Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor

Blood

Volumn 123, Issue 9, 2014, Pages 1422-1424

  Amirache, Fouzia ^a   Lévy, Camille ^a   Costa, Caroline ^a   Mangeot, Philippe Emmanuel ^b   Torbett, Bruce E ^c   Wang, Cathy X ^c   Nègre, Didier ^a   Cosset, François Loïc ^a   Verhoeyen, Els ^a,d  

^a UNIVERSITÉ LYON 1   (France)

^b CENTRE INTERNATIONAL DE RECHERCHE EN INFECTIOLOGIE   (France)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d CENTRE MÉDITERRANÉEN DE MÉDECINE MOLÉCULAIRE C3M   (France)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD34 ANTIBODY; GUANINE NUCLEOTIDE BINDING PROTEIN; LENTIVIRUS VECTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; VESICULAR STOMATITIS VIRUS G PROTEIN PSEUDOTYPED LENTIVIRUS VECTOR; VIRUS ENVELOPE PROTEIN; G PROTEIN, VESICULAR STOMATITIS VIRUS; MEMBRANE PROTEIN;

B LYMPHOCYTE; CELL LINEAGE; CELL STIMULATION; CLINICAL TRIAL (TOPIC); GENE TRANSFER; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNOTHERAPY; LETTER; LEUKODYSTROPHY; MEASLES VIRUS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; UPREGULATION; VESICULAR STOMATITIS VIRUS; WISKOTT ALDRICH SYNDROME; ACTIVE IMMUNIZATION; CELL CULTURE; GENE THERAPY; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY; LENTIVIRINAE; LYMPHOCYTE ACTIVATION; METABOLISM; TRANSPLANTATION; TREATMENT FAILURE; VIRUS ENTRY;

B-LYMPHOCYTES; CELLS, CULTURED; GENETIC THERAPY; GENETIC VECTORS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOTHERAPY, ACTIVE; LENTIVIRUS; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; RECEPTORS, LDL; T-LYMPHOCYTES; TRANSDUCTION, GENETIC; TREATMENT FAILURE; VIRAL ENVELOPE PROTEINS; VIRUS INTERNALIZATION;

EID: 84899683375     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-11-540641     Document Type: Letter

References (9)

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