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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6777-6783

The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors

(6) Xin, Minhang a Wen, Jun a Tang, Feng a Tu, Chongxing a Shen, Han a Zhao, Xinge a

a Jiangsu Simcere Pharmaceutical R and D Co Ltd (China)

Author keywords

Hedgehog signaling; Hedgehog signaling pathway inhibitors; Lead compound; Synthesize

Indexed keywords

BENZAMIDE DERIVATIVE; BMS 833923; LY 2940680; PF 04449913; SARIDEGIB; SONIC HEDGEHOG PROTEIN; SONIDEGIB; TAK 441; UNCLASSIFIED DRUG; VISMODEGIB;

ARTICLE; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VIVO STUDY; POLYMERIZATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ERINACEIDAE;

HEDGEHOG SIGNALING; HEDGEHOG SIGNALING PATHWAY INHIBITORS; LEAD COMPOUND; SYNTHESIZE;

ANIMALS; BENZAMIDES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HALF-LIFE; HEDGEHOG PROTEINS; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84888868222 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.10.022 Document Type: Article

Times cited : (30)

References (27)

1
- 0035822098
- X. Zeng, J.A. Goetz, L.M. Suber, W.J. Scott Jr, C.M. Schreiner, and D.J. Robbins Nature 411 2001 716
- (2001) Nature , vol.411 , pp. 716
- Zeng, X.¹ Goetz, J.A.² Suber, L.M.³ Scott, Jr.W.J.⁴ Schreiner, C.M.⁵ Robbins, D.J.⁶

2
- 84862907616
- Y. Li, M.Y. Maitah, A. Ahmad, D. Kong, B. Bao, and F.H. Sarkar Exp. Opin. Ther. Targets 16 2012 49
- (2012) Exp. Opin. Ther. Targets , vol.16 , pp. 49
- Li, Y.¹ Maitah, M.Y.² Ahmad, A.³ Kong, D.⁴ Bao, B.⁵ Sarkar, F.H.⁶

3
- 0011102935
- D.M. Stone, M. Hynes, M. Armanini, T.A. Swanson, Q. Gu, R.L. Johnson, M.P. Scott, D. Pennica, A. Goddard, H. Phillips, M. Noll, J.E. Hooper, F. Sauvage, and A. Rosenthal Nature 384 1996 129
- (1996) Nature , vol.384 , pp. 129
- Stone, D.M.¹ Hynes, M.² Armanini, M.³ Swanson, T.A.⁴ Gu, Q.⁵ Johnson, R.L.⁶ Scott, M.P.⁷ Pennica, D.⁸ Goddard, A.⁹ Phillips, H.¹⁰ Noll, M.¹¹ Hooper, J.E.¹² Sauvage, F.¹³ Rosenthal, A.¹⁴

4
- 63149124772
- H. Tian, C.A. Callahan, K.J. DuPree, W.C. Darbonne, C.P. Ahn, S.J. Scales, and F. Sauvage Proc. Natl. Acad. Sci. U.S.A. 106 2009 4254
- (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 4254
- Tian, H.¹ Callahan, C.A.² Dupree, K.J.³ Darbonne, W.C.⁴ Ahn, C.P.⁵ Scales, S.J.⁶ Sauvage, F.⁷

5
- 84855888693
- H. Onishi, and M. Katano Cancer Sci. 102 2011 1756
- (2011) Cancer Sci. , vol.102 , pp. 1756
- Onishi, H.¹ Katano, M.²

6
- 33751549095
- L.L. Rubin, and F.J. de Sauvage Nat. Rev. Drug Disc. 5 2006 1026
- (2006) Nat. Rev. Drug Disc. , vol.5 , pp. 1026
- Rubin, L.L.¹ De Sauvage, F.J.²

7
- 80955181031
- J.M. Ng, and T. Curran Nat. Rev. Cancer 11 2011 493
- (2011) Nat. Rev. Cancer , vol.11 , pp. 493
- Ng, J.M.¹ Curran, T.²

8
- 79960935826
- C. Metcalfe, and F.J. de Sauvage Cancer Res. 71 2011 5057
- (2011) Cancer Res. , vol.71 , pp. 5057
- Metcalfe, C.¹ De Sauvage, F.J.²

9
- 77953693899
- A.A. Merchant, and W. Matsui Clin. Cancer Res. 16 2010 3130
- (2010) Clin. Cancer Res. , vol.16 , pp. 3130
- Merchant, A.A.¹ Matsui, W.²

10
- 79957922542
- G. Guerlet, T. Spangenberg, A. Mann, H. Faure, and M. Ruat Bioorg. Med. Chem. Lett. 21 2011 3608
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 3608
- Guerlet, G.¹ Spangenberg, T.² Mann, A.³ Faure, H.⁴ Ruat, M.⁵

11
- 79960351998
- S. Malancona, S. Altamura, G. Filocamo, O. Kinzel, J.I. Hernando, M. Rowley, R. Scarpelli, C. Steinkühler, and P. Jones Bioorg. Med. Chem. Lett. 21 2011 4422
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 4422
- Malancona, S.¹ Altamura, S.² Filocamo, G.³ Kinzel, O.⁴ Hernando, J.I.⁵ Rowley, M.⁶ Scarpelli, R.⁷ Steinkühler, C.⁸ Jones, P.⁹

12
- 79960349060
- O. Kinzel, A. Alfieri, S. Altamura, M. Brunetti, S. Bufali, F. Colaceci, F. Ferrigno, G. Filocamo, M. Fonsi, P. Gallinari, S. Malancona, J.I. Hernando, E. Monteagudo, M.V. Orsale, M.C. Palumbi, V. Pucci, M. Rowley, R. Sasso, R. Scarpelli, C. Steinkühler, and P. Jones Bioorg. Med. Chem. Lett. 21 2011 4429
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 4429
- Kinzel, O.¹ Alfieri, A.² Altamura, S.³ Brunetti, M.⁴ Bufali, S.⁵ Colaceci, F.⁶ Ferrigno, F.⁷ Filocamo, G.⁸ Fonsi, M.⁹ Gallinari, P.¹⁰ Malancona, S.¹¹ Hernando, J.I.¹² Monteagudo, E.¹³ Orsale, M.V.¹⁴ Palumbi, M.C.¹⁵ Pucci, V.¹⁶ Rowley, M.¹⁷ Sasso, R.¹⁸ Scarpelli, R.¹⁹ Steinkühler, C.²⁰ Jones, P.²¹ more..

13
- 81155159749
- M.L. Brown, W. Aaron, R.J. Austin, A. Chong, T. Huang, B. Jiang, J.A. Kaizerman, G. Lee, B.S. Lucas, D.L. McMinn, J. Orf, M. Rong, M.M. Toteva, G. Xu, Q. Ye, W. Zhong, M.R. Degraffenreid, D. Wickramasinghe, J.P. Powers, R. Hungate, and M.G. Johnson Bioorg. Med. Chem. Lett. 21 2011 5206
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 5206
- Brown, M.L.¹ Aaron, W.² Austin, R.J.³ Chong, A.⁴ Huang, T.⁵ Jiang, B.⁶ Kaizerman, J.A.⁷ Lee, G.⁸ Lucas, B.S.⁹ McMinn, D.L.¹⁰ Orf, J.¹¹ Rong, M.¹² Toteva, M.M.¹³ Xu, G.¹⁴ Ye, Q.¹⁵ Zhong, W.¹⁶ Degraffenreid, M.R.¹⁷ Wickramasinghe, D.¹⁸ Powers, J.P.¹⁹ Hungate, R.²⁰ Johnson, M.G.²¹ more..

14
- 80051942180
- J.M. Ontoria, L.L. Bufi, C. Torrisi, A. Bresciani, C. Giomini, M. Rowley, S. Serafini, H. Bin, W. Hao, C. Steinkühler, and P. Jones Bioorg. Med. Chem. Lett. 21 2011 5274
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 5274
- Ontoria, J.M.¹ Bufi, L.L.² Torrisi, C.³ Bresciani, A.⁴ Giomini, C.⁵ Rowley, M.⁶ Serafini, S.⁷ Bin, H.⁸ Hao, W.⁹ Steinkühler, C.¹⁰ Jones, P.¹¹

15
- 80051921468
- E. Muraglia, J.M. Ontoria, D. Branca, G. Dessole, A. Bresciani, M. Fonsi, C. Giuliano, L. Llauger Bufi, E. Monteagudo, M.C. Palumbi, C. Torrisi, M. Rowley, C. Steinkühler, and P. Jones Bioorg. Med. Chem. Lett. 21 2011 5283
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 5283
- Muraglia, E.¹ Ontoria, J.M.² Branca, D.³ Dessole, G.⁴ Bresciani, A.⁵ Fonsi, M.⁶ Giuliano, C.⁷ Llauger Bufi, L.⁸ Monteagudo, E.⁹ Palumbi, M.C.¹⁰ Torrisi, C.¹¹ Rowley, M.¹² Steinkühler, C.¹³ Jones, P.¹⁴

16
- 84867848829
- J. Wang, R.A. Mook Jr., J. Lu, D.M. Gooden, A. Ribeiro, A. Guo, L.S. Barak, H.K. Lyerly, and W. Chen Bioorg. Med. Chem. 20 2012 6751
- (2012) Bioorg. Med. Chem. , vol.20 , pp. 6751
- Wang, J.¹ Mook, Jr.R.A.² Lu, J.³ Gooden, D.M.⁴ Ribeiro, A.⁵ Guo, A.⁶ Barak, L.S.⁷ Lyerly, H.K.⁸ Chen, W.⁹

17
- 57749098407
- S. Peukert, R.K. Jain, A. Geisser, Y. Sun, R. Zhang, A. Bourret, A. Carlson, J. Dasilva, A. Ramamurthy, and J.F. Kelleher Bioorg. Med. Chem. Lett. 19 2009 328
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 328
- Peukert, S.¹ Jain, R.K.² Geisser, A.³ Sun, Y.⁴ Zhang, R.⁵ Bourret, A.⁶ Carlson, A.⁷ Dasilva, J.⁸ Ramamurthy, A.⁹ Kelleher, J.F.¹⁰

18
- 84863172647
- M.J. Munchhof, Q. Li, A. Shavnya, G.V. Borzillo, T.L. Boyden, C.S. Jones, S.D. LaGreca, L. Martinez-Alsina, N. Patel, K. Pelletier, L.A. Reiter, M.D. Robbins, and G.T. Tkalcevic ACS Med. Chem. Lett. 3 2012 106
- (2012) ACS Med. Chem. Lett. , vol.3 , pp. 106
- Munchhof, M.J.¹ Li, Q.² Shavnya, A.³ Borzillo, G.V.⁴ Boyden, T.L.⁵ Jones, C.S.⁶ Lagreca, S.D.⁷ Martinez-Alsina, L.⁸ Patel, N.⁹ Pelletier, K.¹⁰ Reiter, L.A.¹¹ Robbins, M.D.¹² Tkalcevic, G.T.¹³

19
- 84881030230
- S. Peukert, F. He, M. Dai, R. Zhang, Y. Sun, K. Miller-Mislin, M. McEwan, B. Lagu, K. Wang, N. Yusuff, A. Bourret, A. Ramamurthy, A. Vattay, A. Wang, R. Guo, J. Yuan, J. Green, J. Williams, S. Buonamici, J.F. Kelleher, and M. Dorsch ChemMedChem 8 2013 1261
- (2013) ChemMedChem , vol.8 , pp. 1261
- Peukert, S.¹ He, F.² Dai, M.³ Zhang, R.⁴ Sun, Y.⁵ Miller-Mislin, K.⁶ McEwan, M.⁷ Lagu, B.⁸ Wang, K.⁹ Yusuff, N.¹⁰ Bourret, A.¹¹ Ramamurthy, A.¹² Vattay, A.¹³ Wang, A.¹⁴ Guo, R.¹⁵ Yuan, J.¹⁶ Green, J.¹⁷ Williams, J.¹⁸ Buonamici, S.¹⁹ Kelleher, J.F.²⁰ Dorsch, M.²¹ more..

20
- 84861903142
- A. Dlugosz, S. Agrawal, and P. Kirkpatrick Nat. Rev. Drug Disc. 11 2012 437
- (2012) Nat. Rev. Drug Disc. , vol.11 , pp. 437
- Dlugosz, A.¹ Agrawal, S.² Kirkpatrick, P.³

21
- 84888860172
- https://www.thomson-pharma.com/.

22
- 33847381100
- P.J. Hajduk, and J. Greer Nat. Rev. Drug Disc. 6 2007 211
- (2007) Nat. Rev. Drug Disc. , vol.6 , pp. 211
- Hajduk, P.J.¹ Greer, J.²

23
- 79953795527
- S. Möcklinghoff, W.A. van Otterlo, R. Rose, S. Fuchs, T.J. Zimmermann, Seoane. M. Dominguez, H. Waldmann, C. Ottmann, and L. Brunsveld J. Med. Chem. 54 2011 2005
- (2011) J. Med. Chem. , vol.54 , pp. 2005
- Möcklinghoff, S.¹ Van Otterlo, W.A.² Rose, R.³ Fuchs, S.⁴ Zimmermann, T.J.⁵ Dominguez, Seoane.M.⁶ Waldmann, H.⁷ Ottmann, C.⁸ Brunsveld, L.⁹

24
- 79955431673
- H. Tao, Q. Jin, D.I. Koo, X. Liao, N.P. Englund, Y. Wang, A. Ramamurthy, P.G. Schultz, M. Dorsch, J. Kelleher, and X. Wu Chem. Biol. 18 2011 432
- (2011) Chem. Biol. , vol.18 , pp. 432
- Tao, H.¹ Jin, Q.² Koo, D.I.³ Liao, X.⁴ Englund, N.P.⁵ Wang, Y.⁶ Ramamurthy, A.⁷ Schultz, P.G.⁸ Dorsch, M.⁹ Kelleher, J.¹⁰ Wu, X.¹¹

25
- 69949084378
- K.D. Robarge, S.A. Brunton, G.M. Castanedo, Y. Cui, M.S. Dina, R. Goldsmith, S.E. Gould, O. Guichert, J.L. Gunzner, J. Halladay, W. Jia, C. Khojasteh, M.F. Koehler, K. Kotkow, H. La, R.L. Lalonde, K. Lau, L. Lee, D. Marshall, J.C. Marsters Jr., L.J. Murray, C. Qian, L.L. Rubin, L. Salphati, M.S. Stanley, J.H. Stibbard, D.P. Sutherlin, S. Ubhayaker, S. Wang, S. Wong, and M. Xie Bioorg. Med. Chem. Lett. 19 2009 5576
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 5576
- Robarge, K.D.¹ Brunton, S.A.² Castanedo, G.M.³ Cui, Y.⁴ Dina, M.S.⁵ Goldsmith, R.⁶ Gould, S.E.⁷ Guichert, O.⁸ Gunzner, J.L.⁹ Halladay, J.¹⁰ Jia, W.¹¹ Khojasteh, C.¹² Koehler, M.F.¹³ Kotkow, K.¹⁴ La, H.¹⁵ Lalonde, R.L.¹⁶ Lau, K.¹⁷ Lee, L.¹⁸ Marshall, D.¹⁹ Marsters, Jr.J.C.²⁰ more..

26
- 84866246074
- T. Ohashi, Y. Oguro, T. Tanaka, Z. Shiokawa, S. Shibata, Y. Sato, H. Yamakawa, H. Hattori, Y. Yamamoto, S. Kondo, M. Miyamoto, H. Tojo, A. Baba, and S. Sasaki Bioorg. Med. Chem. 20 2012 5496
- (2012) Bioorg. Med. Chem. , vol.20 , pp. 5496
- Ohashi, T.¹ Oguro, Y.² Tanaka, T.³ Shiokawa, Z.⁴ Shibata, S.⁵ Sato, Y.⁶ Yamakawa, H.⁷ Hattori, H.⁸ Yamamoto, Y.⁹ Kondo, S.¹⁰ Miyamoto, M.¹¹ Tojo, H.¹² Baba, A.¹³ Sasaki, S.¹⁴

27
- 84888875433
- D.J. Fenick, and D.E. Falvey J. Org. Chem. 59 1994 479
- (1994) J. Org. Chem. , vol.59 , pp. 479
- Fenick, D.J.¹ Falvey, D.E.²

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