Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 22, 2012, Pages 6751-6757

  Wang, Jiangbo ^a   Mook Jr , Robert A ^a   Lu, Jiuyi ^a   Gooden, David M ^b   Ribeiro, Anthony ^c   Guo, Anchen ^d   Barak, Larry S ^a   Kim Lyerly, H ^a   Chen, Wei ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Hedgehog signaling; High throughput screening; Smo antagonist; Smo mutation; Smoothened

Indexed keywords

BETA ARRESTIN; COMPOUND A8; CYCLOPAMINE; RECEPTOR BLOCKING AGENT; SMOOTHENED PROTEIN; SMOOTHENED RECEPTOR BLOCKING AGENT; SONIC HEDGEHOG PROTEIN; SONIDEGIB; UNCLASSIFIED DRUG; VISMODEGIB;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BASAL CELL CARCINOMA; BINDING COMPETITION; BINDING SITE; CELL PROLIFERATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG STRUCTURE; FEMALE; HAIR GROWTH; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INHIBITION KINETICS; MASS SPECTROMETRY; MEDULLOBLASTOMA; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN FUNCTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; THIN LAYER CHROMATOGRAPHY; WILD TYPE;

ANIMALS; BENZAMIDES; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; HAIR; HEDGEHOG PROTEINS; HUMANS; MICE; MICE, INBRED C57BL; MUTATION; NEURONS; PYRIDINES; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

ERINACEIDAE;

EID: 84867848829     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.09.030     Document Type: Article

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