Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists

Molecular Pharmacology

Volumn 78, Issue 4, 2010, Pages 658-665

  Manetti, Fabrizio ^a   Faure, Helene ^b   Roudaut, Hermine ^b   Gorojankina, Tatiana ^b   Traiffort, Elisabeth ^b   Schoenfelder, Angele ^a,c   Mann, Andre ^c   Solinas, Antonio ^a,c   Taddei, Maurizio ^a   Ruat, Martial ^b  

^a UNIVERSITY OF SIENA   (Italy)

^b CNRS   (France)

^c UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHOXY N [3 (2 METHYLBENZAMIDO)PHENYLCARBAMOTHIOYL] 3 NITROBENZAMIDE; CYCLOPAMINE; MRT 10; MRT 14; MRT 24; MRT 29; MRT 31; MRT 39; MRT 42; N (3 BENZAMIDOPHENYLCARBAMOTHIOYL) 3,4 DIMETHOXYBENZAMIDE; N (3 BENZAMIDOPHENYLCARBAMOTHIOYL) 3,4,5 TRIMETHOXYBENZAMIDE; N (3 BENZAMIDOPHENYLCARBAMOYL) 3,4,5 TRIMETHOXYBENZAMIDE; N [1 (BENZO[D][1,3]DIOXOL 5 YLMETHYL) 5 (PIPERAZINE 1 CARBONYL)PYRROLIDIN 3 YL] N (3 METHOXYBENZYL) 3,3 DIMETHYLBUTANAMIDE; N [3 (3 BIPHENYLCARBONYLTHIOUREIDO)PHENYL]FURAN 2 CARBOXAMIDE; N [3 [3 (3,4 DIMETHOXYBENZOYL)THIOUREIDO]PHENYL]FURAN 2 CARBOXAMIDE; N [4 CHLORO 3 [6 (DIMETHYLAMINO) 1H BENZO[D]IMIDAZOL 2 YL]PHENYL] 2,3 DIHYDROBENZO[B][1,4]DIOXINE 6 CARBOXAMIDE; N [5 (BENZO[D]THIAZOL 2 YL) 2 METHYLPHENYLCARBAMOTHIOYL] 3,4 DIMETHOXYBENZAMIDE; PROTEIN INHIBITOR; SMOOTHENED PROTEIN; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; SMO PROTEIN, MOUSE; THIOUREA;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; IC 50; PHARMACOPHORE; PRIORITY JOURNAL; ANIMAL; ANTAGONISTS AND INHIBITORS; C3H MOUSE; CELL LINE; CHEMISTRY; COMPARATIVE STUDY; DRUG DEVELOPMENT; LIBRARY; METABOLISM; MOUSE; PHYSIOLOGY; PROCEDURES;

ANIMALS; CELL LINE; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; LIBRARIES, DIGITAL; MICE; MICE, INBRED C3H; RECEPTORS, G-PROTEIN-COUPLED; THIOUREA;

EID: 77957245263     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.065102     Document Type: Article

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