Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells

Blood

Volumn 124, Issue 6, 2014, Pages 913-923

  Wang, Cathy X ^a   Sather, Blythe D ^b   Wang, Xuefeng ^b   Adair, Jennifer ^c   Khan, Iram ^b   Singh, Swati ^b   Lang, Shanshan ^a   Adams, Amie ^c   Curinga, Gabrielle ^b   Kiem, Hans Peter ^c   Miao, Carol H ^b   Rawlings, David J ^b,d   Torbett, Bruce E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LENTIVIRUS VECTOR; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOPLASM; DNA INTEGRATION; ENGRAFTMENT; GENE TARGETING; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION; STEM CELL GENE THERAPY; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DRUG EFFECTS; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; LENTIVIRINAE; METABOLISM; NONOBESE DIABETIC MOUSE; PROCEDURES; SCID MOUSE; VIROLOGY; VIRUS ENTRY; XENOGRAFT;

ANIMALS; GENETIC VECTORS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HETEROGRAFTS; HUMANS; LENTIVIRUS; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, SCID; SIROLIMUS; TOR SERINE-THREONINE KINASES; TRANSDUCTION, GENETIC; VIRUS INTERNALIZATION;

EID: 84905745710     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-12-546218     Document Type: Article

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