI, Zon LI, D'Andrea AD, Wong GG, Orkin SH. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature. 1989;339(6224):446-451.
34. Evans T, Felsenfeld G. The erythroid-specific transcription factor Eryf1: a new finger protein. Cell. 1989;58(5):877-885.
35. Tsang AP, Fujiwara Y, Hom DB, Orkin SH. Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes Dev. 1998;12(8):1176-1188.
36. Nuez B, Michalovich D, Bygrave A, Ploemacher R, Grosveld F. Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature. 1995;375(6529):316-318.
37. Gazda HT, Sieff CA. Recent insights into the pathogenesis of Diamond-Blackfan anaemia. Br J Haematol. 2006;135(2):149-157.
38. Wong S, Zhi N, Filippone C, et al. Ex vivo-generated CD36+ erythroid progenitors are highly permissive to human parvovirus B19 replication. J Virol. 2008;82(5):2470-2476.
39. Mortimer PP, Humphries RK, Moore JG, Purcell RH, Young NS. A human parvovirus-like virus inhibits haematopoietic colony formation in vitro. Nature. 1983;302(5907):426-429.
40. Weigel-Kelley KA, Yoder MC, Srivastava A. Recombinant human parvovirus B19 vectors: erythrocyte P antigen is necessary but not sufficient for successful transduction of human hematopoietic cells. J Virol. 2001;75(9):4110-4116.
41. Sparwasser T, Miethke T, Lipford G, et al. Bacterial DNA causes septic shock. Nature. 1997;386(6623):336-337.
42. Patil SD, Rhodes DG, Burgess DJ. DNA-based therapeutics and DNA delivery systems: a comprehensive review. AAPS J. 2005;7(1):E61-E677.
43. Testa U. Apoptotic mechanisms in the control of erythropoiesis. Leukemia. 2004;18(7):1176-1199.
44. Socinski MA, Ershler WB, Tosato G, Blaese RM. Pure red blood cell aplasia associated with chronic Epstein-Barr virus infection: evidence for T cell-mediated suppression of erythroid colony forming units. J Lab Clin Med. 1984;104(6):995-1006.
45. Suzuki K, Mori A, Ishii KJ, et al. Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides. Proc Natl Acad Sci U S A. 1999;96(5):2285-2290.
46. Ishii KJ, Suzuki K, Coban C, et al. Genomic DNA released by dying cells induces the maturation of APCs. J Immunol. 2001;167(5):2602-2607.
47. Yasuda K, Yu P, Kirschning CJ, et al. Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways. J Immunol. 2005;174(10):6129-6136.
48. Ishii KJ, Coban C, Kato H, et al. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol. 2006;7(1):40-48.