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Volumn 25, Issue 5, 2015, Pages 549-565

Hedgehog inhibitors: A patent review (2013-present)

Author keywords

Basal cell carcinoma; Cancer; Hedgehog signaling pathway; Inhibitors; Patent

Indexed keywords

ANTINEOPLASTIC AGENT; BMS 833923; CYCLOPEPTIDE; G PROTEIN COUPLED RECEPTOR; GLASDEGIB; NTW 3729; NVP LEQ 506; PATIDEGIB; PF 5274857; PROTEIN INHIBITOR; SEN 794; SONIC HEDGEHOG PROTEIN; SONIC HEDGEHOG PROTEIN INHIBITOR; SONIDEGIB; SULFONAMIDE; TALADEGIB; UNCLASSIFIED DRUG; VISMODEGIB; ANILIDE; PYRIDINE DERIVATIVE;

EID: 84928328628     PISSN: 13543776     EISSN: 17447674     Source Type: Journal    
DOI: 10.1517/13543776.2015.1019864     Document Type: Review
Times cited : (26)

References (101)
  • 1
    • 84908371590 scopus 로고    scopus 로고
    • Advances in kinase targeting: Current clinical use and clinical trials
    • Rask-Anderson M, Zhang J, Fabbro D, et al. Advances in kinase targeting: current clinical use and clinical trials. Trends Pharmacol Sci 2014;35:604-20
    • (2014) Trends Pharmacol Sci , vol.35 , pp. 604-620
    • Rask-Anderson, M.1    Zhang, J.2    Fabbro, D.3
  • 2
    • 80955181031 scopus 로고    scopus 로고
    • The hedgehog's tale: Developing strategies for targeting cancer
    • Ng JM, Curran T. The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer 2011;11:493-501
    • (2011) Nat Rev Cancer , vol.11 , pp. 493-501
    • Ng, J.M.1    Curran, T.2
  • 3
    • 84878643242 scopus 로고    scopus 로고
    • Hedgehog signaling pathway and cancer therapeutics: Progress to date
    • Ruch JM, Kim EJ. Hedgehog signaling pathway and cancer therapeutics: progress to date. Drugs 2013;73:1-11
    • (2013) Drugs , vol.73 , pp. 1-11
    • Ruch, J.M.1    Kim, E.J.2
  • 4
    • 84855888693 scopus 로고    scopus 로고
    • Hedgehog signaling pathway as therapeutic target in various types of cancer
    • Onishi H, Katano M. Hedgehog signaling pathway as therapeutic target in various types of cancer. Cancer Sci 2011;102:1756-60
    • (2011) Cancer Sci , vol.102 , pp. 1756-1760
    • Onishi, H.1    Katano, M.2
  • 5
    • 67649983452 scopus 로고    scopus 로고
    • Hedgehog-gli signaling pathway inhibitors as anticancer agents
    • Mahindroo N, Punchihewa C, Fujii N. Hedgehog-Gli signaling pathway inhibitors as anticancer agents. J Med Chem 2009;52:3829-45
    • (2009) J Med Chem , vol.52 , pp. 3829-3845
    • Mahindroo, N.1    Punchihewa, C.2    Fujii, N.3
  • 6
    • 68249099424 scopus 로고    scopus 로고
    • Recent patents for hedgehog pathway inhibitors for the treatment of malignancy
    • Tremblay MR, Nesler M, Weatherhead R, et al. Recent patents for hedgehog pathway inhibitors for the treatment of malignancy. Expert Opin Ther Pat 2009;19:1039-56
    • (2009) Expert Opin Ther Pat , vol.19 , pp. 1039-1056
    • Tremblay, M.R.1    Nesler, M.2    Weatherhead, R.3
  • 7
    • 77950647110 scopus 로고    scopus 로고
    • Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics
    • Peukert S, Miller-Moslin K. Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics. ChemMedChem 2010;5:500-12
    • (2010) ChemMedChem , vol.5 , pp. 500-512
    • Peukert, S.1    Miller-Moslin, K.2
  • 8
    • 84862907616 scopus 로고    scopus 로고
    • Targeting the hedgehog signaling pathway in cancer therapy
    • Li Y, Maitah MY, Ahmad A, et al. Targeting the hedgehog signaling pathway in cancer therapy. Expert Opin Ther Targets 2012;16:49-66
    • (2012) Expert Opin Ther Targets , vol.16 , pp. 49-66
    • Li, Y.1    Maitah, M.Y.2    Ahmad, A.3
  • 9
    • 84874059433 scopus 로고    scopus 로고
    • Hedgehog pathway inhibitors: A patent review 2009-present)
    • Hadden MK. Hedgehog pathway inhibitors: a patent review (2009-present). Expert Opin Ther Pat 2013;23:345-61
    • (2013) Expert Opin Ther Pat , vol.23 , pp. 345-361
    • Hadden, M.K.1
  • 10
    • 84903216540 scopus 로고    scopus 로고
    • Recent advances in the design of hedgehog pathway inhibitors for the treatment of malignancies
    • Banerjee U, Hadden MK. Recent advances in the design of hedgehog pathway inhibitors for the treatment of malignancies. Expert Opin Drug Discov 2014;9:751-71
    • (2014) Expert Opin Drug Discov , vol.9 , pp. 751-771
    • Banerjee, U.1    Hadden, M.K.2
  • 11
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in drosophila
    • Nusslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in drosophila. Nature 1980;287:795-801
    • (1980) Nature , vol.287 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 12
    • 0027756145 scopus 로고
    • Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of cns polarity
    • Echelard Y, Epstein DJ, St-Jacques B, et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 1993;75:1417-30
    • (1993) Cell , vol.75 , pp. 1417-1430
    • Echelard, Y.1    Epstein, D.J.2    St-Jacques, B.3
  • 13
    • 84893325901 scopus 로고    scopus 로고
    • Hedgehog signaling pathway inhibitors as cancer suppressing agents
    • Trinh TN, McLaughlin EA, Gordon CP, et al. Hedgehog signaling pathway inhibitors as cancer suppressing agents. Med Chem Comm 2014;5:117-33
    • (2014) Med Chem Comm , vol.5 , pp. 117-133
    • Trinh, T.N.1    McLaughlin, E.A.2    Gordon, C.P.3
  • 14
    • 62549159642 scopus 로고    scopus 로고
    • Hedgehog signal transduction by smoothened: Pharmacological evidence for a 2-step activation process
    • Rohatgi R, Milenkovic L, Corcoran RB, et al. Hedgehog signal transduction by Smoothened: pharmacological evidence for a 2-step activation process. Proc Natl Acad Sci USA 2009;106:3196-201
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 3196-3201
    • Rohatgi, R.1    Milenkovic, L.2    Corcoran, R.B.3
  • 15
    • 77952541851 scopus 로고    scopus 로고
    • New developments in the discovery of small molecule hedgehog pathway antagonists
    • Tremblay MR, McGovern K, Read MA, et al. New developments in the discovery of small molecule hedgehog pathway antagonists. Curr Opin Chem Biol 2010;10:428-35
    • (2010) Curr Opin Chem Biol , vol.10 , pp. 428-435
    • Tremblay, M.R.1    McGovern, K.2    Read, M.A.3
  • 16
  • 17
    • 67650289584 scopus 로고    scopus 로고
    • Mechanisms of hedgehog pathway activation in cancer and implications for therapy
    • Scales SJ, de Sauvage FJ. Mechanisms of hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 2009;30:303-12
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 303-312
    • Scales, S.J.1    De Sauvage, F.J.2
  • 19
    • 84887512714 scopus 로고    scopus 로고
    • Unraveling the therapeutic potential of the hedgehog pathway in cancer
    • This report marks the review of hedgehog pathway and its therapeutic potential for cancer therapy
    • Amakye D, Jaqani Z, Dorsch M. Unraveling the therapeutic potential of the hedgehog pathway in cancer. Nat Med 2013;19:1410-22 . This report marks the review of hedgehog pathway and its therapeutic potential for cancer therapy.
    • (2013) Nat Med , vol.19 , pp. 1410-1422
    • Amakye, D.1    Jaqani, Z.2    Dorsch, M.3
  • 20
    • 79953788948 scopus 로고    scopus 로고
    • Targeting the hedgehog pathway: The development of cyclopamine and the development of anti-cancer drugs targeting the hedgehog pathway
    • Gould A, Missailidis S. Targeting the hedgehog pathway: the development of cyclopamine and the development of anti-cancer drugs targeting the hedgehog pathway. Mini Rev Med Chem 2011;11:200-13
    • (2011) Mini Rev Med Chem , vol.11 , pp. 200-213
    • Gould, A.1    Missailidis, S.2
  • 21
    • 19944433687 scopus 로고    scopus 로고
    • Somatic mutations in the ptch, smoh, sufuh and tp53 genes in sporadic basal cell carcinomas
    • Reifenberger J, Wolter M, Knobbe CB, et al. Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas. Br J Dermatol 2005;152:43-51
    • (2005) Br J Dermatol , vol.152 , pp. 43-51
    • Reifenberger, J.1    Wolter, M.2    Knobbe, C.B.3
  • 22
    • 84864492215 scopus 로고    scopus 로고
    • Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
    • Pugh TJ, Weeraratne SD, Archer TC, et al. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature 2012;488:106-10
    • (2012) Nature , vol.488 , pp. 106-110
    • Pugh, T.J.1    Weeraratne, S.D.2    Archer, T.C.3
  • 23
    • 84864419974 scopus 로고    scopus 로고
    • Dissecting the genomic complexity underlying medulloblastoma
    • Jones DT, Jager N, Kool M, et al. Dissecting the genomic complexity underlying medulloblastoma. Nature 2012;488:100-5
    • (2012) Nature , vol.488 , pp. 100-105
    • Jones, D.T.1    Jager, N.2    Kool, M.3
  • 24
    • 85027950593 scopus 로고    scopus 로고
    • Distinct cellular origin and genetic requirement of hedgehog-gli in postnatal rhabdomyosarcoma genesis
    • Rajurkar M, Huang H, Cotton JL, et al. Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis. Oncogene 2014;33:5370-8
    • (2014) Oncogene , vol.33 , pp. 5370-5378
    • Rajurkar, M.1    Huang, H.2    Cotton, J.L.3
  • 25
    • 84885110343 scopus 로고    scopus 로고
    • Mutations in hedgehog pathway genes in fetal rhabdomyomas
    • Hettmer S, Teot LA, van Hummelen P, et al. Mutations in Hedgehog pathway genes in fetal rhabdomyomas. J Pathol 2013;231:44-52
    • (2013) J Pathol , vol.231 , pp. 44-52
    • Hettmer, S.1    Teot, L.A.2    Van Hummelen, P.3
  • 26
    • 79959885131 scopus 로고    scopus 로고
    • Hedgehog-producing cancer cells respond to and require autocrine hedgehog activity
    • Singh S, Wang Z, Liang FD, et al. Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity. Cancer Res 2011;71:4454-63
    • (2011) Cancer Res , vol.71 , pp. 4454-4463
    • Singh, S.1    Wang, Z.2    Liang, F.D.3
  • 27
    • 52149119128 scopus 로고    scopus 로고
    • A paracrine requirement for hedgehog signalling in cancer
    • Yauch RL, Gould SE, Scales SJ, et al. A paracrine requirement for hedgehog signalling in cancer. Nature 2008;455:406-10
    • (2008) Nature , vol.455 , pp. 406-410
    • Yauch, R.L.1    Gould, S.E.2    Scales, S.J.3
  • 28
    • 34547683699 scopus 로고    scopus 로고
    • Essential role of stromally induced hedgehog signaling in b-cell malignancies
    • Dierks C, Grbic J, Zirlik K, et al. Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nat Med 2007;13:944-51
    • (2007) Nat Med , vol.13 , pp. 944-951
    • Dierks, C.1    Grbic, J.2    Zirlik, K.3
  • 29
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: Premises, promises and challenges
    • Clevers H. The cancer stem cell: premises, promises and challenges. Nat Med 2011;17:313-19
    • (2011) Nat Med , vol.17 , pp. 313-319
    • Clevers, H.1
  • 30
    • 77953693899 scopus 로고    scopus 로고
    • Targeting hedgehog-A cancer stem cell pathway
    • Merchant AA, Matsui W. Targeting Hedgehog-A cancer stem cell pathway. Clin Cancer Res 2010;16:3130-40
    • (2010) Clin Cancer Res , vol.16 , pp. 3130-3140
    • Merchant, A.A.1    Matsui, W.2
  • 31
    • 84905583145 scopus 로고    scopus 로고
    • Canonical and non-canonical hedgehog signaling and the control of metabolism
    • Teperino R, Aberger F, Esterbauer H, et al. Canonical and non-canonical hedgehog signaling and the control of metabolism. Semin Cell Dev Biol 2014;33:81-92
    • (2014) Semin Cell Dev Biol , vol.33 , pp. 81-92
    • Teperino, R.1    Aberger, F.2    Esterbauer, H.3
  • 32
    • 84867536639 scopus 로고    scopus 로고
    • Hedgehog partial agonism drives warburg-like metabolism in muscle and brown fat
    • Teperino R, Amann S, Bayer M, et al. Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell 2012;151:414-26
    • (2012) Cell , vol.151 , pp. 414-426
    • Teperino, R.1    Amann, S.2    Bayer, M.3
  • 33
    • 84858142098 scopus 로고    scopus 로고
    • Hedgehog-egfr cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumor-initiating pancreatic cancer cells
    • Eberl M, Klingler S, Mangelberger D, et al. Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumor-initiating pancreatic cancer cells. EMBO Mol Med 2012;4:218-33
    • (2012) EMBO Mol Med , vol.4 , pp. 218-233
    • Eberl, M.1    Klingler, S.2    Mangelberger, D.3
  • 34
    • 58149506283 scopus 로고    scopus 로고
    • Gli1 is regulated through smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates pdac cell survival and transformation
    • Nolan-Stevaux O, Lau J, Truitt ML, et al. Gli1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev 2009;23:24-36
    • (2009) Genes Dev , vol.23 , pp. 24-36
    • Nolan-Stevaux, O.1    Lau, J.2    Truitt, M.L.3
  • 35
    • 84863252342 scopus 로고    scopus 로고
    • Noncanonical hedgehog signaling
    • Brennan D, Chen X, Cheng L, et al. Noncanonical hedgehog signaling. Vitam Horm 2012;88:55-72
    • (2012) Vitam Horm , vol.88 , pp. 55-72
    • Brennan, D.1    Chen, X.2    Cheng, L.3
  • 36
    • 69949084378 scopus 로고    scopus 로고
    • Gdc-0449-A potent inhibitor of the hedgehog pathway
    • This paper describes the structure and its design for the first approved hedgehog inhibitor vismodegib
    • Robarge KD, Brunton SA, Castanedo GE, et al. GDC-0449-A potent inhibitor of the hedgehog pathway. Bioorg Med Chem Lett 2009;19:5576-81 . This paper describes the structure and its design for the first approved hedgehog inhibitor vismodegib.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 5576-5581
    • Robarge, K.D.1    Brunton, S.A.2    Castanedo, G.E.3
  • 37
    • 84904512281 scopus 로고    scopus 로고
    • Efficacy and safety of vismodegib: A new therapeutic agents in the treatment of basal cell carcinoma
    • Lyons TG, O'Kane GM, Kelly CM. Efficacy and safety of vismodegib: a new therapeutic agents in the treatment of basal cell carcinoma. Expert Opin Drug Saf 2014;13:1125-32
    • (2014) Expert Opin Drug Saf , vol.13 , pp. 1125-1132
    • Lyons, T.G.1    O'Kane, G.M.2    Kelly, C.M.3
  • 39
    • 77956292749 scopus 로고    scopus 로고
    • Discovery of nvp-lde225, a potent and selective smoothened antagonist
    • This paper describes the discovery of the small molecule sonidegib that inhibited the hedgehog via Smo
    • Pan S, Wu X, Jiang J, et al. Discovery of NVP-LDE225, a potent and selective smoothened antagonist. ACS Med Chem Lett 2010;1:130-4 . This paper describes the discovery of the small molecule sonidegib that inhibited the hedgehog via Smo.
    • (2010) ACS Med Chem Lett , vol.1 , pp. 130-134
    • Pan, S.1    Wu, X.2    Jiang, J.3
  • 40
    • 84878112106 scopus 로고    scopus 로고
    • Structure of the human smoothened receptor bound to an antitumor agent
    • This paper reports the first crystal structure of human Smo receptor bound to the small Smo inhibitor LY2940680
    • Wang C, Wu H, Katritch V, et al. Structure of the human smoothened receptor bound to an antitumor agent. Nature 2013;497:338-43 .. This paper reports the first crystal structure of human Smo receptor bound to the small Smo inhibitor LY2940680.
    • (2013) Nature , vol.497 , pp. 338-343
    • Wang, C.1    Wu, H.2    Katritch, V.3
  • 41
    • 84928344035 scopus 로고    scopus 로고
    • Methods and compositions for the treatment of ovarian cancer
    • nRocconi RP, Samant L. Methods and compositions for the treatment of ovarian cancer. WO943255; 2013
    • (2013) WO943255
    • Rocconi, R.P.1    Samant, L.2
  • 42
    • 84863172647 scopus 로고    scopus 로고
    • Discovery of pf-04449913, a potent and orally bioavailable inhibitor of smoothened
    • Munchhof MJ, Li Q, Shavnya A, et al. Discovery of PF-04449913, a potent and orally bioavailable inhibitor of smoothened. ACS Med Chem Lett 2012;3:106-11
    • (2012) ACS Med Chem Lett , vol.3 , pp. 106-111
    • Munchhof, M.J.1    Li, Q.2    Shavnya, A.3
  • 43
    • 84881030230 scopus 로고    scopus 로고
    • Discovery of nvp-leq506, a second-generation inhibitor of smoothened
    • Peukert S, He F, Dai M, et al. Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened. ChemMedChem 2013;8:1261-5
    • (2013) ChemMedChem , vol.8 , pp. 1261-1265
    • Peukert, S.1    He, F.2    Dai, M.3
  • 44
    • 67650723106 scopus 로고    scopus 로고
    • Discovery of a potent and orally active hedgehog pathway antagonist (ipi-926)
    • Tremblay MR, Lescarbeau A, Grogan MJ, et al. Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926). J Med Chem 2009;52:4400-18
    • (2009) J Med Chem , vol.52 , pp. 4400-4418
    • Tremblay, M.R.1    Lescarbeau, A.2    Grogan, M.J.3
  • 45
    • 84857977283 scopus 로고    scopus 로고
    • Hedgehog hopes lifted by approval and stung by failure
    • Allison M. Hedgehog hopes lifted by approval and stung by failure. Nat Biotechnol 2012;30:203
    • (2012) Nat Biotechnol , vol.30 , pp. 203
    • Allison, M.1
  • 46
    • 84892959602 scopus 로고    scopus 로고
    • Results from a phase 2 randomized placebo-controlled double blind study of the hedgehog (hh) pathway antagonist ipi-926 in patients (pts) with advanced chondrosarcoma (cs)
    • New York
    • Wagner AHP, Okuno S, Eriksson M, et al. Results from a phase 2 randomized, placebo-controlled, double blind study of the hedgehog (HH) pathway antagonist IPI-926 in patients (PTS) with advanced chondrosarcoma (CS). Connective tissue oncology society 18th annual meeting; New York; 2013
    • (2013) Connective Tissue Oncology Society 18th Annual Meeting
    • Wagner, A.H.P.1    Okuno, S.2    Eriksson, M.3
  • 47
    • 84866246074 scopus 로고    scopus 로고
    • Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors
    • Ohashi T, Oguro Y, Tanaka T, et al. Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors. Bioorg Med Chem 2012;20:5496-506
    • (2012) Bioorg Med Chem , vol.20 , pp. 5496-5506
    • Ohashi, T.1    Oguro, Y.2    Tanaka, T.3
  • 48
    • 84866234204 scopus 로고    scopus 로고
    • Discovery of the investigational drug tak-441, a pyrrolo[3,2-c]quinoline-4-one derivative as a highly potent and orally active hedgehog signaling inhibitor: Modification of the core skeleton for improved solubility
    • Ohashi T, Oguro Y, Tanaka T, et al. Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]quinoline-4-one derivative as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility. Bioorg Med Chem 2012;20:5507-17
    • (2012) Bioorg Med Chem , vol.20 , pp. 5507-5517
    • Ohashi, T.1    Oguro, Y.2    Tanaka, T.3
  • 49
    • 84893817023 scopus 로고    scopus 로고
    • Inhibition mechanism exploration of investigational drug tak-441 as inhibitor against vismodegib-resistant smoothened mutant
    • Ishii T, Shimizu Y, Nakashima K, et al. Inhibition mechanism exploration of investigational drug TAK-441 as inhibitor against vismodegib-resistant smoothened mutant. Eur J Pharmacol 2014;723:305-13
    • (2014) Eur J Pharmacol , vol.723 , pp. 305-313
    • Ishii, T.1    Shimizu, Y.2    Nakashima, K.3
  • 50
    • 67649921435 scopus 로고    scopus 로고
    • 1-Amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity
    • Miller-Moslin K, Peukert S, Jain RK, et al. 1-Amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity. J Med Chem 2009;52:3954-68
    • (2009) J Med Chem , vol.52 , pp. 3954-3968
    • Miller-Moslin, K.1    Peukert, S.2    Jain, R.K.3
  • 51
    • 77958029696 scopus 로고    scopus 로고
    • Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway
    • Castanedo GM, Wang S, Robarge KD, et al. Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway. Bioorg Med Chem Lett 2010;20:6748-53
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 6748-6753
    • Castanedo, G.M.1    Wang, S.2    Robarge, K.D.3
  • 52
    • 79960351998 scopus 로고    scopus 로고
    • Identification of mk-5710 ((8as)-8a-methyl-1,3-dioxo-2-[(1s,2r)-2-phenylcyclopropyl]-n-(1-phenyl-1hpyrazol-5-yl)hexahydroimidazo[1,5-A] pyrazine-7(1h)-carboxamide), a potent smoothened antagonist for use in hedgehog pathway dependent malignancies, part 1
    • Malancona S, Altamura S, Filocamo G, et al. Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1Hpyrazol-5-yl)hexahydroimidazo[1,5-A] pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in hedgehog pathway dependent malignancies, part 1. Bioorg Med Chem Lett 2011;21:4422-8
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 4422-4428
    • Malancona, S.1    Altamura, S.2    Filocamo, G.3
  • 53
    • 79960349060 scopus 로고    scopus 로고
    • Identification of mk-5710 ((8as)-8amethyl-1,3-dioxo-2-[(1s,2r)-2-phenylcyclo-propyl]-n-(1-phenyl-1hpyrazol-5-yl)hexahydro-imidazo[1,5-A] pyrazine-7(1h)-carboxamide), a potent smoothened antagonist for use in hedgehog pathway dependent malignancies, part 2
    • Kinzel O, Alfieri A, Altamura S, et al. Identification of MK-5710 ((8aS)-8amethyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo-propyl]-N-(1-phenyl-1Hpyrazol-5-yl)hexahydro-imidazo[1,5-A] pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in hedgehog pathway dependent malignancies, part 2. Bioorg Med Chem Lett 2011;21:4429-35
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 4429-4435
    • Kinzel, O.1    Alfieri, A.2    Altamura, S.3
  • 54
    • 81155159749 scopus 로고    scopus 로고
    • Discovery of amide replacements that improve activity and metabolic stability of a bis-Amide smoothened antagonist hit
    • Brown ML, Aaron W, Austin RJ, et al. Discovery of amide replacements that improve activity and metabolic stability of a bis-Amide smoothened antagonist hit. Bioorg Med Chem Lett 2011;21:5206-9
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 5206-5209
    • Brown, M.L.1    Aaron, W.2    Austin, R.J.3
  • 55
    • 80051942180 scopus 로고    scopus 로고
    • Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl] piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors
    • Ontoria JM, Bufi LL, Torrisi C, et al. Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl] piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors. Bioorg Med Chem Lett 2011;21:5274-82
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 5274-5282
    • Ontoria, J.M.1    Bufi, L.L.2    Torrisi, C.3
  • 56
    • 80051921468 scopus 로고    scopus 로고
    • N-(2-Alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl) piperazine-1-carboxamides as highly potent smoothened antagonists
    • Muraglia E, Ontoria JM, Branca D, et al. N-(2-Alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl) piperazine-1-carboxamides as highly potent smoothened antagonists. Bioorg Med Chem Lett 2011;21:5283-8
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 5283-5288
    • Muraglia, E.1    Ontoria, J.M.2    Branca, D.3
  • 57
    • 84867848829 scopus 로고    scopus 로고
    • Identification of a novel smoothened antagonist that potently suppresses hedgehog signaling
    • Wang J, Jr Mook RA, Lu J, et al. Identification of a novel smoothened antagonist that potently suppresses hedgehog signaling. Bioorg Med Chem Lett 2012;20:6751-7
    • (2012) Bioorg Med Chem Lett , vol.20 , pp. 6751-6757
    • Wang, J.1    Mook, R.A.2    Lu, J.3
  • 58
    • 84863434990 scopus 로고    scopus 로고
    • Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of smo
    • Yang B, Hird AW, Russell DJ, et al. Discovery of novel hedgehog antagonists from cell-based screening: isosteric modification of p38 bisamides as potent inhibitors of SMO. Bioorg Med Chem Lett 2012;22:4907-11
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 4907-4911
    • Yang, B.1    Hird, A.W.2    Russell, D.J.3
  • 59
    • 77957245263 scopus 로고    scopus 로고
    • Virtual screening-based discovery and mechanistic characterization of the acylthiourea mrt-10 family of smoothened antagonists
    • Manzetti F, Faure H, Roudaut H, et al. Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family of smoothened antagonists. Mol Pharm 2010;78:658-65
    • (2010) Mol Pharm , vol.78 , pp. 658-665
    • Manzetti, F.1    Faure, H.2    Roudaut, H.3
  • 60
    • 84857402868 scopus 로고    scopus 로고
    • Acylthiourea, acylurea, and acylquanidine derivatives with potent hedgehog inhibiting activity
    • Solinas A, Faure H, Roudaut H, et al. Acylthiourea, acylurea, and acylquanidine derivatives with potent hedgehog inhibiting activity. J Med Chem 2012;55:1559-71
    • (2012) J Med Chem , vol.55 , pp. 1559-1571
    • Solinas, A.1    Faure, H.2    Roudaut, H.3
  • 61
    • 84928336889 scopus 로고    scopus 로고
    • N-Acylthiourea and nacylurea inhibitors of the hedgehog protein signalling pathway
    • Centre National de la Recherche Scientifique
    • Centre National de la Recherche Scientifique. N-Acylthiourea and Nacylurea inhibitors of the hedgehog protein signalling pathway. WO130422; 2009
    • (2009) WO130422
  • 62
    • 84928332160 scopus 로고    scopus 로고
    • Acylguanidine derivatives modulating the hedgehog protein signaling pathway
    • Centre National de la Recherche Scientifique
    • Centre National de la Recherche Scientifique. Acyl guanidine derivatives modulating the hedgehog protein signaling pathway. WO010013; 2011
    • (2011) WO010013
  • 63
    • 77957245263 scopus 로고    scopus 로고
    • Virtual screening-based discovery and mechanistic characterization of the acylthiourea mrt-10 family of smoothened antagonists
    • Manzetti F, Faure H, Roudaut H, et al. Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family of smoothened antagonists. Mol Pharm 2010;78:658-65
    • (2010) Mol Pharm , vol.78 , pp. 658-665
    • Manzetti, F.1    Faure, H.2    Roudaut, H.3
  • 64
    • 84928336511 scopus 로고    scopus 로고
    • Novel compounds modulating the hedgehog protein signaling pathway, marked forms thereof, and applications
    • Centre National de la Recherche Scientifique
    • Centre National de la Recherche Scientifique. Novel compounds modulating the hedgehog protein signaling pathway, marked forms thereof, and applications. WO042082; 2013
    • (2013) WO042082
  • 65
    • 84928319999 scopus 로고    scopus 로고
    • Preparation of smoothened modulators for treatment of proliferative disease
    • Duke University
    • Duke University. Preparation of Smoothened modulators for treatment of proliferative disease. WO043608; 2014
    • (2014) WO043608
  • 66
    • 84928319113 scopus 로고    scopus 로고
    • 4-(3-heteroarylarylamino)quinazoline and 1-(3-heteroarylarylamino) isoquinoline as hedgehog pathway inhibitor and use thereof
    • Impact Therapeutics Inc
    • Impact Therapeutics, Inc. 4-(3-heteroarylarylamino)quinazoline and 1-(3-heteroarylarylamino) isoquinoline as hedgehog pathway inhibitor and use thereof. WO013614; 2013
    • (2013) WO013614
  • 67
    • 84928346114 scopus 로고    scopus 로고
    • Preparation of n-(3-heteroarylaryl)-4-Arylarylcarboxamides as hedgehog pathway inhibitors for treatment of cancer
    • Impact Therapeutics Inc
    • Impact Therapeutics, Inc. Preparation of N-(3-heteroarylaryl)-4-Arylarylcarboxamides as hedgehog pathway inhibitors for treatment of cancer. WO012511; 2014
    • (2014) WO012511
  • 68
    • 84928310574 scopus 로고    scopus 로고
    • Pyrimidinamines and pyridylamines as inhibitors for hedgehog signaling conduction and their preparation pharmaceutical compositions and use in the treatment of cancer
    • Jiangsu Simcere Pharmaceutical Co., Ltd
    • Jiangsu Simcere Pharmaceutical Co., Ltd. Pyrimidinamines and pyridylamines as inhibitors for hedgehog signaling conduction and their preparation, pharmaceutical compositions and use in the treatment of cancer. CN103864770; 2012
    • (2012) CN103864770
  • 69
    • 84928346189 scopus 로고    scopus 로고
    • Preparation of dihydropyranopyrimidine derivatives as hedgehog signaling inhibitor
    • Jiangsu Simcere Pharmaceutical Co Ltd
    • Jiangsu Simcere Pharmaceutical Co., Ltd. Preparation of dihydropyranopyrimidine derivatives as Hedgehog signaling inhibitor. CN103910736; 2013
    • (2013) CN103910736
  • 70
    • 84928328922 scopus 로고    scopus 로고
    • Preparation of heterocyclic compounds as hedgehog signaling path inhibitors
    • Jiangsu Simcere Pharmaceutical Co Ltd
    • Jiangsu Simcere Pharmaceutical Co., Ltd. Preparation of heterocyclic compounds as hedgehog signaling path inhibitors. CN104003990; 2013
    • (2013) CN104003990
  • 71
    • 84888868222 scopus 로고    scopus 로고
    • The discovery of novel n-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors
    • Xin M, Wen J, Tang F, et al. The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as Potent Hedgehog Signaling Pathway Inhibitors. Bioorg Med Chem Lett 2013;23:6777-83
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 6777-6783
    • Xin, M.1    Wen, J.2    Tang, F.3
  • 72
    • 84893650738 scopus 로고    scopus 로고
    • Synthesis and evaluation of n-(2-pyrimidinylamino) benzamides inhibitors of hedgehog signaling pathway
    • Xin M, Wen J, Tang F, et al. Synthesis and evaluation of N-(2-pyrimidinylamino) benzamides inhibitors of hedgehog signaling pathway. Bioorg Med Chem Lett 2014;24:983-8
    • (2014) Bioorg Med Chem Lett , vol.24 , pp. 983-988
    • Xin, M.1    Wen, J.2    Tang, F.3
  • 73
    • 84893729197 scopus 로고    scopus 로고
    • Design synthesis and evaluation of pyrrolo[2,1-f] [1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors
    • Xin M, Zhang L, Tang F, et al. Design, synthesis and evaluation of pyrrolo[2,1-f] [1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors. Bioorg Med Chem 2014;22:1429-40
    • (2014) Bioorg Med Chem , vol.22 , pp. 1429-1440
    • Xin, M.1    Zhang, L.2    Tang, F.3
  • 74
    • 84904429186 scopus 로고    scopus 로고
    • Design synthesis and biological study of 6,7-dihydro-5h-pyrano[2,3-d]pyrimidine derivatives as novel hedgehog signaling pathway inhibitors
    • Xin M, Zhang L, Shen H, et al. Design, synthesis, and biological study of 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine derivatives as novel hedgehog signaling pathway inhibitors. Med Chem Res 2014;23:3784-92
    • (2014) Med Chem Res , vol.23 , pp. 3784-3792
    • Xin, M.1    Zhang, L.2    Shen, H.3
  • 75
    • 84904060981 scopus 로고    scopus 로고
    • Five-membered heteroaromatic ring fused-pyrimidine derivatives: Design synthesis and hedgehog signaling pathway inhibition study
    • Zhang L, Xin M, Shen H, et al. Five-membered heteroaromatic ring fused-pyrimidine derivatives: design, synthesis, and hedgehog signaling pathway inhibition study. Bioorg Med Chem Lett 2014;24:3486-92
    • (2014) Bioorg Med Chem Lett , vol.24 , pp. 3486-3492
    • Zhang, L.1    Xin, M.2    Shen, H.3
  • 76
    • 84904050168 scopus 로고    scopus 로고
    • 4-(Pyrimidin-2-ylamino)benzamide derivatives: Design, synthesis, and hedgehog signaling pathway inhibition study
    • Zhang L, Xin M, Wen J, et al. 4-(Pyrimidin-2-ylamino)benzamide derivatives: design, synthesis, and hedgehog signaling pathway inhibition study. Chin J Org Chem 2014;34:1407-16
    • (2014) Chin J Org Chem , vol.34 , pp. 1407-1416
    • Zhang, L.1    Xin, M.2    Wen, J.3
  • 77
    • 84928343372 scopus 로고    scopus 로고
    • Application of rubia alata cyclopeptides as hedgehog signaling path inhibitor, and their preparation methods and application
    • Kunming Institute of Botany, Chinese Academy of Sciences, P. R. China
    • Kunming Institute of Botany, Chinese Academy of Sciences, P. R. China. Application of rubia alata cyclopeptides as hedgehog signaling path inhibitor, and their preparation methods and application. CN103877562; 2014
    • (2014) CN103877562
  • 78
    • 84928345403 scopus 로고    scopus 로고
    • Treatment of pancreatic and related cancers with 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines
    • Memorial Sloan-kettering Cancer Center, The Rochefeller University
    • Memorial Sloan-kettering Cancer Center, The Rochefeller University. Treatment of pancreatic and related cancers with 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines. WO142253; 2013
    • (2013) WO142253
  • 79
    • 84875424307 scopus 로고    scopus 로고
    • Inhibitors of hedgehog acyltransferase block sonic hedgehog signaling
    • This paper describes the identification of a series of small molecules that inhibit hedgehog signaling pathway vis inhibition of hedgehog acyltransferase
    • Petrova E, Rios-Esteves J, Ouerfelli O, et al. Inhibitors of hedgehog acyltransferase block sonic hedgehog signaling. Nat Chem Biol 2013;9:247-9 .. This paper describes the identification of a series of small molecules that inhibit hedgehog signaling pathway vis inhibition of hedgehog acyltransferase.
    • (2013) Nat Chem Biol , vol.9 , pp. 247-249
    • Petrova, E.1    Rios-Esteves, J.2    Ouerfelli, O.3
  • 80
    • 84928321739 scopus 로고    scopus 로고
    • Preparation of multiple-target antitumor compounds and useful in the treatment of cancer
    • Nanjing Huawei Pharmaceutical Science and Technology Development Co Ltd
    • Nanjing Huawei Pharmaceutical Science and Technology Development Co., Ltd. Preparation of multiple-target antitumor compounds and useful in the treatment of cancer. CN103923066; 2014
    • (2014) CN103923066
  • 81
    • 84928350576 scopus 로고    scopus 로고
    • Preparation of cyclic sulfonamide derivatives as inhibitors of hedgehog signaling pathway
    • Nant Holdings IP LLC
    • Nant Holdings IP, LLC. Preparation of cyclic sulfonamide derivatives as inhibitors of hedgehog signaling pathway. WO071298; 2014
    • (2014) WO071298
  • 83
    • 84862582197 scopus 로고    scopus 로고
    • Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation
    • Wang Y, Arvanites AC, Davidow L, et al. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS Chem Biol 2012;7:1040-8
    • (2012) ACS Chem Biol , vol.7 , pp. 1040-1048
    • Wang, Y.1    Arvanites, A.C.2    Davidow, L.3
  • 84
    • 84928335195 scopus 로고    scopus 로고
    • Preparation of signaling pathway inhibitors for treating tumors and osteoporosis
    • Sichuan University
    • Sichuan University. Preparation of signaling pathway inhibitors for treating tumors and osteoporosis. CN103040824; 2013
    • (2013) CN103040824
  • 85
    • 84894541846 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of novel benzamide derivatives as potent smoothened antagonists
    • Wu TM, Wang DC, Xiang P, et al. Synthesis and biological evaluation of novel benzamide derivatives as potent smoothened antagonists. Bioorg Med Chem Lett 2014;24:1426-31
    • (2014) Bioorg Med Chem Lett , vol.24 , pp. 1426-1431
    • Wu, T.M.1    Wang, D.C.2    Xiang, P.3
  • 86
    • 84928334880 scopus 로고    scopus 로고
    • Aminothiazole-pyridine heterocyclic compounds as hedgehog pathway antagonists and their preparation, pharmaceutical compositions and use in the treatment of cancer
    • Suzhou Yunxuan Pharmaceutical Co Ltd
    • Suzhou Yunxuan Pharmaceutical Co., Ltd. Aminothiazole-pyridine heterocyclic compounds as hedgehog pathway antagonists and their preparation, pharmaceutical compositions and use in the treatment of cancer. CN103524535; 2013
    • (2013) CN103524535
  • 87
    • 84928308986 scopus 로고    scopus 로고
    • Pyrimidine derivatives as hedgehog pathway antagonists and their preparation, pharmaceutical compositions and use in the treatment of cancer
    • Suzhou Yunxuan Pharmaceutical Co Ltd
    • Suzhou Yunxuan Pharmaceutical Co., Ltd. Pyrimidine derivatives as hedgehog pathway antagonists and their preparation, pharmaceutical compositions and use in the treatment of cancer. CN103588771; 2013
    • (2013) CN103588771
  • 88
    • 84928314390 scopus 로고    scopus 로고
    • Preparation of pyridine heterocyclic compounds with hedgehog pathway antagonist activity
    • Suzhou Yunxuan Pharmaceutical Co Ltd
    • Suzhou Yunxuan Pharmaceutical Co., Ltd. Preparation of pyridine heterocyclic compounds with hedgehog pathway antagonist activity. CN103923085; 2014
    • (2014) CN103923085
  • 89
    • 84928316744 scopus 로고    scopus 로고
    • Hedgehog pathway signaling inhibitors and therapeutic applications thereof
    • Xiaohu Z. Hedgehog pathway signaling inhibitors and therapeutic applications thereof. WO113191; 2014
    • (2014) WO113191
    • Xiaohu, Z.1
  • 90
    • 84862908595 scopus 로고    scopus 로고
    • Effective targeting of hedgehog signaling in a medulloblastoma model with pf-5274857, a potent and selective smoothened antagonist that penetrates the blood-brain barrier
    • Rohner A, Spilker ME, Lam JL, et al. Effective targeting of hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective smoothened antagonist that penetrates the blood-brain barrier. Mol Cancer Ther 2012;11:57-65
    • (2012) Mol Cancer Ther , vol.11 , pp. 57-65
    • Rohner, A.1    Spilker, M.E.2    Lam, J.L.3
  • 91
    • 84869449319 scopus 로고    scopus 로고
    • Development of a scalable route to the smo receptor antagonist sen794
    • Betti M, Castagnoli G, Panico A, et al. Development of a scalable route to the SMO receptor antagonist SEN794. Org Process Res Dev 2012;16:1739-45
    • (2012) Org Process Res Dev , vol.16 , pp. 1739-1745
    • Betti, M.1    Castagnoli, G.2    Panico, A.3
  • 92
    • 84899631938 scopus 로고    scopus 로고
    • Scaffold hopping approach to a new series of smoothened antagonist
    • Lu W, Geng D, Sun Z, et al. Scaffold hopping approach to a new series of smoothened antagonist. Bioorg Med Chem Lett 2014;24:2300-4
    • (2014) Bioorg Med Chem Lett , vol.24 , pp. 2300-2304
    • Lu, W.1    Geng, D.2    Sun, Z.3
  • 93
    • 84908667785 scopus 로고    scopus 로고
    • Design, synthesis, and structure-Activity-relationship of tetrahydrothiazolopyridine derivatives as potent smoothened antagonists
    • Ma H, Lu W, Sun Z, et al. Design, synthesis, and structure-Activity-relationship of tetrahydrothiazolopyridine derivatives as potent smoothened antagonists. Eur J Med Chem 2015;89:721-32
    • (2015) Eur J Med Chem , vol.89 , pp. 721-732
    • Ma, H.1    Lu, W.2    Sun, Z.3
  • 94
    • 84928339833 scopus 로고    scopus 로고
    • Imidazo bicycle imminium compounds as antitumor agents
    • The Board of Trustees of The Leland Stanford Junior University This patent describes the a series of imidazo bicycle imminiums that inhibit hedgehog signaling pathway vis targeting Gli1
    • The Board of Trustees of The Leland Stanford Junior University. Imidazo bicycle imminium compounds as antitumor agents. WO192301; 2013 .. This patent describes the a series of imidazo bicycle imminiums that inhibit hedgehog signaling pathway vis targeting Gli1.
    • (2013) WO192301
  • 95
    • 84928316825 scopus 로고    scopus 로고
    • Targeting gli proteins in human cancer by small molecules
    • The Regents of The University of California
    • The Regents of The University of California. Targeting Gli proteins in human cancer by small molecules. WO013190; 2013
    • (2013) WO013190
  • 96
    • 84928322352 scopus 로고    scopus 로고
    • Targeting gli proteins in human cancer by small molecules
    • The Regents of The University of California
    • The Regents of The University of California. Targeting Gli proteins in human cancer by small molecules. WO116651; 2014
    • (2014) WO116651
  • 97
    • 84899463037 scopus 로고    scopus 로고
    • Targeting gli transcription activation by small molecule suppresses tumor growth
    • This paper describes the identification of a series of small molecules that inhibit hedgehog signaling pathway vis regulating Gli expression
    • Bosco-Clement G, Zhang F, Chen Z, et al. Targeting gli transcription activation by small molecule suppresses tumor growth. Oncogene 2014;33:2087-97 .. This paper describes the identification of a series of small molecules that inhibit hedgehog signaling pathway vis regulating Gli expression.
    • (2014) Oncogene , vol.33 , pp. 2087-2097
    • Bosco-Clement, G.1    Zhang, F.2    Chen, Z.3
  • 98
    • 70350496540 scopus 로고    scopus 로고
    • Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma
    • This paper describes the identification of the first Smo mutants that confer resistance to hedgehog pathway inhibition with treatment of vismodegib
    • Yauch RL, Dijkgraaf GJP, Alicke B, et al. Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma. Science 2009;326:572-4 .. This paper describes the identification of the first Smo mutants that confer resistance to hedgehog pathway inhibition with treatment of vismodegib.
    • (2009) Science , vol.326 , pp. 572-574
    • Yauch, R.L.1    Dijkgraaf, G.J.P.2    Alicke, B.3
  • 99
    • 77958060845 scopus 로고    scopus 로고
    • Interfering with resistance to smoothened antagonists by inhibition of the pi3k pathway in medulloblastoma
    • Buonamici S, Williams J, Morriessey M, et al. Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma. Sci Transl Med 2010;2:51ra70
    • (2010) Sci Transl Med , vol.2 , pp. 51ra70
    • Buonamici, S.1    Williams, J.2    Morriessey, M.3
  • 100
    • 84863116579 scopus 로고    scopus 로고
    • Hedgehog and notch signaling regulate self-renewal of undifferentiated pleomorphic sarcomas
    • Wang CYY, Wei Q, Han I, et al. Hedgehog and notch signaling regulate self-renewal of undifferentiated pleomorphic sarcomas. Cancer Res 2012;72:1013-22
    • (2012) Cancer Res , vol.72 , pp. 1013-1022
    • Wang, C.Y.Y.1    Wei, Q.2    Han, I.3
  • 101
    • 84903143748 scopus 로고    scopus 로고
    • A phase ii study of vismodegib, a hedgehog (hh) pathway inhibitor, combined with gemcitabine and nab-paclitaxel (nab-p) in patients (pts) with untreated metastatic pancreatic ductal adenocarcinoma (pda)
    • abstract 257
    • Jesus-Acosta AD, O'Dwyer PJ, Ramanathan RK, et al. A phase II study of vismodegib, a hedgehog (hh) pathway inhibitor, combined with gemcitabine and nab-paclitaxel (nab-P) in patients (pts) with untreated metastatic pancreatic ductal adenocarcinoma (PDA). J Clin Oncol 2014;32(Suppl 3):abstract 257
    • (2014) J Clin Oncol , pp. 32
    • Jesus-Acosta, A.D.1    O'Dwyer, P.J.2    Ramanathan, R.K.3


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