Scaffold hopping approach to a new series of smoothened antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 10, 2014, Pages 2300-2304

  Lu, Wenfeng ^a   Geng, Delong ^a   Sun, Zhijian ^b   Yang, Zhaohui ^a   Ma, Haikuo ^a   Zheng, Jiyue ^a   Zhang, Xiaohu ^a  

^a SOOCHOW UNIVERSITY   (China)

^b BeiGene   (China)

Author keywords

Antagonist; Cancer therapy; GPCR; Hedgehog pathway; Scaffold hopping; Smoothened

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN INHIBITOR; SMOOTHENED PROTEIN; SMOOTHENED PROTEIN ANTAGONIST; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; VISMODEGIB; G PROTEIN COUPLED RECEPTOR; SMO PROTEIN, HUMAN;

ARTICLE; CANCER THERAPY; CONTROLLED STUDY; DRUG SYNTHESIS; HYDROGENATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; NEOPLASMS;

ERINACEIDAE;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; HEDGEHOG PROTEINS; HUMANS; NEOPLASMS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84899631938     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.03.079     Document Type: Article

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