Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6748-6753

  Castanedo, Georgette M ^a   Wang, Shumei ^a   Robarge, Kirk D ^a   Blackwood, Elizabeth ^a   Burdick, Daniel ^a   Chang, Christine ^a   Dijkgraaf, Gerrit J P ^a   Gould, Stephen ^a   Gunzner, Janet ^a   Guichert, Oivin ^b   Halladay, Jason ^a   Khojasteh, Cyrus ^a   Lee, Leslie ^a   Marsters Jr , James C ^a   Murray, Lesley ^a   Peterson, David ^a   Plise, Emile ^a   Salphati, Laurent ^a   De Sauvage, Frederic J ^a   Wong, Susan ^a   Sutherlin, Daniel P ^a   more..

^a GENENTECH INC   (United States)

^b CURIS INC   (United States)

Author keywords

Hedgehog pathway inhibitors

Indexed keywords

AMIDE; CYTOCHROME P450 3A4; GDC 0449; MESSENGER RNA; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG POTENCY; MEDULLOBLASTOMA; MOUSE; NONHUMAN; REACTION OPTIMIZATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TUMOR VOLUME;

AMIDES; ANIMALS; DRUG SCREENING ASSAYS, ANTITUMOR; HEDGEHOG PROTEINS; MICE; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

ERINACEIDAE; RATTUS;

EID: 77958029696     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.134     Document Type: Article

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