IL-1β epitope mapping using site-directed mutagenesis and hydrogen-deuterium exchange mass spectrometry analysis

Biochemistry

Volumn 44, Issue 33, 2005, Pages 11106-11114

  Lu, Jirong ^a   Witcher, Derrick R ^a   White, Melissa A ^a   Wang, Xiliang ^a   Huang, Lihua ^a   Rathnachalam, Radhakrishnan ^a   Beals, John M ^a   Kuhstoss, Stuart ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CONCENTRATION (PROCESS); CRYSTAL STRUCTURE; HYDROPHOBICITY; MASS SPECTROMETRY; MUTAGENESIS; SURFACE PLASMON RESONANCE;

BIACORE EXPERIMENTS; EPITOPE MAPPING; HYDROPHOBIC INTERACTIONS; SALT CONCENTRATIONS;

ANTIBODIES;

EPITOPE; IMMUNOGLOBULIN G1 ANTIBODY; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY HU007; NEUTRALIZING ANTIBODY; SODIUM CHLORIDE; UNCLASSIFIED DRUG; DEUTERIUM; INTERLEUKIN 1;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BINDING ASSAY; BINDING COMPETITION; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION; EPITOPE MAPPING; HUMAN; HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY; LIGAND BINDING; MASS SPECTROMETRY; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; RAT; RECEPTOR AFFINITY; RECEPTOR OCCUPANCY; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; SURFACE PLASMON RESONANCE; ANIMAL; ANTIBODY COMBINING SITE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; IMMUNOLOGY; MACACA; METHODOLOGY; PHYSIOLOGY; POINT MUTATION; PROTEIN CONFORMATION; RABBIT; SPECIES DIFFERENCE;

ORYCTOLAGUS CUNICULUS;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; BINDING SITES, ANTIBODY; DEUTERIUM; EPITOPE MAPPING; HUMANS; INTERLEUKIN-1; MACACA FASCICULARIS; MASS SPECTROMETRY; MICE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN CONFORMATION; RABBITS; RATS; SPECIES SPECIFICITY; SURFACE PLASMON RESONANCE;

EID: 23944523304     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0505464     Document Type: Article

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