A model for cofactor use during HIV-1 reverse transcription and nuclear entry

Current Opinion in Virology

Volumn 4, Issue , 2014, Pages 32-36

  Hilditch, Laura ^a   Towers, Greg J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSID PROTEIN; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR 6; CYCLOPHILIN A; NUCLEOPORIN; NUP358 PROTEIN; PROTEIN; TNPO3 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN; DNA SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; INNATE IMMUNITY; LIFE CYCLE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; REVERSE TRANSCRIPTION; RNA PROCESSING; T LYMPHOCYTE ACTIVATION; VIRUS CAPSID; VIRUS DNA CELL DNA INTERACTION; VIRUS ENTRY; VIRUS UNCOATING;

ACTIVE TRANSPORT, CELL NUCLEUS; BETA KARYOPHERINS; CYCLOPHILIN A; HIV CORE PROTEIN P24; HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; MOLECULAR CHAPERONES; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; NUCLEAR PORE COMPLEX PROTEINS; REVERSE TRANSCRIPTION;

EID: 84890926341     PISSN: 18796257     EISSN: 18796265     Source Type: Journal    
DOI: 10.1016/j.coviro.2013.11.003     Document Type: Review

References (48)

1. A. Fassati, and S.P. Goff Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1 J Virol 75 2001 3626 3635
2. M.D. Miller, C.M. Farnet, and F.D. Bushman Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition J Virol 71 1997 5382 5390
3. K. Lee, Z. Ambrose, T.D. Martin, I. Oztop, A. Mulky, J.G. Julias, N. Vandegraaff, J.G. Baumann, R. Wang, and W. Yuen et al. Flexible use of nuclear import pathways by HIV-1 Cell Host Microbe 7 2010 221 233
4. V. Arfi, J. Lienard, X.N. Nguyen, G. Berger, D. Rigal, J.L. Darlix, and A. Cimarelli Characterization of the behavior of functional viral genomes during the early steps of human immunodeficiency virus type 1 infection J Virol 83 2009 7524 7535
5. N.J. Arhel, S. Souquere-Besse, S. Munier, P. Souque, S. Guadagnini, S. Rutherford, M.C. Prevost, T.D. Allen, and P. Charneau HIV-1 DNA flap formation promotes uncoating of the pre-integration complex at the nuclear pore EMBO J 26 2007 3025 3037
6. C.M. Danielson, and T.J. Hope Imaging of HIV/host protein interactions Curr Top Microbiol Immunol 339 2009 103 123
7. F. Di Nunzio, A. Danckaert, T. Fricke, P. Perez, J. Fernandez, E. Perret, P. Roux, S. Shorte, P. Charneau, and F. Diaz-Griffero et al. Human nucleoporins promote HIV-1 docking at the nuclear pore, nuclear import and integration PLOS ONE 7 2012 e46037
8. M. Lelek, F. Di Nunzio, R. Henriques, P. Charneau, N. Arhel, and C. Zimmer Superresolution imaging of HIV in infected cells with FlAsH-PALM Proc Natl Acad Sci U S A 109 2012 8564 8569
9. A.E. Hulme, O. Perez, and T.J. Hope Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription Proc Natl Acad Sci U S A 108 2011 9975 9980
10. Y. Yang, T. Fricke, and F. Diaz-Griffero Inhibition of reverse transcriptase activity increases stability of the HIV-1 core J Virol 87 2013 683 687
11. B.M. Forshey, U. von Schwedler, W.I. Sundquist, and C. Aiken Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replication J Virol 76 2002 5667 5677
12. R. Yang, J. Shi, I.J. Byeon, J. Ahn, J.H. Sheehan, J. Meiler, A.M. Gronenborn, and C. Aiken Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects Retrovirology 9 2012 30
13. G. Zhao, J.R. Perilla, E.L. Yufenyuy, X. Meng, B. Chen, J. Ning, J. Ahn, A.M. Gronenborn, K. Schulten, and C. Aiken et al. Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics Nature 497 2013 643 646
14. D.J. Dismuke, and C. Aiken Evidence for a functional link between uncoating of the human immunodeficiency virus type 1 core and nuclear import of the viral preintegration complex J Virol 80 2006 3712 3720
15. M. Yamashita, and M. Emerman Capsid is a dominant determinant of retrovirus infectivity in nondividing cells J Virol 78 2004 5670 5678
16. M. Yamashita, O. Perez, T.J. Hope, and M. Emerman Evidence for direct involvement of the capsid protein in HIV infection of nondividing cells PLoS Pathog 3 2007 1502 1510
17. K.A. Matreyek, and A. Engelman The requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid J Virol 85 2011 7818 7827
18. T. Schaller, K.E. Ocwieja, J. Rasaiyaah, A.J. Price, T.L. Brady, S.L. Roth, S. Hue, A.J. Fletcher, K. Lee, and V.N. KewalRamani et al. HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency PLoS Pathog 7 2011 e1002439
19. A.L. Brass, D.M. Dykxhoorn, Y. Benita, N. Yan, A. Engelman, R.J. Xavier, J. Lieberman, and S.J. Elledge Identification of host proteins required for HIV infection through a functional genomic screen Science 319 2008 921 926
20. R. Konig, Y. Zhou, D. Elleder, T.L. Diamond, G.M. Bonamy, J.T. Irelan, C.Y. Chiang, B.P. Tu, P.D. De Jesus, and C.E. Lilley et al. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication Cell 135 2008 49 60
21. F. Christ, W. Thys, J. De Rijck, R. Gijsbers, A. Albanese, D. Arosio, S. Emiliani, J.C. Rain, R. Benarous, and A. Cereseto et al. Transportin-SR2 imports HIV into the nucleus Curr Biol 18 2008 1192 1202
22. L. Krishnan, K.A. Matreyek, I. Oztop, K. Lee, C.H. Tipper, X. Li, M.J. Dar, V.N. Kewalramani, and A. Engelman The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase J Virol 84 2010 397 406
23. E.C. Logue, K.T. Taylor, P.H. Goff, and N.R. Landau The cargo-binding domain of transportin 3 is required for lentivirus nuclear import J Virol 85 2011 12950 12961
24. Y. Koh, X. Wu, A.L. Ferris, K.A. Matreyek, S.J. Smith, K. Lee, V.N. KewalRamani, S.H. Hughes, and A. Engelman Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration J Virol 87 2013 648 658
25. K.E. Ocwieja, T.L. Brady, K. Ronen, A. Huegel, S.L. Roth, T. Schaller, L.C. James, G.J. Towers, J.A. Young, and S.K. Chanda et al. HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2 PLoS Pathog 7 2011 e1001313
26. A. De Iaco, and J. Luban Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus Retrovirology 8 2011 98
27. F. Di Nunzio, T. Fricke, A. Miccio, J.C. Valle-Casuso, P. Perez, P. Souque, E. Rizzi, M. Severgnini, F. Mavilio, and P. Charneau et al. Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV-1 replication Virology 440 2013 8 18
28. T. Fricke, J.C. Valle-Casuso, T.E. White, A. Brandariz-Nunez, W.J. Bosche, N. Reszka, R. Gorelick, and F. Diaz-Griffero The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6 Retrovirology 10 2013 46
29. V.B. Shah, J. Shi, D.R. Hout, I. Oztop, L. Krishnan, J. Ahn, M.S. Shotwell, A. Engelman, and C. Aiken The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating J Virol 87 2013 422 432
30. J.C. Valle-Casuso, F. Di Nunzio, Y. Yang, N. Reszka, M. Lienlaf, N. Arhel, P. Perez, A.L. Brass, and F. Diaz-Griffero TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core J Virol 86 2012 5931 5936
31. R. Zhang, R. Mehla, and A. Chauhan Perturbation of host nuclear membrane component RanBP2 impairs the nuclear import of human immunodeficiency virus-1 preintegration complex (DNA) PLoS ONE 5 2010 e15620
32. A. De Iaco, F. Santoni, A. Vannier, M. Guipponi, S. Antonarakis, and J. Luban TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm Retrovirology 10 2013 20
33. C. Tipper, and J. Sodroski Enhanced autointegration in hyperstable simian immunodeficiency virus capsid mutants blocked after reverse transcription J Virol 87 2013 3628 3639
34. K. Bichel, A.J. Price, T. Schaller, G.J. Towers, S.M. Freund, and L.C. James HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358 Retrovirology 10 2013 81
35. A. Cribier, E. Segeral, O. Delelis, V. Parissi, A. Simon, M. Ruff, R. Benarous, and S. Emiliani Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import Retrovirology 8 2011 104
36. C.L. Woodward, S. Prakobwanakit, S. Mosessian, and S.A. Chow Integrase interacts with nucleoporin NUP153 to mediate the nuclear import of human immunodeficiency virus type 1 J Virol 83 2009 6522 6533
37. T.R. Gamble, F.F. Vajdos, S. Yoo, D.K. Worthylake, M. Houseweart, W.I. Sundquist, and C.P. Hill Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid Cell 87 1996 1285 1294
38. D.A. Bosco, E.Z. Eisenmesser, S. Pochapsky, W.I. Sundquist, and D. Kern Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A Proc Natl Acad Sci U S A 99 2002 5247 5252
39. E.Z. Eisenmesser, O. Millet, W. Labeikovsky, D.M. Korzhnev, M. Wolf-Watz, D.A. Bosco, J.J. Skalicky, L.E. Kay, and D. Kern Intrinsic dynamics of an enzyme underlies catalysis Nature 438 2005 117 121
40. D. Braaten, E.K. Franke, and J. Luban Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription J Virol 70 1996 3551 3560
41. E.K. Franke, and J. Luban Inhibition of HIV-1 replication by cyclosporine A or related compounds correlates with the ability to disrupt the Gag-cyclophilin A interaction Virology 222 1996 279 282
42. J. Luban, K.L. Bossolt, E.K. Franke, G.V. Kalpana, and S.P. Goff Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B Cell 73 1993 1067 1078
43. T. Hori, H. Takeuchi, H. Saito, R. Sakuma, Y. Inagaki, and S. Yamaoka A carboxy-terminally truncated human CPSF6 lacking residues encoded by exon 6 inhibits HIV-1 cDNA synthesis and promotes capsid disassembly J Virol 87 2013 7726 7736
44. A.J. Price, A.J. Fletcher, T. Schaller, T. Elliott, K. Lee, V.N. KewalRamani, J.W. Chin, G.J. Towers, and L.C. James CPSF6 defines a conserved capsid interface that modulates HIV-1 replication PLoS Pathog 8 2012 e1002896
45. K. Lee, A. Mulky, W. Yuen, T.D. Martin, N.R. Meyerson, L. Choi, H. Yu, S.L. Sawyer, and V.N. Kewalramani HIV-1 capsid-targeting domain of cleavage and polyadenylation specificity factor 6 J Virol 86 2012 3851 3860
46. J. Rasaiyaah, C.P. Tan, A.J. Fletcher, A.J. Price, C. Blondeau, L. Hilditch, D.A. Jacques, D.L. Selwood, L.C. James, and M. Noursadeghi et al. HIV-1 evades innate immune recognition through specific cofactor recruitment Nature 503 2013 402 405
47. Z. Ambrose, K. Lee, J. Ndjomou, H. Xu, I. Oztop, J. Matous, T. Takemura, D. Unutmaz, A. Engelman, and S.H. Hughes et al. Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection J Virol 86 2012 4708 4714
48. K.A. Matreyek, S.S. Yucel, X. Li, and A. Engelman Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity PLoS Pathog 9 2013 e1003693