Development of a scalable route to the SMO receptor antagonist SEN794

Organic Process Research and Development

Volumn 16, Issue 11, 2012, Pages 1739-1745

  Betti, Matteo ^a   Castagnoli, Giulio ^a,b   Panico, Alessandro ^a,c   Sanna Coccone, Salvatore ^a   Wiedenau, Paul ^a  

^a Siena Biotech SpA   (Italy)

^b BASF   (Italy)

^c NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE FORMATION; HIGH PURITY; REACTION MIXTURE; RECEPTOR ANTAGONISTS; REDUCING COSTS; TARGET COMPOUND;

AMIDES; CRUDE OIL; PALLADIUM; SYNTHESIS (CHEMICAL);

REACTION INTERMEDIATES;

EID: 84869449319     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op300170q     Document Type: Article

References (13)

1. Jiang, J.; Hui, C. Dev. Cell 2008, 15, 801
2. Yang, L.; Xie, G.; Fan, Q.; Xie, J. Oncogene 2010, 29, 469
3. Mas, C.; Ruiz i Altaba, A. Biochem. Pharmacol. 2010, 80, 712
4. LoRusso, P. M.; Rudin, C. M.; Reddy, J. C.; Tibes, R.; Weiss, G. J.; Borad, M. J.; Hann, C. L.; Brahmer, J. R.; Chang, I.; Darbonne, W. C.; Graham, R. A.; Zerivitz, K. L.; Low, J. A.; Von Hoff, D. D. Clin. Cancer Res. 2011, 17, 2502
5. Pericot, M. G.; Thomas, R. J.; Minetto, G.; Bellini, M.; Wiedenau, P. H.; Betti, M. Compound for the treatment of tumours and tumour metastases. PCT Int. Appl. WO 2012/076413 14/06/2012.
6. Kröhnke, F. Synthesis 1976, 1 (Review)
7. Sasaki, I.; Vendier, L.; Sournia-Saquet, A.; Lacroix, P. G. Eur. J. Inorg. Chem. 2006, 3294
8. Meyers, C.; Maes, B. U. W.; Loones, K. T. J.; Bal, G.; Lemiere, G. L. F.; Dommisse, R. A. J. Org. Chem. 2004, 69, 6010
9. Wang, L.; Green, L.; Li, Z.; McCabe-Dunn, J.; Bu, X.; Welch, C. J.; Li, C.; Wang, T.; Tu, Q.; Bekos, E.; Richardson, D.; Eckert, J.; Cui, J. Org. Process Res. Dev. 2011, 15, 1371
10. Flahive, E. J.; Ewanicki, B. L.; Sach, N. W.; O'Neill-Slawecki, S. A.; Stancovic, N. S.; Yu, S.; Guiness, S. M.; Dunn, J. Org. Process Res. Dev. 2008, 12, 637
11. Rosso, V. M.; Lust, D. A.; Bernot, P. J.; Grosso, J. A.; Modi, S. P.; Rusowicz, A.; Sedergran, T. C.; Simpson, J. H.; Srivastava, S. K.; Humora, M. J.; Anderson, N. G. Org. Process Res. Dev. 1997, 1, 311
12. Urawa, Y; Miyazawa, M.; Ozeki, N.; Ogura, K. Org. Process Res. Dev. 2003, 7, 191
13. Bullock, K. M.; Mitchell, M. B.; Toczko, J. F. Org. Process Res. Dev. 2008, 12, 896