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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 3, 2014, Pages 983-988

Synthesis and evaluation of 4-(2-pyrimidinylamino) benzamides inhibitors of hedgehog signaling pathway

(10) Xin, Minhang a,b Wen, Jun b Tang, Feng b Tu, Chongxing b Huang, Wei b Shen, Han b Zhao, Xinge b Cheng, Lingfei b Wang, Mengyu b Zhang, Liandi b

a XI'AN JIAOTONG UNIVERSITY (China)

b Jiangsu Simcere Pharmaceutical RandD Co Ltd (China)

Author keywords

Hedgehog signaling pathway; Inhibitors; Pharmacokinetic properties; SAR

Indexed keywords

4 (2 PYRIMIDINYLAMINO) BENZAMIDE; ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; VISMODEGIB;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG POTENCY; DRUG SYNTHESIS; NONHUMAN; RAT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ERINACEIDAE;

HEDGEHOG SIGNALING PATHWAY; INHIBITORS; PHARMACOKINETIC PROPERTIES; SAR;

BENZAMIDES; HEDGEHOG PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; PYRIMIDINES; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84893650738 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.12.050 Document Type: Article

Times cited : (19)

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