Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2- phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 1

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 15, 2011, Pages 4422-4428

  Malancona, Savina ^a   Altamura, Sergio ^a   Filocamo, Gessica ^a   Kinzel, Olaf ^a   Hernando, Jose Ignacio Martin ^a   Rowley, Michael ^a   Scarpelli, Rita ^a   Steinkühler, Christian ^a   Jones, Philip ^a  

^a IRBM   (Italy)

Author keywords

Hedgehog inhibitor; Hedgehog pathway; Smoothened antagonist

Indexed keywords

8A METHYL 1,3 DIOXO 2 (2 PHENYLCYCLOPROPYL) N (1 PHENYL 1H PYRAZOL 5 YL)HEXAHYDROIMID AZO[1,5 A]PYRAZINE 7(1H)CARBOXAMIDE; ANTINEOPLASTIC AGENT; HYDANTOIN; MK 5710; PYRAZINE DERIVATIVE; SONIC HEDGEHOG PROTEIN; TRANYLCYPROMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG IDENTIFICATION; HUMAN; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; HEDGEHOG PROTEINS; HUMANS; IMIDAZOLES; NEOPLASMS; PYRAZINES; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

ERINACEIDAE;

EID: 79960351998     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.024     Document Type: Article

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